Organism : Bacillus subtilis | Module List :
BSU14080 ykuH

hypothetical protein (RefSeq)

CircVis
Functional Annotations (0)

Warning: No Functional annotations were found!

GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for BSU14080
(Mouseover regulator name to see its description)

BSU14080 is regulated by 18 influences and regulates 0 modules.
Regulators for BSU14080 ykuH (18)
Regulator Module Operator
BSU01810 157 tf
BSU03880 157 tf
BSU05060 157 tf
BSU05180 157 tf
BSU05460 157 tf
BSU05850 157 tf
BSU19200 157 tf
BSU25100 157 tf
BSU29030 157 tf
BSU08520 151 tf
BSU13880 151 tf
BSU14990 151 tf
BSU19100 151 tf
BSU19200 151 tf
BSU23590 151 tf
BSU24520 151 tf
BSU25100 151 tf
BSU33740 151 tf

Warning: BSU14080 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
5252 7.70e-05 Tgagaat.aTTataA.ATaAg
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5253 9.00e+01 AGaAAggaA.G
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5262 1.60e-03 CTCCTTtctcA
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5263 6.40e-02 ctTtcCaTT.attA.TcgCcGg.C
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for BSU14080

Warning: No Functional annotations were found!

Module neighborhood information for BSU14080

BSU14080 has total of 59 gene neighbors in modules 151, 157
Gene neighbors (59)
Gene Common Name Description Module membership
BSU01800 alkA DNA-3-methyladenine glycosylase (RefSeq) 115, 157
BSU01810 adaA methylphosphotriester-DNA alkyltransferase and transcriptional regulator (AraC/XylS family) (RefSeq) 157, 406
BSU03020 ycgA putative integral inner membrane protein (RefSeq) 157, 161
BSU03970 ycnL putative reductase or disulfide isomerase (RefSeq) 151, 226
BSU04770 ydcH putative transcriptional regulator (RefSeq) 151, 258
BSU05060 lrpB transcriptional regulator (Lrp/AsnC family) (RefSeq) 115, 157
BSU05120 cspC cold-shock protein (RefSeq) 151, 159
BSU05150 ydeC putative transcriptional regulator (AraC/XylS family) (RefSeq) 157, 216
BSU05170 ydeE putative transcriptional regulator (AraC/XylS family) (RefSeq) 115, 157
BSU05210 ydeI hypothetical protein (RefSeq) 115, 157
BSU05290 ydeP putative transcriptional regulator (RefSeq) 151, 200
BSU05300 ydeQ putative NAD(P)H oxidoreductase (RefSeq) 151, 161
BSU05460 ydfL putative transcriptional regulator of efflux transporter (RefSeq) 115, 157
BSU07490 yfmF iron-dicitrate ABC transporter (ATP-binding protein) (RefSeq) 31, 151
BSU07500 yfmE iron-dicitrate ABC transporter (permease) (RefSeq) 66, 151
BSU07670 yflI hypothetical protein (RefSeq) 123, 151
BSU07970 yfjT hypothetical protein (RefSeq) 94, 157
BSU11110 yitS hypothetical protein (RefSeq) 157, 215
BSU11270 yjzD hypothetical protein (RefSeq) 64, 157
BSU11280 yjaU hypothetical protein (RefSeq) 64, 157
BSU11890 yjcK putative ribosomal-protein-alanine N-acetyltransferase (RefSeq) 157, 216
BSU12200 yjiA hypothetical protein (RefSeq) 115, 157
BSU13450 sigI putative RNA polymerase sigma factor SigI (RefSeq) 151, 379
BSU14080 ykuH hypothetical protein (RefSeq) 151, 157
BSU17620 yncB DNA nuclease, lipoprotein (RefSeq) 151, 379
BSU18390 yoeC putative bacteriophage integrase (RefSeq) 94, 157
BSU19020 yobN putative amine oxidase (RefSeq) 114, 157
BSU19190 desK two-component sensor histidine kinase [DesR] (RefSeq) 157, 406
BSU19200 desR two-component response regulator [DesK] (RefSeq) 157, 378
BSU19350 yocS putative sodium-dependent transporter (RefSeq) 157, 365
BSU21750 scuA assembly factor BSco of the Cu(A) site of cytochrome c oxidase (RefSeq) 157, 219
BSU21970 ypeP hypothetical protein (RefSeq) 157, 311
BSU21980 ypdP putative integral inner membrane protein (RefSeq) 157, 311
BSU23000 ypbE hypothetical protein (RefSeq) 151, 311
BSU23010 ypbD putative membrane protease (RefSeq) 151, 226
BSU23020 recQ ATP-dependent DNA helicase (RefSeq) 151, 311
BSU23030 ypbB hypothetical protein (RefSeq) 151, 311
BSU23040 fer ferredoxin (RefSeq) 94, 151
BSU23320 ypzC hypothetical protein (RefSeq) 121, 157
BSU23590 ansR transcriptional regulator of ansAB (Xre family) (RefSeq) 151, 258
BSU25070 ispG 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (RefSeq) 151, 200
BSU25090 yqfW putative nucleotidase (RefSeq) 151, 159
BSU25560 holA DNA polymerase III subunit delta (RefSeq) 151, 159
BSU26620 yrdR putative efflux transporter (RefSeq) 157, 226
BSU27190 yrzI hypothetical protein (RefSeq) 49, 157
BSU28180 ysxD putative integral inner membrane protein (RefSeq) 151, 270
BSU29030 ytcD putative transcriptional regulator (MarD family) (RefSeq) 157, 161
BSU29920 ytmP putative kinase/phosphotransferase (RefSeq) 14, 151
BSU29970 ytkP putative cysteine synthase-like protein (RefSeq) 66, 151
BSU30070 opuD glycine betaine transporter (RefSeq) 14, 151
BSU33030 yuxN putative transcriptional regulator (RefSeq) 151, 216
BSU35530 tagO UDP-N-acetylglucosamine:undecaprenyl-P N-acetylglucosaminyl-1-P transferase (RefSeq) 151, 226
BSU36540 ywnJ putative integral inner membrane protein (RefSeq) 157, 311
BSU37610 ywzC hypothetical protein (RefSeq) 151, 397
BSU37740 bacA bacilysin biosynthesis protein, dehydratase (RefSeq) 157, 217
BSU38360 ywbD putative AdoMet-dependent methyltransferase (RefSeq) 116, 157
BSU38490 menA 1,4-dihydroxy-2-naphthoate octaprenyltransferase (RefSeq) 14, 151
BSU40720 yyaT putative acetyltransferase (RefSeq) 151, 270
BSU40730 yyaS putative integral inner membrane protein (RefSeq) 151, 270
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for BSU14080
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend