Environment and Gene Regulatory Influence Network (EGRIN) model for C. difficile 630

The Environment and Gene Regulatory Influence Network (EGRIN) model of C. difficile 630 was inferred using cMonkey2 and a compendium of 136 transcriptomes (retrieved from the Gene Expression Omnibus repository) with 4,070 sequence features including 35 rRNAs and 90 tRNAs . The C. difficile EGRIN model groups genes in subsets (406 modules in total), that are co-regulated in specific environments, and also identifies the associated, putative cis-acting gene regulatory elements (GREs), which represent potential TF binding locations. Transcriptome compendium included conditions: response to iron limitation, response to oxygen, in vivo vs in vitro growth, short term infection (0, 30, 60, 120 mins), response to commensals and host diet, transition from exponential to stationary phase, fur KO, codY KO, sporulation TF (and sigma factors) KOs.

Explore Regulatory Modules

Displaying 71 - 80 of 406

Candidate transcriptional regulators for each module were determined with a linear regression based approach (Inferelator) and by evaluating the statistical significance of the overlap (Hypergeometric) between modules and putative TF and alternative sigma factor regulons (CcpA, CodY, Fur, PrdR, SigB, SigD, SigE, SigF, SigG, SigH, SigK, Spo0A) compiled from available literature.

* Given that translation start was used to define the 3' end of putative promoters, some cis-regulatory motifs are likely to be ribosome binding sites (i.e., Shine-Dalgarno sequence). RBS is typically a six nucleotide sequence 5'-GGAGGA-3'.

Title	Gene Count	Motif 1 e-value	Motif 2 e-value	Residual	TF Influences
Module_257	7 CD630_17410 - Type: Gene Product:Selenoprotein B,glycine/betaine/sarcosine/D-proline reductase family(sarcosine reductase) \| Pathway: \| COG: Function unknown CD630_08580 - Type: Gene Product:Fragment of transcriptional regulator,sigma-54-dependent (Part 1), PRD domain \| Pathway: \| COG: Signal transduction mechanisms, Signal transduction mechanisms CD630_31001 - Type: Gene Product:Fragment of artefact \| Pathway: \| COG: CD630_27000 - Type: Gene Product:Transcriptional regulator, sigma-54 dependent \| Pathway: \| COG: Transcription CD630_05990 - Type: Gene Product:Fragment of transcriptional regulator, AraCfamily (C-terminal region) \| Pathway: \| COG: Transcription CD630_05460 - Type: Gene Product:Putative membrane protein, DUF975 family \| Pathway: \| COG: Function unknown CD630_23950 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown	`NA`	`NA`	0.42	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_26400 - nrdR Type: Gene Product:Transcriptional regulator, repressor NrdR family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_112	21 CD630_09640 - Type: Gene Product:Putative phage baseplate assembly protein \| Pathway: \| COG: Function unknown CD630_09570 - Type: Gene Product:Putative phage lipoprotein \| Pathway: \| COG: Function unknown CD630_09620 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_11550 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_09590 - Type: Gene Product:Putative phage tail tape measure protein \| Pathway: \| COG: Function unknown CD630_09700 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_09390 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_09630 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_09710 - Type: Gene Product:Putative phage holin protein \| Pathway: \| COG: Function unknown CD630_09670 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_09610 - Type: Gene Product:Putative phage cell wall hydrolase \| Pathway: \| COG: Function unknown CD630_09720 - Type: Gene Product:Putative phage-related cell wall hydrolase(endolysin) \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_11540 - cdPadR1 Type: Gene Product:Transcriptional regulator, PadR family \| Pathway: \| COG: Transcription CD630_09730 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_09650 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_09580 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_09680 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_09600 - Type: Gene Product:Putative phage cell wall hydrolase \| Pathway: \| COG: Function unknown CD630_09690 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_09660 - Type: Gene Product:Putative phage tail fiber protein \| Pathway: \| COG: Function unknown CD630_09400 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown	6.7	`NA`	0.42	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_04500 - Type: Gene Product:Putative transcriptional regulator \| Pathway: \| COG: Transcription CD630_30540 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_179	26 CD630_01080 - nrdD Type: Gene Product:Anaerobic ribonucleoside triphosphate reductase \| Pathway: \| COG: Nucleotide transport and metabolism CD630_11650 - Type: Gene Product:Putative ribosome-associated protein \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_r0050 - 23s_rRNA Type: Gene Product: \| Pathway: \| COG: CD630_r0280 - 23s_rRNA Type: Gene Product: \| Pathway: \| COG: CD630_11630 - rpmA Type: Gene Product:50S ribosomal protein L27 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_11610 - rplU Type: Gene Product:50S ribosomal protein L21 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_06770 - sigT Type: Gene Product:Extra-Cytoplasmic Function sigma factors, ECFfamily \| Pathway: \| COG: Transcription CD630_11590 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_11640 - obgE Type: Gene Product:Spo0B-associated GTP-binding protein \| Pathway: \| COG: Energy production and conversion CD630_24400 - Type: Gene Product:Putative metal-dependent hydrolase \| Pathway: \| COG: Nucleotide transport and metabolism CD630_r0230 - 23s_rRNA Type: Gene Product: \| Pathway: \| COG: CD630_t0810 - tRNA-Leu Type: Gene Product: \| Pathway: \| COG: CD630_01090 - nrdG Type: Gene Product:Anaerobic ribonucleoside-triphosphatereductase-activating protein \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_31760 - glnF Type: Gene Product:RNA polymerase sigma-54 factor \| Pathway: \| COG: Transcription CD630_11600 - rng Type: Gene Product:Ribonuclease G (RNase G) (Cytoplasmic axialfilament protein) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_11620 - Type: Gene Product:Putative ribosome-associated protein \| Pathway: \| COG: Function unknown CD630_24390 - Type: Gene Product:Putative diacylglycerol kinase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_11580 - Type: Gene Product:Putative radical SAM-superfamily protein \| Pathway: \| COG: Energy production and conversion CD630_06760 - rsiT Type: Gene Product:Anti Sigma factors, ECF family \| Pathway: \| COG: Function unknown CD630_01070 - aspC Type: Gene Product:Aspartate aminotransferase \| Pathway: \| COG: Amino acid transport and metabolism CD630_24360 - Type: Gene Product:Putative divalent cation transporter, MgtEfamily \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_r0150 - 5s_rRNA Type: Gene Product: \| Pathway: \| COG:	0.000000026	0.00000027	0.42	Inferelator: 4 Hypergeometric: 0 TF Influences from Inferelator CD630_06480 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_16920 - Type: Gene Product:Transcriptional regulator, ArsR family \| Pathway: \| COG: Transcription CD630_23900 - Type: Gene Product:Transcriptional regulator, beta-lactamsrepressor \| Pathway: \| COG: Transcription CD630_30540 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_344	19 CD630_12480 - rnc Type: Gene Product:ribonuclease III \| Pathway: \| COG: Transcription CD630_11770 - fapR Type: Gene Product:Transcriptional regulator, DeoR family (Fattyacid and phospholipid biosynthesis regulator) \| Pathway: \| COG: Transcription CD630_11810 - fabD Type: Gene Product:Malonyl CoA-acyl carrier protein transacylase(MCT) \| Pathway: \| COG: Lipid transport and metabolism CD630_11840 - fabF Type: Gene Product:3-oxoacyl-[acyl-carrier-protein] synthase 2 \| Pathway: Lipid metabolism \| COG: Lipid transport and metabolism CD630_12530 - rpsP Type: Gene Product:30S ribosomal protein S16 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_11780 - plsX Type: Gene Product:Fatty acid/phospholipid synthesis protein PlsX \| Pathway: Lipid metabolism \| COG: Lipid transport and metabolism CD630_21200 - Type: Gene Product:Putative 2-nitropropane dioxygenase \| Pathway: \| COG: Function unknown CD630_12520 - ffh Type: Gene Product:Signal recognition particle protein \| Pathway: \| COG: Intracellular trafficking, secretion, and vesicular transport CD630_12570 - rplS Type: Gene Product:50S ribosomal protein L19 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_12500 - smc Type: Gene Product:Structural maintenance chromosome protein SMC \| Pathway: \| COG: Cell cycle control, cell division, chromosome partitioning CD630_01770 - cfa Type: Gene Product:Cyclopropane-fatty-acyl-phospholipid synthase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_12470 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_12511 - Type: Gene Product:Putative DNA-binding regulator \| Pathway: \| COG: Function unknown CD630_12460 - efp Type: Gene Product:Elongation factor P (EF-P) \| Pathway: Protein biosynthesis \| COG: Translation, ribosomal structure and biogenesis CD630_12540 - Type: Gene Product:Putative RNA-binding protein \| Pathway: \| COG: Function unknown CD630_11830 - acpP Type: Gene Product:Acyl carrier protein (ACP) \| Pathway: Lipid metabolism \| COG: Lipid transport and metabolism CD630_12490 - Type: Gene Product:Putative radical SAM-superfamily protein \| Pathway: \| COG: Chromatin structure and dynamics, Transcription CD630_12550 - rimM Type: Gene Product:16S rRNA processing protein RimM \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_12560 - trmD Type: Gene Product:tRNA (guanine-N(1)-)-methyltransferase(M1G-methyltransferase) (tRNA [GM37] methyltransferase ) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis	0.38	2.8	0.42	Inferelator: 4 Hypergeometric: 0 TF Influences from Inferelator CD630_11770 - fapR Type: Gene Product:Transcriptional regulator, DeoR family (Fattyacid and phospholipid biosynthesis regulator) \| Pathway: \| COG: Transcription CD630_16920 - Type: Gene Product:Transcriptional regulator, ArsR family \| Pathway: \| COG: Transcription CD630_17820 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_23900 - Type: Gene Product:Transcriptional regulator, beta-lactamsrepressor \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_219	20 CD630_28620 - Type: Gene Product:Putative peptidase, M19 family \| Pathway: \| COG: Amino acid transport and metabolism CD630_35320 - phnM Type: Gene Product:Putative carbon-phosphorus lyase complex subunit \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_10200 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_35310 - Type: Gene Product:Putative polymerase/histidinol phosphatase-like \| Pathway: \| COG: Function unknown CD630_35340 - phnK Type: Gene Product:ABC-type transport system, phosphonate-specificATP-binding protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_04350 - Type: Gene Product:Putative sigma factor Tn1549-like, CTn2-Orf31 \| Pathway: \| COG: Function unknown CD630_35350 - phnJ Type: Gene Product:Putative phosphonate metabolism protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_01650 - Type: Gene Product:Putative amino acid transporter \| Pathway: \| COG: Amino acid transport and metabolism CD630_10190 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_35300 - Type: Gene Product:ABC-type transport system, iron-familyATP-binding protein \| Pathway: \| COG: Amino acid transport and metabolism CD630_35280 - Type: Gene Product:ABC-type transport system, iron-familyextracellular solute-binding protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_01660 - Type: Gene Product:Putative peptidase, M20D family \| Pathway: \| COG: Amino acid transport and metabolism CD630_28600 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_18780 - Type: Gene Product:Putative sigma factor Tn1549-like, CTn5-Orf38 \| Pathway: \| COG: Function unknown CD630_10210 - Type: Gene Product:Putative spore coat protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_35360 - phnI Type: Gene Product:Putative phosphonate metabolism protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_35370 - phnH Type: Gene Product:Putative phosphonate metabolism protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_35380 - phnG Type: Gene Product:Putative phosphonate metabolism protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_28590 - Type: Gene Product:Putative D-aminoacylase \| Pathway: \| COG: Secondary metabolites biosynthesis, transport and catabolism CD630_28610 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown	0.35	`NA`	0.43	Inferelator: 2 Hypergeometric: 1 TF Influences from Inferelator CD630_04500 - Type: Gene Product:Putative transcriptional regulator \| Pathway: \| COG: Transcription CD630_27320 - Type: Gene Product:Transcriptional regulator, sigma-54-dependent \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test CD630_12750 - codY Type: Gene Product:Transcriptional regulator, GTP-sensingpleiotropic repressor \| Pathway: \| COG: Transcription
Module_315	32 CD630_28450 - rbr Type: Gene Product:Rubrerythrin \| Pathway: \| COG: Energy production and conversion CD630_14920 - Type: Gene Product:Histidine kinase, negative regulator ofsporulation \| Pathway: \| COG: Signal transduction mechanisms CD630_04430 - ortA Type: Gene Product:2-amino-4-ketopentanoate thiolase alpha subunit \| Pathway: \| COG: Function unknown CD630_04470 - Type: Gene Product:Putative reactivating factor foradenosylcobalamine-dependent D-ornithine aminomutase \| Pathway: \| COG: Function unknown CD630_06710 - Type: Gene Product:Putative enzyme, glyoxalase family \| Pathway: \| COG: Amino acid transport and metabolism CD630_04450 - oraS Type: Gene Product:D-ornithine aminomutase S component \| Pathway: \| COG: Function unknown CD630_08200 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_35420 - spmA Type: Gene Product:Spore maturation protein A \| Pathway: \| COG: Function unknown CD630_35810 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_08640 - Type: Gene Product:Maltose-6'-phosphate glucosidase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_04480 - orr Type: Gene Product:ornithine racemase \| Pathway: \| COG: Amino acid transport and metabolism CD630_17610 - Type: Gene Product:Putative phenazine biosynthesis PhzC/PhzFprotein \| Pathway: \| COG: Function unknown CD630_13010 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: CD630_19060 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_19050 - Type: Gene Product:Site-specific recombinase, resolvase family \| Pathway: \| COG: Replication, recombination and repair CD630_19040 - Type: Gene Product:ABC-type transport system, permease \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_01560 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_04420 - ord Type: Gene Product:2,4-diaminopentanoate dehydrogenase \| Pathway: \| COG: Amino acid transport and metabolism CD630_04460 - oraE Type: Gene Product:D-ornithine aminomutase E component \| Pathway: \| COG: Function unknown CD630_19860 - miaB Type: Gene Product:(Dimethylallyl)adenosine tRNAmethylthiotransferase miaB (tRNA-i(6)A37methylthiotransferase) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_15830 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_08210 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_35820 - Type: Gene Product:Putative pseudouridine synthase RsuA-like \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_04440 - ortB Type: Gene Product:2-amino-4-ketopentanoate thiolase beta subunit \| Pathway: \| COG: Function unknown CD630_08630 - Type: Gene Product:PTS system, lactose/cellobiose-family IIAcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_04490 - Type: Gene Product:Na+/H+ antiporter, NhaA family \| Pathway: \| COG: Energy production and conversion CD630_23330 - mtlR Type: Gene Product:Transcription antiterminator, PTS operonregulator \| Pathway: \| COG: Transcription CD630_35410 - spmB Type: Gene Product:Spore maturation protein B \| Pathway: \| COG: Function unknown CD630_35800 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_35830 - Type: Gene Product:Transcriptional regulator, MerR family \| Pathway: \| COG: Transcription CD630_17600 - Type: Gene Product:Putative iron-sulfur protein \| Pathway: \| COG: Energy production and conversion CD630_14020 - glpQ Type: Gene Product:Glycerophosphoryl diester phosphodiesterase \| Pathway: \| COG: Energy production and conversion	0.00000000000083	`NA`	0.43	Inferelator: 1 Hypergeometric: 1 TF Influences from Inferelator CD630_26430 - sigE Type: Gene Product:RNA polymerase sigma-E factor \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test CD630_12750 - codY Type: Gene Product:Transcriptional regulator, GTP-sensingpleiotropic repressor \| Pathway: \| COG: Transcription
Module_127	27 CD630_01920 - cls Type: Gene Product:Cardiolipin synthetase 1 \| Pathway: \| COG: Lipid transport and metabolism CD630_33040 - clpX Type: Gene Product:ATP-dependent Clp protease ATP-binding subunitclpX \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_24490 - Type: Gene Product:Putative methyltransferase \| Pathway: \| COG: Function unknown CD630_01900 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_01890 - Type: Gene Product:Transcriptional regulator, LysR family \| Pathway: \| COG: Transcription CD630_22260 - sat Type: Gene Product:Streptogramin A acetyltransferase (Virginiamycinacetyltransferase D) (Vat(D)) \| Pathway: \| COG: Function unknown CD630_34680 - atpD Type: Gene Product:ATP synthase subunit beta \| Pathway: \| COG: Energy production and conversion CD630_01950 - Type: Gene Product:Putative NCAIR-mutase (PurE)-related protein \| Pathway: \| COG: Function unknown CD630_34700 - atpA Type: Gene Product:ATPase subunit alpha \| Pathway: \| COG: Energy production and conversion CD630_22640 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_24500 - prmA Type: Gene Product:Ribosomal protein L11 methyltransferase (L11Mtase) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_33070 - Type: Gene Product:Putative phosphoesterase \| Pathway: \| COG: Function unknown CD630_22520 - Type: Gene Product:Glutamate 2,3-aminomutase \| Pathway: \| COG: Amino acid transport and metabolism CD630_20260 - Type: Gene Product:Putative acetyltransferase \| Pathway: \| COG: Function unknown CD630_24020 - Type: Gene Product:Putative cell wall hydrolase;phosphatase-associated protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_24480 - Type: Gene Product:Putative MiaB-like tRNA modifying enzyme \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_33050 - clpP1 Type: Gene Product:ATP-dependent Clp protease proteolytic subunit 1 \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_01910 - Type: Gene Product:Putative DNA glycosylase \| Pathway: \| COG: Replication, recombination and repair CD630_34690 - atpG Type: Gene Product:ATP synthase gamma chain \| Pathway: \| COG: Energy production and conversion CD630_07550 - pilJ Type: Gene Product:Type IV pilus protein \| Pathway: \| COG: Intracellular trafficking, secretion, and vesicular transport CD630_34710 - atpH Type: Gene Product:ATP synthase subunit delta \| Pathway: \| COG: Energy production and conversion CD630_34750 - atpI Type: Gene Product:ATP synthase subunit I \| Pathway: \| COG: Function unknown CD630_33080 - rph Type: Gene Product:Bifunctional enzyme, tRNA nucleotidyltransferase; Nucleoside-triphosphatase \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_24470 - Type: Gene Product:Putative histidine triad (HIT) protein \| Pathway: \| COG: Nucleotide transport and metabolism, Carbohydrate transport and metabolism CD630_22630 - prsA Type: Gene Product:Peptidyl-prolyl cis-trans isomerase, PpiC-type \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_33060 - tig Type: Gene Product:Trigger factor (TF) \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_36130 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown	`NA`	`NA`	0.43	Inferelator: 3 Hypergeometric: 0 TF Influences from Inferelator CD630_11770 - fapR Type: Gene Product:Transcriptional regulator, DeoR family (Fattyacid and phospholipid biosynthesis regulator) \| Pathway: \| COG: Transcription CD630_16920 - Type: Gene Product:Transcriptional regulator, ArsR family \| Pathway: \| COG: Transcription CD630_17820 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_323	22 CD630_19170 - eutE Type: Gene Product:Ethanolamine acetaldehyde oxydoreductase \| Pathway: \| COG: Energy production and conversion CD630_30920 - Type: Gene Product:Putative amino acid permease \| Pathway: \| COG: Amino acid transport and metabolism CD630_19480 - Type: Gene Product:ABC-type transport system, permease \| Pathway: \| COG: Defense mechanisms CD630_31020 - Type: Gene Product:Putative peptidase, M20 family, peptidase Vrelated \| Pathway: \| COG: Amino acid transport and metabolism CD630_32110 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_06500 - Type: Gene Product:Putative peptidase, S9 family \| Pathway: \| COG: Amino acid transport and metabolism CD630_19470 - Type: Gene Product:ABC-type transport system, ATP-binding protein \| Pathway: \| COG: Defense mechanisms CD630_19230 - Type: Gene Product:Ethanolamine carboxysome structural protein, BMCfamily \| Pathway: \| COG: Amino acid transport and metabolism CD630_19250 - eutQ Type: Gene Product:Ethanolamine utilization protein, Cupin barrelsfamily \| Pathway: \| COG: Amino acid transport and metabolism CD630_20010 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_30930 - Type: Gene Product:Putative gamma-glutamyl-gamma-aminobutyratehydrolase \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_06490 - Type: Gene Product:Putative peptidase, S9 family \| Pathway: \| COG: Amino acid transport and metabolism CD630_32100 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_31150 - bglA Type: Gene Product:6-phospho-beta-glucosidase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_32090 - Type: Gene Product:Transcriptional regulator, PadR family \| Pathway: \| COG: Transcription CD630_31010 - Type: Gene Product:PTS system, glucose-like IIBC component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_06510 - Type: Gene Product:Putative permease \| Pathway: \| COG: Function unknown CD630_19190 - eutT Type: Gene Product:Ethanolamine corrinoid cobalaminadenosyltransferase \| Pathway: \| COG: Amino acid transport and metabolism CD630_32201 - Type: Gene Product:Small acid-soluble spore protein \| Pathway: \| COG: Function unknown CD630_32200 - Type: Gene Product:Putative methyltransferase \| Pathway: \| COG: Secondary metabolites biosynthesis, transport and catabolism CD630_19200 - eutD Type: Gene Product:Putative phosphotransacetylase \| Pathway: Polyol metabolism \| COG: Secondary metabolites biosynthesis, transport and catabolism CD630_19240 - eutH Type: Gene Product:Ethanolamine transport protein \| Pathway: \| COG: Amino acid transport and metabolism	0.01	`NA`	0.43	Inferelator: 0 Hypergeometric: 1 TF Influences from Inferelator `No TF influences from Inferelator` TF Influences from Hypergeometric Test CD630_32450 - prdR Type: Gene Product:Transcriptional regulator, sigma-54-dependent \| Pathway: \| COG: Transcription
Module_228	20 CD630_11480 - Type: Gene Product:Putative penicillin-binding protein with aN-terminal TonB-box \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_21360 - uppS Type: Gene Product:Undecaprenyl pyrophosphate synthetase \| Pathway: \| COG: Lipid transport and metabolism CD630_21361 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_23340 - mtlA Type: Gene Product:PTS system, mannitol-specific, IICB component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_11510 - minE Type: Gene Product:Cell division topological specificity factor \| Pathway: \| COG: Cell cycle control, cell division, chromosome partitioning CD630_21380 - pyrH Type: Gene Product:Uridylate kinase (UK) (Uridine monophosphatekinase) (UMP kinase) (UMPK) \| Pathway: Pyrimidine metabolism \| COG: Nucleotide transport and metabolism CD630_21350 - cdsA Type: Gene Product:Phosphatidate cytidylyltransferase CdsA \| Pathway: Phospholipid metabolism \| COG: Lipid transport and metabolism CD630_11530 - mgsA Type: Gene Product:Methylglyoxal synthase (MGS) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_11460 - mreC Type: Gene Product:Rod shape-determining protein MreC \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_11520 - mrdB Type: Gene Product:Rod shape-determining protein MrdB \| Pathway: \| COG: Cell cycle control, cell division, chromosome partitioning CD630_23320 - mtlF Type: Gene Product:PTS system, mannitol-specific, EIIA component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_23330 - mtlR Type: Gene Product:Transcription antiterminator, PTS operonregulator \| Pathway: \| COG: Transcription CD630_21400 - rpsB Type: Gene Product:30S ribosomal protein S2 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_23310 - mtlD Type: Gene Product:Mannitol-1-phosphate 5-dehydrogenase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_11470 - Type: Gene Product:Putative permease \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_11450 - mreB2 Type: Gene Product:Rod shape-determining protein MreB \| Pathway: \| COG: Cell cycle control, cell division, chromosome partitioning CD630_11440 - radC Type: Gene Product:DNA repair protein RadC homolog \| Pathway: \| COG: Replication, recombination and repair CD630_11490 - minC Type: Gene Product:Cell division regulator (septum placement) \| Pathway: \| COG: Cell cycle control, cell division, chromosome partitioning CD630_21390 - tsf Type: Gene Product:Elongation factor Ts (EF-Ts) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_11430 - Type: Gene Product:Putative Maf-like protein \| Pathway: \| COG: Cell cycle control, cell division, chromosome partitioning	`NA`	`NA`	0.43	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_16860 - Type: Gene Product:Transcriptional regulator, repressor-like \| Pathway: \| COG: Transcription CD630_17820 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_404	13 CD630_04990 - Type: Gene Product:Putative replication initiation factor Tn5397,CTn3-Orf20 \| Pathway: \| COG: Transcription CD630_04991 - Type: Gene Product:Putative conjugative transposon protein Tn5397,CTn3-Orf19 \| Pathway: \| COG: Function unknown CD630_05010 - Type: Gene Product:Putative conjugative transposon protein Tn5397,CTn3-Orf17 \| Pathway: \| COG: Function unknown CD630_04980 - Type: Gene Product:Putative cell-division FtsK/SpoIIIE-familyprotein Tn5397, CTn3-Orf21 \| Pathway: \| COG: Cell cycle control, cell division, chromosome partitioning CD630_33860 - Type: Gene Product:Putative antirestriction protein Tn916-like,CTn7-Orf22 \| Pathway: \| COG: Function unknown CD630_05030 - Type: Gene Product:Putative membrane protein Tn5397, CTn3-Orf15 \| Pathway: \| COG: Function unknown CD630_04960 - Type: Gene Product:Putative conjugative transposon protein DUF961family Tn5397, CTn3-Orf23 \| Pathway: \| COG: Function unknown CD630_05020 - Type: Gene Product:Putative ATPase Tn5397, CTn3-Orf16 \| Pathway: \| COG: Function unknown CD630_05000 - Type: Gene Product:Putative antirestriction protein Tn5397,CTn3-Orf18 \| Pathway: \| COG: Function unknown CD630_04970 - Type: Gene Product:Putative conjugative transposon protein DUF961family Tn5397, CTn3-Orf22 \| Pathway: \| COG: Function unknown CD630_33850 - Type: Gene Product:Putative antirestriction protein Tn916-like,CTn7-Orf21 \| Pathway: \| COG: Function unknown CD630_10940 - Type: Gene Product:Putative RNA polymerase sigma factor Tn1549-like,CTn4-Orf31 \| Pathway: \| COG: Function unknown CD630_33910 - Type: Gene Product:Putative conjugative transposon protein DUF961family Tn916-like, CTn7-Orf30 \| Pathway: \| COG: Function unknown	0.12	0.51	0.43	Inferelator: 0 Hypergeometric: 0 TF Influences from Inferelator `No TF influences from Inferelator` TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`