Module 252 Residual: 0.55

Title Bicluster Model Residual Score
bicluster_0252 v02 0.55 -9.84
Displaying 1 - 17 of 17
Rv1410c EmrB/QacA family drug resistance transporter

Details for Rv1410c - EmrB/QacA family drug resistance transporter

GO Terms: GO:0005887, GO:0008144, GO:0009405, GO:0015562

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.11 | In vitro Essential: NA | In vivo Essential: 0.04

Go to Gene Page: Rv1410c

Tuberculist Genomic Region

Rv1411c Lipoprotein LprG

Details for Rv1411c - Lipoprotein LprG

GO Terms: GO:0005886, GO:0009405

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.63 | In vitro Essential: NA | In vivo Essential: 0.10

Go to Gene Page: Rv1411c

Tuberculist Genomic Region

Rv2152c UDP-N-acetylmuramate--alanine ligase (EC 6.3.2.8)

Details for Rv2152c - UDP-N-acetylmuramate--alanine ligase (EC 6.3.2.8)

GO Terms: GO:0008150, GO:0008150, GO:0008150, GO:0008150, GO:0008150, GO:0008150, GO:0008763, GO:0040007

PATRIC Pathways: D-Glutamine and D-glutamate metabolism, Peptidoglycan biosynthesis

Essentiality: Griffin Essential: 0.00 | In vitro Essential: 0.02 | In vivo Essential: NA

Go to Gene Page: Rv2152c

Tuberculist Genomic Region

Rv2153c UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase (EC 2.4.1.227)

Details for Rv2153c - UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase (EC 2.4.1.227)

GO Terms: GO:0008150, GO:0008150, GO:0008150, GO:0008150, GO:0008150, GO:0040007

PATRIC Pathways: Peptidoglycan biosynthesis

Essentiality: Griffin Essential: 0.00 | In vitro Essential: 0.05 | In vivo Essential: NA

Go to Gene Page: Rv2153c

Tuberculist Genomic Region

Rv2197c Possible membrane protein

Details for Rv2197c - Possible membrane protein

GO Terms: NA

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.96 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv2197c

Tuberculist Genomic Region

Rv2198c Putative membrane protein MmpS3

Details for Rv2198c - Putative membrane protein MmpS3

GO Terms: GO:0005887

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.00 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv2198c

Tuberculist Genomic Region

Rv2537c 3-dehydroquinate dehydratase II (EC 4.2.1.10)

Details for Rv2537c - 3-dehydroquinate dehydratase II (EC 4.2.1.10)

GO Terms: GO:0003855, GO:0003855, GO:0040007, GO:0051260

PATRIC Pathways: Phenylalanine, tyrosine and tryptophan biosynthesis

Essentiality: Griffin Essential: 0.03 | In vitro Essential: 0.08 | In vivo Essential: NA

Go to Gene Page: Rv2537c

Tuberculist Genomic Region

Rv2538c 3-dehydroquinate synthase (EC 4.2.3.4)

Details for Rv2538c - 3-dehydroquinate synthase (EC 4.2.3.4)

GO Terms: GO:0003856, GO:0003856, GO:0005618, GO:0005886, GO:0009073, GO:0040007

PATRIC Pathways: Phenylalanine, tyrosine and tryptophan biosynthesis

Essentiality: Griffin Essential: 0.01 | In vitro Essential: 0.11 | In vivo Essential: NA

Go to Gene Page: Rv2538c

Tuberculist Genomic Region

Rv2539c Shikimate kinase I (EC 2.7.1.71)

Details for Rv2539c - Shikimate kinase I (EC 2.7.1.71)

GO Terms: GO:0004765, GO:0004765, GO:0040007

PATRIC Pathways: Phenylalanine, tyrosine and tryptophan biosynthesis

Essentiality: Griffin Essential: 0.08 | In vitro Essential: 0.04 | In vivo Essential: NA

Go to Gene Page: Rv2539c

Tuberculist Genomic Region

Rv2559c ATPase, AAA family

Details for Rv2559c - ATPase, AAA family

GO Terms: NA

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.85 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv2559c

Tuberculist Genomic Region

Rv2753c Dihydrodipicolinate synthase (EC 4.2.1.52)

Details for Rv2753c - Dihydrodipicolinate synthase (EC 4.2.1.52)

GO Terms: GO:0008840, GO:0005886, GO:0040007, GO:0051289

PATRIC Pathways: Lysine biosynthesis

Essentiality: Griffin Essential: 0.01 | In vitro Essential: 0.07 | In vivo Essential: NA

Go to Gene Page: Rv2753c

Tuberculist Genomic Region

Rv2921c Signal recognition particle receptor protein FtsY (=alpha subunit) (TC 3.A.5.1.1)

Details for Rv2921c - Signal recognition particle receptor protein FtsY (=alpha subunit) (TC 3.A.5.1.1)

GO Terms: GO:0006614, GO:0003723, GO:0009986, GO:0005525, GO:0016020, GO:0005886

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.00 | In vitro Essential: NA | In vivo Essential: 0.27

Go to Gene Page: Rv2921c

Tuberculist Genomic Region

Rv3305c Possible N-acyl-L-amino acid amidohydrolase amiA1 (EC 3.5.1.-)

