Organism : Bacillus subtilis | Module List :
BSU28930 lytS

two-component sensor histidine kinase [LytT] (RefSeq)

CircVis
Functional Annotations (8)
Function System
Putative regulator of cell autolysis cog/ cog
two-component sensor activity go/ molecular_function
two-component signal transduction system (phosphorelay) go/ biological_process
ATP binding go/ molecular_function
cellular cell wall organization go/ biological_process
integral to membrane go/ cellular_component
peptidyl-histidine phosphorylation go/ biological_process
Two-component system kegg/ kegg pathway
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for BSU28930
(Mouseover regulator name to see its description)

BSU28930 is regulated by 24 influences and regulates 0 modules.
Regulators for BSU28930 lytS (24)
Regulator Module Operator
BSU01810 172 tf
BSU02970 172 tf
BSU13150 172 tf
BSU15690 172 tf
BSU15970 172 tf
BSU16600 172 tf
BSU19200 172 tf
BSU23210 172 tf
BSU24320 172 tf
BSU30020 172 tf
BSU36020 172 tf
BSU37160 172 tf
BSU40670 172 tf
BSU40800 172 tf
BSU03080 339 tf
BSU04060 339 tf
BSU08300 339 tf
BSU26390 339 tf
BSU26720 339 tf
BSU28400 339 tf
BSU30020 339 tf
BSU30460 339 tf
BSU33740 339 tf
BSU40670 339 tf

Warning: BSU28930 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
5292 1.70e+00 AAAAAAaCAgTCAgCCGCAA
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5293 1.50e+01 AACAtGagCcTTTTGgCaG
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5612 1.00e+00 AGCaTGTTcTc.TtTTgttGct
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5613 4.10e+01 AaATaAAacAtgagCCTTtTGgcA
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for BSU28930

BSU28930 is enriched for 8 functions in 3 categories.
Enrichment Table (8)
Function System
Putative regulator of cell autolysis cog/ cog
two-component sensor activity go/ molecular_function
two-component signal transduction system (phosphorelay) go/ biological_process
ATP binding go/ molecular_function
cellular cell wall organization go/ biological_process
integral to membrane go/ cellular_component
peptidyl-histidine phosphorylation go/ biological_process
Two-component system kegg/ kegg pathway
Module neighborhood information for BSU28930

BSU28930 has total of 44 gene neighbors in modules 172, 339
Gene neighbors (44)
Gene Common Name Description Module membership
BSU03070 mdr multidrug-efflux transporter (RefSeq) 11, 339
BSU03080 ycgE putative transcriptional regulator (RefSeq) 132, 339
BSU08350 estB secreted esterase / lipase (RefSeq) 240, 339
BSU09050 yhcE putative integral inner membrane orphan protein (RefSeq) 11, 339
BSU09070 yhcG putative ABC transporter ATP-binding protein (RefSeq) 11, 339
BSU12240 yjkA putative ABC transporter (permease) (RefSeq) 132, 339
BSU12250 yjkB putative phosphate ABC transporter (ATP-binding protein) (RefSeq) 132, 339
BSU17790 yndH hypothetical protein (RefSeq) 107, 339
BSU17810 yndK putative phage/plasmid replication protein (RefSeq) 165, 339
BSU26700 azlD branched-chain amino acid transporter (RefSeq) 67, 339
BSU26710 azlC branched-chain amino acid transporter (RefSeq) 67, 339
BSU26720 azlB transcriptional regulator (Lrp/AsnC family) (RefSeq) 67, 339
BSU28650 ysgA putative RNA methylase (RefSeq) 132, 339
BSU28920 lytT two-component response regulator [LytS] (RefSeq) 172, 339
BSU28930 lytS two-component sensor histidine kinase [LytT] (RefSeq) 172, 339
BSU28940 ysaA putative phosphatase (RefSeq) 172, 339
BSU30430 ytrD ABC transporter, permease component (RefSeq) 190, 339
BSU30440 ytrC ABC transporter, permease component (RefSeq) 190, 339
BSU30450 ytrB ABC transporter (ATP-binding protein) (RefSeq) 190, 339
BSU30460 ytrA transcriptional regulator (GntR family) (RefSeq) 190, 339
BSU30810 ytxM putative esterase (RefSeq) 132, 339
BSU33330 lysP lysine permease (RefSeq) 319, 339
BSU33460 yvgT putative integral inner membrane protein (RefSeq) 132, 339
BSU33740 yvaV putative transcriptional regulator (RefSeq) 132, 339
BSU34700 yvcR putative ABC transporter (ATP-binding protein) (RefSeq) 325, 339
BSU34720 yvcP two-component response regulator [YvcQ] (RefSeq) 325, 339
BSU34820 bmrA efflux transporter (ATP-binding and permease protein) (RefSeq) 102, 339
BSU36220 ywqG hypothetical protein (RefSeq) 274, 339
BSU36240 ywqE protein tyrosine-phosphatase (RefSeq) 1, 339
BSU36770 ywmB hypothetical protein (RefSeq) 172, 325
BSU36780 ywzB hypothetical protein (RefSeq) 172, 325
BSU36800 atpC F0F1 ATP synthase subunit epsilon (RefSeq) 106, 172
BSU36810 atpD F0F1 ATP synthase subunit beta (RefSeq) 106, 172
BSU36820 atpG F0F1 ATP synthase subunit gamma (RefSeq) 106, 172
BSU36830 atpA F0F1 ATP synthase subunit alpha (RefSeq) 106, 172
BSU36840 atpH F0F1 ATP synthase subunit delta (RefSeq) 106, 172
BSU36860 atpE F0F1 ATP synthase subunit C (RefSeq) 106, 172
BSU36870 atpB F0F1 ATP synthase subunit A (RefSeq) 106, 172
BSU36880 atpI ATP synthase (subunit i) (RefSeq) 172, 325
BSU38500 dltA D-alanine--poly(phosphoribitol) ligase subunit 1 (RefSeq) 15, 172
BSU38510 dltB putative D-alanine esterase for lipoteichoic acid and wall teichoic acid (RefSeq) 15, 172
BSU38520 dltC D-alanine--poly(phosphoribitol) ligase subunit 2 (RefSeq) 172, 325
BSU38530 dltD putative D-alanine esterase for lipoteichoic acid and wall teichoic acid synthesis (RefSeq) 15, 172
BSU40490 yycA putative integral inner membrane protein; putative glycosyl transferase (RefSeq) 132, 339
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for BSU28930
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend