Rv3574 Transcriptional regulator kstR (Rv3574), TetR family

Rv3574 (Transcriptional regulator kstR (Rv3574), TetR family) is predicted to be co-regulated in modules bicluster_0199 with residual 0.54 and bicluster_0200 with residual 0.45.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 0.00 and 0.00 for bicluster_0199 and 0.00 and 0.16 for bicluster_0200 respectively.

These modules are enriched for following go terms: coenzyme binding, oxidoreductase activity.

This gene is found to be for growth on cholesterol.

Mutant available?: Yes

Displaying 21 - 30 of 138
Gene Target Differential Expression Distance Expression pvalue Type
No -150 0.07 0.84562 CDS
3-oxoacyl-[acyl-carrier protein] reductase (EC 1.1.1.100)
Repressed -54 -1.26 0.0000000000000114 CDS
Rv3128c-like protein
Repressed -70 -0.86 0.0498337 Primary.TSS
Gamma-glutamyltranspeptidase (EC 2.3.2.2)
No -146 0.01 0.969528 CDS
Enoyl-CoA hydratase [isoleucine degradation] (EC 4.2.1.17) / 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35) / 3-hydroxybutyryl-CoA epimerase (EC 5.1.2.3)
No -17 -0.06 0.827142 Internal.TSS
Cyclohexanone monooxygenase (EC 1.14.13.22)
No -26 -0.66 0.1252 Primary.TSS
Hydride transferase 1 (Fragment)
Repressed 38 -0.99 0.0000000401 CDS
Hydride transferase 1 (Fragment)
Repressed 11 -0.77 0.00014975 CDS
antigen 34 kDa
No -104 0.12 0.425939 Primary.TSS
IMP cyclohydrolase (EC 3.5.4.10) / Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3)
No -133 -0.34 0.106467 CDS
not assigned to any KEGG Pathway.
GO:0003677

DNA binding

DNA binding

Details: 
Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid).
GO Category: 
molecular_function
37
Total items in this category:  
GO:0042803

protein homodimerization activity

protein homodimerization activity

Details: 
Interacting selectively and non-covalently with an identical protein to form a homodimer.
GO Category: 
molecular_function
83
Total items in this category:  
Description:Expression data from transcription factor over expression experiments. TFOE are matched to the ChIP-seq experiment done simultaneously. This dataset is described in Rustad et al. 2014, Genome Biology.
BioProject Accession GEO Series References Repository Sample Method Sample Type
PRJNA254351 GSM1427008 GSE59086 25232098 GEO Tiling Array RNA
PRJNA254351 GSM1427009 GSE59086 25232098 GEO Tiling Array RNA
PRJNA254351 GSM1427010 GSE59086 25232098 GEO Tiling Array RNA
PRJNA254351 GSM1427011 GSE59086 25232098 GEO Tiling Array RNA
PRJNA254351 GSM1427012 GSE59086 25232098 GEO Tiling Array RNA
PRJNA254351 GSM1427008 GSE59086 25232098 GEO Tiling Array RNA
PRJNA254351 GSM1427009 GSE59086 25232098 GEO Tiling Array RNA
PRJNA254351 GSM1427010 GSE59086 25232098 GEO Tiling Array RNA
PRJNA254351 GSM1427011 GSE59086 25232098 GEO Tiling Array RNA
PRJNA254351 GSM1427012 GSE59086 25232098 GEO Tiling Array RNA

TRIP log2 fold abundance change

NA
Displaying 1 - 17 of 17
Condition Count Day Doublings Fitness U.I Plots
D0U 27 0 0.00 12.17 U
D3I 3 3 3.83 11.79 I
D3U 3 3 3.83 10.90 U
D5I 9 5 6.00 10.89 I
D5U 17 5 6.00 11.76 U
D7I 18 7 8.14 10.15 I
D7U 19 7 8.14 11.31 U
D14I 4 14 15.63 4.32 I
D14U 4 14 15.63 8.47 U
D17I 3 17 19.15 2.30 I
D17U 3 17 19.15 7.41 U
D21I 4 21 23.23 2.50 I
D21U 4 21 23.23 7.03 U
D24I 3 24 26.60 I
D24U 3 24 26.60 5.82 U
D28I 4 28 30.61 I
D28U 4 28 30.61 5.94 U