Environment and Gene Regulatory Influence Network (EGRIN) model for C. difficile 630

The Environment and Gene Regulatory Influence Network (EGRIN) model of C. difficile 630 was inferred using cMonkey2 and a compendium of 136 transcriptomes (retrieved from the Gene Expression Omnibus repository) with 4,070 sequence features including 35 rRNAs and 90 tRNAs . The C. difficile EGRIN model groups genes in subsets (406 modules in total), that are co-regulated in specific environments, and also identifies the associated, putative cis-acting gene regulatory elements (GREs), which represent potential TF binding locations. Transcriptome compendium included conditions: response to iron limitation, response to oxygen, in vivo vs in vitro growth, short term infection (0, 30, 60, 120 mins), response to commensals and host diet, transition from exponential to stationary phase, fur KO, codY KO, sporulation TF (and sigma factors) KOs.

Explore Regulatory Modules

Displaying 361 - 370 of 406

Candidate transcriptional regulators for each module were determined with a linear regression based approach (Inferelator) and by evaluating the statistical significance of the overlap (Hypergeometric) between modules and putative TF and alternative sigma factor regulons (CcpA, CodY, Fur, PrdR, SigB, SigD, SigE, SigF, SigG, SigH, SigK, Spo0A) compiled from available literature.

* Given that translation start was used to define the 3' end of putative promoters, some cis-regulatory motifs are likely to be ribosome binding sites (i.e., Shine-Dalgarno sequence). RBS is typically a six nucleotide sequence 5'-GGAGGA-3'.

Title	Gene Count	Motif 1 e-value	Motif 2 e-value	Residual	TF Influences
Module_406	21 CD630_33310 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn6-Orf7 \| Pathway: \| COG: Function unknown CD630_14860 - Type: Gene Product:Putative ribosome recycling factor \| Pathway: \| COG: CD630_09420 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_33930 - rumA Type: Gene Product:23S rRNA (uracil-5-)-methyltransferase RumA (23SrRNA(M-5-U1939)-methyltransferase) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_09410 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_29190 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_31990 - Type: Gene Product:ABC-type transport system, multidrug-familypermease \| Pathway: \| COG: Function unknown CD630_34540 - Type: Gene Product:Putative nucleotide-binding protein \| Pathway: \| COG: Function unknown CD630_14850 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_30800 - Type: Gene Product:PTS system, lactose/cellobiose-family IIAcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_14281 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_14280 - Type: Gene Product:Transcriptional regulator, hxlR family \| Pathway: \| COG: Transcription CD630_29230 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_23040 - Type: Gene Product:Transcriptional regulator, beta-lactams repressorPhage-type \| Pathway: \| COG: Transcription CD630_14290 - Type: Gene Product:Putative acyl-CoA N-acyltransferase \| Pathway: \| COG: Function unknown CD630_31020 - Type: Gene Product:Putative peptidase, M20 family, peptidase Vrelated \| Pathway: \| COG: Amino acid transport and metabolism CD630_29210 - Type: Gene Product:Putative phage portal protein \| Pathway: \| COG: Function unknown CD630_25170 - Type: Gene Product:Transcriptional regulator, beta-lactamsrepressor \| Pathway: \| COG: Transcription CD630_31010 - Type: Gene Product:PTS system, glucose-like IIBC component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_09461 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_09460 - Type: Gene Product:Putative phage minor head protein \| Pathway: \| COG: Signal transduction mechanisms	0.00000000042	0.000000035	0.60	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_34990 - spoVT Type: Gene Product:Stage V sporulation protein T \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_324	28 CD630_25520 - Type: Gene Product:Putative phosphosugar isomerase \| Pathway: \| COG: Function unknown CD630_35590 - ftsH2 Type: Gene Product:Cell division protease FtsH2 \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_27260 - glyA Type: Gene Product:Serine hydroxymethyltransferase \| Pathway: One-carbon metabolism \| COG: Amino acid transport and metabolism CD630_14840 - ssuA Type: Gene Product:ABC-type transport system,alkanesulfonates-family extracellular solute-bindingprotein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_01100 - Type: Gene Product:Conserved hypothetical protein, CHP00159 family \| Pathway: \| COG: Function unknown CD630_30900 - treR Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_14820 - ssuC Type: Gene Product:ABC-type transport system, sulfonates-familypermease \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_16490 - Type: Gene Product:ABC-type transport system, iron-familyATP-binding protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_29940 - nrdF Type: Gene Product:Ribonucleoside-diphosphate reductase subunit beta(Ribonucleotide reductase small subunit) \| Pathway: Genetic information processing \| COG: Nucleotide transport and metabolism CD630_30380 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_16470 - Type: Gene Product:ABC-type transport system, iron-family permease \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_25510 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_27270 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_25530 - Type: Gene Product:PTS system, fructose/mannitol-family IICcomponent (Disrupted IStron) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_14830 - ssuB Type: Gene Product:ABC-type transport system, sulfonates-familyATP-binding protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_14810 - Type: Gene Product:Putative tryptophan RNA-binding attenuationprotein \| Pathway: \| COG: Signal transduction mechanisms CD630_16480 - Type: Gene Product:ABC-type transport system, iron-family permease \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_01111 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_01110 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_30910 - treA Type: Gene Product:Trehalose-6-phosphate hydrolase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_32190 - hslO Type: Gene Product:33 kDa chaperonin (Heat shock protein 33 homolog)(HSP33) \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_29930 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Transcription CD630_16500 - Type: Gene Product:ABC-type transport system, iron-familyextracellular substrate-binding protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_29950 - nrdE Type: Gene Product:Ribonucleoside-diphosphate reductase subunitalpha (Ribonucleotide reductase large subunit) \| Pathway: Genetic information processing \| COG: Nucleotide transport and metabolism CD630_16220 - Type: Gene Product:Putative lipoprotein \| Pathway: \| COG: Function unknown CD630_27280 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_30400 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_35600 - tilS Type: Gene Product:tRNA(Ile)-lysidine synthase (tRNA(Ile)-lysidinesynthetase) (tRNA(Ile)-2-lysyl-cytidine synthase) \| Pathway: \| COG: Cell cycle control, cell division, chromosome partitioning	0.0000000014	0.13	0.60	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_22140 - SinR Type: Gene Product:Transcriptional regulator, HTH-type \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_278	29 CD630_12630 - Type: Gene Product:Putative FMN-dependent dehydrogenase \| Pathway: \| COG: Energy production and conversion CD630_12610 - Type: Gene Product:Putative ribonucleotide-diphosphate reductase \| Pathway: \| COG: Nucleotide transport and metabolism CD630_07990 - Type: Gene Product:Putative beta-alanine CoA-transferase, familyIII \| Pathway: \| COG: Energy production and conversion CD630_29940 - nrdF Type: Gene Product:Ribonucleoside-diphosphate reductase subunit beta(Ribonucleotide reductase small subunit) \| Pathway: Genetic information processing \| COG: Nucleotide transport and metabolism CD630_32080 - Type: Gene Product:Transcriptional regulator, MarR family \| Pathway: \| COG: Transcription CD630_09190 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_09170 - Type: Gene Product:Putative phage recombination protein Bet \| Pathway: \| COG: Replication, recombination and repair CD630_17090 - mobA Type: Gene Product:Molybdopterin-guanine