Module 35 Residual: 0.52

Title Bicluster Model Residual Score
bicluster_0035 v02 0.52 -13.26
Displaying 1 - 15 of 15
Rv0389 Phosphoribosylglycinamide formyltransferase 2 (EC 2.1.2.-)

Details for Rv0389 - Phosphoribosylglycinamide formyltransferase 2 (EC 2.1.2.-)

GO Terms: GO:0005829

PATRIC Pathways: Amino sugar and nucleotide sugar metabolism

Essentiality: Griffin Essential: 0.90 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv0389

Tuberculist Genomic Region

Rv0751c 3-hydroxyisobutyrate dehydrogenase (EC 1.1.1.31)

Details for Rv0751c - 3-hydroxyisobutyrate dehydrogenase (EC 1.1.1.31)

GO Terms: GO:0008442

PATRIC Pathways: Valine, leucine and isoleucine degradation

Essentiality: Griffin Essential: 0.87 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv0751c

Tuberculist Genomic Region

Rv0752c Acyl-CoA dehydrogenase, short-chain specific (EC 1.3.99.2)

Details for Rv0752c - Acyl-CoA dehydrogenase, short-chain specific (EC 1.3.99.2)

GO Terms: GO:0004085

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.87 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv0752c

Tuberculist Genomic Region

Rv0753c Methylmalonate-semialdehyde dehydrogenase (EC 1.2.1.27)

Details for Rv0753c - Methylmalonate-semialdehyde dehydrogenase (EC 1.2.1.27)

GO Terms: GO:0004491, GO:0005886

PATRIC Pathways: Propanoate metabolism, Inositol phosphate metabolism, Valine, leucine and isoleucine degradation

Essentiality: Griffin Essential: 0.99 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv0753c

Tuberculist Genomic Region

Rv0754 PE-PGRS FAMILY PROTEIN

Details for Rv0754 - PE-PGRS FAMILY PROTEIN

GO Terms: NA

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.22 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv0754

Tuberculist Genomic Region

Rv0775 Transcriptional regulator, TetR family

Details for Rv0775 - Transcriptional regulator, TetR family

GO Terms: GO:0005618, GO:0005886

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.99 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv0775

Tuberculist Genomic Region

Rv1997 Probable cation-transporting ATPase F (EC 3.6.3.-)

Details for Rv1997 - Probable cation-transporting ATPase F (EC 3.6.3.-)

GO Terms: GO:0005618, GO:0005886, GO:0005887, GO:0071500

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.84 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv1997

Tuberculist Genomic Region

Rv2003c

Details for Rv2003c -

GO Terms: NA

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.83 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv2003c

Tuberculist Genomic Region

Rv2004c

Details for Rv2004c -

GO Terms: GO:0005618, GO:0046812

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.18 | In vitro Essential: NA | In vivo Essential: 0.36

Go to Gene Page: Rv2004c

Tuberculist Genomic Region

Rv2159c

Details for Rv2159c -

GO Terms: GO:0005618, GO:0005886

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.95 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv2159c

Tuberculist Genomic Region

Rv2629

Details for Rv2629 -

GO Terms: GO:0001666, GO:0005829, GO:0005886

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.96 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv2629

Tuberculist Genomic Region

Rv2630 Archease

Details for Rv2630 - Archease

GO Terms: NA

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.72 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv2630

Tuberculist Genomic Region

Rv2665

Details for Rv2665 -

GO Terms: NA

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.17 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv2665

Tuberculist Genomic Region

Rv2964 Formyltetrahydrofolate deformylase (EC 3.5.1.10)

Details for Rv2964 - Formyltetrahydrofolate deformylase (EC 3.5.1.10)

GO Terms: GO:0008864

PATRIC Pathways: One carbon pool by folate, Glyoxylate and dicarboxylate metabolism

Essentiality: Griffin Essential: 0.88 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv2964

Tuberculist Genomic Region

Rv3916c Conserved hypothetical protein

Details for Rv3916c - Conserved hypothetical protein

GO Terms: GO:0005886, GO:0051409

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.17 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv3916c

Tuberculist Genomic Region

Displaying 1 - 1 of 1
Motif 1 Motif 2
e-value: 0.012 e-value: 130
Displaying 1 - 1 of 1
Arsenical resistance operon repressor
regulates 5 modules
Weight: 
0.25
up-regulates
Bifunctional uroporphyrinogen-III synthetase/response regulator domain protein
regulates 38 modules
Weight: 
0.24
up-regulates
Two component transcriptional regulatory protein DevR
regulates 19 modules
Weight: 
0.16
up-regulates
Displaying 1 - 1 of 1
Module GO Term Enrichment Descriptions
GO:0016742 hydroxymethyl-, formyl- and related tran...
Displaying 1 - 13 of 13
GO:0005829 |

cytosol

GO:0008442 |

3-hydroxyisobutyrate dehydrogenase activity

GO:0004085 |

butyryl-CoA dehydrogenase activity

GO:0004491 |

methylmalonate-semialdehyde dehydrogenase (acylating) activity

GO:0005886 |

plasma membrane

GO:0005618 |

cell wall

GO:0005887 |

integral to plasma membrane

GO:0071500 |

cellular response to nitrosative stress

GO:0046812 |

host cell surface binding

GO:0001666 |

response to hypoxia

GO:0008864 |

formyltetrahydrofolate deformylase activity

GO:0051409 |

response to nitrosative stress