Organism : Methanococcus maripaludis S2 | Module List :
MMP1444

methionine aminopeptidase

CircVis
Functional Annotations (4)
Function System
Methionine aminopeptidase cog/ cog
methionyl aminopeptidase activity go/ molecular_function
proteolysis go/ biological_process
met_pdase_II tigr/ tigrfam
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for MMP1444
(Mouseover regulator name to see its description)

MMP1444 is regulated by 27 influences and regulates 0 modules.
Regulators for MMP1444 (27)
Regulator Module Operator
MMP0036 20 tf
MMP0041 20 tf
MMP0052
MMP0097
20 combiner
MMP0052
MMP0257
20 combiner
MMP0052
MMP0480
20 combiner
MMP0097
MMP0631
20 combiner
MMP0097
MMP1052
20 combiner
MMP1137
MMP1646
20 combiner
MMP0052 61 tf
MMP0052
MMP0097
61 combiner
MMP0052
MMP0257
61 combiner
MMP0097 61 tf
MMP0097
MMP0527
61 combiner
MMP0097
MMP1015
61 combiner
MMP0568 61 tf
MMP1015 61 tf
MMP0036
MMP0840
51 combiner
MMP0052
MMP0257
51 combiner
MMP0097 51 tf
MMP1015 51 tf
MMP1347
Formate
51 combiner
MMP0052 92 tf
MMP0052
MMP0257
92 combiner
MMP0257 92 tf
MMP0257
MMP1376
92 combiner
MMP0568
MMP1100
92 combiner
MMP0907 92 tf

Warning: MMP1444 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 8 motifs predicted.

Motif Table (8)
Motif Id e-value Consensus Motif Logo
701 1.70e+01 ggtGATTT
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702 1.00e+04 CCCAAGTc
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763 7.30e+03 CTGCTaCTGAGG
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764 2.80e+04 GcACCTGTtG
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783 5.60e+03 GccGAGG
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784 7.80e+03 GccGACAG
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841 3.90e+02 ccGGtGat
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842 3.30e+03 GGCGCcAtCC
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for MMP1444

MMP1444 is enriched for 4 functions in 3 categories.
Enrichment Table (4)
Function System
Methionine aminopeptidase cog/ cog
methionyl aminopeptidase activity go/ molecular_function
proteolysis go/ biological_process
met_pdase_II tigr/ tigrfam
Module neighborhood information for MMP1444

MMP1444 has total of 84 gene neighbors in modules 20, 51, 61, 92
Gene neighbors (84)
Gene Common Name Description Module membership
MMP0026 DP2 DNA polymerase II large subunit 25, 41, 92
MMP0036 tfe transcription initiation factor E subunit alpha 49, 87, 92, 129
MMP0043 isopentenyl pyrophosphate isomerase 61, 92
MMP0044 beta-lactamase domain-containing protein 11, 20
MMP0045 idsA bifunctional short chain isoprenyl diphosphate synthase 20, 61
MMP0046 hypothetical protein MMP0046 20, 51, 140
MMP0060 rplX 50S ribosomal protein LX 61, 96, 138
MMP0061 aIF6 translation initiation factor IF-6 8, 61, 96, 138
MMP0062 50S ribosomal protein L31e 61, 77, 96, 128, 138
MMP0074 hypothetical protein MMP0074 51, 140
MMP0091 hypothetical protein MMP0091 51, 106
MMP0093 50S ribosomal protein L21e 8, 11, 20
MMP0099 major facilitator transporter 14, 92
MMP0116 argC N-acetyl-gamma-glutamyl-phosphate reductase 8, 51
MMP0134 hypothetical protein MMP0134 24, 92
MMP0141 hypothetical protein MMP0141 41, 51
MMP0142 thiamine pyrophosphate dependent protein 17, 41, 51
MMP0155 hypothetical protein MMP0155 61, 87
MMP0249 rpl37ae 50S ribosomal protein L37Ae 61, 77
MMP0250 putative RNA-associated protein 61, 77
MMP0268 truA tRNA pseudouridine synthase A 49, 51
MMP0286 hypothetical protein MMP0286 29, 51
MMP0384 hypothetical protein MMP0384 61, 87
MMP0405 gch3 GTP cyclohydrolase III 19, 92
MMP0440 DNA-directed RNA polymerase subunit E' 51, 61
MMP0441 rpoE2 DNA-directed RNA polymerase subunit E 51, 61
MMP0442 hypothetical protein MMP0442 3, 51, 61
MMP0443 rps24e 30S ribosomal protein S24e 3, 51, 96, 97
MMP0444 30S ribosomal protein S27ae 3, 51, 97
MMP0457 DEAD/DEAH box helicase domain-containing protein 61, 92
MMP0530 hypothetical protein MMP0530 92, 140
MMP0566 AMP-binding domain-containing protein 92, 109
MMP0596 C/D box methylation guide ribonucleoprotein complex aNOP56 subunit 20, 81
MMP0639 50S ribosomal protein L24e 16, 92, 130
MMP0640 rps28e 30S ribosomal protein S28e 16, 92, 130
MMP0641 rpl7ae 50S ribosomal protein L7Ae 16, 92, 130
MMP0670 hypothetical protein MMP0670 41, 51
MMP0671 ywbE hypothetical protein MMP0671 51, 87
MMP0682 hypothetical protein MMP0682 67, 92
MMP0694 beta-lactamase-like protein 51, 109, 149
MMP0695 psmB proteasome subunit beta 51, 92
MMP0760 hypothetical protein MMP0760 22, 67, 92
MMP0884 hypothetical protein MMP0884 39, 51
MMP0901 ATP/GTP-binding motif-containing protein 20, 51
MMP0943 taqD glycerol-3-phosphate cytidyltransferase 92, 111
MMP0975 modA molybdenum ABC transporter solute-binding protein 64, 92
MMP1064 adenylate cyclase 4, 51
MMP1131 peptide chain release factor 1 20, 81
MMP1208 aIF2_gamma translation initiation factor IF-2 subunit gamma 20, 61, 96
MMP1211 hypothetical protein MMP1211 89, 92
MMP1289 rpl10e 50S ribosomal protein L10e 3, 92, 105
MMP1318 lysS lysyl-tRNA synthetase 20, 21
MMP1319 rps13p 30S ribosomal protein S13P 92, 103, 118
MMP1361 rpoB2 DNA-directed RNA polymerase subunit beta'' 25, 92, 109, 149
MMP1379 thyA thymidylate synthase 64, 92
MMP1380 chlorohydrolase 51, 92
MMP1381 beta-lactamase-like protein 51, 92
MMP1396 aminotransferase 64, 92
MMP1399 aspartate/glutamate/uridylate kinase 51, 61
MMP1400 hypothetical protein MMP1400 61, 92, 97, 105
MMP1401 ef1B elongation factor 1-beta 61, 96, 97, 105
MMP1403 rpl22p 50S ribosomal protein L22P 3, 61, 92, 96, 97, 105
MMP1431 2pgk 2-phosphoglycerate kinase 49, 51
MMP1432 purA adenylosuccinate synthetase 29, 51, 130
MMP1434 nusG transcription antitermination protein NusG 29, 61
MMP1443 ATP/GTP-binding motif-containing protein 20, 61, 92
MMP1444 methionine aminopeptidase 20, 51, 61, 92
MMP1445 guaA GMP synthase subunit A 20, 61
MMP1472 hypothetical protein MMP1472 11, 61
MMP1473 hypothetical protein MMP1473 11, 20
MMP1474 ileS isoleucyl-tRNA synthetase 16, 20
MMP1480 aconitase family 60, 87, 92
MMP1509 hypothetical protein MMP1509 11, 20
MMP1511 amino acid carrier protein 19, 92
MMP1543 rpl3p 50S ribosomal protein L3P 63, 92, 128
MMP1579 rps15p 30S ribosomal protein S15P 61, 138
MMP1590 ExsB family protein 24, 51
MMP1594 hypothetical protein MMP1594 51, 143
MMP1705 creatininase 8, 11, 20
MMP1706 H/ACA RNA-protein complex component Nop10p 20, 21
MMP1707 aIF2_alpha translation initiation factor IF-2 subunit alpha 20, 21
MMP1708 rps27e 30S ribosomal protein S27e 11, 20
MMP1709 rpl44e 50S ribosomal protein L44e 11, 20
MMP1710 hypothetical protein MMP1710 20, 87, 92
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for MMP1444
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend