Organism : Rhodobacter sphaeroides 2.4.1 | Module List :
RSP_1292

putative Aldehyde dehydrogenase (NCBI)

CircVis
Functional Annotations (21)
Function System
NAD-dependent aldehyde dehydrogenases cog/ cog
aldehyde dehydrogenase (NAD) activity go/ molecular_function
metabolic process go/ biological_process
Glycolysis / Gluconeogenesis kegg/ kegg pathway
Pentose and glucuronate interconversions kegg/ kegg pathway
Ascorbate and aldarate metabolism kegg/ kegg pathway
Fatty acid metabolism kegg/ kegg pathway
Valine leucine and isoleucine degradation kegg/ kegg pathway
Lysine degradation kegg/ kegg pathway
Arginine and proline metabolism kegg/ kegg pathway
Histidine metabolism kegg/ kegg pathway
Tryptophan metabolism kegg/ kegg pathway
beta-Alanine metabolism kegg/ kegg pathway
Glycerolipid metabolism kegg/ kegg pathway
Pyruvate metabolism kegg/ kegg pathway
Chloroalkane and chloroalkene degradation kegg/ kegg pathway
Propanoate metabolism kegg/ kegg pathway
Limonene and pinene degradation kegg/ kegg pathway
Metabolic pathways kegg/ kegg pathway
Biosynthesis of secondary metabolites kegg/ kegg pathway
Microbial metabolism in diverse environments kegg/ kegg pathway
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for RSP_1292
(Mouseover regulator name to see its description)

RSP_1292 is regulated by 28 influences and regulates 0 modules.
Regulators for RSP_1292 (28)
Regulator Module Operator
RSP_0068 91 tf
RSP_0386 91 tf
RSP_0394 91 tf
RSP_0611 91 tf
RSP_0774 91 tf
RSP_1034 91 tf
RSP_1243 91 tf
RSP_1286 91 tf
RSP_2324 91 tf
RSP_2533 91 tf
RSP_2572 91 tf
RSP_2888 91 tf
RSP_2963 91 tf
RSP_3528 91 tf
RSP_0032 107 tf
RSP_0122 107 tf
RSP_0327 107 tf
RSP_0394 107 tf
RSP_0395 107 tf
RSP_0591 107 tf
RSP_0755 107 tf
RSP_1032 107 tf
RSP_1550 107 tf
RSP_1606 107 tf
RSP_1712 107 tf
RSP_2165 107 tf
RSP_3022 107 tf
RSP_3309 107 tf

Warning: RSP_1292 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
7902 6.60e+02 tcccGCccgcgcGcT
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7903 2.10e+03 ATCCGcGCCgatGtGcAATG
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7934 5.30e+00 cCAGAaGCaGa
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7935 1.70e+02 AggATggggGC
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for RSP_1292

RSP_1292 is enriched for 21 functions in 3 categories.
Enrichment Table (21)
Function System
NAD-dependent aldehyde dehydrogenases cog/ cog
aldehyde dehydrogenase (NAD) activity go/ molecular_function
metabolic process go/ biological_process
Glycolysis / Gluconeogenesis kegg/ kegg pathway
Pentose and glucuronate interconversions kegg/ kegg pathway
Ascorbate and aldarate metabolism kegg/ kegg pathway
Fatty acid metabolism kegg/ kegg pathway
Valine leucine and isoleucine degradation kegg/ kegg pathway
Lysine degradation kegg/ kegg pathway
Arginine and proline metabolism kegg/ kegg pathway
Histidine metabolism kegg/ kegg pathway
Tryptophan metabolism kegg/ kegg pathway
beta-Alanine metabolism kegg/ kegg pathway
Glycerolipid metabolism kegg/ kegg pathway
Pyruvate metabolism kegg/ kegg pathway
Chloroalkane and chloroalkene degradation kegg/ kegg pathway
Propanoate metabolism kegg/ kegg pathway
Limonene and pinene degradation kegg/ kegg pathway
Metabolic pathways kegg/ kegg pathway
Biosynthesis of secondary metabolites kegg/ kegg pathway
Microbial metabolism in diverse environments kegg/ kegg pathway
Module neighborhood information for RSP_1292

RSP_1292 has total of 60 gene neighbors in modules 91, 107
Gene neighbors (60)
Gene Common Name Description Module membership
RSP_0010 RSP_0010 homoserine O-succinyltransferase (NCBI) 91, 133
RSP_0011 RSP_0011 Predicted hydrolases or acyltransferases (alpha/beta hydrolase) (NCBI) 91, 366
RSP_0013 RSP_0013 hypothetical protein (NCBI) 68, 91
RSP_0014 RSP_0014 transcriptional regulator, TetR family (NCBI) 91, 215
RSP_0148 RSP_0148 Signal transduction histidine kinase (NCBI) 107, 335
RSP_0149 RSP_0149 CheY-like receiver protein (NCBI) 107, 112
RSP_0153 RSP_0153 hypothetical protein (NCBI) 107, 278
RSP_0198 RSP_0198 Phosphatidylglycerophosphate synthase (NCBI) 107, 121
RSP_0365 RSP_0365 hypothetical protein (NCBI) 107, 185
RSP_0388 RSP_0388 hypothetical protein (NCBI) 107, 377
RSP_0392 RSP_0392 probable lactoylglutathione lyase (NCBI) 107, 239
RSP_0393 RSP_0393 probable riboflavin biosynthesis protein (NCBI) 107, 323
RSP_0552 RSP_0552 putative multidrug transporter, SMR family, DMT Superfamily (NCBI) 107, 302
RSP_0774 RSP_0774 RNA binding protein (NCBI) 91, 184
RSP_0795 RSP_0795 hypothetical protein (NCBI) 107, 185
RSP_0865 RSP_0865 hypothetical protein (NCBI) 107, 345
RSP_0935 RSP_0935 MiaB-like Radical SAM protein (NCBI) 63, 107
RSP_1018 RSP_1018 Glycolate oxidase iron-sulfur subunit (NCBI) 91, 148
RSP_1019 RSP_1019 putative glycolate oxidase subunit protein (NCBI) 91, 148
RSP_1032 RSP_1032 possible O6-methylguanine-DNA methyltransferase (NCBI) 76, 107
RSP_1034 pdhR Pyruvate dehydrogenase complex repressor (NCBI) 91, 148
RSP_1130 RSP_1130 hypothetical membrane protein (NCBI) 54, 91
RSP_1172 dnaJ Chaperone, DnaJ (NCBI) 91, 297
RSP_1234 aroE putative shikimate 5-dehydrogenase (NCBI) 107, 308
RSP_1292 RSP_1292 putative Aldehyde dehydrogenase (NCBI) 91, 107
RSP_1487 RSP_1487 hypothetical protein (NCBI) 91, 289
RSP_1488 RSP_1488 Possible glyoxalase (NCBI) 91, 289
RSP_1516 RSP_1516 putative S-adenosyl L-homocystein hydrolase (NCBI) 91, 197
RSP_1558 RSP_1558 putative 2-dehydropantoate 2-reductase (NCBI) 107, 136
RSP_1895 RSP_1895 Small-conductance mechanosensitive ion channel (NCBI) 91, 231
RSP_1899 RSP_1899 Predicted ATPase (NCBI) 91, 220
RSP_1900 RSP_1900 hypothetical protein (NCBI) 91, 233
RSP_1901 RSP_1901 Hypothetical protein with TPR repeat (NCBI) 91, 245
RSP_1965 RSP_1965 Putative Membrane Fusion Protein Family member (NCBI) 107, 247
RSP_1971 rnd Ribonuclease D (NCBI) 51, 107
RSP_1984 RSP_1984 histidinol-phosphate-aminotransferase (NCBI) 107, 171
RSP_2127 purS Component of phosphoribosylformylglycinamidine (FGAM) synthetase (NCBI) 107, 261
RSP_2165 putR transcriptional regulator, AsnC family (NCBI) 107, 126
RSP_2241 hisI Phosphoribosyl-ATP pyrophosphohydrolase (NCBI) 107, 294
RSP_2263 RSP_2263 hypothetical protein (NCBI) 91, 125
RSP_2282 chrA Chromate efflux pump, ChrA (NCBI) 10, 107
RSP_2287 RSP_2287 ChaC-like protein (NCBI) 107, 317
RSP_2411 RSP_2411 hypothetical protein (NCBI) 20, 107
RSP_2456 radA DNA Repair Protein (NCBI) 39, 91
RSP_2605 RSP_2605 hypothetical protein (NCBI) 91, 197
RSP_2606 RSP_2606 ArsR family Arsenical Resistance Operon Repressor (NCBI) 91, 197
RSP_2607 RSP_2607 nitrilotriacetate monooxygenase component B (NCBI) 91, 197
RSP_2608 corA magnesium/cobalt transport protein, MIT family (NCBI) 91, 197
RSP_2642 RSP_2642 hypothetical protein (NCBI) 107, 121
RSP_2810 RSP_2810 ABC transporter, ATPase subunit (NCBI) 91, 294
RSP_2903 RSP_2903 Probable PpiC-type peptidyl-prolyl cis-trans isomerase (NCBI) 107, 223
RSP_3071 RSP_3071 putative hydroxypyruvate reductase/glycerate kinase (NCBI) 107, 329
RSP_3107 RSP_3107 hypothetical protein (NCBI) 91, 350
RSP_3309 RSP_3309 transcriptional regulator, AraC family (NCBI) 63, 107
RSP_3350 RSP_3350 Lipocalin-related protein (NCBI) 107, 293
RSP_3384 RSP_3384 mandelate racemase/muconate lactonizing enzyme family protein (NCBI) 91, 346
RSP_3435 RSP_3435 possible DNA-binding protein (NCBI) 91, 316
RSP_3456 RSP_3456 Putative dihydrodipicolinate synthase (NCBI) 61, 91
RSP_3695 argE putative acetylornithine deacetylase (acetylornithinase) (NCBI) 1, 107
RSP_3785 RSP_3785 putative bacteriophage-related protein (NCBI) 91, 105
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for RSP_1292
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend