Module 271 Residual: 0.56

Title Bicluster Model Residual Score
bicluster_0271 v02 0.56 -22.32
Displaying 1 - 16 of 16
Rv1652 N-acetyl-gamma-glutamyl-phosphate reductase (EC 1.2.1.38)

Details for Rv1652 - N-acetyl-gamma-glutamyl-phosphate reductase (EC 1.2.1.38)

GO Terms: GO:0003942, GO:0040007, GO:0042803

PATRIC Pathways: Arginine and proline metabolism

Essentiality: Griffin Essential: 0.00 | In vitro Essential: 0.05 | In vivo Essential: NA

Go to Gene Page: Rv1652

Tuberculist Genomic Region

Rv1653 Glutamate N-acetyltransferase (EC 2.3.1.35) / N-acetylglutamate synthase (EC 2.3.1.1)

Details for Rv1653 - Glutamate N-acetyltransferase (EC 2.3.1.35) / N-acetylglutamate synthase (EC 2.3.1.1)

GO Terms: GO:0040007

PATRIC Pathways: Arginine and proline metabolism, Arginine and proline metabolism

Essentiality: Griffin Essential: 0.15 | In vitro Essential: 0.12 | In vivo Essential: 0.17

Go to Gene Page: Rv1653

Tuberculist Genomic Region

Rv1654 Acetylglutamate kinase (EC 2.7.2.8)

Details for Rv1654 - Acetylglutamate kinase (EC 2.7.2.8)

GO Terms: GO:0003991, GO:0005886, GO:0040007

PATRIC Pathways: Arginine and proline metabolism

Essentiality: Griffin Essential: 0.12 | In vitro Essential: 0.04 | In vivo Essential: NA

Go to Gene Page: Rv1654

Tuberculist Genomic Region

Rv1655 Acetylornithine aminotransferase (EC 2.6.1.11)

Details for Rv1655 - Acetylornithine aminotransferase (EC 2.6.1.11)

GO Terms: GO:0040007

PATRIC Pathways: Lysine biosynthesis, Arginine and proline metabolism

Essentiality: Griffin Essential: 0.01 | In vitro Essential: 0.02 | In vivo Essential: NA

Go to Gene Page: Rv1655

Tuberculist Genomic Region

Rv1656 Ornithine carbamoyltransferase (EC 2.1.3.3)

Details for Rv1656 - Ornithine carbamoyltransferase (EC 2.1.3.3)

GO Terms: GO:0004585, GO:0004585, GO:0006526, GO:0040007, GO:0070207

PATRIC Pathways: Arginine and proline metabolism

Essentiality: Griffin Essential: 0.08 | In vitro Essential: 0.04 | In vivo Essential: NA

Go to Gene Page: Rv1656

Tuberculist Genomic Region

Rv1658 Argininosuccinate synthase (EC 6.3.4.5)

Details for Rv1658 - Argininosuccinate synthase (EC 6.3.4.5)

GO Terms: GO:0004055, GO:0005829, GO:0005886, GO:0040007

PATRIC Pathways: Arginine and proline metabolism, Alanine, aspartate and glutamate metabolism

Essentiality: Griffin Essential: 0.00 | In vitro Essential: 0.04 | In vivo Essential: NA

Go to Gene Page: Rv1658

Tuberculist Genomic Region

Rv1659 Argininosuccinate lyase (EC 4.3.2.1)

Details for Rv1659 - Argininosuccinate lyase (EC 4.3.2.1)

GO Terms: GO:0004056, GO:0040007

PATRIC Pathways: Arginine and proline metabolism, Alanine, aspartate and glutamate metabolism

Essentiality: Griffin Essential: 0.02 | In vitro Essential: 0.07 | In vivo Essential: NA

Go to Gene Page: Rv1659

Tuberculist Genomic Region

Rv2403c Lipoprotein LppR

Details for Rv2403c - Lipoprotein LppR

GO Terms: NA

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.59 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv2403c

Tuberculist Genomic Region

Rv2404c Translation elongation factor LepA

Details for Rv2404c - Translation elongation factor LepA

GO Terms: GO:0006412, GO:0005525, GO:0005618, GO:0005829

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.98 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv2404c

Tuberculist Genomic Region

Rv2783c Polyribonucleotide nucleotidyltransferase (EC 2.7.7.8)

Details for Rv2783c - Polyribonucleotide nucleotidyltransferase (EC 2.7.7.8)

GO Terms: GO:0004654, GO:0005829, GO:0005886

PATRIC Pathways: Pyrimidine metabolism, Purine metabolism

Essentiality: Griffin Essential: 0.00 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv2783c

Tuberculist Genomic Region

Rv2796c PROBABLE CONSERVED LIPOPROTEIN LPPV

Details for Rv2796c - PROBABLE CONSERVED LIPOPROTEIN LPPV

GO Terms: NA

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.78 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv2796c

Tuberculist Genomic Region

Rv2798c

Details for Rv2798c -

GO Terms: NA

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.53 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv2798c

Tuberculist Genomic Region

Rv2799 Possible membrane protein

Details for Rv2799 - Possible membrane protein

GO Terms: NA

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 1.00 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv2799

Tuberculist Genomic Region

Rv2800 Possible hydrolase

Details for Rv2800 - Possible hydrolase

GO Terms: GO:0005618, GO:0005886

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 1.00 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv2800

Tuberculist Genomic Region

Rv2703 RNA polymerase sigma factor SigB

Details for Rv2703 - RNA polymerase sigma factor SigB

GO Terms: GO:0003700, GO:0006355, GO:0016987, GO:0030528, GO:0003677, GO:0006352, GO:0003677, GO:0005515, GO:0005886, GO:0009405, GO:0009415, GO:0016987, GO:0040007, GO:0052572

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.00 | In vitro Essential: 0.09 | In vivo Essential: NA

Go to Gene Page: Rv2703

Tuberculist Genomic Region

Rv2782c FIG007959: peptidase, M16 family

Details for Rv2782c - FIG007959: peptidase, M16 family

GO Terms: GO:0005886

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.36 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv2782c

Tuberculist Genomic Region

Displaying 1 - 1 of 1
Motif 1 Motif 2
e-value: 0.013 e-value: 0.027
Displaying 1 - 1 of 1
Arginine pathway regulatory protein ArgR, repressor of arg regulon
regulates 31 modules
Weight: 
0.23
up-regulates
Transcriptional regulator, TetR family
regulates 54 modules
Weight: 
0.20
up-regulates
\Transcriptional regulator, TetR family\\\""
regulates 32 modules
Weight: 
0.17
up-regulates
regulates 52 modules
Weight: 
-0.14
down-regulates
Uracil phosphoribosyltransferase (EC 2.4.2.9) / Pyrimidine operon regulatory protein PyrR
regulates 90 modules
Weight: 
0.10
up-regulates
Displaying 1 - 1 of 1
Module GO Term Enrichment Descriptions
GO:0046394 | GO:0016053 carboxylic acid biosynthetic process | organic acid biosynthetic process
Displaying 1 - 26 of 26
GO:0003942 |

N-acetyl-gamma-glutamyl-phosphate reductase activity

GO:0040007 |

growth

GO:0042803 |

protein homodimerization activity

GO:0003991 |

acetylglutamate kinase activity

GO:0005886 |

plasma membrane

GO:0004585 |

ornithine carbamoyltransferase activity

GO:0006526 |

arginine biosynthetic process

GO:0070207 |

protein homotrimerization

GO:0004055 |

argininosuccinate synthase activity

GO:0005829 |

cytosol

GO:0004056 |

argininosuccinate lyase activity

GO:0006412 |

translation

GO:0005525 |

GTP binding

GO:0005618 |

cell wall

GO:0004654 |

polyribonucleotide nucleotidyltransferase activity

GO:0003700 |

sequence-specific DNA binding transcription factor activity

GO:0006355 |

regulation of transcription, DNA-dependent

GO:0016987 |

sigma factor activity

GO:0030528 |

transcription regulator activity

GO:0003677 |

DNA binding

GO:0006352 |

DNA-dependent transcription, initiation

GO:0005515 |

protein binding

GO:0009405 |

pathogenesis

GO:0009415 |

response to water stimulus

GO:0052572 |

response to host immune response