Environment and Gene Regulatory Influence Network (EGRIN) model for C. difficile 630

The Environment and Gene Regulatory Influence Network (EGRIN) model of C. difficile 630 was inferred using cMonkey2 and a compendium of 136 transcriptomes (retrieved from the Gene Expression Omnibus repository) with 4,070 sequence features including 35 rRNAs and 90 tRNAs . The C. difficile EGRIN model groups genes in subsets (406 modules in total), that are co-regulated in specific environments, and also identifies the associated, putative cis-acting gene regulatory elements (GREs), which represent potential TF binding locations. Transcriptome compendium included conditions: response to iron limitation, response to oxygen, in vivo vs in vitro growth, short term infection (0, 30, 60, 120 mins), response to commensals and host diet, transition from exponential to stationary phase, fur KO, codY KO, sporulation TF (and sigma factors) KOs.

Explore Regulatory Modules

Displaying 191 - 200 of 406

Candidate transcriptional regulators for each module were determined with a linear regression based approach (Inferelator) and by evaluating the statistical significance of the overlap (Hypergeometric) between modules and putative TF and alternative sigma factor regulons (CcpA, CodY, Fur, PrdR, SigB, SigD, SigE, SigF, SigG, SigH, SigK, Spo0A) compiled from available literature.

* Given that translation start was used to define the 3' end of putative promoters, some cis-regulatory motifs are likely to be ribosome binding sites (i.e., Shine-Dalgarno sequence). RBS is typically a six nucleotide sequence 5'-GGAGGA-3'.

Title	Gene Count	Motif 1 e-value	Motif 2 e-value	Residual	TF Influences
Module_274	12 CD630_19640 - Type: Gene Product:Putative transcriptional regulator \| Pathway: \| COG: Transcription CD630_28860 - Type: Gene Product:Putative drug/sodium antiporter, MATE family \| Pathway: \| COG: Defense mechanisms CD630_16510 - Type: Gene Product:Putative signaling protein \| Pathway: \| COG: Signal transduction mechanisms CD630_22850 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_10020 - Type: Gene Product:Putative nucleotide/oligonucleotide bindingprotein \| Pathway: \| COG: Function unknown CD630_18820 - Type: Gene Product:Site-specific recombinase \| Pathway: \| COG: Replication, recombination and repair CD630_25980 - Type: Gene Product:Putative oligosaccharide deacetylase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_13350 - Type: Gene Product:Transcriptional regulator, MarR family \| Pathway: \| COG: Transcription CD630_08510 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_25990 - Type: Gene Product:Putative transcriptional regulator \| Pathway: \| COG: Transcription CD630_36460 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_08520 - Type: Gene Product:Transcriptional regulator, MarR family \| Pathway: \| COG: Transcription	0.0000019	`NA`	0.50	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_19590 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_25990 - Type: Gene Product:Putative transcriptional regulator \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_81	18 CD630_23900 - Type: Gene Product:Transcriptional regulator, beta-lactamsrepressor \| Pathway: \| COG: Transcription CD630_24540 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_25320 - Type: Gene Product:Aminotransferase, alanine--glyoxylatetransaminase \| Pathway: \| COG: Amino acid transport and metabolism CD630_23880 - Type: Gene Product:Putative peptidoglycan-binding/hydrolysingprotein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_25300 - Type: Gene Product:Transcriptional regulator, AraC family \| Pathway: \| COG: Transcription CD630_24510 - Type: Gene Product:Putative CRISPR-associated ATP-dependenthelicase \| Pathway: \| COG: Replication, recombination and repair CD630_25310 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_25290 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_t0250 - tRNA-Met Type: Gene Product: \| Pathway: \| COG: CD630_24530 - Type: Gene Product:Putative CRISPR-associated negativeautoregulator \| Pathway: \| COG: Replication, recombination and repair CD630_15180 - feoA Type: Gene Product:Ferrous iron transport protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_24520 - Type: Gene Product:Putative CRISPR-associated protein \| Pathway: \| COG: Replication, recombination and repair CD630_06840 - Type: Gene Product:Putative ATP-dependent peptidase, M41 family \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_23890 - Type: Gene Product:Putative beta-lactams signal-transducer \| Pathway: \| COG: Transcription, Signal transduction mechanisms CD630_15120 - panC Type: Gene Product:Pantothenate synthetase \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism CD630_15170 - feoB Type: Gene Product:Ferrous iron transport protein B \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_15130 - panB Type: Gene Product:Ketopantoate hydroxymethyltransferase \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism CD630_15140 - panG Type: Gene Product:Putative ketopantoate reductase \| Pathway: \| COG: Coenzyme transport and metabolism	0.0000088	`NA`	0.50	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_23900 - Type: Gene Product:Transcriptional regulator, beta-lactamsrepressor \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_33	18 CD630_t0070 - tRNA-Gly Type: Gene Product: \| Pathway: \| COG: CD630_t0350 - tRNA-Gln Type: Gene Product: \| Pathway: \| COG: CD630_t0150 - tRNA-Ser Type: Gene Product: \| Pathway: \| COG: CD630_t0330 - tRNA-Gly Type: Gene Product: \| Pathway: \| COG: CD630_t0780 - tRNA-Arg Type: Gene Product: \| Pathway: \| COG: CD630_t0400 - tRNA-Met Type: Gene Product: \| Pathway: \| COG: CD630_t0320 - tRNA-Leu Type: Gene Product: \| Pathway: \| COG: CD630_t0110 - tRNA-Tyr Type: Gene Product: \| Pathway: \| COG: CD630_t0580 - tRNA-Ser Type: Gene Product: \| Pathway: \| COG: CD630_t0340 - tRNA-Arg Type: Gene Product: \| Pathway: \| COG: CD630_t0390 - tRNA-Met Type: Gene Product: \| Pathway: \| COG: CD630_t0120 - tRNA-Leu Type: Gene Product: \| Pathway: \| COG: CD630_t0200 - tRNA-His Type: Gene Product: \| Pathway: \| COG: CD630_t0410 - tRNA-His Type: Gene Product: \| Pathway: \| COG: CD630_t0300 - tRNA-Thr Type: Gene Product: \| Pathway: \| COG: CD630_t0590 - tRNA-Pro Type: Gene Product: \| Pathway: \| COG: CD630_t0310 - tRNA-Tyr Type: Gene Product: \| Pathway: \| COG:	0	0	0.50	Inferelator: 0 Hypergeometric: 0 TF Influences from Inferelator `No TF influences from Inferelator` TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_98	23 CD630_27260 - glyA Type: Gene Product:Serine hydroxymethyltransferase \| Pathway: One-carbon metabolism \| COG: Amino acid transport and metabolism CD630_10030 - fumA Type: Gene Product:Fumarate hydratase class I, subunit A \| Pathway: \| COG: Energy production and conversion CD630_22080 - Type: Gene Product:Transcriptional regulator, MarR family \| Pathway: \| COG: Transcription CD630_17500 - Type: Gene Product:Putative CoA enzyme activase \| Pathway: \| COG: Lipid transport and metabolism CD630_10050 - Type: Gene Product:Putative NAD-dependent malic enzyme \| Pathway: \| COG: Energy production and conversion CD630_06670 - cdd4 Type: Gene Product:ABC-type transport system,lantibiotic/multidrug-family ATP-binding protein \| Pathway: \| COG: Defense mechanisms CD630_06650 - cdd2 Type: Gene Product:ABC-type transport system,lantibiotic/multidrug-family permease \| Pathway: \| COG: Function unknown CD630_06690 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_17490 - Type: Gene Product:Putative 2-hydroxyacyl-CoA dehydratase \| Pathway: \| COG: Amino acid transport and metabolism CD630_23080 - Type: Gene Product:Transcriptional regulator, HTH-type \| Pathway: \| COG: Transcription CD630_09770 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_09750 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_27270 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_09870 - Type: Gene Product:Putative phosphatase/hydrolase \| Pathway: \| COG: Replication, recombination and repair CD630_10040 - fumB Type: Gene Product:Fumarate hydratase class I, subunit B \| Pathway: \| COG: Energy production and conversion CD630_06660 - cdd3 Type: Gene Product:ABC-type transport system,lantibiotic/multidrug-family permease \| Pathway: \| COG: Function unknown CD630_06680 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_27280 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_23070 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_09880 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_09760 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_13920 - Type: Gene Product:Putative endoribonuclease \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_22070 - Type: Gene Product:Putative flavodoxin \| Pathway: \| COG: Function unknown	0.00019	0	0.50	Inferelator: 0 Hypergeometric: 0 TF Influences from Inferelator `No TF influences from Inferelator` TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_343	23 CD630_33701 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn7-Orf2 \| Pathway: \| COG: Function unknown CD630_26760 - thlA2 Type: Gene Product:Acetoacetyl-CoA thiolase 2 \| Pathway: \| COG: Lipid transport and metabolism CD630_02210 - purG Type: Gene Product:Phosphoribosylformylglycinamidine cyclo-ligase \| Pathway: Purine metabolism \| COG: Nucleotide transport and metabolism CD630_28190 - Type: Gene Product:Putative amino acid racemase \| Pathway: \| COG: Amino acid transport and metabolism CD630_02230 - purH Type: Gene Product:Bifunctional purine biosynthesis protein purH[Includes: Phosphoribosylaminoimidazolecarboxamideformyltransferase ; IMP cyclohydrolase] \| Pathway: Purine metabolism \| COG: Nucleotide transport and metabolism CD630_26770 - scoA Type: Gene Product:Succinyl CoA:3-oxoacid CoA-transferase subunit A \| Pathway: \| COG: Lipid transport and metabolism CD630_02250 - purL Type: Gene Product:Phosphoribosylformylglycinamidine synthase \| Pathway: Purine metabolism \| COG: Nucleotide transport and metabolism CD630_22320 - asrB Type: Gene Product:Anaerobic sulfite reductase subunit B \| Pathway: \| COG: Energy production and conversion CD630_22300 - Type: Gene Product:Putative formate/nitrite transporter \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_26790 - bdhA Type: Gene Product:3-hydroxybutyrate dehydrogenase \| Pathway: \| COG: Function unknown CD630_06110 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_04760 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_33710 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn7-Orf3 \| Pathway: \| COG: Function unknown CD630_02200 - purF Type: Gene Product:Amidophosphoribosyltransferase \| Pathway: Purine metabolism \| COG: Nucleotide transport and metabolism CD630_02240 - purD Type: Gene Product:Phosphoribosylamine--glycine ligase \| Pathway: Purine metabolism \| COG: Nucleotide transport and metabolism CD630_02220 - purN Type: Gene Product:Phosphoribosylglycinamide formyltransferase \| Pathway: Purine metabolism \| COG: Nucleotide transport and metabolism CD630_22310 - asrC Type: Gene Product:Anaerobic sulfite reductase subunit C \| Pathway: \| COG: Energy production and conversion CD630_22330 - asrA Type: Gene Product:Anaerobic sulfite reductase subunit A (Anaerobicsulfite reductase iron-sulfur subunit) \| Pathway: \| COG: Energy production and conversion CD630_06100 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_26800 - Type: Gene Product:Putative permease \| Pathway: \| COG: Amino acid transport and metabolism, Carbohydrate transport and metabolism CD630_26780 - scoB Type: Gene Product:Succinyl CoA:3-oxoacid CoA-transferase subunit B \| Pathway: \| COG: Lipid transport and metabolism CD630_04750 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Replication, recombination and repair CD630_33720 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn7-Orf4 \| Pathway: \| COG:	0.25	1.2	0.50	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_06930 - Type: Gene Product:Transcriptional regulator, MerR family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_262	12 CD630_19260 - eutR Type: Gene Product:Fragment of transcription regulator, AraC family(C-terminal region) \| Pathway: \| COG: Transcription CD630_20131 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_17410 - Type: Gene Product:Selenoprotein B,glycine/betaine/sarcosine/D-proline reductase family(sarcosine reductase) \| Pathway: \| COG: Function unknown CD630_22210 - Type: Gene Product:Fragment of putative extrachromosomal protein(C-terminal region) \| Pathway: \| COG: Function unknown CD630_23150 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_05990 - Type: Gene Product:Fragment of transcriptional regulator, AraCfamily (C-terminal region) \| Pathway: \| COG: Transcription CD630_20102 - Type: Gene Product:Fragment of putative transcriptional regulator(C-terminal region) \| Pathway: \| COG: Transcription CD630_01800 - Type: Gene Product:Fragment of conserved hypothetical protein(N-terminal region) \| Pathway: \| COG: Transcription, Signal transduction mechanisms CD630_23620 - Type: Gene Product:Fragment of ABC-type transport system, permease(Part 2) \| Pathway: \| COG: Function unknown, Inorganic ion transport and metabolism CD630_23950 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_17591 - Type: Gene Product:Fragment of conserved hypothetical protein,UPF0027 family (C-terminal region) \| Pathway: \| COG: CD630_20021 - Type: Gene Product:Fragment of conserved hypothetical protein(N-terminal region) \| Pathway: \| COG: Function unknown	`NA`	`NA`	0.50	Inferelator: 3 Hypergeometric: 0 TF Influences from Inferelator CD630_23160 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_26400 - nrdR Type: Gene Product:Transcriptional regulator, repressor NrdR family \| Pathway: \| COG: Transcription CD630_33530 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_68	4 CD630_12910 - dacF Type: Gene Product:D-alanyl-D-alanine carboxypeptidase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_12900 - Type: Gene Product:Putative small acid-soluble spore protein SASP \| Pathway: \| COG: CD630_07080 - pepD Type: Gene Product:Peptidase D, aminoacyl-histidine dipeptidase \| Pathway: \| COG: Amino acid transport and metabolism CD630_32220 - sdaB Type: Gene Product:L-serine dehydratase \| Pathway: \| COG: Amino acid transport and metabolism	`NA`	`NA`	0.50	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_06290 - Type: Gene Product:Transcriptional regulator, Crp family \| Pathway: \| COG: Transcription CD630_25990 - Type: Gene Product:Putative transcriptional regulator \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_167	28 CD630_19260 - eutR Type: Gene Product:Fragment of transcription regulator, AraC family(C-terminal region) \| Pathway: \| COG: Transcription CD630_21210 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_25980 - Type: Gene Product:Putative oligosaccharide deacetylase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_32570 - Type: Gene Product:Putative polysaccharide deacetylase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_05560 - Type: Gene Product:Putative sugar isomerase / endonuclease \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_05520 - prsW Type: Gene Product:Site-1 protease \| Pathway: \| COG: Function unknown CD630_05540 - sip2 Type: Gene Product:Signal peptidase type I \| Pathway: \| COG: Intracellular trafficking, secretion, and vesicular transport CD630_05500 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_32580 - Type: Gene Product:Iron hydrogenase \| Pathway: \| COG: Energy production and conversion CD630_34880 - gtaB Type: Gene Product:UTP--glucose-1-phosphate uridylyltransferase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_23730 - Type: Gene Product:Putative CstA-like carbon starvation protein \| Pathway: \| COG: Signal transduction mechanisms CD630_07120 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_33120 - Type: Gene Product:Transporter, Major Facilitator Superfamily (MFS) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_15750 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_27190 - Type: Gene Product:Putative polysaccharide deacetylase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_24580 - Type: Gene Product:Transporter, Major Facilitator Superfamily (MFS) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_05570 - Type: Gene Product:Putative uridine kinase \| Pathway: \| COG: Nucleotide transport and metabolism CD630_25990 - Type: Gene Product:Putative transcriptional regulator \| Pathway: \| COG: Transcription CD630_05550 - sip2 Type: Gene Product:Signal peptidase type I \| Pathway: \| COG: Intracellular trafficking, secretion, and vesicular transport CD630_14300 - pdaA Type: Gene Product:Exported N-acetylmuramic acid deacetylase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_05510 - sleC Type: Gene Product:Spore exo-acting lytic transglycosylase \| Pathway: \| COG: Function unknown CD630_05530 - Type: Gene Product:Putative RNA methyltransferase \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_14630 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_30070 - Type: Gene Product:Putative L,D-transpeptidases \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_23052 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_15790 - Type: Gene Product:Two-component sensor histidine kinase,sporulation-associated spo0A \| Pathway: \| COG: Signal transduction mechanisms CD630_22520 - Type: Gene Product:Glutamate 2,3-aminomutase \| Pathway: \| COG: Amino acid transport and metabolism CD630_34890 - Type: Gene Product:Putative oligoendopeptidase F, peptidase M3Bfamily \| Pathway: \| COG: Amino acid transport and metabolism	0.00000029	`NA`	0.51	Inferelator: 5 Hypergeometric: 1 TF Influences from Inferelator CD630_06290 - Type: Gene Product:Transcriptional regulator, Crp family \| Pathway: \| COG: Transcription CD630_25990 - Type: Gene Product:Putative transcriptional regulator \| Pathway: \| COG: Transcription CD630_26420 - sigG Type: Gene Product:RNA polymerase sigma-G factor \| Pathway: \| COG: Transcription CD630_26430 - sigE Type: Gene Product:RNA polymerase sigma-E factor \| Pathway: \| COG: Transcription CD630_34990 - spoVT Type: Gene Product:Stage V sporulation protein T \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test CD630_12140 - spo0A Type: Gene Product:Stage 0 sporulation protein A \| Pathway: \| COG: Signal transduction mechanisms
Module_377	23 CD630_20690 - Type: Gene Product:Putative molybdopterin cofactor biosynthesisprotein \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism CD630_10500 - Type: Gene Product:ABC-type transport system, multidrug-familyATP-binding protein \| Pathway: \| COG: Defense mechanisms CD630_10520 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_14510 - folB Type: Gene Product:Dihydroneopterin aldolase \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism CD630_14430 - Type: Gene Product:Putative Ca++-chelating serine protease, SCP-likeextracellular domain protein \| Pathway: \| COG: Secondary metabolites biosynthesis, transport and catabolism CD630_20710 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_02940 - Type: Gene Product:ABC-type transport system,bacitracin/multidrug-family permease \| Pathway: \| COG: Function unknown CD630_14470 - pabC Type: Gene Product:Aminodeoxychorismate lyase(4-amino-4-deoxychorismate lyase) (ADC lyase) (ADCL) \| Pathway: \| COG: Amino acid transport and metabolism CD630_14530 - aroF Type: Gene Product:Phospho-2-dehydro-3-deoxyheptonate aldolase \| Pathway: \| COG: Amino acid transport and metabolism CD630_14450 - pabA Type: Gene Product:Para-aminobenzoate/anthranilate synthaseglutamine amidotransferase component II [Includes:Para-aminobenzoate synthase glutamine amidotransferasecomponent II; Anthranilate synthase component II] \| Pathway: \| COG: Amino acid transport and metabolism CD630_10480 - Type: Gene Product:Putative phosphodiesterase \| Pathway: \| COG: Function unknown CD630_14490 - folE Type: Gene Product:GTP cyclohydrolase 1 (GTP cyclohydrolase I)(GTP-CH-I) \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism CD630_10530 - Type: Gene Product:Putative aminoacyl-tRNA synthetase-associateddomain \| Pathway: \| COG: Function unknown CD630_10510 - Type: Gene Product:ABC-type transport system, multidrug-familypermease \| Pathway: \| COG: CD630_14500 - folP Type: Gene Product:Dihydropteroate synthase \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism CD630_20700 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_14520 - folK Type: Gene Product:2-amino-4-hydroxy-6-hydroxymethyldihydropteridinepyrophosphokinase \| Pathway: \| COG: Coenzyme transport and metabolism CD630_14440 - Type: Gene Product:Putative exported polysaccharide deacetylase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_14460 - pabB Type: Gene Product:Para-aminobenzoate synthase component I \| Pathway: \| COG: Amino acid transport and metabolism, Coenzyme transport and metabolism CD630_02930 - Type: Gene Product:ABC-type transport system,bacitracin/multidrug-family ATP-binding protein \| Pathway: \| COG: Defense mechanisms CD630_10490 - ppnK Type: Gene Product:Inorganic polyphosphate/ATP-NAD kinase(Poly(P)/ATP NAD kinase) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_14480 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_34770 - Type: Gene Product:Putative dCMP deaminase \| Pathway: \| COG: Nucleotide transport and metabolism	0.00042	0.04	0.51	Inferelator: 3 Hypergeometric: 0 TF Influences from Inferelator CD630_16920 - Type: Gene Product:Transcriptional regulator, ArsR family \| Pathway: \| COG: Transcription CD630_16930 - Type: Gene Product:Putative dinitrogenase iron-molybdenum cofactor \| Pathway: \| COG: Function unknown CD630_17820 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_39	22 CD630_36360 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: CD630_36361 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_04790 - spaE Type: Gene Product:ABC-type transport system,lantibiotic/multidrug-family permease \| Pathway: \| COG: Function unknown CD630_22990 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_11261 - Type: Gene Product:Transcriptional regulator, HTH-type \| Pathway: \| COG: Transcription CD630_27130 - ldtcd2 Type: Gene Product:L,D-transpeptidases \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_04850 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_27150 - gtaB Type: Gene Product:UTP--glucose-1-phosphate uridylyltransferase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_04620 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_04810 - spaR Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_04640 - Type: Gene Product:Putative beta-lactamase-like hydrolase \| Pathway: \| COG: Function unknown CD630_36350 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_36370 - Type: Gene Product:Putative NADPH-dependent FMN reductase \| Pathway: \| COG: Function unknown CD630_11270 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_04780 - spaF Type: Gene Product:ABC-type transport system,lantibiotic/multidrug-family ATP-binding protein \| Pathway: \| COG: Defense mechanisms CD630_36380 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_27140 - galE Type: Gene Product:UDP-glucose 4-epimerase \| Pathway: Carbohydrate metabolism \| COG: Cell wall/membrane/envelope biogenesis CD630_04630 - Type: Gene Product:Transcriptional regulator, TetR family \| Pathway: \| COG: Transcription CD630_04800 - spaG Type: Gene Product:ABC-type transport system,lantibiotic/multidrug-family permease \| Pathway: \| COG: Function unknown CD630_04860 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_04820 - spaK Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_04610 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms	0.5	`NA`	0.51	Inferelator: 2 Hypergeometric: 2 TF Influences from Inferelator CD630_01710 - rex Type: Gene Product:Transcriptional regulator, Redox-sensingrepressor Rex \| Pathway: \| COG: Transcription CD630_02760 - Type: Gene Product:Transcriptional regulator, AraC family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test CD630_07720 - sigF Type: Gene Product:RNA polymerase sigma-F factor \| Pathway: \| COG: Transcription CD630_26430 - sigE Type: Gene Product:RNA polymerase sigma-E factor \| Pathway: \| COG: Transcription