Rv1379 Uracil phosphoribosyltransferase (EC 188.8.131.52) / Pyrimidine operon regulatory protein PyrR
|Symbol||Product||Feature Type||Start||End||Strand||Length||AA Length||is TF|
|Rv1379||pyrR||Uracil phosphoribosyltransferase (EC 184.108.40.206) / Pyrimidine operon regulatory protein PyrR||CDS||1552654||1553235||+||582||193||TRUE|
Rv1379 (Uracil phosphoribosyltransferase (EC 220.127.116.11) / Pyrimidine operon regulatory protein PyrR) is predicted to be co-regulated in modules bicluster_0137 with residual 0.49 and bicluster_0484 with residual 0.42.
This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 850.00 and 1,200.00 for bicluster_0137 and 270.00 and 200.00 for bicluster_0484 respectively.
These modules are enriched for following go terms: 'de novo' pyrimidine nucleobase biosynth..., pyrimidine-containing compound biosynthe..., pyrimidine-containing compound metabolic..., organonitrogen compound metabolic proces..., nucleobase-containing small molecule met..., carbon-nitrogen ligase activity, with gl... .
This gene is found to be non-essential for growth on cholesterol.
|Gene Target||Differential Expression||Distance||Expression||pvalue||Type|
|Product (LegacyBRC)||Product (RefSeq)|
|Bifunctional protein pyrR||bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase|
|BioCyc Gene Page||Cellular Overview Map|
|Cholesterol Essentiality||t-test p-value||Cholesterol/Glycerol Ratio|
How essentiality calculations were done?
The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.