Environment and Gene Regulatory Influence Network (EGRIN) model for C. difficile 630

The Environment and Gene Regulatory Influence Network (EGRIN) model of C. difficile 630 was inferred using cMonkey2 and a compendium of 136 transcriptomes (retrieved from the Gene Expression Omnibus repository) with 4,070 sequence features including 35 rRNAs and 90 tRNAs . The C. difficile EGRIN model groups genes in subsets (406 modules in total), that are co-regulated in specific environments, and also identifies the associated, putative cis-acting gene regulatory elements (GREs), which represent potential TF binding locations. Transcriptome compendium included conditions: response to iron limitation, response to oxygen, in vivo vs in vitro growth, short term infection (0, 30, 60, 120 mins), response to commensals and host diet, transition from exponential to stationary phase, fur KO, codY KO, sporulation TF (and sigma factors) KOs.

Explore Regulatory Modules

Displaying 81 - 90 of 406

Candidate transcriptional regulators for each module were determined with a linear regression based approach (Inferelator) and by evaluating the statistical significance of the overlap (Hypergeometric) between modules and putative TF and alternative sigma factor regulons (CcpA, CodY, Fur, PrdR, SigB, SigD, SigE, SigF, SigG, SigH, SigK, Spo0A) compiled from available literature.

* Given that translation start was used to define the 3' end of putative promoters, some cis-regulatory motifs are likely to be ribosome binding sites (i.e., Shine-Dalgarno sequence). RBS is typically a six nucleotide sequence 5'-GGAGGA-3'.

Title	Gene Count	Motif 1 e-value	Motif 2 e-value	Residual	TF Influences
Module_219	20 CD630_28620 - Type: Gene Product:Putative peptidase, M19 family \| Pathway: \| COG: Amino acid transport and metabolism CD630_35320 - phnM Type: Gene Product:Putative carbon-phosphorus lyase complex subunit \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_10200 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_35310 - Type: Gene Product:Putative polymerase/histidinol phosphatase-like \| Pathway: \| COG: Function unknown CD630_35340 - phnK Type: Gene Product:ABC-type transport system, phosphonate-specificATP-binding protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_04350 - Type: Gene Product:Putative sigma factor Tn1549-like, CTn2-Orf31 \| Pathway: \| COG: Function unknown CD630_35350 - phnJ Type: Gene Product:Putative phosphonate metabolism protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_01650 - Type: Gene Product:Putative amino acid transporter \| Pathway: \| COG: Amino acid transport and metabolism CD630_10190 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_35300 - Type: Gene Product:ABC-type transport system, iron-familyATP-binding protein \| Pathway: \| COG: Amino acid transport and metabolism CD630_35280 - Type: Gene Product:ABC-type transport system, iron-familyextracellular solute-binding protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_01660 - Type: Gene Product:Putative peptidase, M20D family \| Pathway: \| COG: Amino acid transport and metabolism CD630_28600 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_18780 - Type: Gene Product:Putative sigma factor Tn1549-like, CTn5-Orf38 \| Pathway: \| COG: Function unknown CD630_10210 - Type: Gene Product:Putative spore coat protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_35360 - phnI Type: Gene Product:Putative phosphonate metabolism protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_35370 - phnH Type: Gene Product:Putative phosphonate metabolism protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_35380 - phnG Type: Gene Product:Putative phosphonate metabolism protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_28590 - Type: Gene Product:Putative D-aminoacylase \| Pathway: \| COG: Secondary metabolites biosynthesis, transport and catabolism CD630_28610 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown	0.35	`NA`	0.43	Inferelator: 2 Hypergeometric: 1 TF Influences from Inferelator CD630_04500 - Type: Gene Product:Putative transcriptional regulator \| Pathway: \| COG: Transcription CD630_27320 - Type: Gene Product:Transcriptional regulator, sigma-54-dependent \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test CD630_12750 - codY Type: Gene Product:Transcriptional regulator, GTP-sensingpleiotropic repressor \| Pathway: \| COG: Transcription
Module_315	32 CD630_28450 - rbr Type: Gene Product:Rubrerythrin \| Pathway: \| COG: Energy production and conversion CD630_14920 - Type: Gene Product:Histidine kinase, negative regulator ofsporulation \| Pathway: \| COG: Signal transduction mechanisms CD630_04430 - ortA Type: Gene Product:2-amino-4-ketopentanoate thiolase alpha subunit \| Pathway: \| COG: Function unknown CD630_04470 - Type: Gene Product:Putative reactivating factor foradenosylcobalamine-dependent D-ornithine aminomutase \| Pathway: \| COG: Function unknown CD630_06710 - Type: Gene Product:Putative enzyme, glyoxalase family \| Pathway: \| COG: Amino acid transport and metabolism CD630_04450 - oraS Type: Gene Product:D-ornithine aminomutase S component \| Pathway: \| COG: Function unknown CD630_08200 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_35420 - spmA Type: Gene Product:Spore maturation protein A \| Pathway: \| COG: Function unknown CD630_35810 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_08640 - Type: Gene Product:Maltose-6'-phosphate glucosidase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_04480 - orr Type: Gene Product:ornithine racemase \| Pathway: \| COG: Amino acid transport and metabolism CD630_17610 - Type: Gene Product:Putative phenazine biosynthesis PhzC/PhzFprotein \| Pathway: \| COG: Function unknown CD630_13010 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: CD630_19060 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_19050 - Type: Gene Product:Site-specific recombinase, resolvase family \| Pathway: \| COG: Replication, recombination and repair CD630_19040 - Type: Gene Product:ABC-type transport system, permease \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_01560 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_04420 - ord Type: Gene Product:2,4-diaminopentanoate dehydrogenase \| Pathway: \| COG: Amino acid transport and metabolism CD630_04460 - oraE Type: Gene Product:D-ornithine aminomutase E component \| Pathway: \| COG: Function unknown CD630_19860 - miaB Type: Gene Product:(Dimethylallyl)adenosine tRNAmethylthiotransferase miaB (tRNA-i(6)A37methylthiotransferase) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_15830 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_08210 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_35820 - Type: Gene Product:Putative pseudouridine synthase RsuA-like \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_04440 - ortB Type: Gene Product:2-amino-4-ketopentanoate thiolase beta subunit \| Pathway: \| COG: Function unknown CD630_08630 - Type: Gene Product:PTS system, lactose/cellobiose-family IIAcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_04490 - Type: Gene Product:Na+/H+ antiporter, NhaA family \| Pathway: \| COG: Energy production and conversion CD630_23330 - mtlR Type: Gene Product:Transcription antiterminator, PTS operonregulator \| Pathway: \| COG: Transcription CD630_35410 - spmB Type: Gene Product:Spore maturation protein B \| Pathway: \| COG: Function unknown CD630_35800 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_35830 - Type: Gene Product:Transcriptional regulator, MerR family \| Pathway: \| COG: Transcription CD630_17600 - Type: Gene Product:Putative iron-sulfur protein \| Pathway: \| COG: Energy production and conversion CD630_14020 - glpQ Type: Gene Product:Glycerophosphoryl diester phosphodiesterase \| Pathway: \| COG: Energy production and conversion	0.00000000000083	`NA`	0.43	Inferelator: 1 Hypergeometric: 1 TF Influences from Inferelator CD630_26430 - sigE Type: Gene Product:RNA polymerase sigma-E factor \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test CD630_12750 - codY Type: Gene Product:Transcriptional regulator, GTP-sensingpleiotropic repressor \| Pathway: \| COG: Transcription
Module_127	27 CD630_01920 - cls Type: Gene Product:Cardiolipin synthetase 1 \| Pathway: \| COG: Lipid transport and metabolism CD630_33040 - clpX Type: Gene Product:ATP-dependent Clp protease ATP-binding subunitclpX \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_24490 - Type: Gene Product:Putative methyltransferase \| Pathway: \| COG: Function unknown CD630_01900 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_01890 - Type: Gene Product:Transcriptional regulator, LysR family \| Pathway: \| COG: Transcription CD630_22260 - sat Type: Gene Product:Streptogramin A acetyltransferase (Virginiamycinacetyltransferase D) (Vat(D)) \| Pathway: \| COG: Function unknown CD630_34680 - atpD Type: Gene Product:ATP synthase subunit beta \| Pathway: \| COG: Energy production and conversion CD630_01950 - Type: Gene Product:Putative NCAIR-mutase (PurE)-related protein \| Pathway: \| COG: Function unknown CD630_34700 - atpA Type: Gene Product:ATPase subunit alpha \| Pathway: \| COG: Energy production and conversion CD630_22640 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_24500 - prmA Type: Gene Product:Ribosomal protein L11 methyltransferase (L11Mtase) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_33070 - Type: Gene Product:Putative phosphoesterase \| Pathway: \| COG: Function unknown CD630_22520 - Type: Gene Product:Glutamate 2,3-aminomutase \| Pathway: \| COG: Amino acid transport and metabolism CD630_20260 - Type: Gene Product:Putative acetyltransferase \| Pathway: \| COG: Function unknown CD630_24020 - Type: Gene Product:Putative cell wall hydrolase;phosphatase-associated protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_24480 - Type: Gene Product:Putative MiaB-like tRNA modifying enzyme \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_33050 - clpP1 Type: Gene Product:ATP-dependent Clp protease proteolytic subunit 1 \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_01910 - Type: Gene Product:Putative DNA glycosylase \| Pathway: \| COG: Replication, recombination and repair CD630_34690 - atpG Type: Gene Product:ATP synthase gamma chain \| Pathway: \| COG: Energy production and conversion CD630_07550 - pilJ Type: Gene Product:Type IV pilus protein \| Pathway: \| COG: Intracellular trafficking, secretion, and vesicular transport CD630_34710 - atpH Type: Gene Product:ATP synthase subunit delta \| Pathway: \| COG: Energy production and conversion CD630_34750 - atpI Type: Gene Product:ATP synthase subunit I \| Pathway: \| COG: Function unknown CD630_33080 - rph Type: Gene Product:Bifunctional enzyme, tRNA nucleotidyltransferase; Nucleoside-triphosphatase \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_24470 - Type: Gene Product:Putative histidine triad (HIT) protein \| Pathway: \| COG: Nucleotide transport and metabolism, Carbohydrate transport and metabolism CD630_22630 - prsA Type: Gene Product:Peptidyl-prolyl cis-trans isomerase, PpiC-type \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_33060 - tig Type: Gene Product:Trigger factor (TF) \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_36130 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown	`NA`	`NA`	0.43	Inferelator: 3 Hypergeometric: 0 TF Influences from Inferelator CD630_11770 - fapR Type: Gene Product:Transcriptional regulator, DeoR family (Fattyacid and phospholipid biosynthesis regulator) \| Pathway: \| COG: Transcription CD630_16920 - Type: Gene Product:Transcriptional regulator, ArsR family \| Pathway: \| COG: Transcription CD630_17820 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_404	13 CD630_04990 - Type: Gene Product:Putative replication initiation factor Tn5397,CTn3-Orf20 \| Pathway: \| COG: Transcription CD630_04991 - Type: Gene Product:Putative conjugative transposon protein Tn5397,CTn3-Orf19 \| Pathway: \| COG: Function unknown CD630_05010 - Type: Gene Product:Putative conjugative transposon protein Tn5397,CTn3-Orf17 \| Pathway: \| COG: Function unknown CD630_04980 - Type: Gene Product:Putative cell-division FtsK/SpoIIIE-familyprotein Tn5397, CTn3-Orf21 \| Pathway: \| COG: Cell cycle control, cell division, chromosome partitioning CD630_33860 - Type: Gene Product:Putative antirestriction protein Tn916-like,CTn7-Orf22 \| Pathway: \| COG: Function unknown CD630_05030 - Type: Gene Product:Putative membrane protein Tn5397, CTn3-Orf15 \| Pathway: \| COG: Function unknown CD630_04960 - Type: Gene Product:Putative conjugative transposon protein DUF961family Tn5397, CTn3-Orf23 \| Pathway: \| COG: Function unknown CD630_05020 - Type: Gene Product:Putative ATPase Tn5397, CTn3-Orf16 \| Pathway: \| COG: Function unknown CD630_05000 - Type: Gene Product:Putative antirestriction protein Tn5397,CTn3-Orf18 \| Pathway: \| COG: Function unknown CD630_04970 - Type: Gene Product:Putative conjugative transposon protein DUF961family Tn5397, CTn3-Orf22 \| Pathway: \| COG: Function unknown CD630_33850 - Type: Gene Product:Putative antirestriction protein Tn916-like,CTn7-Orf21 \| Pathway: \| COG: Function unknown CD630_10940 - Type: Gene Product:Putative RNA polymerase sigma factor Tn1549-like,CTn4-Orf31 \| Pathway: \| COG: Function unknown CD630_33910 - Type: Gene Product:Putative conjugative transposon protein DUF961family Tn916-like, CTn7-Orf30 \| Pathway: \| COG: Function unknown	0.12	0.51	0.43	Inferelator: 0 Hypergeometric: 0 TF Influences from Inferelator `No TF influences from Inferelator` TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_375	15 CD630_24040 - Type: Gene Product:DNA topoisomerase type IA \| Pathway: \| COG: Replication, recombination and repair CD630_15400 - Type: Gene Product:ABC-type transport system, permease protein \| Pathway: \| COG: Defense mechanisms CD630_15030 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_15410 - Type: Gene Product:Putative drug/sodium antiporter, MATE family \| Pathway: \| COG: Defense mechanisms CD630_31050 - Type: Gene Product:Putative iron-containing alcohol dehydrogenase \| Pathway: \| COG: Energy production and conversion CD630_31040 - Type: Gene Product:Putative hydrolase, HAD superfamily, IIBsubfamily; putative sugar phosphatase \| Pathway: \| COG: Function unknown CD630_03330 - ppaC Type: Gene Product:Putative inorganic pyrophosphatase \| Pathway: \| COG: Energy production and conversion CD630_15330 - Type: Gene Product:ABC-type transport system, permease \| Pathway: \| COG: Defense mechanisms CD630_28230 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_33610 - Type: Gene Product:Putative drug/sodium antiporter, MATE family \| Pathway: \| COG: Defense mechanisms CD630_31030 - Type: Gene Product:PTS system, glucose-like IIA component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_15040 - Type: Gene Product:ABC-type transport system, multidrug-familyATP-binding protein \| Pathway: \| COG: Defense mechanisms CD630_15320 - Type: Gene Product:ABC-type transport system, ATP-binding protein \| Pathway: \| COG: Defense mechanisms CD630_14650 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_15050 - Type: Gene Product:ABC-type transport system, multidrug-familypermease \| Pathway: \| COG:	0.001	`NA`	0.43	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_10640 - ccpA Type: Gene Product:Transcriptional regulator, LacI family \| Pathway: \| COG: Transcription CD630_32800 - Type: Gene Product:Sigma-54 dpendent regulator, PTS fructose family \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_35	9 CD630_31460 - Type: Gene Product:Fragment of putative sortase B (Part 1) \| Pathway: \| COG: Intracellular trafficking, secretion, and vesicular transport CD630_19904 - Type: Gene Product:Fragment of conserved hypothetical protein \| Pathway: \| COG: CD630_23910 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: CD630_09401 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_09780 - Type: Gene Product:Transcriptional regulator, beta-lactams repressorPhage-type \| Pathway: \| COG: CD630_19820 - Type: Gene Product:Fragment of putative phenazine biosynthesisprotein (Part 1) \| Pathway: \| COG: Function unknown, Function unknown CD630_12360 - Type: Gene Product:Fragment of putative phage protein (part 1) \| Pathway: \| COG: CD630_05780 - Type: Gene Product:Transporter, Major Facilitator Superfamily (MFS) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_22180 - int Type: Gene Product:Fragment of putative integrase (C-terminalregion) \| Pathway: \| COG: Replication, recombination and repair	`NA`	`NA`	0.43	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_05790 - Type: Gene Product:Transcriptional regulator, TetR family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_177	21 CD630_05690 - Type: Gene Product:Putative lipoprotein \| Pathway: \| COG: Function unknown CD630_24640 - hemN Type: Gene Product:Oxygen-independent coproporphyrinogen-III oxidase(Coproporphyrinogenase) (Coprogen oxidase) \| Pathway: \| COG: Coenzyme transport and metabolism CD630_24670 - lepA Type: Gene Product:GTP-binding protein LepA \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_24620 - grpE Type: Gene Product:Protein grpE (HSP-70 cofactor) \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_27440 - relA Type: Gene Product:GTP pyrophosphokinase (RelA/SpoT) \| Pathway: \| COG: Transcription, Signal transduction mechanisms CD630_27400 - hisS Type: Gene Product:Histidyl-tRNA synthetase (Histidine--tRNA ligase)(HisRS) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_24660 - Type: Gene Product:Putative tRNA-nucleotidyltransferase/Poly(A)polymerase family member \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_27240 - Type: Gene Product:Putative polysaccharide deacetylase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_01450 - Type: Gene Product:Putative resolvase, S1 RNA-bindingdomain-containing protein \| Pathway: \| COG: Transcription CD630_27250 - Type: Gene Product:Putative monogalactosyldiacylglycerol synthase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_05700 - Type: Gene Product:Putative lipoprotein \| Pathway: \| COG: Function unknown CD630_24630 - hrcA Type: Gene Product:Transcriptional regulator, Heat-induciblerepressor HrcA \| Pathway: \| COG: Transcription CD630_24600 - dnaJ Type: Gene Product:Chaperone protein DnaJ \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_27410 - hemZ Type: Gene Product:Coproporphyrinogen III oxidase \| Pathway: \| COG: Coenzyme transport and metabolism CD630_01460 - Type: Gene Product:Putative hydrolase \| Pathway: \| COG: Secondary metabolites biosynthesis, transport and catabolism CD630_28400 - serS1 Type: Gene Product:Seryl-tRNA synthetase 1 (Seryl-tRNA(Ser/Sec)synthetase 1) (Serine--tRNA ligase 1) (SerRS 1) \| Pathway: Aminoacyl-tRNA biosynthesis \| COG: Translation, ribosomal structure and biogenesis CD630_24610 - dnaK Type: Gene Product:Chaperone protein dnaK (Heat shock protein 70)(Heat shock 70 kDa protein) (HSP70) \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_27450 - apt Type: Gene Product:Adenine phosphoribosyltransferase (APRT) \| Pathway: Purine metabolism \| COG: Nucleotide transport and metabolism CD630_27430 - dtd Type: Gene Product:D-tyrosyl-tRNA(Tyr) deacylase \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_27230 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_27420 - Type: Gene Product:Putative hydrolase beta-lactamase-like \| Pathway: \| COG: Secondary metabolites biosynthesis, transport and catabolism	0.0000000037	`NA`	0.44	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_23830 - Type: Gene Product:Transcriptional regulator, sigma-54-dependent \| Pathway: \| COG: Transcription CD630_24630 - hrcA Type: Gene Product:Transcriptional regulator, Heat-induciblerepressor HrcA \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_194	20 CD630_08330 - acnB Type: Gene Product:Aconitate hydratase (Citrate hydro-lyase) \| Pathway: \| COG: Energy production and conversion CD630_08810 - Type: Gene Product:Putative protein modulating protease activity \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_33230 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_27210 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_09960 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_08340 - icd Type: Gene Product:Isocitrate dehydrogenase NAD-dependent \| Pathway: \| COG: Amino acid transport and metabolism CD630_07590 - plfB Type: Gene Product:Formate acetyltransferase (Pyruvateformate-lyase) \| Pathway: \| COG: Energy production and conversion CD630_07580 - pflA Type: Gene Product:Pyruvate formate-lyase activating enzyme \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_08800 - Type: Gene Product:Putative protease \| Pathway: \| COG: Function unknown CD630_36680 - rstA Type: Gene Product:Regulator of sporulation and toxins \| Pathway: \| COG: Transcription CD630_36650 - Type: Gene Product:Conserved hypothetical protein, DUF951 family \| Pathway: \| COG: Function unknown CD630_08320 - aksA Type: Gene Product:Trans-homoaconitate synthase \| Pathway: \| COG: Amino acid transport and metabolism CD630_33240 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_28300 - zmp1 Type: Gene Product:Extracellular Zinc metalloprotease \| Pathway: \| COG: Function unknown CD630_36670 - Type: Gene Product:Conserved hypothetical protein, TusA family \| Pathway: \| COG: Function unknown CD630_27220 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_36660 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_09940 - Type: Gene Product:Putative serine-pyruvate aminotransferase \| Pathway: \| COG: Amino acid transport and metabolism CD630_36640 - Type: Gene Product:Putative aminotransferase \| Pathway: \| COG: Transcription CD630_09950 - serA Type: Gene Product:Putative D-3-phosphoglycerate dehydrogenase \| Pathway: \| COG: Amino acid transport and metabolism	0.0000076	2.8	0.44	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_27220 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_43	25 CD630_15880 - Type: Gene Product:ABC-type transport system, sugar-family permease \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_13781 - Type: Gene Product:Transcriptional regulator, Phage-type \| Pathway: \| COG: Function unknown CD630_17720 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_20101 - ermC Type: Gene Product:23S rRNA methylase leader peptide \| Pathway: \| COG: CD630_15860 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_15970 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_13782 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_15840 - Type: Gene Product:Transcriptional regulator, repressor ROK family \| Pathway: \| COG: Carbohydrate transport and metabolism, Transcription CD630_20751 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_09341 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_12310 - Type: Gene Product:Putative site-specific recombinase \| Pathway: \| COG: Replication, recombination and repair CD630_01800 - Type: Gene Product:Fragment of conserved hypothetical protein(N-terminal region) \| Pathway: \| COG: Transcription, Signal transduction mechanisms CD630_13011 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_15890 - Type: Gene Product:ABC-type transport system, sugar-familyextracellular solute-binding protein \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_15870 - Type: Gene Product:ABC-type transport system, sugar-familyATP-binding protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_12100 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_04371 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_29661 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_15850 - Type: Gene Product:Putative N-acetylglucosamine kinase NAGK-like \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_31110 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_12300 - Type: Gene Product:RNA polymerase sigma-K factor SigK (Part 2) \| Pathway: \| COG: Transcription, Transcription	0.0000000000018	`NA`	0.44	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_15840 - Type: Gene Product:Transcriptional regulator, repressor ROK family \| Pathway: \| COG: Carbohydrate transport and metabolism, Transcription CD630_30870 - Type: Gene Product:Transcriptional regulator, RpiR family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_351	3 CD630_12650 - Type: Gene Product:Transcriptional regulator, CarD family \| Pathway: \| COG: Transcription CD630_26330 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Energy production and conversion CD630_20660 - Type: Gene Product:Putative integrase \| Pathway: \| COG: Replication, recombination and repair	`NA`	`NA`	0.44	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_12650 - Type: Gene Product:Transcriptional regulator, CarD family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`