Module 458 Residual: 0.58

Title Bicluster Model Residual Score
bicluster_0458 v02 0.58 -4.33
Displaying 1 - 20 of 20
Rv2138 Lipoprotein LppL

Details for Rv2138 - Lipoprotein LppL

GO Terms: GO:0040007

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.00 | In vitro Essential: 0.15 | In vivo Essential: NA

Go to Gene Page: Rv2138

Tuberculist Genomic Region

Rv2785c SSU ribosomal protein S15p (S13e)

Details for Rv2785c - SSU ribosomal protein S15p (S13e)

GO Terms: GO:0005840, GO:0003735, GO:0006412, GO:0005622, GO:0005886

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.12 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv2785c

Tuberculist Genomic Region

Rv3205c

Details for Rv3205c -

GO Terms: GO:0005886

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.61 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv3205c

Tuberculist Genomic Region

Rv3285 Biotin carboxylase of acetyl-CoA carboxylase (EC 6.3.4.14) / Biotin carboxyl carrier protein of acetyl-CoA carboxylase

Details for Rv3285 - Biotin carboxylase of acetyl-CoA carboxylase (EC 6.3.4.14) / Biotin carboxyl carrier protein of acetyl-CoA carboxylase

GO Terms: GO:0003989, GO:0005515, GO:0005886, GO:0009317, GO:0040007

PATRIC Pathways: Fatty acid biosynthesis

Essentiality: Griffin Essential: 0.00 | In vitro Essential: 0.08 | In vivo Essential: NA

Go to Gene Page: Rv3285

Tuberculist Genomic Region

Rv0049

Details for Rv0049 -

GO Terms: NA

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.90 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv0049

Tuberculist Genomic Region

Rv0462 Dihydrolipoamide dehydrogenase (EC 1.8.1.4)

Details for Rv0462 - Dihydrolipoamide dehydrogenase (EC 1.8.1.4)

GO Terms: GO:0004148, GO:0004148, GO:0005515, GO:0005576, GO:0005829, GO:0005886, GO:0016655, GO:0040007, GO:0042803, GO:0045254, GO:0045454, GO:0050660, GO:0055114, GO:0070404, GO:0004591

PATRIC Pathways: Glycolysis / Gluconeogenesis, Citrate cycle (TCA cycle), Pyruvate metabolism, Valine, leucine and isoleucine degradation, Glycine, serine and threonine metabolism

Essentiality: Griffin Essential: 0.00 | In vitro Essential: 0.13 | In vivo Essential: NA

Go to Gene Page: Rv0462

Tuberculist Genomic Region

Rv0463 Possible membrane protein

Details for Rv0463 - Possible membrane protein

GO Terms: NA

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.63 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv0463

Tuberculist Genomic Region

Rv0558 Ubiquinone/menaquinone biosynthesis methyltransferase UbiE (EC 2.1.1.-) @ 2-heptaprenyl-1,4-naphthoquinone methyltransferase (EC 2.1.1.163)

Details for Rv0558 - Ubiquinone/menaquinone biosynthesis methyltransferase UbiE (EC 2.1.1.-) @ 2-heptaprenyl-1,4-naphthoquinone methyltransferase (EC 2.1.1.163)

GO Terms: GO:0008168, GO:0005886, GO:0040007

PATRIC Pathways: Ubiquinone and other terpenoid-quinone biosynthesis

Essentiality: Griffin Essential: 0.00 | In vitro Essential: 0.14 | In vivo Essential: NA

Go to Gene Page: Rv0558

Tuberculist Genomic Region

Rv1294 Homoserine dehydrogenase (EC 1.1.1.3)

Details for Rv1294 - Homoserine dehydrogenase (EC 1.1.1.3)

GO Terms: GO:0004412, GO:0005886, GO:0040007

PATRIC Pathways: Cysteine and methionine metabolism, Glycine, serine and threonine metabolism, Lysine biosynthesis

Essentiality: Griffin Essential: 0.00 | In vitro Essential: 0.02 | In vivo Essential: NA

Go to Gene Page: Rv1294

Tuberculist Genomic Region

Rv2074

Details for Rv2074 -

GO Terms: GO:0005576

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.78 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv2074

Tuberculist Genomic Region

Rv2241 Pyruvate dehydrogenase E1 component (EC 1.2.4.1)

Details for Rv2241 - Pyruvate dehydrogenase E1 component (EC 1.2.4.1)

GO Terms: GO:0004739, GO:0000287, GO:0004739, GO:0005576, GO:0005886, GO:0045254, GO:0055114

PATRIC Pathways: Pyruvate metabolism, Valine, leucine and isoleucine biosynthesis, Glycolysis / Gluconeogenesis, Butanoate metabolism, Citrate cycle (TCA cycle)

Essentiality: Griffin Essential: 0.00 | In vitro Essential: NA | In vivo Essential: 0.27

Go to Gene Page: Rv2241

Tuberculist Genomic Region

Rv2309c Integrase

Details for Rv2309c - Integrase

GO Terms: NA

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.27 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv2309c

Tuberculist Genomic Region

Rv2605c Acyl-CoA thioesterase II (EC 3.1.2.-)

Details for Rv2605c - Acyl-CoA thioesterase II (EC 3.1.2.-)

GO Terms: GO:0005886

PATRIC Pathways: Fatty acid biosynthesis, Biosynthesis of unsaturated fatty acids, alpha-Linolenic acid metabolism, Benzoate degradation via hydroxylation, Limonene and pinene degradation

Essentiality: Griffin Essential: 0.25 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv2605c

Tuberculist Genomic Region

Rv3050c Transcriptional regulator, TetR family

Details for Rv3050c - Transcriptional regulator, TetR family

GO Terms: GO:0005618

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.40 | In vitro Essential: NA | In vivo Essential: 0.19

Go to Gene Page: Rv3050c

Tuberculist Genomic Region

Rv3221c Biotin carboxyl carrier protein

Details for Rv3221c - Biotin carboxyl carrier protein

GO Terms: NA

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.31 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv3221c

Tuberculist Genomic Region

Rv3277

Details for Rv3277 -

GO Terms: NA

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.01 | In vitro Essential: NA | In vivo Essential: 0.10

Go to Gene Page: Rv3277

Tuberculist Genomic Region

Rv3283 Thiosulfate sulfurtransferase, rhodanese (EC 2.8.1.1)

Details for Rv3283 - Thiosulfate sulfurtransferase, rhodanese (EC 2.8.1.1)

GO Terms: GO:0005618, GO:0005829, GO:0005886

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.99 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv3283

Tuberculist Genomic Region

Rv3284 Sulfur acceptor protein SufE for iron-sulfur cluster assembly

Details for Rv3284 - Sulfur acceptor protein SufE for iron-sulfur cluster assembly

GO Terms: NA

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.92 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv3284

Tuberculist Genomic Region

Rv3708c Aspartate-semialdehyde dehydrogenase (EC 1.2.1.11)

Details for Rv3708c - Aspartate-semialdehyde dehydrogenase (EC 1.2.1.11)

GO Terms: GO:0004073, GO:0004073, GO:0005886, GO:0040007

PATRIC Pathways: Glycine, serine and threonine metabolism, Lysine biosynthesis, Cysteine and methionine metabolism

Essentiality: Griffin Essential: 0.01 | In vitro Essential: 0.05 | In vivo Essential: NA

Go to Gene Page: Rv3708c

Tuberculist Genomic Region

Rv3709c Aspartokinase (EC 2.7.2.4)

Details for Rv3709c - Aspartokinase (EC 2.7.2.4)

GO Terms: GO:0004072, GO:0005886, GO:0040007

PATRIC Pathways: Cysteine and methionine metabolism, Lysine biosynthesis, Glycine, serine and threonine metabolism

Essentiality: Griffin Essential: 0.00 | In vitro Essential: 0.05 | In vivo Essential: NA

Go to Gene Page: Rv3709c

Tuberculist Genomic Region

Displaying 1 - 1 of 1
Motif 1 Motif 2
e-value: 0.15 e-value: 30000
Displaying 1 - 1 of 1
Module GO Term Enrichment Descriptions
GO:1901564 | GO:0044238 | GO:0044281 | GO:0044283 | GO:0044711 | GO:1901566 organonitrogen compound metabolic proces... | primary metabolic process | small molecule metabolic process | small molecule biosynthetic process | single-organism biosynthetic process | organonitrogen compound biosynthetic pro...
Displaying 1 - 28 of 28
GO:0040007 |

growth

GO:0005840 |

ribosome

GO:0003735 |

structural constituent of ribosome

GO:0006412 |

translation

GO:0005622 |

intracellular

GO:0005886 |

plasma membrane

GO:0003989 |

acetyl-CoA carboxylase activity

GO:0005515 |

protein binding

GO:0009317 |

acetyl-CoA carboxylase complex

GO:0004148 |

dihydrolipoyl dehydrogenase activity

GO:0005576 |

extracellular region

GO:0005829 |

cytosol

GO:0016655 |

oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor

GO:0042803 |

protein homodimerization activity

GO:0045254 |

pyruvate dehydrogenase complex

GO:0045454 |

cell redox homeostasis

GO:0050660 |

flavin adenine dinucleotide binding

GO:0055114 |

oxidation-reduction process

GO:0070404 |

NADH binding

GO:0004591 |

oxoglutarate dehydrogenase (succinyl-transferring) activity

GO:0008168 |

methyltransferase activity

GO:0004412 |

homoserine dehydrogenase activity

GO:0004739 |

pyruvate dehydrogenase (acetyl-transferring) activity

GO:0000287 |

magnesium ion binding

GO:0005618 |

cell wall

GO:0004073 |

aspartate-semialdehyde dehydrogenase activity

GO:0004072 |

aspartate kinase activity