Rv3919c rRNA small subunit 7-methylguanosine (m7G) methyltransferase GidB

Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv3919c gid rRNA small subunit 7-methylguanosine (m7G) methyltransferase GidB CDS 4407528 4408202 - 675 224 FALSE

Rv3919c (rRNA small subunit 7-methylguanosine (m7G) methyltransferase GidB) is predicted to be co-regulated in modules bicluster_0209 with residual 0.57 and bicluster_0224 with residual 0.55.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 0.00 and 1,300.00 for bicluster_0209 and 480.00 and 27.00 for bicluster_0224 respectively.

These modules are enriched for following go terms: regulation of cellular process, regulation of biological process, biological regulation.

This gene is found to be for growth on cholesterol.

Mutant available?:

Displaying 1 - 1 of 1
Gene Target Differential Expression Distance Expression pvalue Type
No results were found
Displaying 1 - 7 of 7
ChipSeq TF Differential Expression Distance Expression pvalue Type
No 44 -0.19 0.999609 Internal.TSS
Transcriptional regulator, PadR family
No -67 -0.23 0.962221 Internal.TSS
No -92 -0.19 0.999609 CDS
Transcriptional regulator, TetR family
No 54 -0.16 0.854466 Internal.TSS
Transcriptional regulator, TetR family
No 24 -0.02 0.992046 CDS
Transcriptional regulator, TetR family
No -33 -0.07 0.957738 Internal.TSS
transcriptional regulator, ArsR family
No 47 0.12 0.667139 CDS
Motif 1 Motif 2 Residual
Motif Bicluster: 
Motif Bicluster: 
Motif Bicluster: 
Motif Bicluster: 
Product (LegacyBRC) Product (RefSeq)
Ribosomal RNA small subunit methyltransferase G 16S rRNA methyltransferase GidB
Operon # Operon
2555 - -
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics


Not assigned Not assigned
Locus Tuberculist Genome View


Locus Tag KEGG Pathways


not assigned to any KEGG Pathway.
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network


GI Number Protein ID Blast Conserved Domains
15611055 NP_218436.1 Run

plasma membrane

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO Category: 
Total items in this category:  
Description:Expression data from transcription factor over expression experiments. TFOE are matched to the ChIP-seq experiment done simultaneously. This dataset is described in Rustad et al. 2014, Genome Biology.
Quantitative Proteomics Data
t-test p-value Cholesterol/Glycerol Ratio
0.010000 0.35

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated:
p-value INH: