Environment and Gene Regulatory Influence Network (EGRIN) model for C. difficile 630

The Environment and Gene Regulatory Influence Network (EGRIN) model of C. difficile 630 was inferred using cMonkey2 and a compendium of 136 transcriptomes (retrieved from the Gene Expression Omnibus repository) with 4,070 sequence features including 35 rRNAs and 90 tRNAs . The C. difficile EGRIN model groups genes in subsets (406 modules in total), that are co-regulated in specific environments, and also identifies the associated, putative cis-acting gene regulatory elements (GREs), which represent potential TF binding locations. Transcriptome compendium included conditions: response to iron limitation, response to oxygen, in vivo vs in vitro growth, short term infection (0, 30, 60, 120 mins), response to commensals and host diet, transition from exponential to stationary phase, fur KO, codY KO, sporulation TF (and sigma factors) KOs.

Explore Regulatory Modules

Displaying 211 - 220 of 406

Candidate transcriptional regulators for each module were determined with a linear regression based approach (Inferelator) and by evaluating the statistical significance of the overlap (Hypergeometric) between modules and putative TF and alternative sigma factor regulons (CcpA, CodY, Fur, PrdR, SigB, SigD, SigE, SigF, SigG, SigH, SigK, Spo0A) compiled from available literature.

* Given that translation start was used to define the 3' end of putative promoters, some cis-regulatory motifs are likely to be ribosome binding sites (i.e., Shine-Dalgarno sequence). RBS is typically a six nucleotide sequence 5'-GGAGGA-3'.

Title	Gene Count	Motif 1 e-value	Motif 2 e-value	Residual	TF Influences
Module_330	18 CD630_15660 - ilvB Type: Gene Product:Acetolactate synthase large subunit \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_14760 - Type: Gene Product:Putative signaling protein \| Pathway: \| COG: Signal transduction mechanisms CD630_28490 - phnXW Type: Gene Product:Bifunctional phosphonoacetaldehydehydrolase/aminoethylphosphonate transaminase [Includes:Phosphonoacetaldehyde hydrolase ;2-aminoethylphosphonate--pyruvate transaminase] \| Pathway: \| COG: Amino acid transport and metabolism CD630_28800 - celC Type: Gene Product:PTS system, cellobiose-specific IIA component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_15650 - ilvC Type: Gene Product:Ketol-acid reductoisomerase \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_28810 - celG Type: Gene Product:Putative cellobiose-phosphate degrading protein \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_28840 - celA Type: Gene Product:PTS system, cellobiose-specific IIB component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_05660 - Type: Gene Product:Putative tRNA/rRNA methyltransferase \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_19350 - spoVS Type: Gene Product:Stage V sporulation protein S \| Pathway: \| COG: Function unknown CD630_05670 - Type: Gene Product:Conserved hypothetical protein, DegV family \| Pathway: \| COG: Function unknown CD630_24800 - Type: Gene Product:Putative hydrolase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_08110 - Type: Gene Product:Putative cyclic di-GMP regulatory protein \| Pathway: \| COG: Signal transduction mechanisms CD630_12650 - Type: Gene Product:Transcriptional regulator, CarD family \| Pathway: \| COG: Transcription CD630_18930 - Type: Gene Product:Putative oligonucleotide binding regulator \| Pathway: \| COG: Function unknown CD630_28830 - celB Type: Gene Product:PTS system, cellobiose-specific IIC component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_08070 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_28820 - celF Type: Gene Product:Cellobiose-6-phosphate hydrolase, family 4 \| Pathway: \| COG: Carbohydrate transport and metabolism	0	`NA`	0.51	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_17820 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_363	22 CD630_24630 - hrcA Type: Gene Product:Transcriptional regulator, Heat-induciblerepressor HrcA \| Pathway: \| COG: Transcription CD630_20120 - hydD Type: Gene Product:Putative hydrolase \| Pathway: \| COG: Function unknown CD630_20730 - xdhA Type: Gene Product:Xanthine dehydrogenase, molybdenum bindingsubunit \| Pathway: \| COG: Energy production and conversion CD630_08220 - Type: Gene Product:ABC-type transport system, multidrug-familyATP-binding protein \| Pathway: \| COG: Defense mechanisms CD630_15020 - deoC Type: Gene Product:Deoxyribose-phosphate aldolase(Phosphodeoxyriboaldolase) (Deoxyriboaldolase) (DERA) \| Pathway: Carbohydrate degradation \| COG: Nucleotide transport and metabolism CD630_08240 - Type: Gene Product:ABC-type transport system, multidrug-familypermease \| Pathway: \| COG: Function unknown CD630_16370 - Type: Gene Product:Putative calcium-transporting ATPase \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_16350 - terD Type: Gene Product:Tellurium resistance protein \| Pathway: \| COG: Signal transduction mechanisms CD630_01320 - Type: Gene Product:Putative DNA helicase, RecD/TraA type \| Pathway: \| COG: Replication, recombination and repair CD630_25490 - Type: Gene Product:ABC-type transport system, sugar-family permease \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_16410 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_16430 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_25470 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_20130 - hydR Type: Gene Product:Transcriptional regulator, TetR family \| Pathway: \| COG: Transcription CD630_08230 - Type: Gene Product:ABC-type transport system, multidrug-familypermease \| Pathway: \| COG: Function unknown CD630_20740 - Type: Gene Product:Putative FAD-binding subunit of xanthinedehydrogenase \| Pathway: \| COG: Energy production and conversion CD630_16400 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_01330 - Type: Gene Product:Putative phosphoribosyl transferase \| Pathway: \| COG: Function unknown CD630_16380 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_25480 - Type: Gene Product:ABC-type transport system, sugar-family permease \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_16420 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_25500 - Type: Gene Product:ABC-type transport system, sugar-familyextracellular solute-binding protein \| Pathway: \| COG: Carbohydrate transport and metabolism	0.00025	2.4	0.51	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_11770 - fapR Type: Gene Product:Transcriptional regulator, DeoR family (Fattyacid and phospholipid biosynthesis regulator) \| Pathway: \| COG: Transcription CD630_19100 - eutV Type: Gene Product:Two-component response regulator, Ethanolaminespecific \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_395	18 CD630_05760 - virS Type: Gene Product:Sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_07760 - Type: Gene Product:Transcriptional regulator, LacI family \| Pathway: \| COG: Transcription CD630_06010 - ogt1 Type: Gene Product:Methylated-DNA-[protein]-cysteineS-methyltransferase 1 \| Pathway: \| COG: Replication, recombination and repair CD630_27650 - LcpA Type: Gene Product:Surface-anchoring factors, LytR-CpsA-Psr-likeprotein \| Pathway: \| COG: Transcription CD630_13420 - Type: Gene Product:Putative ribonuclease \| Pathway: \| COG: Replication, recombination and repair CD630_20760 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_33670 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_06640 - tcdC Type: Gene Product:Negative regulator of toxin gene expression \| Pathway: \| COG: Function unknown CD630_09790 - Type: Gene Product:Transcriptional regulator, beta-lactams repressorPhage-type \| Pathway: \| COG: Transcription CD630_20650 - Type: Gene Product:Transcriptional regulator, beta-lactamsrepressor \| Pathway: \| COG: Transcription CD630_01810 - Type: Gene Product:Putative membrane-associated metalloprotease, M56family \| Pathway: \| COG: Transcription, Signal transduction mechanisms CD630_08290 - Type: Gene Product:Putative metallo-beta-lactamase superfamilyprotein \| Pathway: \| COG: Function unknown CD630_34080 - Type: Gene Product:Putative DNA mismatch repair ATPase MutS \| Pathway: \| COG: Replication, recombination and repair CD630_12490 - Type: Gene Product:Putative radical SAM-superfamily protein \| Pathway: \| COG: Chromatin structure and dynamics, Transcription CD630_26030 - cdtR Type: Gene Product:Clostridium difficile binary toxin regulatorygene, LytTR family \| Pathway: \| COG: Signal transduction mechanisms CD630_01830 - Type: Gene Product:Putative cell wall hydrolase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_00300 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_01780 - Type: Gene Product:Putative ATPase \| Pathway: \| COG: Function unknown	0.00051	`NA`	0.51	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_18100 - Type: Gene Product:Transcriptional regulator, beta-lactamsrepressor \| Pathway: \| COG: Transcription CD630_35440 - Type: Gene Product:Transcriptional regulator, AsnC/Lrp family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_175	12 CD630_19904 - Type: Gene Product:Fragment of conserved hypothetical protein \| Pathway: \| COG: CD630_21710 - Type: Gene Product:Fragment of putative sodium:dicarboxylatesymporter (Part 2) \| Pathway: \| COG: Energy production and conversion, Energy production and conversion CD630_05102 - Type: Gene Product:Fragment of putative conjugative transposonprotein Tn5397, CTn3-Orf5 (C-terminal region) \| Pathway: \| COG: CD630_23011 - Type: Gene Product:Fragment of putative phage protein (C-terminalregion) \| Pathway: \| COG: CD630_09030 - Type: Gene Product:Fragment of putative oxydoreductase (Part 1) \| Pathway: \| COG: Energy production and conversion, Energy production and conversion CD630_33580 - Type: Gene Product:Fragment of C-terminal transcriptional regulator,AsnC/Lrp family \| Pathway: \| COG: Transcription CD630_14370 - Type: Gene Product:Fragment of transcriptional regulator,sigma-54-dependent (N-terminal region) \| Pathway: \| COG: Transcription CD630_33810 - Type: Gene Product:Fragment of putative membrane protein Tn916-like,CTn7-orf17 (Part 2) \| Pathway: \| COG: Function unknown, Function unknown CD630_08080 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_06780 - Type: Gene Product:Fragment of conserved hypothetical protein(C-terminal region) \| Pathway: \| COG: CD630_22840 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_17452 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG:	`NA`	`NA`	0.51	Inferelator: 0 Hypergeometric: 0 TF Influences from Inferelator `No TF influences from Inferelator` TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_108	11 CD630_05240 - Type: Gene Product:Putative peptidase, M20 family \| Pathway: \| COG: Amino acid transport and metabolism CD630_17151 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_08660 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_18990 - Type: Gene Product:Putative dCMP deaminase \| Pathway: \| COG: Nucleotide transport and metabolism CD630_15960 - map2 Type: Gene Product:Methionine aminopeptidase Map2 (MAP) (PeptidaseM) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_08990 - dinB Type: Gene Product:DNA polymerase IV (Pol IV) \| Pathway: \| COG: Replication, recombination and repair CD630_14680 - Type: Gene Product:Putative iron-sulfur protein \| Pathway: \| COG: Energy production and conversion CD630_21241 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_17770 - Type: Gene Product:Putative arsenate reductase \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_06550 - Type: Gene Product:Putative beta-lactamase-like protein \| Pathway: \| COG: Function unknown CD630_23040 - Type: Gene Product:Transcriptional regulator, beta-lactams repressorPhage-type \| Pathway: \| COG: Transcription	`NA`	`NA`	0.51	Inferelator: 3 Hypergeometric: 0 TF Influences from Inferelator CD630_16930 - Type: Gene Product:Putative dinitrogenase iron-molybdenum cofactor \| Pathway: \| COG: Function unknown CD630_19100 - eutV Type: Gene Product:Two-component response regulator, Ethanolaminespecific \| Pathway: \| COG: Signal transduction mechanisms CD630_26650 - Type: Gene Product:Transcriptional regulator, AraC family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_124	25 CD630_10600 - Type: Gene Product:Putative pseudouridylate synthase \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_22480 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_19500 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_09390 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_17260 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_10440 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_14580 - wrbA Type: Gene Product:Putative flavodoxin protein \| Pathway: \| COG: Function unknown CD630_23000 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_17980 - Type: Gene Product:Transcriptional regulator, LysR family \| Pathway: \| COG: Transcription CD630_14550 - sigA1 Type: Gene Product:RNA polymerase sigma factor SigA1 (sigma-43) \| Pathway: \| COG: Transcription CD630_17960 - Type: Gene Product:Putative nitrite and sulfite reductase subunit \| Pathway: \| COG: Energy production and conversion CD630_06370 - Type: Gene Product:Putative acetyltransferase \| Pathway: \| COG: Function unknown CD630_08800 - Type: Gene Product:Putative protease \| Pathway: \| COG: Function unknown CD630_15080 - Type: Gene Product:Putative iron-sulfur binding protein \| Pathway: \| COG: Energy production and conversion CD630_08820 - glgC Type: Gene Product:Glucose-1-phosphate adenylyltransferase \| Pathway: Glycan biosynthesis \| COG: Carbohydrate transport and metabolism CD630_22490 - Type: Gene Product:Putative ATPase \| Pathway: \| COG: Secondary metabolites biosynthesis, transport and catabolism CD630_14570 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_14540 - dnaG Type: Gene Product:DNA primase \| Pathway: \| COG: Replication, recombination and repair CD630_14560 - Type: Gene Product:Putative SAM-dependent methyltransferase \| Pathway: \| COG: Function unknown CD630_09400 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_05103 - Type: Gene Product:Putative conjugative transposon protein Tn5397,CTn3-Orf4 \| Pathway: \| COG: CD630_17970 - Type: Gene Product:Coenzyme A disulfide reductase (CoA-disulfidereductase) (CoADR) \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_08810 - Type: Gene Product:Putative protein modulating protease activity \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_23960 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_29260 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown	0.000067	`NA`	0.51	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_20480 - Type: Gene Product:Transcriptional regulator, RpiR family \| Pathway: \| COG: Transcription CD630_20610 - Type: Gene Product:Conserved hypothetical protein, DUF1121 family \| Pathway: \| COG: Function unknown TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_94	5 CD630_14240 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_18800 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_31580 - Type: Gene Product:Transcriptional regulator, TRAP family \| Pathway: \| COG: Function unknown CD630_06580 - cdu1 Type: Gene Product:Transcriptional regulator, beta-lactamsrepressor \| Pathway: \| COG: Transcription CD630_27880 - Type: Gene Product:Putative membrane protein, GtrA family \| Pathway: \| COG: Function unknown	`NA`	`NA`	0.51	Inferelator: 3 Hypergeometric: 0 TF Influences from Inferelator CD630_06290 - Type: Gene Product:Transcriptional regulator, Crp family \| Pathway: \| COG: Transcription CD630_06580 - cdu1 Type: Gene Product:Transcriptional regulator, beta-lactamsrepressor \| Pathway: \| COG: Transcription CD630_23900 - Type: Gene Product:Transcriptional regulator, beta-lactamsrepressor \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_95	30 CD630_30090 - Type: Gene Product:Putative pyridine nucleotide-disulphideoxidoreductase, class I \| Pathway: \| COG: Energy production and conversion CD630_32410 - prdB Type: Gene Product:Proline reductase (selenocysteine) \| Pathway: \| COG: Function unknown CD630_01700 - Type: Gene Product:ABC-type transport system, ATP-binding protein \| Pathway: \| COG: Function unknown CD630_24050 - Type: Gene Product:Transcriptional regulator, MarR family \| Pathway: \| COG: Transcription CD630_07790 - Type: Gene Product:Putative amidohydrolase, M20D peptidase family \| Pathway: \| COG: Amino acid transport and metabolism CD630_07910 - Type: Gene Product:Conserved hypothetical protein, UPF0029 family \| Pathway: \| COG: Function unknown CD630_32380 - Type: Gene Product:Putative component of proline reductaseprdE-like \| Pathway: \| COG: Function unknown CD630_30100 - Type: Gene Product:Putative cytochrome C assembly protein \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_07770 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_24080 - Type: Gene Product:Putative multidrug efflux pump \| Pathway: \| COG: Function unknown CD630_12810 - mnmA Type: Gene Product:tRNA-specific 2-thiouridylase MnmA \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_07040 - Type: Gene Product:Putative metal-dependent phosphohydrolase \| Pathway: \| COG: Function unknown CD630_24060 - Type: Gene Product:Putative lipoprotein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_01710 - rex Type: Gene Product:Transcriptional regulator, Redox-sensingrepressor Rex \| Pathway: \| COG: Transcription CD630_32400 - prdD Type: Gene Product:Proline reductase PrdD \| Pathway: \| COG: Function unknown CD630_07780 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_14930 - Type: Gene Product:Putative 3-methyladenine DNA glycosylase \| Pathway: \| COG: Replication, recombination and repair CD630_24070 - Type: Gene Product:Putative multidrug efflux pump \| Pathway: \| COG: Defense mechanisms CD630_10620 - acpP Type: Gene Product:Acyl carrier protein (ACP) \| Pathway: Lipid metabolism \| COG: Lipid transport and metabolism CD630_07800 - Type: Gene Product:Conserved hypothetical protein, DUF1177 family \| Pathway: \| COG: Function unknown CD630_01690 - Type: Gene Product:Putative drug/sodium antiporter, MATE family \| Pathway: \| COG: Defense mechanisms CD630_16740 - Type: Gene Product:Putative NADPH-dependent FMN reductase \| Pathway: \| COG: Function unknown CD630_30110 - Type: Gene Product:Transcriptional regulator, HxlR family DUF24 \| Pathway: \| COG: Transcription CD630_07030 - Type: Gene Product:Putative peptidase, U32 family \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_32390 - prdE Type: Gene Product:Proline reductase PrdE \| Pathway: \| COG: Function unknown CD630_07050 - Type: Gene Product:Putative hydrolase, NUDIX family \| Pathway: \| COG: Replication, recombination and repair CD630_32360 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_32370 - prdF Type: Gene Product:Proline racemase \| Pathway: \| COG: Amino acid transport and metabolism CD630_31080 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_24730 - rpsT Type: Gene Product:30S ribosomal protein S20 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis	0.00000046	0.72	0.51	Inferelator: 3 Hypergeometric: 3 TF Influences from Inferelator CD630_06700 - Type: Gene Product:Transcriptional regulator, beta-lactamsrepressor \| Pathway: \| COG: Transcription CD630_18100 - Type: Gene Product:Transcriptional regulator, beta-lactamsrepressor \| Pathway: \| COG: Transcription CD630_24120 - Type: Gene Product:Putative negative regulator of gluconeogenesis \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test CD630_32450 - prdR Type: Gene Product:Transcriptional regulator, sigma-54-dependent \| Pathway: \| COG: Transcription CD630_10640 - ccpA Type: Gene Product:Transcriptional regulator, LacI family \| Pathway: \| COG: Transcription CD630_31760 - glnF Type: Gene Product:RNA polymerase sigma-54 factor \| Pathway: \| COG: Transcription
Module_15	20 CD630_09900 - leuC Type: Gene Product:3-isopropylmalate dehydratase large subunit \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_17160 - Type: Gene Product:Putative permease \| Pathway: \| COG: Nucleotide transport and metabolism CD630_25000 - argH Type: Gene Product:Argininosuccinate lyase (Arginosuccinase) (ASAL) \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_25210 - leuS Type: Gene Product:Leucyl-tRNA synthetase \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_09910 - leuD Type: Gene Product:3-isopropylmalate dehydratase small subunit \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_22450 - asnC Type: Gene Product:Asparaginyl-tRNA synthetase (Asparagine--tRNAligase) (AsnRS) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_32560 - valS Type: Gene Product:valyl-tRNA synthetase \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_17170 - Type: Gene Product:Conserved hypothetical protein, DUF917 family \| Pathway: \| COG: Function unknown CD630_00500 - proS Type: Gene Product:Prolyl-tRNA synthetase \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_26950 - asnA Type: Gene Product:Aspartate--ammonia ligase (Asparagine synthetaseA) \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_05740 - thrS Type: Gene Product:Threonyl-tRNA synthetase \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_26940 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_00140 - serS1 Type: Gene Product:Seryl-tRNA synthetase 1 \| Pathway: Aminoacyl-tRNA biosynthesis \| COG: Translation, ribosomal structure and biogenesis CD630_17180 - Type: Gene Product:Putative hydantoinase (Disrupted IStron) \| Pathway: \| COG: Amino acid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism, Amino acid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism CD630_00490 - proS Type: Gene Product:Prolyl-tRNA synthetase \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_09890 - leuA Type: Gene Product:2-isopropylmalate synthase \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_15800 - hom2 Type: Gene Product:Homoserine dehydrogenase \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_09920 - leuB Type: Gene Product:3-isopropylmalate dehydrogenase \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_15810 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_15210 - tyrS Type: Gene Product:Tyrosyl-tRNA synthetase (Tyrosine--tRNA ligase)(TyrRS) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis	3.89995e-41	2e-16	0.51	Inferelator: 4 Hypergeometric: 0 TF Influences from Inferelator CD630_06700 - Type: Gene Product:Transcriptional regulator, beta-lactamsrepressor \| Pathway: \| COG: Transcription CD630_19100 - eutV Type: Gene Product:Two-component response regulator, Ethanolaminespecific \| Pathway: \| COG: Signal transduction mechanisms CD630_20480 - Type: Gene Product:Transcriptional regulator, RpiR family \| Pathway: \| COG: Transcription CD630_34990 - spoVT Type: Gene Product:Stage V sporulation protein T \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_146	14 CD630_29530 - Type: Gene Product:ABC-type transport system, iron-familyextracellular solute-binding protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_06250 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_01670 - Type: Gene Product:Transcriptional regulator, sigma-54-dependent \| Pathway: \| COG: Transcription CD630_31860 - Type: Gene Product:Transcriptional regulator, sigma-54-dependent \| Pathway: \| COG: Transcription CD630_33650 - Type: Gene Product:Putative diguanylate kinase signaling protein \| Pathway: \| COG: Signal transduction mechanisms CD630_27350 - cwp14 Type: Gene Product:Putative cell wall-binding protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_12100 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_28370 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_27020 - brnQ Type: Gene Product:Branched-chain amino acid transport system IIcarrier protein \| Pathway: \| COG: Amino acid transport and metabolism CD630_04380 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_30840 - garK Type: Gene Product:Glycerate kinase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_31630 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_06640 - tcdC Type: Gene Product:Negative regulator of toxin gene expression \| Pathway: \| COG: Function unknown CD630_27950 - cwp11 Type: Gene Product:Cell wall binding protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis	0.0000000000028	`NA`	0.52	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_27320 - Type: Gene Product:Transcriptional regulator, sigma-54-dependent \| Pathway: \| COG: Transcription CD630_32600 - phoU Type: Gene Product:Phosphate uptake regulator, PhoU \| Pathway: \| COG: Inorganic ion transport and metabolism TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`