Module 82 Residual: 0.54

Title Bicluster Model Residual Score
bicluster_0082 v02 0.54 -8.78
Displaying 1 - 13 of 13
Rv0950c Phage peptidoglycan binding endopeptidase

Details for Rv0950c - Phage peptidoglycan binding endopeptidase

GO Terms: NA

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.15 | In vitro Essential: NA | In vivo Essential: 0.29

Go to Gene Page: Rv0950c

Tuberculist Genomic Region

Rv1172c PE-PGRS FAMILY PROTEIN

Details for Rv1172c - PE-PGRS FAMILY PROTEIN

GO Terms: NA

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.64 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv1172c

Tuberculist Genomic Region

Rv1617 Pyruvate kinase (EC 2.7.1.40)

Details for Rv1617 - Pyruvate kinase (EC 2.7.1.40)

GO Terms: GO:0004743, GO:0005829, GO:0005886, GO:0040007

PATRIC Pathways: Glycolysis / Gluconeogenesis, Purine metabolism, Carbon fixation in photosynthetic organisms, Pyruvate metabolism

Essentiality: Griffin Essential: 0.00 | In vitro Essential: 0.08 | In vivo Essential: NA

Go to Gene Page: Rv1617

Tuberculist Genomic Region

Rv1618 Acyl-CoA thioesterase II (EC 3.1.2.-)

Details for Rv1618 - Acyl-CoA thioesterase II (EC 3.1.2.-)

GO Terms: NA

PATRIC Pathways: Fatty acid biosynthesis, Limonene and pinene degradation, Benzoate degradation via hydroxylation, Biosynthesis of unsaturated fatty acids, alpha-Linolenic acid metabolism

Essentiality: Griffin Essential: 0.99 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv1618

Tuberculist Genomic Region

Rv2357c Glycyl-tRNA synthetase (EC 6.1.1.14)

Details for Rv2357c - Glycyl-tRNA synthetase (EC 6.1.1.14)

GO Terms: GO:0004820, GO:0005886, GO:0040007

PATRIC Pathways: Aminoacyl-tRNA biosynthesis

Essentiality: Griffin Essential: 0.00 | In vitro Essential: 0.18 | In vivo Essential: NA

Go to Gene Page: Rv2357c

Tuberculist Genomic Region

Rv2430c PPE family protein

Details for Rv2430c - PPE family protein

GO Terms: GO:0005515, GO:0005576

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.92 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv2430c

Tuberculist Genomic Region

Rv2443

Details for Rv2443 -

GO Terms: NA

PATRIC Pathways: NA

Essentiality: Griffin Essential: 1.00 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv2443

Tuberculist Genomic Region

Rv3377c Ent-copalyl diphosphate synthase

Details for Rv3377c - Ent-copalyl diphosphate synthase

GO Terms: GO:0035439, GO:0035440, GO:0052572

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.00 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv3377c

Tuberculist Genomic Region

Rv3378c

Details for Rv3378c -

GO Terms: GO:0016102, GO:0016791, GO:0052572

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.00 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv3378c

Tuberculist Genomic Region

Rv3646c DNA topoisomerase I (EC 5.99.1.2)

Details for Rv3646c - DNA topoisomerase I (EC 5.99.1.2)

GO Terms: GO:0003917, GO:0000287, GO:0003917, GO:0005618, GO:0005829, GO:0005886, GO:0040007

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.00 | In vitro Essential: 0.07 | In vivo Essential: NA

Go to Gene Page: Rv3646c

Tuberculist Genomic Region

Rv3722c Aspartate transaminase (EC 2.6.1.1) Rv2264c Possible molecular chaperone DnaK

Details for Rv2264c - Possible molecular chaperone DnaK

GO Terms: NA

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.85 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv2264c

Tuberculist Genomic Region

Rv2289 CDP-diacylglycerol pyrophosphatase (EC 3.6.1.26)

Details for Rv2289 - CDP-diacylglycerol pyrophosphatase (EC 3.6.1.26)

GO Terms: GO:0008715, GO:0005576, GO:0005886

PATRIC Pathways: Glycerophospholipid metabolism

Essentiality: Griffin Essential: 0.93 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv2289

Tuberculist Genomic Region

Displaying 1 - 1 of 1
Motif 1 Motif 2
e-value: 1300 e-value: 10000
Displaying 1 - 1 of 1
Transcriptional regulator, TetR family
regulates 14 modules
Weight: 
0.13
up-regulates
RNA polymerase sigma-54 factor RpoN
regulates 27 modules
Weight: 
0.12
up-regulates
regulates 52 modules
Weight: 
-0.10
down-regulates
Sporulation regulatory protein WhiD
regulates 6 modules
Weight: 
0.10
up-regulates
Transcriptional regulator, TetR family
regulates 54 modules
Weight: 
0.09
up-regulates
regulates 4 modules
Weight: 
0.08
up-regulates
Transcriptional regulator, ArsR family
regulates 25 modules
Weight: 
-0.08
down-regulates
regulates 23 modules
Weight: 
-0.08
down-regulates
HspR, transcriptional repressor of DnaK operon
regulates 13 modules
Weight: 
0.08
up-regulates
Uracil phosphoribosyltransferase (EC 2.4.2.9) / Pyrimidine operon regulatory protein PyrR
regulates 90 modules
Weight: 
0.08
up-regulates
Transcriptional regulator, ArsR family
regulates 19 modules
Weight: 
-0.07
down-regulates
Possible transcriptional regulatory protein
regulates 46 modules
Weight: 
0.07
up-regulates
DNA-binding response regulator
regulates 5 modules
Weight: 
-0.07
down-regulates
Transcriptional regulator, TetR family
regulates 9 modules
Weight: 
-0.06
down-regulates
Mn-dependent transcriptional regulator MntR
regulates 10 modules
Weight: 
0.06
up-regulates
Transcriptional regulator, GntR family
regulates 22 modules
Weight: 
-0.06
down-regulates
RNA polymerase sigma-70 factor
regulates 7 modules
Weight: 
0.06
up-regulates
RNA polymerase sigma factor SigB
regulates 61 modules
Weight: 
0.06
up-regulates
regulates 3 modules
Weight: 
0.05
up-regulates
cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases
regulates 28 modules
Weight: 
0.05
up-regulates
Histone protein Lsr2
regulates 12 modules
Weight: 
-0.05
down-regulates
Transcriptional regulator, FUR family
regulates 9 modules
Weight: 
-0.05
down-regulates
Transcriptional regulator, MarR family
regulates 19 modules
Weight: 
0.04
up-regulates
Transcriptional regulator, MarR family
regulates 11 modules
Weight: 
0.04
up-regulates
regulates 40 modules
Weight: 
0.04
up-regulates
Phosphate transport system regulatory protein PhoU
regulates 14 modules
Weight: 
0.04
up-regulates
Transcriptional regulator, HxlR family
regulates 2 modules
Weight: 
0.04
up-regulates
Transcriptional regulator, TetR family
regulates 5 modules
Weight: 
0.03
up-regulates
Displaying 1 - 1 of 1
Module GO Term Enrichment Descriptions
No enrichment
Displaying 1 - 17 of 17
GO:0004743 |

pyruvate kinase activity

GO:0005829 |

cytosol

GO:0005886 |

plasma membrane

GO:0040007 |

growth

GO:0004820 |

glycine-tRNA ligase activity

GO:0005515 |

protein binding

GO:0005576 |

extracellular region

GO:0035439 |

halimadienyl-diphosphate synthase activity

GO:0035440 |

tuberculosinol biosynthetic process

GO:0052572 |

response to host immune response

GO:0016102 |

diterpenoid biosynthetic process

GO:0016791 |

phosphatase activity

GO:0003917 |

DNA topoisomerase type I activity

GO:0000287 |

magnesium ion binding

GO:0005618 |

cell wall

GO:0008715 |

CDP-diacylglycerol diphosphatase activity