Module 142 Residual: 0.59

Title Bicluster Model Residual Score
bicluster_0142 v02 0.59 -8.20
Displaying 1 - 18 of 18
Rv0005 DNA gyrase subunit B (EC 5.99.1.3)

Details for Rv0005 - DNA gyrase subunit B (EC 5.99.1.3)

GO Terms: GO:0003918, GO:0000287, GO:0003918, GO:0005524, GO:0005618, GO:0005886, GO:0040007, GO:0046982

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.00 | In vitro Essential: 0.02 | In vivo Essential: NA

Go to Gene Page: Rv0005

Tuberculist Genomic Region

Rv0006 DNA gyrase subunit A (EC 5.99.1.3)

Details for Rv0006 - DNA gyrase subunit A (EC 5.99.1.3)

GO Terms: GO:0003918, GO:0000287, GO:0003918, GO:0005515, GO:0005524, GO:0005886, GO:0046982

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.00 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv0006

Tuberculist Genomic Region

Rv0867c

Details for Rv0867c -

GO Terms: GO:0005576, GO:0010629, GO:0040010

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.75 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv0867c

Tuberculist Genomic Region

Rv0932c Phosphate ABC transporter, periplasmic phosphate-binding protein PstS (TC 3.A.1.7.1)

Details for Rv0932c - Phosphate ABC transporter, periplasmic phosphate-binding protein PstS (TC 3.A.1.7.1)

GO Terms: GO:0006810, GO:0005215, GO:0005576, GO:0005886, GO:0006817

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.79 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv0932c

Tuberculist Genomic Region

Rv1391 Phosphopantothenoylcysteine decarboxylase (EC 4.1.1.36) / Phosphopantothenoylcysteine synthetase (EC 6.3.2.5)

Details for Rv1391 - Phosphopantothenoylcysteine decarboxylase (EC 4.1.1.36) / Phosphopantothenoylcysteine synthetase (EC 6.3.2.5)

GO Terms: GO:0005886, GO:0040007

PATRIC Pathways: Pantothenate and CoA biosynthesis, Pantothenate and CoA biosynthesis

Essentiality: Griffin Essential: 0.00 | In vitro Essential: 0.09 | In vivo Essential: NA

Go to Gene Page: Rv1391

Tuberculist Genomic Region

Rv1481 Possible membrane protein

Details for Rv1481 - Possible membrane protein

GO Terms: GO:0005886, GO:0005887

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.00 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv1481

Tuberculist Genomic Region

Rv2146c FIG021764: Possible membrane protein

Details for Rv2146c - FIG021764: Possible membrane protein

GO Terms: GO:0005576

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.39 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv2146c

Tuberculist Genomic Region

Rv2703 RNA polymerase sigma factor SigB

Details for Rv2703 - RNA polymerase sigma factor SigB

GO Terms: GO:0003700, GO:0006355, GO:0016987, GO:0030528, GO:0003677, GO:0006352, GO:0003677, GO:0005515, GO:0005886, GO:0009405, GO:0009415, GO:0016987, GO:0040007, GO:0052572

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.00 | In vitro Essential: 0.09 | In vivo Essential: NA

Go to Gene Page: Rv2703

Tuberculist Genomic Region

Rv2901c Protein often found in Actinomycetes clustered with signal peptidase and/or RNaseHII

Details for Rv2901c - Protein often found in Actinomycetes clustered with signal peptidase and/or RNaseHII

GO Terms: GO:0005886

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.72 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv2901c

Tuberculist Genomic Region

Rv3212 Cell division protein DivIC (FtsB), stabilizes FtsL against RasP cleavage

Details for Rv3212 - Cell division protein DivIC (FtsB), stabilizes FtsL against RasP cleavage

GO Terms: GO:0005829, GO:0005886

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.00 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv3212

Tuberculist Genomic Region

Rv3710 2-isopropylmalate synthase (EC 2.3.3.13)

Details for Rv3710 - 2-isopropylmalate synthase (EC 2.3.3.13)

GO Terms: GO:0003852, GO:0000287, GO:0005576, GO:0005886, GO:0008270, GO:0030145, GO:0030955, GO:0040007, GO:0042803

PATRIC Pathways: Pyruvate metabolism, Valine, leucine and isoleucine biosynthesis

Essentiality: Griffin Essential: 0.00 | In vitro Essential: 0.04 | In vivo Essential: NA

Go to Gene Page: Rv3710

Tuberculist Genomic Region

Rv3858c Glutamate synthase [NADPH] small chain (EC 1.4.1.13)

Details for Rv3858c - Glutamate synthase [NADPH] small chain (EC 1.4.1.13)

GO Terms: GO:0004355, GO:0005829, GO:0005886, GO:0040007

PATRIC Pathways: Alanine, aspartate and glutamate metabolism, Nitrogen metabolism

Essentiality: Griffin Essential: 0.00 | In vitro Essential: 0.04 | In vivo Essential: NA

Go to Gene Page: Rv3858c

Tuberculist Genomic Region

Rv3859c Glutamate synthase [NADPH] large chain (EC 1.4.1.13)

Details for Rv3859c - Glutamate synthase [NADPH] large chain (EC 1.4.1.13)

GO Terms: GO:0004355, GO:0005515, GO:0005829, GO:0005886, GO:0040007

PATRIC Pathways: Nitrogen metabolism, Alanine, aspartate and glutamate metabolism

Essentiality: Griffin Essential: 0.00 | In vitro Essential: 0.03 | In vivo Essential: NA

Go to Gene Page: Rv3859c

Tuberculist Genomic Region

Rv1223 serine protease

Details for Rv1223 - serine protease

GO Terms: GO:0005886, GO:0005887, GO:0040007

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.00 | In vitro Essential: 0.13 | In vivo Essential: NA

Go to Gene Page: Rv1223

Tuberculist Genomic Region

Rv1224 Twin-arginine translocation protein TatB

Details for Rv1224 - Twin-arginine translocation protein TatB

GO Terms: GO:0008150, GO:0008150, GO:0008150, GO:0040007

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.09 | In vitro Essential: NA | In vivo Essential: 0.38

Go to Gene Page: Rv1224

Tuberculist Genomic Region

Rv1300 Methylase of polypeptide chain release factors

Details for Rv1300 - Methylase of polypeptide chain release factors

GO Terms: GO:0040007

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.00 | In vitro Essential: 0.08 | In vivo Essential: NA

Go to Gene Page: Rv1300

Tuberculist Genomic Region

Rv1301 \YrdC/Sua5 family protein, required for threonylcarbamoyladenosine (t(6)A) formation in tRNA\\\""

Details for Rv1301 - \YrdC/Sua5 family protein, required for threonylcarbamoyladenosine (t(6)A) formation in tRNA\\\""

GO Terms: GO:0040007

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.00 | In vitro Essential: 0.11 | In vivo Essential: NA

Go to Gene Page: Rv1301

Tuberculist Genomic Region

Rv2394 Gamma-glutamyltranspeptidase (EC 2.3.2.2)

Details for Rv2394 - Gamma-glutamyltranspeptidase (EC 2.3.2.2)

GO Terms: GO:0003840, GO:0005886

PATRIC Pathways: Cyanoamino acid metabolism, Taurine and hypotaurine metabolism, Glutathione metabolism, Arachidonic acid metabolism

Essentiality: Griffin Essential: 0.98 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv2394