Details for Rv3305c - Possible N-acyl-L-amino acid amidohydrolase amiA1 (EC 3.5.1.-)

GO Terms: NA

PATRIC Pathways: Butirosin and neomycin biosynthesis, Lipopolysaccharide biosynthesis, Sphingolipid metabolism, Fluorobenzoate degradation, Lysine biosynthesis, Glutathione metabolism, Amino sugar and nucleotide sugar metabolism, Caprolactam degradation

Essentiality: Griffin Essential: 0.15 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv3305c

Tuberculist Genomic Region

Rv3306c Catalyzes the cleavage of p-aminobenzoyl-glutamate to p-aminobenzoate and glutamate, subunit A

Details for Rv3306c - Catalyzes the cleavage of p-aminobenzoyl-glutamate to p-aminobenzoate and glutamate, subunit A

GO Terms: NA

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.61 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv3306c

Tuberculist Genomic Region

Rv2157c UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase (EC 6.3.2.10)

Details for Rv2157c - UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase (EC 6.3.2.10)

GO Terms: GO:0047480, GO:0008150, GO:0040007

PATRIC Pathways: Lysine biosynthesis, Peptidoglycan biosynthesis

Essentiality: Griffin Essential: 0.01 | In vitro Essential: 0.03 | In vivo Essential: NA

Go to Gene Page: Rv2157c

Tuberculist Genomic Region

Rv2922c Chromosome partition protein smc

Details for Rv2922c - Chromosome partition protein smc

GO Terms: GO:0005524, GO:0005515, GO:0005694, GO:0051276, GO:0005618, GO:0005829, GO:0005886

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.49 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv2922c

Tuberculist Genomic Region

Rv3593 Beta-lactamase (EC 3.5.2.6)

Details for Rv3593 - Beta-lactamase (EC 3.5.2.6)

GO Terms: GO:0040007

PATRIC Pathways: beta-Lactam resistance, Penicillin and cephalosporin biosynthesis

Essentiality: Griffin Essential: 0.00 | In vitro Essential: 0.10 | In vivo Essential: NA

Go to Gene Page: Rv3593

Tuberculist Genomic Region

Displaying 1 - 1 of 1
Motif 1 Motif 2
e-value: 930 e-value: 3100
Displaying 1 - 1 of 1
COG0714: MoxR-like ATPases
regulates 31 modules
Weight: 
0.19
up-regulates
regulates 40 modules
Weight: 
0.11
up-regulates
Transcriptional regulator, MarR family
regulates 12 modules
Weight: 
-0.10
down-regulates
regulates 10 modules
Weight: 
0.08
up-regulates
putative RNA polymerase sigma factor
regulates 10 modules
Weight: 
0.08
up-regulates
regulates 26 modules
Weight: 
0.07
up-regulates
Arginine pathway regulatory protein ArgR, repressor of arg regulon
regulates 31 modules
Weight: 
0.07
up-regulates
response regulator
regulates 69 modules
Weight: 
0.06
up-regulates
Transcriptional regulator, MarR family
regulates 19 modules
Weight: 
0.06
up-regulates
RNA polymerase sigma factor SigB
regulates 61 modules
Weight: 
0.06
up-regulates
regulates 43 modules
Weight: 
0.05
up-regulates
regulates 18 modules
Weight: 
0.04
up-regulates
Displaying 1 - 1 of 1
Module GO Term Enrichment Descriptions
GO:0008360 | GO:0022603 | GO:0022604 | GO:0050793 | GO:0000902 | GO:0009653 | GO:0032502 | GO:0032989 | GO:0044767 | GO:0048856 | GO:0048869 | GO:0051128 | GO:0016043 regulation of cell shape | regulation of anatomical structure morph... | regulation of cell morphogenesis | regulation of developmental process | cell morphogenesis | anatomical structure morphogenesis | developmental process | cellular component morphogenesis | single-organism developmental process | anatomical structure development | cellular developmental process | regulation of cellular component organiz... | cellular component organization
Displaying 1 - 28 of 28
GO:0005887 |

integral to plasma membrane

GO:0008144 |

drug binding

GO:0009405 |

pathogenesis

GO:0015562 |

efflux transmembrane transporter activity

GO:0005886 |

plasma membrane

GO:0008150 |

biological_process

GO:0008763 |

UDP-N-acetylmuramate-L-alanine ligase activity

GO:0040007 |

growth

GO:0003855 |

3-dehydroquinate dehydratase activity

GO:0051260 |

protein homooligomerization

GO:0003856 |

3-dehydroquinate synthase activity

GO:0005618 |

cell wall

GO:0009073 |

aromatic amino acid family biosynthetic process

GO:0004765 |

shikimate kinase activity

GO:0008840 |

dihydrodipicolinate synthase activity

GO:0051289 |

protein homotetramerization

GO:0006614 |

SRP-dependent cotranslational protein targeting to membrane

GO:0003723 |

RNA binding

GO:0009986 |

cell surface

GO:0005525 |

GTP binding

GO:0016020 |

membrane

GO:0047480 |

UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity

GO:0005524 |

ATP binding

GO:0005515 |

protein binding

GO:0005694 |

chromosome

GO:0051276 |

chromosome organization

GO:0005829 |

cytosol