Organism : Methanococcus maripaludis S2 | Module List :
MMP0061 aIF6

translation initiation factor IF-6

CircVis
Functional Annotations (4)
Function System
Translation initiation factor 6 (eIF-6) cog/ cog
mature ribosome assembly go/ biological_process
ribosome binding go/ molecular_function
eIF-6 tigr/ tigrfam
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for MMP0061
(Mouseover regulator name to see its description)

MMP0061 is regulated by 26 influences and regulates 0 modules.
Regulators for MMP0061 aIF6 (26)
Regulator Module Operator
MMP0052 138 tf
MMP0052
MMP0097
138 combiner
MMP0052
MMP0257
138 combiner
MMP0097
MMP0527
138 combiner
MMP0460 138 tf
MMP0568 138 tf
MMP1065 138 tf
MMP0052 96 tf
MMP0052
MMP1304
96 combiner
MMP0097
MMP1052
96 combiner
MMP0460 96 tf
MMP1015 96 tf
MMP1447 96 tf
MMP0052 61 tf
MMP0052
MMP0097
61 combiner
MMP0052
MMP0257
61 combiner
MMP0097 61 tf
MMP0097
MMP0527
61 combiner
MMP0097
MMP1015
61 combiner
MMP0568 61 tf
MMP1015 61 tf
H2 8 ef
MMP0217
MMP1646
8 combiner
MMP0465
Formate
8 combiner
MMP1210
MMP1646
8 combiner
MMP1304 8 tf

Warning: MMP0061 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 8 motifs predicted.

Motif Table (8)
Motif Id e-value Consensus Motif Logo
677 6.30e-02 cccgcaGgTTCaactcccccTccc
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678 8.30e-01 aGGTGATTTT
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783 5.60e+03 GccGAGG
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784 7.80e+03 GccGACAG
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849 1.70e+02 gAGGTGc
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850 1.60e+04 CCcTGCc
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927 1.20e+02 cGaGGaGa
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928 4.00e+03 GGCTcATC
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for MMP0061

MMP0061 is enriched for 4 functions in 3 categories.
Enrichment Table (4)
Function System
Translation initiation factor 6 (eIF-6) cog/ cog
mature ribosome assembly go/ biological_process
ribosome binding go/ molecular_function
eIF-6 tigr/ tigrfam
Module neighborhood information for MMP0061

MMP0061 has total of 100 gene neighbors in modules 8, 61, 96, 138
Gene neighbors (100)
Gene Common Name Description Module membership
MMP0025 hypothetical protein MMP0025 8, 52
MMP0043 isopentenyl pyrophosphate isomerase 61, 92
MMP0045 idsA bifunctional short chain isoprenyl diphosphate synthase 20, 61
MMP0059 hypothetical protein MMP0059 8, 58, 64
MMP0060 rplX 50S ribosomal protein LX 61, 96, 138
MMP0061 aIF6 translation initiation factor IF-6 8, 61, 96, 138
MMP0062 50S ribosomal protein L31e 61, 77, 96, 128, 138
MMP0075 abortive infection protein 96, 136
MMP0093 50S ribosomal protein L21e 8, 11, 20
MMP0094 putative pseudouridylate synthase 8, 11
MMP0103 pyridoxal biosynthesis lyase PdxS 8, 27, 77
MMP0116 argC N-acetyl-gamma-glutamyl-phosphate reductase 8, 51
MMP0127 hmd H(2)-dependent methylenetetrahydromethanopterin dehydrogenase 8, 77
MMP0150 hypothetical protein MMP0150 11, 138
MMP0151 rpl40e 50S ribosomal protein L40e 11, 138
MMP0155 hypothetical protein MMP0155 61, 87
MMP0163 arsA arsenite-activated ATPase ArsA 16, 96
MMP0183 ribB 3,4-dihydroxy-2-butanone 4-phosphate synthase 8, 70
MMP0242 hypothetical protein MMP0242 8, 39, 96
MMP0245 pfdB prefoldin subunit beta 96, 138
MMP0249 rpl37ae 50S ribosomal protein L37Ae 61, 77
MMP0250 putative RNA-associated protein 61, 77
MMP0290 nac nascent polypeptide-associated complex protein 8, 78
MMP0309 DsrE family protein 8, 78
MMP0317 hypothetical protein MMP0317 77, 96
MMP0350 hexapeptide repeat-containing transferase 80, 96
MMP0370 hypothetical protein MMP0370 77, 96
MMP0371 hypothetical protein MMP0371 8, 70
MMP0382 putative ATPase RIL 8, 70, 78
MMP0384 hypothetical protein MMP0384 61, 87
MMP0407 hypothetical protein MMP0407 8, 19, 89
MMP0414 thrS threonyl-tRNA synthetase 8, 81, 112
MMP0440 DNA-directed RNA polymerase subunit E' 51, 61
MMP0441 rpoE2 DNA-directed RNA polymerase subunit E 51, 61
MMP0442 hypothetical protein MMP0442 3, 51, 61
MMP0443 rps24e 30S ribosomal protein S24e 3, 51, 96, 97
MMP0457 DEAD/DEAH box helicase domain-containing protein 61, 92
MMP0539 leuB multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase 7, 8
MMP0540 purC phosphoribosylaminoimidazole-succinocarboxamide synthase 8, 112, 143
MMP0572 slyD FKBP-type peptidylprolyl isomerase 11, 96
MMP0574 hypothetical protein MMP0574 11, 138
MMP0575 gatC aspartyl/glutamyl-tRNA amidotransferase subunit C 11, 138
MMP0576 dapA dihydrodipicolinate synthase 11, 18, 138
MMP0577 rps17E 30S ribosomal protein S17e 11, 18, 138
MMP0578 aroQ chorismate mutase 11, 18, 96, 138
MMP0597 flpA fibrillarin 8, 16, 81
MMP0629 hypothetical protein MMP0629 8, 39
MMP0645 mdh malate dehydrogenase 8, 39, 136
MMP0650 ilvB acetolactate synthase catalytic subunit 8, 39
MMP0651 ilvH acetolactate synthase 3 regulatory subunit 8, 39
MMP0657 hypothetical protein MMP0657 8, 29, 96
MMP0668 hypothetical protein MMP0668 3, 96, 105
MMP0687 tpiA triosephosphate isomerase 8, 13
MMP0697 leuS leucyl-tRNA synthetase 8, 143
MMP0704 ParA type ATPase 8, 78, 112
MMP0736 PRC-barrel domain-containing protein 8, 19, 38
MMP0737 L-aspartate dehydrogenase 8, 38
MMP0816 seryl-tRNA synthetase-like protein 8, 70
MMP0898 cellulose-binding protein 8, 70
MMP0946 gatB aspartyl/glutamyl-tRNA amidotransferase subunit B 8, 81, 96
MMP0965 formylmethanofuran dehydrogenase subunit E-like protein 8, 39, 136
MMP0971 purB adenylosuccinate lyase 8, 11
MMP1013 carB carbamoyl-phosphate synthase large subunit 77, 96
MMP1021 hypothetical protein MMP1021 8, 21
MMP1023 TetR family transcriptional regulator 8, 21, 78
MMP1070 hypothetical protein MMP1070 8, 15
MMP1113 transketoloase, C terminal half 96, 120
MMP1147 rpl37e 50S ribosomal protein L37e 18, 96, 138
MMP1208 aIF2_gamma translation initiation factor IF-2 subunit gamma 20, 61, 96
MMP1213 hypothetical protein MMP1213 8, 89
MMP1254 purM phosphoribosylaminoimidazole synthetase 96, 120
MMP1260 hypothetical protein MMP1260 40, 96
MMP1308 tal putative translaldolase 8, 16, 112
MMP1321 rps11p 30S ribosomal protein S11P 8, 105, 118
MMP1352 ribulose-1,5-biphosphate synthetase 7, 8, 78
MMP1399 aspartate/glutamate/uridylate kinase 51, 61
MMP1400 hypothetical protein MMP1400 61, 92, 97, 105
MMP1401 ef1B elongation factor 1-beta 61, 96, 97, 105
MMP1403 rpl22p 50S ribosomal protein L22P 3, 61, 92, 96, 97, 105
MMP1433 rpl11p 50S ribosomal protein L11P 96, 97, 105
MMP1434 nusG transcription antitermination protein NusG 29, 61
MMP1443 ATP/GTP-binding motif-containing protein 20, 61, 92
MMP1444 methionine aminopeptidase 20, 51, 61, 92
MMP1445 guaA GMP synthase subunit A 20, 61
MMP1472 hypothetical protein MMP1472 11, 61
MMP1512 alr alanine racemase 8, 21
MMP1513 ald alanine dehydrogenase 8, 21
MMP1515 hsp60 chaperonin GroEL 77, 96
MMP1527 aspartate aminotransferase 8, 21
MMP1531 hypothetical protein MMP1531 8, 66
MMP1579 rps15p 30S ribosomal protein S15P 61, 138
MMP1588 serA D-3-phosphoglycerate dehydrogenase 7, 8, 27, 77
MMP1646 hypothetical protein MMP1646 96, 136
MMP1656 glutamine amidotransferase subunit PdxT 8, 137
MMP1698 hypothetical protein MMP1698 4, 8
MMP1705 creatininase 8, 11, 20
Unanno_15 None 8, 44
Unanno_17 None 8, 126
Unanno_19 None 77, 138
Unanno_8 None 8, 78
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for MMP0061
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend