Environment and Gene Regulatory Influence Network (EGRIN) model for C. difficile 630

The Environment and Gene Regulatory Influence Network (EGRIN) model of C. difficile 630 was inferred using cMonkey2 and a compendium of 136 transcriptomes (retrieved from the Gene Expression Omnibus repository) with 4,070 sequence features including 35 rRNAs and 90 tRNAs . The C. difficile EGRIN model groups genes in subsets (406 modules in total), that are co-regulated in specific environments, and also identifies the associated, putative cis-acting gene regulatory elements (GREs), which represent potential TF binding locations. Transcriptome compendium included conditions: response to iron limitation, response to oxygen, in vivo vs in vitro growth, short term infection (0, 30, 60, 120 mins), response to commensals and host diet, transition from exponential to stationary phase, fur KO, codY KO, sporulation TF (and sigma factors) KOs.

Explore Regulatory Modules

Displaying 11 - 20 of 406

Candidate transcriptional regulators for each module were determined with a linear regression based approach (Inferelator) and by evaluating the statistical significance of the overlap (Hypergeometric) between modules and putative TF and alternative sigma factor regulons (CcpA, CodY, Fur, PrdR, SigB, SigD, SigE, SigF, SigG, SigH, SigK, Spo0A) compiled from available literature.

* Given that translation start was used to define the 3' end of putative promoters, some cis-regulatory motifs are likely to be ribosome binding sites (i.e., Shine-Dalgarno sequence). RBS is typically a six nucleotide sequence 5'-GGAGGA-3'.

Title	Gene Count	Motif 1 e-value	Motif 2 e-value	Residual	TF Influences
Module_242	19 CD630_11970 - spoiIIIAF Type: Gene Product:Stage III sporulation protein AF \| Pathway: \| COG: Function unknown CD630_01250 - spoIIQ Type: Gene Product:Stage II sporulation protein Q \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_05970 - cotF Type: Gene Product:Spore coat protein \| Pathway: \| COG: Function unknown CD630_24420 - spoIV Type: Gene Product:Stage IV sporulation protein \| Pathway: \| COG: Function unknown CD630_01240 - spoIID Type: Gene Product:Stage II sporulation protein D \| Pathway: \| COG: Cell cycle control, cell division, chromosome partitioning CD630_11930 - spoIIIAB Type: Gene Product:Stage III sporulation protein AB \| Pathway: \| COG: Function unknown CD630_11990 - spoIIIAH Type: Gene Product:Stage III sporulation protein AH \| Pathway: \| COG: Function unknown CD630_11920 - spoIIIAA Type: Gene Product:Stage III sporulation protein AA \| Pathway: \| COG: Function unknown CD630_11960 - spoIIIAE Type: Gene Product:Stage III sporulation protein AE \| Pathway: \| COG: Function unknown CD630_24000 - cotJB2 Type: Gene Product:Spore coat peptide assembly protein CotJB 2 \| Pathway: \| COG: Function unknown CD630_05980 - cotCB Type: Gene Product:Spore-coat protein CotCB; manganese catalase \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_11980 - spoIIIAG Type: Gene Product:Stage III sporulation protein AG \| Pathway: \| COG: Function unknown CD630_11940 - spoIIIAC Type: Gene Product:Stage III sporulation protein AC \| Pathway: \| COG: Function unknown CD630_24010 - cotD Type: Gene Product:Spore coat protein CotD; manganese catalase \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_01260 - spoIIID Type: Gene Product:Stage III sporulation protein D \| Pathway: \| COG: Transcription CD630_05960 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_23990 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_32980 - Type: Gene Product:Putative ATP/GTP-binding protein \| Pathway: \| COG: Function unknown CD630_11950 - spoIIIAD Type: Gene Product:Stage III sporulation protein AD \| Pathway: \| COG: Function unknown	0	`NA`	0.24	Inferelator: 1 Hypergeometric: 3 TF Influences from Inferelator CD630_34990 - spoVT Type: Gene Product:Stage V sporulation protein T \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test CD630_12140 - spo0A Type: Gene Product:Stage 0 sporulation protein A \| Pathway: \| COG: Signal transduction mechanisms CD630_26430 - sigE Type: Gene Product:RNA polymerase sigma-E factor \| Pathway: \| COG: Transcription CD630_12300 - Type: Gene Product:RNA polymerase sigma-K factor SigK (Part 2) \| Pathway: \| COG: Transcription, Transcription
Module_193	21 CD630_06512 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_36360 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: CD630_36361 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_06030 - Type: Gene Product:Fragment of putative membrane protein (C-terminalregion) \| Pathway: \| COG: CD630_03540 - Type: Gene Product:Fragment of putative membrane protein (Part 1) \| Pathway: \| COG: CD630_20141 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_32561 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_36350 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_32471 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_29100 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_34391 - Type: Gene Product:Putative spore-associated protein \| Pathway: \| COG: CD630_25622 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_29140 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_29071 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_23591 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_03901 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_29160 - Type: Gene Product:Putative phage major capsid protein \| Pathway: \| COG: Function unknown CD630_29170 - Type: Gene Product:Putative scaffold protein \| Pathway: \| COG: Function unknown CD630_29090 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_36380 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_31501 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG:	0	`NA`	0.25	Inferelator: 4 Hypergeometric: 2 TF Influences from Inferelator CD630_02760 - Type: Gene Product:Transcriptional regulator, AraC family \| Pathway: \| COG: Transcription CD630_12390 - Type: Gene Product:Transcriptional regulator, beta-lactams repressorPhage-type \| Pathway: \| COG: Transcription CD630_16860 - Type: Gene Product:Transcriptional regulator, repressor-like \| Pathway: \| COG: Transcription CD630_23160 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test CD630_07720 - sigF Type: Gene Product:RNA polymerase sigma-F factor \| Pathway: \| COG: Transcription CD630_26430 - sigE Type: Gene Product:RNA polymerase sigma-E factor \| Pathway: \| COG: Transcription
Module_392	28 CD630_32471 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_20431 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_20100 - ermB Type: Gene Product:rRNA adenine N-6-methyltransferase \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_20061 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_20751 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_10631 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_03901 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_22242 - Type: Gene Product:Putative extrachromosomal origin protein \| Pathway: \| COG: CD630_25622 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_26871 - Type: Gene Product:Putative spore associated protein \| Pathway: \| COG: Function unknown CD630_23591 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_20091 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_10630 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_34391 - Type: Gene Product:Putative spore-associated protein \| Pathway: \| COG: CD630_20070 - ermB Type: Gene Product:rRNA adenine N-6-methyltransferase \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_10632 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_10633 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_10900 - rgbS Type: Gene Product:Fragment of two-component sensor histidine kinase(N-terminal region) \| Pathway: \| COG: Signal transduction mechanisms CD630_t0670 - tRNA-Leu Type: Gene Product: \| Pathway: \| COG: CD630_06512 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_06511 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_22670 - Type: Gene Product:Fragment of membrane protein, abortiveinfection-type protein (Part 2) \| Pathway: \| COG: Function unknown CD630_20080 - Type: Gene Product:Putative hydrolase \| Pathway: \| COG: Cell cycle control, cell division, chromosome partitioning CD630_35511 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_35512 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_31501 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_20141 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_33271 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn6-Orf3 \| Pathway: \| COG:	0.00029	`NA`	0.26	Inferelator: 3 Hypergeometric: 1 TF Influences from Inferelator CD630_26400 - nrdR Type: Gene Product:Transcriptional regulator, repressor NrdR family \| Pathway: \| COG: Transcription CD630_26420 - sigG Type: Gene Product:RNA polymerase sigma-G factor \| Pathway: \| COG: Transcription CD630_34990 - spoVT Type: Gene Product:Stage V sporulation protein T \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test CD630_12140 - spo0A Type: Gene Product:Stage 0 sporulation protein A \| Pathway: \| COG: Signal transduction mechanisms
Module_72	20 CD630_23540 - grdE Type: Gene Product:Glycine reductase complex component B subunitsalpha and beta (Selenoprotein PB alpha/beta) [Contains:Betaine reductase component B subunit beta; Betainereductase component B subunit alpha] \| Pathway: \| COG: Function unknown CD630_01170 - Type: Gene Product:Putative ferredoxin/flavodoxin oxidoreductase,beta subunit \| Pathway: \| COG: Energy production and conversion CD630_r0060 - 5s_rRNA Type: Gene Product: \| Pathway: \| COG: CD630_23550 - trxA2 Type: Gene Product:Thioredoxin 2 (Trx2) \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_23570 - grdX Type: Gene Product:Putative glycine reductase complex component \| Pathway: \| COG: Function unknown CD630_01160 - Type: Gene Product:Putative ferredoxin/flavodoxin oxidoreductase,alpha subunit \| Pathway: \| COG: Energy production and conversion CD630_01180 - Type: Gene Product:Putative ferredoxin/flavodoxin oxidoreductase,gamma subunit \| Pathway: \| COG: Energy production and conversion CD630_01740 - cooS Type: Gene Product:Carbon monoxide dehydrogenase \| Pathway: \| COG: Energy production and conversion CD630_01190 - glmM Type: Gene Product:Phosphoglucosamine mutase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_01140 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_01150 - Type: Gene Product:Putative 4Fe-4S ferredoxin, iron-sulfur bindingdomain protein, delta subunit \| Pathway: \| COG: Energy production and conversion CD630_01760 - Type: Gene Product:Putative oxidoreductase, NAD/FAD binding subunit \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_01130 - buk Type: Gene Product:Butyrate kinase (BK) (Branched-chain carboxylicacid kinase) \| Pathway: \| COG: Energy production and conversion CD630_01750 - Type: Gene Product:Putative oxidoreductase, Fe-S subunit \| Pathway: \| COG: Energy production and conversion CD630_23520 - grdA Type: Gene Product:Glycine reductase complex selenoprotein A(selenocysteine) \| Pathway: \| COG: Energy production and conversion CD630_01790 - gluD Type: Gene Product:NAD-specific glutamate dehydrogenase \| Pathway: \| COG: Amino acid transport and metabolism CD630_23560 - trxB3 Type: Gene Product:Thioredoxin reductase 3 \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_01120 - ptb Type: Gene Product:phosphate butyryltransferase \| Pathway: \| COG: Energy production and conversion CD630_23510 - grdB Type: Gene Product:Glycine reductase complex component B gammasubunit (selenocysteine) \| Pathway: \| COG: Function unknown	6.7	`NA`	0.26	Inferelator: 2 Hypergeometric: 2 TF Influences from Inferelator CD630_16920 - Type: Gene Product:Transcriptional regulator, ArsR family \| Pathway: \| COG: Transcription CD630_16930 - Type: Gene Product:Putative dinitrogenase iron-molybdenum cofactor \| Pathway: \| COG: Function unknown TF Influences from Hypergeometric Test CD630_32450 - prdR Type: Gene Product:Transcriptional regulator, sigma-54-dependent \| Pathway: \| COG: Transcription CD630_10640 - ccpA Type: Gene Product:Transcriptional regulator, LacI family \| Pathway: \| COG: Transcription
Module_399	18 CD630_26200 - Type: Gene Product:Putative RNA-binding cell division protein \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_26190 - Type: Gene Product:Putative cell-division initiation protein DivIVA \| Pathway: \| COG: Cell cycle control, cell division, chromosome partitioning CD630_26210 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_01940 - groL Type: Gene Product:60 kDa chaperonin (Protein Cpn60) (GroELprotein) \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_26230 - Type: Gene Product:Putative pyridoxal 5'-phosphate-dependent enzyme \| Pathway: \| COG: Nucleotide transport and metabolism CD630_19390 - accB Type: Gene Product:Acetyl-CoA carboxylase subunit \| Pathway: Lipid metabolism \| COG: Lipid transport and metabolism CD630_19380 - accC Type: Gene Product:Acetyl-CoA carboxylase subunit \| Pathway: Lipid metabolism \| COG: Lipid transport and metabolism CD630_19370 - accD Type: Gene Product:Acetyl-CoA carboxylase subunit beta \| Pathway: Lipid metabolism \| COG: Lipid transport and metabolism CD630_01930 - groS Type: Gene Product:10 kDa chaperonin (Protein Cpn10) (GroESprotein) \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_34740 - atpB Type: Gene Product:ATP synthase subunit a \| Pathway: \| COG: Energy production and conversion CD630_34720 - atpF Type: Gene Product:ATP synthase subunit b \| Pathway: \| COG: Energy production and conversion CD630_34730 - atpE Type: Gene Product:ATP synthase subunit c \| Pathway: \| COG: Energy production and conversion CD630_34760 - atpZ Type: Gene Product:ATP synthase transporter \| Pathway: \| COG: Function unknown CD630_34670 - atpC Type: Gene Product:ATP synthase epsilon chain \| Pathway: \| COG: Energy production and conversion CD630_26220 - sepF Type: Gene Product:Cell division protein SepF \| Pathway: \| COG: Function unknown CD630_26240 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_34750 - atpI Type: Gene Product:ATP synthase subunit I \| Pathway: \| COG: Function unknown CD630_19360 - accA Type: Gene Product:Acetyl-coenzyme A carboxylase carboxyltransferase subunit alpha \| Pathway: Lipid metabolism \| COG: Lipid transport and metabolism	`NA`	`NA`	0.26	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_17820 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_67	16 CD630_32780 - Type: Gene Product:PTS system, mannose/fructose/sorbose IIAcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_04480 - orr Type: Gene Product:ornithine racemase \| Pathway: \| COG: Amino acid transport and metabolism CD630_32790 - Type: Gene Product:PTS system, mannose/fructose/sorbose IIBcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_32760 - Type: Gene Product:PTS system, mannose/fructose/sorbose IIDcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_04490 - Type: Gene Product:Na+/H+ antiporter, NhaA family \| Pathway: \| COG: Energy production and conversion CD630_04440 - ortB Type: Gene Product:2-amino-4-ketopentanoate thiolase beta subunit \| Pathway: \| COG: Function unknown CD630_32750 - Type: Gene Product:Putative phosphosugar isomerase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_04420 - ord Type: Gene Product:2,4-diaminopentanoate dehydrogenase \| Pathway: \| COG: Amino acid transport and metabolism CD630_32770 - Type: Gene Product:PTS system, mannose/fructose/sorbose IICcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_31260 - bglG Type: Gene Product:Transcription antiterminator, PTS operonregulator \| Pathway: \| COG: Transcription CD630_04430 - ortA Type: Gene Product:2-amino-4-ketopentanoate thiolase alpha subunit \| Pathway: \| COG: Function unknown CD630_04460 - oraE Type: Gene Product:D-ornithine aminomutase E component \| Pathway: \| COG: Function unknown CD630_04470 - Type: Gene Product:Putative reactivating factor foradenosylcobalamine-dependent D-ornithine aminomutase \| Pathway: \| COG: Function unknown CD630_31240 - bglA Type: Gene Product:6-phospho-beta-glucosidase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_04450 - oraS Type: Gene Product:D-ornithine aminomutase S component \| Pathway: \| COG: Function unknown CD630_31250 - bglF Type: Gene Product:PTS system, beta-glucoside-specific IIABCcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism	`NA`	`NA`	0.27	Inferelator: 1 Hypergeometric: 1 TF Influences from Inferelator CD630_26430 - sigE Type: Gene Product:RNA polymerase sigma-E factor \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test CD630_12750 - codY Type: Gene Product:Transcriptional regulator, GTP-sensingpleiotropic repressor \| Pathway: \| COG: Transcription
Module_212	15 CD630_00840 - rplE Type: Gene Product:50S ribosomal protein L5 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_00760 - rplB Type: Gene Product:50S ribosomal protein L2 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_00880 - rpsE Type: Gene Product:30S ribosomal protein S5 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_00881 - rpmD Type: Gene Product:50S ribosomal protein L30 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_00680 - rpsL Type: Gene Product:30S ribosomal protein S12 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_00941 - rpmJ Type: Gene Product:50S ribosomal protein L36 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_00690 - rpsG Type: Gene Product:30S ribosomal protein S7 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_00990 - rplQ Type: Gene Product:50S ribosomal protein L17 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_00850 - rpsH Type: Gene Product:30S ribosomal protein S8 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_00960 - rpsK Type: Gene Product:30S ribosomal protein S11 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_00841 - rpsZ Type: Gene Product:30S ribosomal protein S14 type Z \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_00710 - tuf Type: Gene Product:Elongation factor EFTu/EF1A (EF-Tu) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_00970 - rpsD Type: Gene Product:30S ribosomal protein S4 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_00800 - rplP Type: Gene Product:50S ribosomal protein L16 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_00801 - rpmC Type: Gene Product:50S ribosomal protein L29 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis	`NA`	`NA`	0.28	Inferelator: 0 Hypergeometric: 0 TF Influences from Inferelator `No TF influences from Inferelator` TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_252	4 CD630_21341 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_07390 - Type: Gene Product:Putative exported protein \| Pathway: \| COG: CD630_12340 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_18440 - Type: Gene Product:Fragment of conserved hypothetical protein (Part1) \| Pathway: \| COG: Function unknown	`NA`	`NA`	0.29	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_13810 - Type: Gene Product:Transcriptional regulator, TetR family \| Pathway: \| COG: Transcription CD630_16880 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_8	19 CD630_34260 - cbiF Type: Gene Product:Cobalt-precorrin-4 C(11)-methyltransferase(Cobalt-precorrin-3 methylase) \| Pathway: \| COG: Coenzyme transport and metabolism CD630_34190 - hemB Type: Gene Product:Delta-aminolevulinic acid dehydratase(porphobilinogen synthase) \| Pathway: \| COG: Coenzyme transport and metabolism CD630_34340 - cobB Type: Gene Product:Cobyrinic acid A,C-diamide synthase \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism CD630_34270 - cbiT Type: Gene Product:Cobalt-precorrin-6Y C(15)-methyltransferase \| Pathway: \| COG: Coenzyme transport and metabolism CD630_34350 - cobQ Type: Gene Product:Cobyric acid synthase CobQ \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism CD630_34290 - cbiD Type: Gene Product:Cobalt-precorrin-6A synthase [deacetylating] \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism CD630_34710 - atpH Type: Gene Product:ATP synthase subunit delta \| Pathway: \| COG: Energy production and conversion CD630_34230 - cbiJ Type: Gene Product:Cobalt-precorrin-6A reductase \| Pathway: \| COG: Coenzyme transport and metabolism CD630_34280 - cbiE Type: Gene Product:Cobalt-precorrin-6Y C(5)-methyltransferase(Cobalt-precorrin-6 methyltransferase) (Cobalt-precorrin-6Ymethylase) \| Pathway: \| COG: Coenzyme transport and metabolism CD630_34250 - cbiG Type: Gene Product:Cobalamin biosynthesis protein CbiG \| Pathway: \| COG: Coenzyme transport and metabolism CD630_34700 - atpA Type: Gene Product:ATPase subunit alpha \| Pathway: \| COG: Energy production and conversion CD630_34240 - cbiH Type: Gene Product:Cobalt-precorrin-3B C(17)-methyltransferase(Cobalt-precorrin-3 methyltransferase) (Cobalt-precorrin-3methylase) \| Pathway: \| COG: Coenzyme transport and metabolism CD630_34210 - hemC Type: Gene Product:Porphobilinogen deaminase (PBG)(Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogensynthase) \| Pathway: Porphyrin-containing compound metabolism \| COG: Coenzyme transport and metabolism CD630_34200 - cobA + hemD Type: Gene Product:Bifunctional uroporphyrinogen-IIImethyltransferase/uroporphyrinogen-III synthase \| Pathway: \| COG: Coenzyme transport and metabolism CD630_34220 - cbiK Type: Gene Product:Sirohydrochlorin cobaltochelatase \| Pathway: \| COG: Coenzyme transport and metabolism CD630_34730 - atpE Type: Gene Product:ATP synthase subunit c \| Pathway: \| COG: Energy production and conversion CD630_34690 - atpG Type: Gene Product:ATP synthase gamma chain \| Pathway: \| COG: Energy production and conversion CD630_34300 - cbiC Type: Gene Product:Cobalt-precorrin-8X methylmutase(Cobalt-precorrin isomerase) (HBA synthase) \| Pathway: \| COG: Coenzyme transport and metabolism CD630_34680 - atpD Type: Gene Product:ATP synthase subunit beta \| Pathway: \| COG: Energy production and conversion	`NA`	`NA`	0.31	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_11770 - fapR Type: Gene Product:Transcriptional regulator, DeoR family (Fattyacid and phospholipid biosynthesis regulator) \| Pathway: \| COG: Transcription CD630_17820 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_303	21 CD630_16360 - terD Type: Gene Product:Tellurium resistance protein \| Pathway: \| COG: Signal transduction mechanisms CD630_08250 - rbr Type: Gene Product:Rubrerythrin \| Pathway: \| COG: Energy production and conversion CD630_21540 - Type: Gene Product:Putative ATP/GTP-binding protein \| Pathway: \| COG: Function unknown CD630_24320 - glyS Type: Gene Product:Glycyl-tRNA synthetase beta subunit(Glycine--tRNA ligase beta subunit) (GlyRS) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_15250 - Type: Gene Product:Putative iron-sulfur protein \| Pathway: \| COG: Energy production and conversion CD630_21570 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_15240 - Type: Gene Product:Putative rubrerythrin \| Pathway: \| COG: Energy production and conversion CD630_11250 - Type: Gene Product:Nitroreductase-family protein \| Pathway: \| COG: Function unknown CD630_16340 - terD Type: Gene Product:Tellurium resistance protein \| Pathway: \| COG: Signal transduction mechanisms CD630_21550 - bioB Type: Gene Product:Biotin synthase \| Pathway: \| COG: Coenzyme transport and metabolism CD630_25130 - Type: Gene Product:Putative translation inhibitor endoribonuclease \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_15260 - pyrC Type: Gene Product:Dihydroorotase (DHOase) \| Pathway: Pyrimidine metabolism \| COG: Nucleotide transport and metabolism CD630_15370 - aspB Type: Gene Product:Putative glutamate synthase \| Pathway: \| COG: Amino acid transport and metabolism CD630_25140 - tdcB Type: Gene Product:Threonine dehydratase II \| Pathway: \| COG: Amino acid transport and metabolism CD630_15360 - Type: Gene Product:Ferredoxin--NADP(+) reductase subunit alpha \| Pathway: \| COG: Energy production and conversion CD630_21560 - thiH Type: Gene Product:Thiamine biosynthesis protein ThiH \| Pathway: \| COG: Coenzyme transport and metabolism CD630_08260 - Type: Gene Product:Putative ferric-uptake regulator \| Pathway: \| COG: Transcription CD630_21530 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_22200 - Type: Gene Product:Putative cyclic nucleotides-binding protein \| Pathway: \| COG: Signal transduction mechanisms CD630_24330 - glyQ Type: Gene Product:Glycyl-tRNA synthetase alpha subunit(Glycine--tRNA ligase alpha subunit) (GlyRS) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_08270 - rbo Type: Gene Product:Rubredoxin oxidoreductase (desulfoferrodoxin) \| Pathway: \| COG: Energy production and conversion	0	`NA`	0.31	Inferelator: 3 Hypergeometric: 0 TF Influences from Inferelator CD630_08260 - Type: Gene Product:Putative ferric-uptake regulator \| Pathway: \| COG: Transcription CD630_16920 - Type: Gene Product:Transcriptional regulator, ArsR family \| Pathway: \| COG: Transcription CD630_22200 - Type: Gene Product:Putative cyclic nucleotides-binding protein \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`