Tuberculist Genomic Region

Displaying 1 - 1 of 1
Motif 1 Motif 2
e-value: 420 e-value: 7300
Displaying 1 - 1 of 1
Transcriptional regulator, TetR family
regulates 32 modules
Weight: 
0.12
up-regulates
Transcriptional regulator, TetR family
regulates 5 modules
Weight: 
0.10
up-regulates
Transcriptional regulatory protein
regulates 18 modules
Weight: 
0.10
up-regulates
TetR/ACRR family transcriptional regulator
regulates 7 modules
Weight: 
0.09
up-regulates
Sporulation regulatory protein WhiD
regulates 6 modules
Weight: 
0.09
up-regulates
regulates 26 modules
Weight: 
0.08
up-regulates
RNA polymerase sigma factor RpoE
regulates 30 modules
Weight: 
0.08
up-regulates
WhiB-type transcription regulator
regulates 2 modules
Weight: 
0.08
up-regulates
Histone protein Lsr2
regulates 12 modules
Weight: 
-0.08
down-regulates
putative two-component system response regulator
regulates 5 modules
Weight: 
-0.08
down-regulates
Zinc uptake regulation protein ZUR
regulates 7 modules
Weight: 
-0.07
down-regulates
COG0714: MoxR-like ATPases
regulates 31 modules
Weight: 
0.07
up-regulates
Transcriptional regulator, TetR family
regulates 12 modules
Weight: 
0.07
up-regulates
Transcriptional regulator, MarR family
regulates 19 modules
Weight: 
0.07
up-regulates
\Transcriptional regulator, TetR family\\\""
regulates 32 modules
Weight: 
0.07
up-regulates
Hydrogen peroxide-inducible genes activator
regulates 4 modules
Weight: 
-0.06
down-regulates
Cys regulon transcriptional activator CysB
regulates 5 modules
Weight: 
-0.06
down-regulates
Arginine pathway regulatory protein ArgR, repressor of arg regulon
regulates 31 modules
Weight: 
0.06
up-regulates
Transcriptional regulator, ArsR family
regulates 28 modules
Weight: 
-0.06
down-regulates
DNA-binding protein HU / low-complexity, AKP-rich domain
regulates 3 modules
Weight: 
-0.06
down-regulates
Transcriptional regulator, GntR family
regulates 22 modules
Weight: 
-0.05
down-regulates
cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases
regulates 28 modules
Weight: 
0.05
up-regulates
regulates 10 modules
Weight: 
0.04
up-regulates
Transcriptional regulator, ArsR family
regulates 25 modules
Weight: 
-0.02
down-regulates
Displaying 1 - 1 of 1
Module GO Term Enrichment Descriptions
GO:0006265 | GO:0006536 | GO:0043650 | GO:0071103 | GO:0003916 DNA topological change | glutamate metabolic process | dicarboxylic acid biosynthetic process | DNA conformation change | DNA topoisomerase activity
Displaying 1 - 33 of 33
GO:0003918 |

DNA topoisomerase (ATP-hydrolyzing) activity

GO:0000287 |

magnesium ion binding

GO:0005524 |

ATP binding

GO:0005618 |

cell wall

GO:0005886 |

plasma membrane

GO:0040007 |

growth

GO:0046982 |

protein heterodimerization activity

GO:0005515 |

protein binding

GO:0005576 |

extracellular region

GO:0010629 |

negative regulation of gene expression

GO:0040010 |

positive regulation of growth rate

GO:0006810 |

transport

GO:0005215 |

transporter activity

GO:0006817 |

phosphate ion transport

GO:0005887 |

integral to plasma membrane

GO:0003700 |

sequence-specific DNA binding transcription factor activity

GO:0006355 |

regulation of transcription, DNA-dependent

GO:0016987 |

sigma factor activity

GO:0030528 |

transcription regulator activity

GO:0003677 |

DNA binding

GO:0006352 |

DNA-dependent transcription, initiation

GO:0009405 |

pathogenesis

GO:0009415 |

response to water stimulus

GO:0052572 |

response to host immune response

GO:0005829 |

cytosol

GO:0003852 |

2-isopropylmalate synthase activity

GO:0008270 |

zinc ion binding

GO:0030145 |

manganese ion binding

GO:0030955 |

potassium ion binding

GO:0042803 |

protein homodimerization activity

GO:0004355 |

glutamate synthase (NADPH) activity

GO:0008150 |

biological_process

GO:0003840 |

gamma-glutamyltransferase activity