Organism : Bacillus subtilis | Module List :
BSU32200 yutJ

putative NADH dehydrogenase (RefSeq)

CircVis
Functional Annotations (5)
Function System
NADH dehydrogenase, FAD-containing subunit cog/ cog
NADH dehydrogenase activity go/ molecular_function
electron transport go/ biological_process
flavin adenine dinucleotide binding go/ molecular_function
Oxidative phosphorylation kegg/ kegg pathway
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for BSU32200
(Mouseover regulator name to see its description)

BSU32200 is regulated by 20 influences and regulates 0 modules.
Regulators for BSU32200 yutJ (20)
Regulator Module Operator
BSU04160 187 tf
BSU09830 187 tf
BSU10860 187 tf
BSU16900 187 tf
BSU24220 187 tf
BSU25250 187 tf
BSU28820 187 tf
BSU29740 187 tf
BSU00830 245 tf
BSU10560 245 tf
BSU10860 245 tf
BSU15880 245 tf
BSU16600 245 tf
BSU22120 245 tf
BSU23210 245 tf
BSU24320 245 tf
BSU29740 245 tf
BSU30020 245 tf
BSU35200 245 tf
BSU37080 245 tf

Warning: BSU32200 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
5320 5.80e+01 gAttgAaaaGg
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5321 3.20e+04 GCGCGC
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5432 7.20e+01 GaaAAagAAggaaAtGtgC
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5433 2.50e+04 aGGGGA
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for BSU32200

BSU32200 is enriched for 5 functions in 3 categories.
Enrichment Table (5)
Function System
NADH dehydrogenase, FAD-containing subunit cog/ cog
NADH dehydrogenase activity go/ molecular_function
electron transport go/ biological_process
flavin adenine dinucleotide binding go/ molecular_function
Oxidative phosphorylation kegg/ kegg pathway
Module neighborhood information for BSU32200

BSU32200 has total of 42 gene neighbors in modules 187, 245
Gene neighbors (42)
Gene Common Name Description Module membership
BSU02780 ycdA putative lipoprotein (RefSeq) 60, 245
BSU04140 pbpC penicillin-binding lipoprotein 3 (RefSeq) 80, 245
BSU04620 acpS 4'-phosphopantetheinyl transferase (RefSeq) 245, 255
BSU05900 thiL thiamine monophosphate kinase (RefSeq) 1, 245
BSU11620 yjbO pseudouridylate synthase (RefSeq) 155, 187
BSU12230 hemD uroporphyrinogen-III synthase (RefSeq) 187, 252
BSU14850 ftsW cell-division protein (RefSeq) 187, 193
BSU15930 rnc ribonuclease III (RefSeq) 245, 343
BSU15940 smc chromosome condensation and segregation SMC ATPase (RefSeq) 142, 245
BSU15950 ftsY signal recognition particle (docking protein) (RefSeq) 125, 245
BSU16010 ylqD hypothetical protein (RefSeq) 245, 253
BSU16030 trmD tRNA (guanine-N(1)-)-methyltransferase (RefSeq) 125, 245
BSU16060 rnhB ribonuclease HII (RefSeq) 7, 187
BSU16070 ylqG putative glycosyltransferase (RefSeq) 7, 187
BSU16920 pgsA CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase (RefSeq) 48, 245
BSU16930 cinA competence damage-inducible protein A (RefSeq) 48, 245
BSU16970 ymdB hypothetical protein (RefSeq) 32, 245
BSU17040 mutS DNA mismatch repair protein MutS (RefSeq) 79, 245
BSU22460 ypjH putative enzyme in leucine catabolism or biotin metabolism (RefSeq) 187, 382
BSU22470 ypjG hypothetical protein (RefSeq) 187, 382
BSU22600 aroE 3-phosphoshikimate 1-carboxyvinyltransferase (RefSeq) 187, 385
BSU22610 tyrA prephenate dehydrogenase (RefSeq) 107, 187
BSU22760 hepS heptaprenyl diphosphate synthase component I (RefSeq) 15, 187
BSU22870 fni isopentenyl pyrophosphate isomerase (RefSeq) 187, 193
BSU24870 glpG membrane endopeptidase (RefSeq) 187, 252
BSU25030 yqgC putative integral inner membrane protein (RefSeq) 187, 377
BSU27630 yrvD hypothetical protein (RefSeq) 63, 187
BSU27700 yajC preprotein translocase subunit YajC (RefSeq) 221, 245
BSU27730 ruvB Holliday junction DNA helicase RuvB (RefSeq) 221, 245
BSU27740 ruvA Holliday junction DNA helicase RuvA (RefSeq) 221, 245
BSU28080 folC folyl-polyglutamate synthase (RefSeq) 245, 343
BSU28090 valS valyl-tRNA synthetase (RefSeq) 245, 343
BSU28350 ysnB phosphoesterase (RefSeq) 187, 243
BSU28360 ysnA nucleoside-triphosphatase (RefSeq) 187, 243
BSU28370 rph ribonuclease PH (RefSeq) 155, 187
BSU29460 moaB molybdopterin GTP-binding precursor Z biosynthesis component (RefSeq) 187, 243
BSU32200 yutJ putative NADH dehydrogenase (RefSeq) 187, 245
BSU36260 ywqC modulator of YwqD protein tyrosine kinase activity (RefSeq) 187, 197
BSU36370 fabZ (3R)-hydroxymyristoyl-ACP dehydratase (RefSeq) 128, 245
BSU40830 yyaK putative integral inner membrane protein (RefSeq) 187, 255
VIMSS37406 VIMSS37406 None 164, 187
VIMSS39516 VIMSS39516 None 98, 187
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for BSU32200
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend