Environment and Gene Regulatory Influence Network (EGRIN) model for C. difficile 630

The Environment and Gene Regulatory Influence Network (EGRIN) model of C. difficile 630 was inferred using cMonkey2 and a compendium of 136 transcriptomes (retrieved from the Gene Expression Omnibus repository) with 4,070 sequence features including 35 rRNAs and 90 tRNAs . The C. difficile EGRIN model groups genes in subsets (406 modules in total), that are co-regulated in specific environments, and also identifies the associated, putative cis-acting gene regulatory elements (GREs), which represent potential TF binding locations. Transcriptome compendium included conditions: response to iron limitation, response to oxygen, in vivo vs in vitro growth, short term infection (0, 30, 60, 120 mins), response to commensals and host diet, transition from exponential to stationary phase, fur KO, codY KO, sporulation TF (and sigma factors) KOs.

Explore Regulatory Modules

Displaying 161 - 170 of 406

Candidate transcriptional regulators for each module were determined with a linear regression based approach (Inferelator) and by evaluating the statistical significance of the overlap (Hypergeometric) between modules and putative TF and alternative sigma factor regulons (CcpA, CodY, Fur, PrdR, SigB, SigD, SigE, SigF, SigG, SigH, SigK, Spo0A) compiled from available literature.

* Given that translation start was used to define the 3' end of putative promoters, some cis-regulatory motifs are likely to be ribosome binding sites (i.e., Shine-Dalgarno sequence). RBS is typically a six nucleotide sequence 5'-GGAGGA-3'.

Title	Gene Count	Motif 1 e-value	Motif 2 e-value	Residual	TF Influences
Module_391	24 CD630_36051 - Type: Gene Product:Ferredoxin \| Pathway: \| COG: Energy production and conversion CD630_13840 - Type: Gene Product:Putative lamB-like protein, UPF0271 family \| Pathway: \| COG: Amino acid transport and metabolism CD630_13860 - Type: Gene Product:Putative allophanate hydrolase subunit 1 \| Pathway: \| COG: Amino acid transport and metabolism CD630_36080 - Type: Gene Product:ABC-type transport system, ATP-binding protein \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_10010 - Type: Gene Product:ABC-type transport system,nitrate/sulfonate/taurine ATP-binding protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_09980 - Type: Gene Product:Putative iron-sulfur protein \| Pathway: \| COG: Energy production and conversion CD630_01340 - Type: Gene Product:Transcription antiterminator, PTS operonregulator \| Pathway: \| COG: Transcription CD630_19810 - Type: Gene Product:Transcriptional regulator, hxlR family \| Pathway: \| COG: Transcription CD630_06390 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_16750 - Type: Gene Product:Transcriptional regulator, hxlR family \| Pathway: \| COG: Transcription CD630_02780 - Type: Gene Product:Transcriptional regulator, hxlR family \| Pathway: \| COG: Transcription CD630_25060 - LinCd Type: Gene Product:Transporter, Major Facilitator Superfamily (MFS) \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_21070 - Type: Gene Product:Xanthine/uracil/thiamine/ascorbate permeasefamily protein \| Pathway: \| COG: Function unknown CD630_36060 - Type: Gene Product:Putative hydrolase \| Pathway: \| COG: Function unknown CD630_13870 - Type: Gene Product:Putative allophanate hydrolase subunit 2 \| Pathway: \| COG: Amino acid transport and metabolism CD630_13850 - Type: Gene Product:Putative natural resistance-associated macrophageprotein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_10000 - Type: Gene Product:ABC-type transport system,nitrate/sulfonate/taurine permease \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_09990 - Type: Gene Product:ABC-type transport system,nitrate/sulfonate/taurine extracellular solute-bindingprotein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_24920 - Type: Gene Product:Two-component sensor histidine kinase,sporulation-associated spo0A \| Pathway: \| COG: Signal transduction mechanisms CD630_02790 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_16740 - Type: Gene Product:Putative NADPH-dependent FMN reductase \| Pathway: \| COG: Function unknown CD630_33560 - Type: Gene Product:Transcriptional regulator, hxlR family \| Pathway: \| COG: Transcription CD630_36070 - Type: Gene Product:Putative iron-sulfur assembly protein \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_25050 - Type: Gene Product:Transcriptional regulator, TetR family \| Pathway: \| COG: Transcription	0.00000061	0.0000024	0.48	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_01710 - rex Type: Gene Product:Transcriptional regulator, Redox-sensingrepressor Rex \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_136	25 CD630_13660 - Type: Gene Product:Putative phage tail protein \| Pathway: \| COG: Function unknown CD630_12440 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_13620 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_13640 - Type: Gene Product:Putative phage XkdM-like protein \| Pathway: \| COG: Function unknown CD630_13700 - Type: Gene Product:Putative phage XkdS-like protein \| Pathway: \| COG: Function unknown CD630_12420 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_13720 - Type: Gene Product:Putative phage XkdT-like protein \| Pathway: \| COG: Function unknown CD630_13680 - Type: Gene Product:Putative phage cell wall XkdQ-like hydrolase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_14150 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_13760 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_13740 - Type: Gene Product:Putative beta-lactamase-inhibitor protein II \| Pathway: \| COG: Cell cycle control, cell division, chromosome partitioning, Cytoskeleton CD630_25710 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_30410 - pepI Type: Gene Product:Proline iminopeptidase (Proline aminopeptidase)(PIP), peptidase S33 family \| Pathway: \| COG: Amino acid transport and metabolism CD630_14170 - Type: Gene Product:Putative ATP-binding protein \| Pathway: \| COG: Amino acid transport and metabolism CD630_13670 - Type: Gene Product:Putative phage XkdP-like protein \| Pathway: \| COG: Function unknown CD630_13651 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_13650 - Type: Gene Product:Putative phage XkdN-like protein \| Pathway: \| COG: Function unknown CD630_13630 - Type: Gene Product:Putative phage XkdK-like protein \| Pathway: \| COG: Function unknown CD630_12430 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_13710 - Type: Gene Product:Putative baseplate assembly predicted J-like \| Pathway: \| COG: Function unknown CD630_13730 - Type: Gene Product:Putative phage tail fiber protein \| Pathway: \| COG: Function unknown CD630_13690 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_25700 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_14140 - Type: Gene Product:Putative oxidoreductase, Fe-S subunit \| Pathway: \| COG: Function unknown CD630_14160 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown	0.000016	`NA`	0.48	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_30540 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_57	26 CD630_17640 - Type: Gene Product:Putative phenylalanyl-tRNA synthetase beta chain \| Pathway: \| COG: Function unknown CD630_28050 - ruvB Type: Gene Product:Holliday junction ATP-dependent DNA helicaseRuvB \| Pathway: \| COG: Replication, recombination and repair CD630_28070 - ruvC Type: Gene Product:Crossover junction endodeoxyribonuclease RuvC(Holliday junction nuclease RuvC) (Holliday junctionresolvase RuvC) \| Pathway: \| COG: Replication, recombination and repair CD630_13310 - sip3 Type: Gene Product:Signal peptidase I, S26A family \| Pathway: \| COG: Intracellular trafficking, secretion, and vesicular transport CD630_27870 - cwp84 Type: Gene Product:Cell surface protein \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_13330 - Type: Gene Product:Putative phage tyrosine recombinase \| Pathway: \| COG: Replication, recombination and repair CD630_13270 - pgsA Type: Gene Product:CDP-diacylglycerol--glycerol-3-phosphate3-phosphatidyltransferase \| Pathway: \| COG: Lipid transport and metabolism CD630_25960 - Type: Gene Product:Putative pseudouridylate synthase, RluC/RluDfamily \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_35810 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_17630 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_22620 - Type: Gene Product:Transporter, Major Facilitator Superfamily (MFS) \| Pathway: \| COG: Amino acid transport and metabolism CD630_06170 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_28060 - ruvA Type: Gene Product:Holliday junction ATP-dependent DNA helicaseRuvA \| Pathway: \| COG: Replication, recombination and repair CD630_35830 - Type: Gene Product:Transcriptional regulator, MerR family \| Pathway: \| COG: Transcription CD630_17650 - Type: Gene Product:Putative hydrolase, NUDIX family \| Pathway: \| COG: Replication, recombination and repair CD630_27880 - Type: Gene Product:Putative membrane protein, GtrA family \| Pathway: \| COG: Function unknown CD630_31640 - rnr Type: Gene Product:Ribonuclease R \| Pathway: \| COG: Transcription CD630_13340 - purB Type: Gene Product:Adenylosuccinate lyase \| Pathway: Purine metabolism \| COG: Nucleotide transport and metabolism CD630_19510 - Type: Gene Product:putative Acyl-CoA N-acyltransferase \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_13260 - rimO Type: Gene Product:Ribosomal protein S12 methylthiotransferase \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_29830 - Type: Gene Product:Putative Helix-Turn-Helix DNA-binding protein \| Pathway: \| COG: Transcription CD630_13240 - ftsK Type: Gene Product:DNA FtsK/SpoIIIE translocase \| Pathway: \| COG: Cell cycle control, cell division, chromosome partitioning CD630_13320 - uppP1 Type: Gene Product:Undecaprenyl-diphosphatase 1 (Undecaprenylpyrophosphate phosphatase 1) (Bacitracin resistance protein1) \| Pathway: \| COG: Defense mechanisms CD630_25970 - lspA Type: Gene Product:Lipoprotein signal peptidase (Prolipoproteinsignal peptidase) (Signal peptidase II) (SPase II) \| Pathway: Protein modification \| COG: Cell wall/membrane/envelope biogenesis, Intracellular trafficking, secretion, and vesicular transport CD630_35820 - Type: Gene Product:Putative pseudouridine synthase RsuA-like \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_21250 - Type: Gene Product:Putative acetyltransferase \| Pathway: \| COG: Function unknown	9e-17	0	0.48	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_08870 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_20480 - Type: Gene Product:Transcriptional regulator, RpiR family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_265	5 CD630_22600 - Type: Gene Product:Transporter, Major Facilitator Superfamily (MFS) \| Pathway: \| COG: Amino acid transport and metabolism CD630_24220 - Type: Gene Product:Sodium:alanine symporter \| Pathway: \| COG: Amino acid transport and metabolism CD630_12600 - brnQ-2 Type: Gene Product:Branched chain amino acid transport systemcarrier protein \| Pathway: \| COG: Amino acid transport and metabolism CD630_24210 - Type: Gene Product:Putative amidohydrolase, M20D family \| Pathway: \| COG: Amino acid transport and metabolism CD630_31690 - Type: Gene Product:Putative malate transporter \| Pathway: \| COG: Function unknown	3.1	`NA`	0.49	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_10230 - Type: Gene Product:Putative transcriptional regulator, HTH \| Pathway: \| COG: Transcription CD630_15580 - sigV Type: Gene Product:Extra-Cytoplasmic Function sigma factors, ECFfamily \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_26	6 CD630_07570 - Type: Gene Product:Phosphodiesterases protein \| Pathway: \| COG: Signal transduction mechanisms CD630_18311 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_20160 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_18430 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_10150 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms	`NA`	`NA`	0.49	Inferelator: 0 Hypergeometric: 0 TF Influences from Inferelator `No TF influences from Inferelator` TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_201	23 CD630_24870 - Type: Gene Product:PTS system, fructose-like IIB component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_30600 - Type: Gene Product:Phospho-alpha-glucosidase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_25110 - Type: Gene Product:Transcription antiterminator, PTS operonregulator \| Pathway: \| COG: Transcription CD630_24650 - Type: Gene Product:Putative amino acid/polyamine transporter \| Pathway: \| COG: Amino acid transport and metabolism CD630_24850 - Type: Gene Product:Putative Xaa-Pro aminopeptidase, M24 family \| Pathway: \| COG: Amino acid transport and metabolism CD630_03900 - bglG Type: Gene Product:Transcription antiterminator, PTS operonregulator \| Pathway: \| COG: Transcription CD630_25090 - Type: Gene Product:Putative glycoside hydrolase, family 4 \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_05070 - Type: Gene Product:Putative conjugative transposon protein Tn5397,CTn3-Orf13 \| Pathway: \| COG: Function unknown CD630_24890 - Type: Gene Product:Transcription antiterminator, PTS operonregulator \| Pathway: \| COG: Transcription CD630_30580 - Type: Gene Product:PTS system, alpha-glucoside-specific IIAcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_03880 - bglF Type: Gene Product:PTS system, beta-glucoside-specific IIABCcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_25100 - Type: Gene Product:PTS system, glucose-like IIBC component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_25120 - Type: Gene Product:PTS system, glucose-like IIA component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_24860 - Type: Gene Product:PTS system, fructose-like IIC component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_23280 - Type: Gene Product:Sigma-54 dpendent regulator, PTS fructose family \| Pathway: \| COG: Signal transduction mechanisms CD630_24840 - Type: Gene Product:Putative pyridoxal phosphate-dependenttransferase \| Pathway: \| COG: Amino acid transport and metabolism CD630_25080 - Type: Gene Product:Transcriptional regulator, AraC family \| Pathway: \| COG: Transcription CD630_05060 - Type: Gene Product:Reverse transcriptase/maturase/endonuclease,Group II intron \| Pathway: \| COG: Replication, recombination and repair CD630_24880 - Type: Gene Product:PTS system, fructose-like IIA component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_30590 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: CD630_03890 - bglA Type: Gene Product:6-phospho-beta-glucosidase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_25070 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_30570 - Type: Gene Product:Transporter, Major Facilitator Superfamily (MFS) \| Pathway: \| COG: Carbohydrate transport and metabolism	0	`NA`	0.49	Inferelator: 1 Hypergeometric: 1 TF Influences from Inferelator CD630_25080 - Type: Gene Product:Transcriptional regulator, AraC family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test CD630_12750 - codY Type: Gene Product:Transcriptional regulator, GTP-sensingpleiotropic repressor \| Pathway: \| COG: Transcription
Module_218	19 CD630_04351 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn2-Orf32 \| Pathway: \| COG: CD630_04360 - Type: Gene Product:Putative recombinase Tn1549-like, CTn2-Orf34 \| Pathway: \| COG: Replication, recombination and repair CD630_21140 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_33722 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn7-Orf6 \| Pathway: \| COG: Function unknown CD630_21130 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms	`NA`	`NA`	0.49	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_21140 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_29	15 CD630_10960 - Type: Gene Product:ABC-type transport system, multidrug-familypermease Tn1549-like, CTn4-Orf29 \| Pathway: \| COG: Function unknown CD630_33640 - Type: Gene Product:ABC-type transport system, multidrug-familyATP-binding protein \| Pathway: \| COG: Function unknown CD630_10970 - Type: Gene Product:ABC-type transport system, multidrug-familyATP-binding protein Tn1549-like, CTn4-Orf28 \| Pathway: \| COG: Defense mechanisms CD630_33620 - Type: Gene Product:ABC-type transport system, multidrug-familypermease \| Pathway: \| COG: Function unknown CD630_10950 - Type: Gene Product:ABC-type transport system, multidrug-familypermease Tn1549-like, CTn4-Orf30 \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_33680 - Type: Gene Product:Putative ribosome biogenesis GTPase RsgA;putative EngC-like GTPase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_33630 - Type: Gene Product:ABC-type transport system, multidrug-familypermease \| Pathway: \| COG: Function unknown CD630_10991 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn4-Orf25 \| Pathway: \| COG: Function unknown CD630_10990 - Type: Gene Product:Two-component response regulator, Tn1549-like,CTn4-Orf26 \| Pathway: \| COG: Signal transduction mechanisms CD630_33681 - Type: Gene Product:Putative zinc finger protein \| Pathway: \| COG: Function unknown CD630_10980 - Type: Gene Product:Two-component sensor histidine kinase,Tn1549-like, CTn4-Orf27 \| Pathway: \| COG: Signal transduction mechanisms CD630_03810 - Type: Gene Product:Putative replication initiation factorTn916-like, CTn1-Orf26 \| Pathway: \| COG: Transcription CD630_03790 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn1-Orf24 \| Pathway: \| COG: Function unknown CD630_11000 - Type: Gene Product:Transcriptional regulator, HTH-type Tn1549-like,CTn4-Orf24 \| Pathway: \| COG: Transcription CD630_03800 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn1-Orf25 \| Pathway: \| COG: Function unknown	0.000037	0.000066	0.49	Inferelator: 3 Hypergeometric: 0 TF Influences from Inferelator CD630_02760 - Type: Gene Product:Transcriptional regulator, AraC family \| Pathway: \| COG: Transcription CD630_05310 - Type: Gene Product:Transcriptional regulator, DeoR family \| Pathway: \| COG: Transcription CD630_32800 - Type: Gene Product:Sigma-54 dpendent regulator, PTS fructose family \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_269	20 CD630_14090 - Type: Gene Product:Putative competence-damage inducible protein,CinA family \| Pathway: \| COG: Coenzyme transport and metabolism CD630_08760 - Type: Gene Product:ABC-type transport system, sugar-familyextracellular solute-binding protein \| Pathway: \| COG: Function unknown CD630_14080 - ddl Type: Gene Product:D-alanine--D-alanine ligase (D-alanylalaninesynthetase) (D-Ala-D-Ala ligase) \| Pathway: Cell wall biogenesis \| COG: Cell wall/membrane/envelope biogenesis CD630_14100 - Type: Gene Product:Putative hydrolase, HAD superfamily, subfamilyIIB \| Pathway: \| COG: Function unknown CD630_02170 - Type: Gene Product:Putative nitroreductase \| Pathway: \| COG: Energy production and conversion CD630_08750 - Type: Gene Product:ABC-type transport system, sugar-family permease \| Pathway: \| COG: Function unknown CD630_08730 - Type: Gene Product:ABC-type transport system sugar-familyextracellular solute-binding lipoprotein \| Pathway: \| COG: Function unknown CD630_10140 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_14070 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_08770 - Type: Gene Product:ABC-type transport system, sugar-familyATP-binding protein \| Pathway: \| COG: Function unknown CD630_19550 - Type: Gene Product:ABC-type transport system, ATP-binding protein \| Pathway: \| COG: Defense mechanisms CD630_14060 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_14050 - Type: Gene Product:ABC-type transport system, ATP-binding protein \| Pathway: \| COG: Function unknown CD630_08740 - Type: Gene Product:ABC-type transport system, sugar-familyATP-binding protein \| Pathway: \| COG: Function unknown CD630_10130 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_19570 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_08780 - Type: Gene Product:ABC-type transport system, sugar-specificpermease \| Pathway: \| COG: Function unknown CD630_19560 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_17590 - Type: Gene Product:Putative SAM-dependent methyltransferase \| Pathway: \| COG: Function unknown CD630_19540 - Type: Gene Product:ABC-type transport system, permease \| Pathway: \| COG: Defense mechanisms	0.0000057	0	0.49	Inferelator: 3 Hypergeometric: 1 TF Influences from Inferelator CD630_11770 - fapR Type: Gene Product:Transcriptional regulator, DeoR family (Fattyacid and phospholipid biosynthesis regulator) \| Pathway: \| COG: Transcription CD630_19100 - eutV Type: Gene Product:Two-component response regulator, Ethanolaminespecific \| Pathway: \| COG: Signal transduction mechanisms CD630_26650 - Type: Gene Product:Transcriptional regulator, AraC family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test CD630_12750 - codY Type: Gene Product:Transcriptional regulator, GTP-sensingpleiotropic repressor \| Pathway: \| COG: Transcription
Module_397	27 CD630_10660 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_03040 - Type: Gene Product:Conserved hypothetical protein, DUF1355 family \| Pathway: \| COG: Function unknown CD630_35190 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_07610 - Type: Gene Product:Putative ATP-dependent RNA helicase \| Pathway: \| COG: Replication, recombination and repair CD630_31840 - dpaL Type: Gene Product:Diaminopropionate ammonia-lyase \| Pathway: \| COG: Amino acid transport and metabolism CD630_34620 - Type: Gene Product:Putative antitoxin EndoAI \| Pathway: \| COG: Transcription CD630_01200 - glmS Type: Gene Product:Glucosamine--fructose-6-phosphateaminotransferase [isomerizing] \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_34640 - GerS Type: Gene Product:Lipoprotein regulator, germination \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_34660 - acpS Type: Gene Product:Holo-[acyl-carrier-protein] synthase \| Pathway: \| COG: Lipid transport and metabolism CD630_03110 - GerG Type: Gene Product:Germination regulator \| Pathway: \| COG: CD630_10650 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_03030 - argE Type: Gene Product:Acetylornithine deacetylase ArgE \| Pathway: \| COG: Amino acid transport and metabolism CD630_06600 - tcdB Type: Gene Product:Toxin B \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_35200 - Type: Gene Product:Putative cation efflux protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_31790 - pyrD Type: Gene Product:Dihydroorotate dehydrogenase, catalytic subunit \| Pathway: \| COG: Nucleotide transport and metabolism CD630_07600 - Type: Gene Product:Putative Ca2+/Na+ antiporter \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_34630 - alr2 Type: Gene Product:Alanine racemase 2 \| Pathway: Amino-acid biosynthesis \| COG: Cell wall/membrane/envelope biogenesis CD630_25621 - rpmB Type: Gene Product:50S ribosomal protein L28 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_31830 - Type: Gene Product:Putative peptidase, M20 family \| Pathway: \| COG: Amino acid transport and metabolism CD630_34610 - EndoA Type: Gene Product:Endoribonuclease toxin \| Pathway: \| COG: Signal transduction mechanisms CD630_31810 - Type: Gene Product:Putative amidohydrolase \| Pathway: \| COG: Nucleotide transport and metabolism CD630_03320 - bclA1 Type: Gene Product:Exosporium glycoprotein \| Pathway: \| COG: Intracellular trafficking, secretion, and vesicular transport, Extracellular structures CD630_34650 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown	0.00046	0.02	0.49	Inferelator: 2 Hypergeometric: 2 TF Influences from Inferelator CD630_06290 - Type: Gene Product:Transcriptional regulator, Crp family \| Pathway: \| COG: Transcription CD630_34990 - spoVT Type: Gene Product:Stage V sporulation protein T \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test CD630_12140 - spo0A Type: Gene Product:Stage 0 sporulation protein A \| Pathway: \| COG: Signal transduction mechanisms CD630_26430 - sigE Type: Gene Product:RNA polymerase sigma-E factor \| Pathway: \| COG: Transcription