Organism : Clostridium acetobutylicum | Module List :
CAC2253

Membrane-associated sensory histidine kinase-like ATPase (NCBI ptt file)

CircVis
Functional Annotations (6)
Function System
Signal transduction histidine kinase cog/ cog
two-component sensor activity go/ molecular_function
two-component signal transduction system (phosphorelay) go/ biological_process
ATP binding go/ molecular_function
integral to membrane go/ cellular_component
protein dimerization activity go/ molecular_function
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for CAC2253
(Mouseover regulator name to see its description)

CAC2253 is regulated by 27 influences and regulates 0 modules.
Regulators for CAC2253 (27)
Regulator Module Operator
CAC0191 82 tf
CAC0201 82 tf
CAC0569 82 tf
CAC0841 82 tf
CAC0849 82 tf
CAC1467 82 tf
CAC1559 82 tf
CAC1578 82 tf
CAC1766 82 tf
CAC1869 82 tf
CAC2060 82 tf
CAC2084 82 tf
CAC2690 82 tf
CAC3037 82 tf
CAC3192 82 tf
CAC0144 106 tf
CAC0841 106 tf
CAC1559 106 tf
CAC1766 106 tf
CAC2052 106 tf
CAC2060 106 tf
CAC2084 106 tf
CAC3192 106 tf
CAC3216 106 tf
CAC3267 106 tf
CAC3345 106 tf
CAC3409 106 tf

Warning: CAC2253 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
6818 3.00e-06 GgAgGg
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6819 8.90e+03 CTGCTGC
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6864 4.40e-02 GgAGGg.T
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6865 6.50e+03 CGAGGTG
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for CAC2253

CAC2253 is enriched for 6 functions in 3 categories.
Enrichment Table (6)
Function System
Signal transduction histidine kinase cog/ cog
two-component sensor activity go/ molecular_function
two-component signal transduction system (phosphorelay) go/ biological_process
ATP binding go/ molecular_function
integral to membrane go/ cellular_component
protein dimerization activity go/ molecular_function
Module neighborhood information for CAC2253

CAC2253 has total of 44 gene neighbors in modules 82, 106
Gene neighbors (44)
Gene Common Name Description Module membership
CAC0040 CAC0040 Uncharacterized small conserved protein, homolog of yfjA/yukE B.subtilis (NCBI ptt file) 82, 251
CAC0111 CAC0111 Glutamine-binding periplasmic protein fused to glutamine permease (NCBI ptt file) 106, 278
CAC0112 glnQ Glutamine ABC transporter (ATP-binding protein) (NCBI ptt file) 106, 302
CAC0168 CAC0168 T-RNA-processing ribonuclease BN (NCBI ptt file) 82, 207
CAC0208 CAC0208 Predicted membrane protein; CF-20 family (NCBI ptt file) 82, 302
CAC0209 CAC0209 Predicted membrane protein; CF-20 family (NCBI ptt file) 82, 366
CAC0237 CAC0237 ABC transporter, permease component (NCBI ptt file) 106, 287
CAC0290 CAC0290 Sensory transduction histidine kinases (NCBI ptt file) 82, 91
CAC0386 licC PTS cellobiose-specific component IIC (NCBI ptt file) 82, 285
CAC0539 manB Beta-mannanase ManB, contains ChW-repeats (NCBI ptt file) 82, 251
CAC0584 CAC0584 Precorrin-6B methylase 1 CobL1/CbiE (NCBI ptt file) 106, 117
CAC0630 CAC0630 Peptide chain ralease factor 3 (RF-3) (NCBI ptt file) 82, 160
CAC0633 CAC0633 Predicted phosphatase (NCBI ptt file) 82, 151
CAC0783 CAC0783 Uncharacterized low-complexity protein (NCBI ptt file) 82, 251
CAC0784 CAC0784 ATP-dependent RNA helicase, superfamily II (NCBI ptt file) 82, 251
CAC1272 CAC1272 Predicted membrane protein (NCBI ptt file) 106, 215
CAC1279 hemN Coproporphyrinogen III oxidase (NCBI ptt file) 3, 106
CAC1615 CAC1615 Predicted glycosyltransferase (NCBI ptt file) 69, 82
CAC1760 CAC1760 Signal peptidase I (NCBI ptt file) 106, 194
CAC1821 purB Adenylosuccinate lyase (NCBI ptt file) 106, 297
CAC1852 CAC1852 Magnesium and cobalt transport protein (NCBI ptt file) 106, 346
CAC1858 CAC1858 MoxR-like ATPase (NCBI ptt file) 64, 106
CAC2174 CAC2174 Glycosyltransferase (NCBI ptt file) 82, 346
CAC2253 CAC2253 Membrane-associated sensory histidine kinase-like ATPase (NCBI ptt file) 82, 106
CAC2265 CAC2265 Uncharacterized conserved membrane protein (NCBI ptt file) 106, 297
CAC2266 CAC2266 Uncharacterized conserved membrane protein (fragment) (NCBI ptt file) 106, 297
CAC2323 CAC2323 Predicted membrane protein (NCBI ptt file) 5, 82
CAC2324 CAC2324 Glycosyltransferase (NCBI ptt file) 82, 215
CAC2338 CAC2338 Lysine decarboxylase (NCBI ptt file) 82, 285
CAC2370 CAC2370 Uncharacterized protein, YrfI family (NCBI ptt file) 106, 194
CAC2371 CAC2371 S-adenosylmethionine-dependent methyltransferase (NCBI ptt file) 106, 194
CAC2397 CAC2397 Hypothetical protein (NCBI ptt file) 106, 296
CAC2432 CAC2432 Predicted permease (NCBI ptt file) 82, 106
CAC2601 CAC2601 S-adenosylmethionine decarboxylase (NCBI ptt file) 82, 225
CAC2658 glnA Glutamine synthetase type III (NCBI ptt file) 99, 106
CAC2912 araN Sugar-binding periplasmic protein (NCBI ptt file) 82, 235
CAC2913 CAC2913 Hypothetical protein (NCBI ptt file) 82, 235
CAC3010 CAC3010 ATP-dependent RNA helicase (superfamily II), YDBR B.subtilis ortholog (NCBI ptt file) 84, 106
CAC3099 truA Pseudouridylate synthase, TRUA (NCBI ptt file) 106, 255
CAC3100 CAC3100 Predicted permease (Cobalt permease subfamily) (NCBI ptt file) 84, 106
CAC3212 CAC3212 Fusion of Uroporphyrinogen-III methylase related protein and MAZG family protein, YABN B.subtilis ortholog (NCBI ptt file) 82, 302
CAC3260 asnS Aspartyl/asparaginyl-tRNA synthetase (NCBI ptt file) 82, 292
CAC3668 CAC3668 MDR-type permease (NCBI ptt file) 82, 251
CAC3675 CAC3675 Hypothetical secreted protein (NCBI ptt file) 106, 151
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for CAC2253
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend