Environment and Gene Regulatory Influence Network (EGRIN) model for C. difficile 630

The Environment and Gene Regulatory Influence Network (EGRIN) model of C. difficile 630 was inferred using cMonkey2 and a compendium of 136 transcriptomes (retrieved from the Gene Expression Omnibus repository) with 4,070 sequence features including 35 rRNAs and 90 tRNAs . The C. difficile EGRIN model groups genes in subsets (406 modules in total), that are co-regulated in specific environments, and also identifies the associated, putative cis-acting gene regulatory elements (GREs), which represent potential TF binding locations. Transcriptome compendium included conditions: response to iron limitation, response to oxygen, in vivo vs in vitro growth, short term infection (0, 30, 60, 120 mins), response to commensals and host diet, transition from exponential to stationary phase, fur KO, codY KO, sporulation TF (and sigma factors) KOs.

Explore Regulatory Modules

Displaying 41 - 50 of 406

Candidate transcriptional regulators for each module were determined with a linear regression based approach (Inferelator) and by evaluating the statistical significance of the overlap (Hypergeometric) between modules and putative TF and alternative sigma factor regulons (CcpA, CodY, Fur, PrdR, SigB, SigD, SigE, SigF, SigG, SigH, SigK, Spo0A) compiled from available literature.

* Given that translation start was used to define the 3' end of putative promoters, some cis-regulatory motifs are likely to be ribosome binding sites (i.e., Shine-Dalgarno sequence). RBS is typically a six nucleotide sequence 5'-GGAGGA-3'.

Title	Gene Count	Motif 1 e-value	Motif 2 e-value	Residual	TF Influences
Module_293	23 CD630_33860 - Type: Gene Product:Putative antirestriction protein Tn916-like,CTn7-Orf22 \| Pathway: \| COG: Function unknown CD630_03650 - Type: Gene Product:ABC-type transport system, multidrug-familypermease Tn916-like, CTn1-Orf10 \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_33840 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn7-Orf20 \| Pathway: \| COG: Function unknown CD630_03760 - Type: Gene Product:Putative antirestriction protein Tn916-like,CTn1-Orf21 \| Pathway: \| COG: Function unknown CD630_03670 - Type: Gene Product:Two-component sensor histidine kinase,Tn916-like, CTn1-Orf12 \| Pathway: \| COG: Signal transduction mechanisms CD630_03720 - Type: Gene Product:Putative cell wall hydrolase Tn916-like,CTn1-Orf17 \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_03740 - Type: Gene Product:Putative ATPase Tn916-like, CTn1-Orf19 \| Pathway: \| COG: Function unknown CD630_03700 - Type: Gene Product:Transcriptional regulator, HTH-type Tn916-like,CTn1-Orf15 \| Pathway: \| COG: Transcription CD630_33290 - Type: Gene Product:Putative RNA polymerase sigma factor Tn916-like,CTn6-Orf5 \| Pathway: \| COG: Function unknown CD630_03690 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn1-Orf14 \| Pathway: \| COG: Function unknown CD630_33790 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn7-Orf15 \| Pathway: \| COG: Function unknown CD630_11030 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn4-Orf21 \| Pathway: \| COG: Function unknown CD630_11010 - Type: Gene Product:Putative mobilization protein Tn1549-like,CTn4-Orf23 \| Pathway: \| COG: Function unknown CD630_03770 - Type: Gene Product:Putative antirestriction protein Tn916-like,CTn1-Orf22 \| Pathway: \| COG: Function unknown CD630_33850 - Type: Gene Product:Putative antirestriction protein Tn916-like,CTn7-Orf21 \| Pathway: \| COG: Function unknown CD630_03660 - Type: Gene Product:ABC-type transport system, multidrug-familyATP-binding protein Tn916-like, CTn1-Orf11 \| Pathway: \| COG: Defense mechanisms CD630_33830 - Type: Gene Product:Putative ATPase Tn916-like, CTn7-Orf19 \| Pathway: \| COG: Function unknown CD630_03750 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn1-Orf20 \| Pathway: \| COG: Function unknown CD630_03680 - Type: Gene Product:Two-component response regulator, Tn916-like,CTn1-Orf13 \| Pathway: \| COG: Signal transduction mechanisms CD630_03710 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn1-Orf16 \| Pathway: \| COG: Function unknown CD630_03730 - Type: Gene Product:Putative membrane protein Tn916-like, CTn1-Orf18 \| Pathway: \| COG: Function unknown CD630_33800 - Type: Gene Product:Putative cell wall hydrolase Tn916-like,CTn7-Orf16 \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_11020 - Type: Gene Product:Putative endonuclease relaxase Tn1549-like,CTn4-Orf22 \| Pathway: \| COG: Intracellular trafficking, secretion, and vesicular transport	0.000000000012	0.000000098	0.37	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_01710 - rex Type: Gene Product:Transcriptional regulator, Redox-sensingrepressor Rex \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_309	14 CD630_t0410 - tRNA-His Type: Gene Product: \| Pathway: \| COG: CD630_t0520 - tRNA-Tyr Type: Gene Product: \| Pathway: \| COG: CD630_t0390 - tRNA-Met Type: Gene Product: \| Pathway: \| COG: CD630_t0070 - tRNA-Gly Type: Gene Product: \| Pathway: \| COG: CD630_t0370 - tRNA-Ser Type: Gene Product: \| Pathway: \| COG: CD630_t0630 - tRNA-Phe Type: Gene Product: \| Pathway: \| COG: CD630_t0290 - tRNA-Asp Type: Gene Product: \| Pathway: \| COG: CD630_t0240 - tRNA-Leu Type: Gene Product: \| Pathway: \| COG: CD630_t0430 - tRNA-Cys Type: Gene Product: \| Pathway: \| COG: CD630_t0190 - tRNA-Pro Type: Gene Product: \| Pathway: \| COG: CD630_t0740 - tRNA-Gly Type: Gene Product: \| Pathway: \| COG: CD630_t0270 - tRNA-Gly Type: Gene Product: \| Pathway: \| COG: CD630_36400 - Type: Gene Product:Putative ribokinase family sugar kinase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_t0170 - tRNA-Met Type: Gene Product: \| Pathway: \| COG:	0	0	0.37	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_27320 - Type: Gene Product:Transcriptional regulator, sigma-54-dependent \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_183	17 CD630_30470 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_30460 - murQ Type: Gene Product:N-acetylmuramic acid 6-phosphate etherase \| Pathway: Amino-sugar metabolism \| COG: Carbohydrate transport and metabolism CD630_07870 - Type: Gene Product:Putative metal-binding protein \| Pathway: \| COG: Function unknown CD630_07890 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_30480 - Type: Gene Product:PTS system, lactose/cellobiose-family IICmembrane component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_07900 - Type: Gene Product:Putative hydrolase, NUDIX family \| Pathway: \| COG: Replication, recombination and repair CD630_07880 - Type: Gene Product:Putative GTP-binding protein, HflX type \| Pathway: \| COG: Function unknown CD630_13020 - Type: Gene Product:Putative MazG-like pyrophosphohydrolase \| Pathway: \| COG: Function unknown CD630_30490 - Type: Gene Product:PTS system, lactose/cellobiose-family IIBsubunit \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_13030 - npdA Type: Gene Product:NAD-dependent deacetylase, Sir2 family \| Pathway: \| COG: Transcription CD630_14380 - Type: Gene Product:Putative TPR repeat-containing protein \| Pathway: \| COG: Function unknown CD630_23050 - pilW Type: Gene Product:Type IV pilus protein \| Pathway: \| COG: Function unknown CD630_16230 - Type: Gene Product:NADH-oxygen oxidoreductase \| Pathway: \| COG: Energy production and conversion CD630_22150 - SinR Type: Gene Product:Transcriptional regulator, HTH-type \| Pathway: \| COG: Transcription CD630_15220 - Type: Gene Product:Putative polysaccharide deacetylase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_22140 - SinR Type: Gene Product:Transcriptional regulator, HTH-type \| Pathway: \| COG: Transcription CD630_13040 - acd Type: Gene Product:Mannosyl-glycoproteinendo-beta-N-acetylglucosamidase \| Pathway: \| COG: Carbohydrate transport and metabolism	0.0000000004	0.0000012	0.37	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_19310 - lexA Type: Gene Product:Transcriptional regulator, LexA repressor \| Pathway: \| COG: Transcription CD630_35440 - Type: Gene Product:Transcriptional regulator, AsnC/Lrp family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_311	19 CD630_11500 - minD Type: Gene Product:Septum site-determining protein MinD (Celldivision inhibitor MinD) \| Pathway: \| COG: Cell cycle control, cell division, chromosome partitioning CD630_25900 - dapF Type: Gene Product:Diaminopimelate epimerase (DAP epimerase) \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_25850 - def2 Type: Gene Product:Peptide deformylase 2 (PDF 2) (Polypeptidedeformylase 2 ) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_25790 - Type: Gene Product:Putative phosphatase, 2C family \| Pathway: \| COG: Signal transduction mechanisms CD630_36550 - purA Type: Gene Product:Adenylosuccinate synthetase (IMP--aspartateligase) (AdSS) (AMPSase) \| Pathway: Purine metabolism \| COG: Nucleotide transport and metabolism CD630_25760 - Type: Gene Product:Putative GTPase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_25800 - Type: Gene Product:Putative radical SAM-family protein \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_25820 - Type: Gene Product:Putative metal-dependent peptidase \| Pathway: \| COG: Function unknown CD630_11460 - mreC Type: Gene Product:Rod shape-determining protein MreC \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_25890 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_25750 - rpe Type: Gene Product:Ribulose-phosphate 3-epimerase(Pentose-5-phosphate 3-epimerase) (PPE) (R5P3E) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_02190 - purC Type: Gene Product:Phosphoribosylaminoimidazole-succinocarboxamidesynthase \| Pathway: Purine metabolism \| COG: Nucleotide transport and metabolism CD630_25880 - gmk Type: Gene Product:Guanylate kinase (GMP kinase) \| Pathway: \| COG: Nucleotide transport and metabolism CD630_36560 - Type: Gene Product:Conserved hypothetical protein with a TonB box \| Pathway: \| COG: CD630_25770 - fabG Type: Gene Product:3-oxoacyl-[acyl-carrier-protein] reductase(3-ketoacyl- acyl carrier protein reductase) \| Pathway: \| COG: Function unknown CD630_25780 - Type: Gene Product:Putative serine/threonine-protein kinase andphosphatase \| Pathway: \| COG: Signal transduction mechanisms CD630_25840 - fmt Type: Gene Product:Methionyl-tRNA formyltransferase \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_02180 - purE Type: Gene Product:Phosphoribosylaminoimidazole carboxylasecatalytic subunit \| Pathway: Purine metabolism \| COG: Nucleotide transport and metabolism CD630_25870 - coaBC Type: Gene Product:Coenzyme A biosynthesis bifunctional proteinCoaBC; phosphopantothenoylcysteinesynthetase/decarboxylase \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism	`NA`	`NA`	0.37	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_17820 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_184	21 CD630_02480 - fliF Type: Gene Product:Flagellar M-ring protein FliF \| Pathway: \| COG: Cell motility CD630_02620 - flhB Type: Gene Product:Bifunctional flagellar biosynthesis proteinFliR/FlhB \| Pathway: \| COG: Cell motility CD630_02630 - flhA Type: Gene Product:Flagellar biosynthesis protein FlhA \| Pathway: \| COG: Cell motility CD630_02490 - fliG Type: Gene Product:Flagellar motor switch protein FliG \| Pathway: \| COG: Cell motility CD630_02640 - flhF Type: Gene Product:Flagellar biosynthesis regulator FlhF(Flagella-associated GTP-binding protein) \| Pathway: \| COG: Cell motility CD630_02510 - fliI Type: Gene Product:ATP synthase subunit beta FliI \| Pathway: \| COG: Cell motility, Intracellular trafficking, secretion, and vesicular transport CD630_02650 - flhG Type: Gene Product:Flagellar number regulator FlhG \| Pathway: \| COG: Cell cycle control, cell division, chromosome partitioning CD630_02470 - fliE Type: Gene Product:Flagellar hook-basal body complex protein FliE \| Pathway: \| COG: Cell motility CD630_02600 - fliP Type: Gene Product:Flagellar biosynthesis protein FliP \| Pathway: \| COG: Cell motility CD630_02551 - FlbD Type: Gene Product:Flagellar protein FlbD \| Pathway: \| COG: Cell motility CD630_02530 - fliK Type: Gene Product:Flagellar hook-length control protein FliK \| Pathway: \| COG: Cell motility CD630_02460 - flgC Type: Gene Product:Flagellar basal-body rod protein FlgC \| Pathway: \| COG: Cell motility CD630_02520 - fliJ Type: Gene Product:Flagellar protein FliJ \| Pathway: \| COG: Cell motility CD630_02570 - motB Type: Gene Product:Flagellar motor rotation protein MotB (Chemotaxisprotein MotB) \| Pathway: \| COG: Cell motility CD630_02670 - Type: Gene Product:Putative flagellar protein \| Pathway: \| COG: CD630_02560 - motA Type: Gene Product:Flagellar motor rotation protein MotA \| Pathway: \| COG: Cell motility CD630_02540 - flgD Type: Gene Product:Basal-body rod modification protein FlgD \| Pathway: \| COG: Cell motility CD630_02450 - flgB Type: Gene Product:Flagellar basal-body rod protein FlgB \| Pathway: \| COG: Cell motility CD630_02580 - fliL Type: Gene Product:Flagellar basal body-associated protein FliL \| Pathway: \| COG: Cell motility CD630_02660 - sigD Type: Gene Product:RNA polymerase sigma-28 factor for flagellaroperon \| Pathway: \| COG: Transcription CD630_02610 - fliQ Type: Gene Product:Flagellar biosynthetic protein FliQ \| Pathway: \| COG: Cell motility	`NA`	`NA`	0.37	Inferelator: 2 Hypergeometric: 1 TF Influences from Inferelator CD630_02660 - sigD Type: Gene Product:RNA polymerase sigma-28 factor for flagellaroperon \| Pathway: \| COG: Transcription CD630_22140 - SinR Type: Gene Product:Transcriptional regulator, HTH-type \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test CD630_02660 - sigD Type: Gene Product:RNA polymerase sigma-28 factor for flagellaroperon \| Pathway: \| COG: Transcription
Module_162	20 CD630_09430 - Type: Gene Product:Putative phage DNA-binding protein \| Pathway: \| COG: Function unknown CD630_36260 - Type: Gene Product:Putative 4-hydroxy-2-oxoglutarate aldolase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_36300 - Type: Gene Product:PTS system, fructose/mannitol-family IIBcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_28970 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_36310 - Type: Gene Product:Transcription antiterminator, PTS operonregulator \| Pathway: \| COG: Transcription CD630_29020 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_36290 - Type: Gene Product:PTS system, fructose/mannitol-family IICcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_28960 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_36430 - Type: Gene Product:Dihydroorotase \| Pathway: \| COG: Function unknown CD630_36420 - Type: Gene Product:Putative selenocysteine synthase \| Pathway: \| COG: Amino acid transport and metabolism CD630_09440 - Type: Gene Product:Putative phage terminase, large subunit \| Pathway: \| COG: Replication, recombination and repair CD630_29070 - Type: Gene Product:Putative phage lipoprotein \| Pathway: \| COG: Function unknown CD630_28990 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_36280 - Type: Gene Product:Putative phosphosugar isomerase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_09450 - Type: Gene Product:Putative phage portal protein \| Pathway: \| COG: Function unknown CD630_36440 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_36410 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_36270 - dapA4 Type: Gene Product:Dihydrodipicolinate synthase 4 (DHDPS) \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_29000 - Type: Gene Product:Putative phage tail protein \| Pathway: \| COG: Function unknown CD630_29060 - Type: Gene Product:Putative phage protein \| Pathway: \| COG:	0.02	`NA`	0.37	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_02760 - Type: Gene Product:Transcriptional regulator, AraC family \| Pathway: \| COG: Transcription CD630_36390 - Type: Gene Product:Transcriptional regulator, LysR family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_42	18 CD630_03850 - Type: Gene Product:Putative conjugative transposon protein DUF961family Tn916-like, CTn1-Orf30 \| Pathway: \| COG: Function unknown CD630_03851 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_03840 - Type: Gene Product:Putative conjugative transposon protein DUF961family Tn916-like, CTn1-Orf29 \| Pathway: \| COG: Function unknown CD630_03860 - Type: Gene Product:Putative cell surface protein \| Pathway: \| COG: Function unknown CD630_03600 - Type: Gene Product:Transcriptional regulator, GntR family,Tn916-like, CTn1-Orf5 \| Pathway: \| COG: Transcription CD630_33920 - Type: Gene Product:Putative cell surface protein \| Pathway: \| COG: Function unknown CD630_33790 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn7-Orf15 \| Pathway: \| COG: Function unknown CD630_33890 - Type: Gene Product:Putative cell-division FtsK/SpoIIIE-familyprotein Tn916-like, CTn7-Orf28 \| Pathway: \| COG: Cell cycle control, cell division, chromosome partitioning CD630_03630 - Type: Gene Product:ABC-type transport system, permease Tn916-like,CTn1-Orf8 \| Pathway: \| COG: Defense mechanisms CD630_03610 - Type: Gene Product:Two-component sensor histidine kinase Tn916-like,CTn1-Orf6 \| Pathway: \| COG: Signal transduction mechanisms CD630_03620 - Type: Gene Product:Two-component response regulator Tn916-like,CTn1-Orf7 \| Pathway: \| COG: Signal transduction mechanisms CD630_33800 - Type: Gene Product:Putative cell wall hydrolase Tn916-like,CTn7-Orf16 \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_03820 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn1-Orf27 \| Pathway: \| COG: CD630_03640 - Type: Gene Product:ABC-type transport system, ATP-binding proteinTn916-like, CTn1-Orf9 \| Pathway: \| COG: Defense mechanisms CD630_03830 - Type: Gene Product:Putative cell-division FtsK/SpoIIIE-familyprotein Tn916-like, CTn1-Orf28 \| Pathway: \| COG: Cell cycle control, cell division, chromosome partitioning CD630_33900 - Type: Gene Product:Putative conjugative transposon protein DUF961family Tn196-like, CTn7-Orf29 \| Pathway: \| COG: Function unknown CD630_33840 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn7-Orf20 \| Pathway: \| COG: Function unknown CD630_33830 - Type: Gene Product:Putative ATPase Tn916-like, CTn7-Orf19 \| Pathway: \| COG: Function unknown	0.000028	0.11	0.38	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_20920 - Type: Gene Product:Transcriptional regulator, sigma-54-dependent \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_358	23 CD630_02500 - fliH Type: Gene Product:Flagellar assembly protein FliH \| Pathway: \| COG: Cell motility CD630_02490 - fliG Type: Gene Product:Flagellar motor switch protein FliG \| Pathway: \| COG: Cell motility CD630_02640 - flhF Type: Gene Product:Flagellar biosynthesis regulator FlhF(Flagella-associated GTP-binding protein) \| Pathway: \| COG: Cell motility CD630_02470 - fliE Type: Gene Product:Flagellar hook-basal body complex protein FliE \| Pathway: \| COG: Cell motility CD630_02600 - fliP Type: Gene Product:Flagellar biosynthesis protein FliP \| Pathway: \| COG: Cell motility CD630_02660 - sigD Type: Gene Product:RNA polymerase sigma-28 factor for flagellaroperon \| Pathway: \| COG: Transcription CD630_02520 - fliJ Type: Gene Product:Flagellar protein FliJ \| Pathway: \| COG: Cell motility CD630_02620 - flhB Type: Gene Product:Bifunctional flagellar biosynthesis proteinFliR/FlhB \| Pathway: \| COG: Cell motility CD630_02560 - motA Type: Gene Product:Flagellar motor rotation protein MotA \| Pathway: \| COG: Cell motility CD630_02540 - flgD Type: Gene Product:Basal-body rod modification protein FlgD \| Pathway: \| COG: Cell motility CD630_02580 - fliL Type: Gene Product:Flagellar basal body-associated protein FliL \| Pathway: \| COG: Cell motility CD630_02480 - fliF Type: Gene Product:Flagellar M-ring protein FliF \| Pathway: \| COG: Cell motility CD630_02650 - flhG Type: Gene Product:Flagellar number regulator FlhG \| Pathway: \| COG: Cell cycle control, cell division, chromosome partitioning CD630_02510 - fliI Type: Gene Product:ATP synthase subunit beta FliI \| Pathway: \| COG: Cell motility, Intracellular trafficking, secretion, and vesicular transport CD630_02550 - flgE Type: Gene Product:Flagellar hook protein FlgE (Distal rod protein) \| Pathway: \| COG: Cell motility CD630_02551 - FlbD Type: Gene Product:Flagellar protein FlbD \| Pathway: \| COG: Cell motility CD630_02530 - fliK Type: Gene Product:Flagellar hook-length control protein FliK \| Pathway: \| COG: Cell motility CD630_02460 - flgC Type: Gene Product:Flagellar basal-body rod protein FlgC \| Pathway: \| COG: Cell motility CD630_02670 - Type: Gene Product:Putative flagellar protein \| Pathway: \| COG: CD630_02570 - motB Type: Gene Product:Flagellar motor rotation protein MotB (Chemotaxisprotein MotB) \| Pathway: \| COG: Cell motility CD630_02630 - flhA Type: Gene Product:Flagellar biosynthesis protein FlhA \| Pathway: \| COG: Cell motility CD630_02610 - fliQ Type: Gene Product:Flagellar biosynthetic protein FliQ \| Pathway: \| COG: Cell motility CD630_02590 - fliZ Type: Gene Product:Flagellar protein FliZ \| Pathway: \| COG: Cell motility	`NA`	`NA`	0.39	Inferelator: 2 Hypergeometric: 1 TF Influences from Inferelator CD630_02660 - sigD Type: Gene Product:RNA polymerase sigma-28 factor for flagellaroperon \| Pathway: \| COG: Transcription CD630_22140 - SinR Type: Gene Product:Transcriptional regulator, HTH-type \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test CD630_02660 - sigD Type: Gene Product:RNA polymerase sigma-28 factor for flagellaroperon \| Pathway: \| COG: Transcription
Module_56	21 CD630_09180 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_09260 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_09380 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_09190 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_09340 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_09270 - Type: Gene Product:Putative phage DNA modification methylase \| Pathway: \| COG: Replication, recombination and repair CD630_09350 - Type: Gene Product:Putative S-adenosyl-L-methionine-dependentmethyltransferase \| Pathway: \| COG: Replication, recombination and repair CD630_09290 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_09170 - Type: Gene Product:Putative phage recombination protein Bet \| Pathway: \| COG: Replication, recombination and repair CD630_09300 - Type: Gene Product:Putative phage reductase \| Pathway: \| COG: Function unknown CD630_09280 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_09250 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_09360 - Type: Gene Product:Putative phage endodeoxyribonuclease \| Pathway: \| COG: Replication, recombination and repair CD630_09370 - Type: Gene Product:Putative phage anti-repressor \| Pathway: \| COG: Transcription CD630_09210 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_09301 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_09120 - Type: Gene Product:Putative phage DNA-binding protein \| Pathway: \| COG: CD630_09330 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_09220 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_09320 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_09310 - Type: Gene Product:Putative phage protein \| Pathway: \| COG:	`NA`	`NA`	0.39	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_22140 - SinR Type: Gene Product:Transcriptional regulator, HTH-type \| Pathway: \| COG: Transcription CD630_30540 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_243	21 CD630_24950 - selA Type: Gene Product:L-seryl-tRNA(Sec) selenium transferase(Selenocysteine synthase) (Sec synthase)(Selenocysteinyl-tRNA(Sec) synthase ) \| Pathway: Aminoacyl-tRNA biosynthesis \| COG: Amino acid transport and metabolism CD630_24980 - dacF Type: Gene Product:D-alanyl-D-alanine carboxypeptidase (putativesporulation-specific penicillin-binding protein) \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_24930 - selB Type: Gene Product:Selenocysteinyl-tRNA-specific translation factor \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_35140 - prs Type: Gene Product:Ribose-phosphate pyrophosphokinase \| Pathway: Metabolic intermediate biosynthesis \| COG: Nucleotide transport and metabolism CD630_01940 - groL Type: Gene Product:60 kDa chaperonin (Protein Cpn60) (GroELprotein) \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_25240 - nadD Type: Gene Product:Nicotinate-nucleotide adenylyltransferase \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism CD630_24970 - comE Type: Gene Product:Competence protein ComEA \| Pathway: \| COG: Replication, recombination and repair CD630_25230 - Type: Gene Product:Putative hydrolase \| Pathway: \| COG: Coenzyme transport and metabolism CD630_24960 - selD Type: Gene Product:Selenide, water dikinase (Selenophosphatesynthetase) (Selenium donor protein) \| Pathway: \| COG: Amino acid transport and metabolism CD630_27290 - Type: Gene Product:Putative regulator of the sigma(E) factor \| Pathway: \| COG: Signal transduction mechanisms CD630_01930 - groS Type: Gene Product:10 kDa chaperonin (Protein Cpn10) (GroESprotein) \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_21770 - Type: Gene Product:ABC-type transport system,cystine/aminoacid-family extracellular solute-bindingprotein \| Pathway: \| COG: Amino acid transport and metabolism CD630_25220 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_21760 - Type: Gene Product:ABC-type transport system,cystine/aminoacid-family permease \| Pathway: \| COG: Amino acid transport and metabolism CD630_35150 - glmU Type: Gene Product:Bifunctional protein GlmU [Includes:UDP-N-acetylglucosamine pyrophosphorylase ;Glucosamine-1-phosphate N-acetyltransferase] \| Pathway: Nucleotide-sugar biosynthesis \| COG: Cell wall/membrane/envelope biogenesis CD630_27310 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: CD630_21720 - Type: Gene Product:ABC-type transport system,cystine/aminoacid-family ATP-binding protein \| Pathway: \| COG: Amino acid transport and metabolism CD630_21750 - Type: Gene Product:ABC-type transport system,cystine/aminoacid-family permease \| Pathway: \| COG: Amino acid transport and metabolism CD630_21740 - Type: Gene Product:ABC-type transport system,cystine/aminoacid-family extracellular solute-bindingprotein \| Pathway: \| COG: Amino acid transport and metabolism, Signal transduction mechanisms CD630_27300 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_21730 - Type: Gene Product:Putative peptidase, M20D family \| Pathway: \| COG: Amino acid transport and metabolism	1.2	`NA`	0.39	Inferelator: 1 Hypergeometric: 1 TF Influences from Inferelator CD630_27220 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test CD630_32450 - prdR Type: Gene Product:Transcriptional regulator, sigma-54-dependent \| Pathway: \| COG: Transcription