dinucleotide biosynthesisprotein A \| Pathway: \| COG: Coenzyme transport and metabolism CD630_09200 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_32070 - Type: Gene Product:Putative multi antimicrobial extrusion protein,MatE family \| Pathway: \| COG: Defense mechanisms CD630_09150 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_18960 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_08110 - Type: Gene Product:Putative cyclic di-GMP regulatory protein \| Pathway: \| COG: Signal transduction mechanisms CD630_09110 - Type: Gene Product:Transcriptional regulator, Phage-type \| Pathway: \| COG: CD630_09130 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_12620 - rnhB Type: Gene Product:Ribonuclease HII (RNase HII) \| Pathway: \| COG: Replication, recombination and repair CD630_07980 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_06720 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_12640 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_17690 - Type: Gene Product:Putative CoA enzyme activase \| Pathway: \| COG: Lipid transport and metabolism CD630_29930 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Transcription CD630_17080 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_29950 - nrdE Type: Gene Product:Ribonucleoside-diphosphate reductase subunitalpha (Ribonucleotide reductase large subunit) \| Pathway: Genetic information processing \| COG: Nucleotide transport and metabolism CD630_09230 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_09160 - Type: Gene Product:Putative phage protein involved in bacteriophageresistance \| Pathway: \| COG: Function unknown CD630_09120 - Type: Gene Product:Putative phage DNA-binding protein \| Pathway: \| COG: CD630_17100 - Type: Gene Product:Putative NAD(P)-binding protein \| Pathway: \| COG: Function unknown CD630_09140 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_18950 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown	0.000013	`NA`	0.61	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_23900 - Type: Gene Product:Transcriptional regulator, beta-lactamsrepressor \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_50	42 CD630_20350 - Type: Gene Product:Putative sporulation integral membrane protein \| Pathway: \| COG: Function unknown CD630_18591 - Type: Gene Product:Transcriptional regulator, AbrB family;Tn1549-like, CTn5-Orf17 \| Pathway: \| COG: Transcription CD630_18590 - Type: Gene Product:DNA topoisomerase protein, type IA, Tn1549-like,CTn5-Orf16 \| Pathway: \| COG: Replication, recombination and repair CD630_24610 - dnaK Type: Gene Product:Chaperone protein dnaK (Heat shock protein 70)(Heat shock 70 kDa protein) (HSP70) \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_18550 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn5-Orf11 \| Pathway: \| COG: Function unknown CD630_18620 - Type: Gene Product:Putative DNA/RNA helicase Tn1549-like,CTn5-Orf21 \| Pathway: \| COG: Replication, recombination and repair CD630_31480 - Type: Gene Product:Hypothetical protein \| Pathway: \| COG: Function unknown CD630_20390 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_18571 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn5-Orf14 \| Pathway: \| COG: Function unknown CD630_18570 - Type: Gene Product:Putative cell wall hydrolase Tn1549-like,CTn5-Orf13 \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_18530 - Type: Gene Product:Putative membrane protein Tn1549-like, CTn5-Orf9 \| Pathway: \| COG: Function unknown CD630_18510 - Type: Gene Product:Putative single-strand DNA-binding proteinTn1549-like, CTn5-Orf7 \| Pathway: \| COG: Function unknown CD630_10170 - Type: Gene Product:ABC-type transport system, multidrug-familyATP-binding protein/permease \| Pathway: \| COG: Defense mechanisms CD630_22660 - Type: Gene Product:Putative oxidoreductase, FAD dependent \| Pathway: \| COG: Energy production and conversion CD630_33100 - Type: Gene Product:Putative D-isomer specific 2-hydroxyaciddehydrogenase \| Pathway: \| COG: Amino acid transport and metabolism, Coenzyme transport and metabolism CD630_22620 - Type: Gene Product:Transporter, Major Facilitator Superfamily (MFS) \| Pathway: \| COG: Amino acid transport and metabolism CD630_10180 - Type: Gene Product:ABC-type transport system, multidrug-familyATP-binding protein/permease \| Pathway: \| COG: Defense mechanisms CD630_18600 - Type: Gene Product:Putative conjugative transposon protein DUF1016family, Tn1549-like, CTn5-Orf18 \| Pathway: \| COG: Function unknown CD630_18580 - Type: Gene Product:Putative cell surface protein Tn1549-like,CTn5-Orf15 \| Pathway: \| COG: Function unknown CD630_24600 - dnaJ Type: Gene Product:Chaperone protein DnaJ \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_33120 - Type: Gene Product:Transporter, Major Facilitator Superfamily (MFS) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_20400 - Type: Gene Product:Transcriptional regulator, MerR family \| Pathway: \| COG: Transcription CD630_24640 - hemN Type: Gene Product:Oxygen-independent coproporphyrinogen-III oxidase(Coproporphyrinogenase) (Coprogen oxidase) \| Pathway: \| COG: Coenzyme transport and metabolism CD630_24620 - grpE Type: Gene Product:Protein grpE (HSP-70 cofactor) \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_20360 - Type: Gene Product:Putative peptidylarginine deiminase \| Pathway: \| COG: Amino acid transport and metabolism CD630_31490 - Type: Gene Product:DNA helicase \| Pathway: \| COG: Replication, recombination and repair CD630_18540 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn5-Orf10 \| Pathway: \| COG: Function unknown CD630_19941 - Type: Gene Product:Transcriptional regulator, ArsR family \| Pathway: \| COG: Transcription CD630_19940 - Type: Gene Product:Putative membrane protein, DUF1648 family \| Pathway: \| COG: Function unknown CD630_18560 - Type: Gene Product:Putative hydrolase Tn1549-like, CTn5-Orf12 \| Pathway: \| COG: Intracellular trafficking, secretion, and vesicular transport CD630_18610 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn5-Orf19 \| Pathway: \| COG: Secondary metabolites biosynthesis, transport and catabolism CD630_20380 - Type: Gene Product:Putative drug/sodium antiporter, MATE family \| Pathway: \| COG: Defense mechanisms CD630_18520 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn5-Orf8 \| Pathway: \| COG: Function unknown CD630_36140 - Type: Gene Product:Conserved hypothetical protein, DUF1130 family \| Pathway: \| COG: Function unknown CD630_05650 - nth Type: Gene Product:Endonuclease III \| Pathway: \| COG: Replication, recombination and repair CD630_33110 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_22650 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_18630 - Type: Gene Product:Putative single-strand DNA-binding proteinTn1549-like, CTn5-Orf22 \| Pathway: \| COG: Function unknown CD630_20370 - Type: Gene Product:Putative acyl-CoA acyltransferase \| Pathway: \| COG: Function unknown CD630_31500 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown	0	0	0.61	Inferelator: 3 Hypergeometric: 0 TF Influences from Inferelator CD630_01710 - rex Type: Gene Product:Transcriptional regulator, Redox-sensingrepressor Rex \| Pathway: \| COG: Transcription CD630_16920 - Type: Gene Product:Transcriptional regulator, ArsR family \| Pathway: \| COG: Transcription CD630_17820 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_350	22 CD630_10600 - Type: Gene Product:Putative pseudouridylate synthase \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_08850 - glgP Type: Gene Product:Glycogen phosphorylase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_10540 - bcd2 Type: Gene Product:Butyryl-CoA dehydrogenase \| Pathway: \| COG: Lipid transport and metabolism CD630_10560 - etfA Type: Gene Product:Electron transfer flavoprotein subunit alpha \| Pathway: \| COG: Energy production and conversion CD630_16550 - Type: Gene Product:Putative Na+/H+ antiporter NhaC-like \| Pathway: \| COG: Energy production and conversion CD630_10580 - hbd Type: Gene Product:3-hydroxybutyryl-CoA dehydrogenase \| Pathway: \| COG: Lipid transport and metabolism CD630_17750 - Type: Gene Product:ABC-type transport system, aminoacid-familypermease \| Pathway: \| COG: Amino acid transport and metabolism CD630_25370 - Type: Gene Product:Putative membrane-associated5'-nucleotidase/phosphoesterase \| Pathway: \| COG: Nucleotide transport and metabolism CD630_08840 - glgA Type: Gene Product:Glycogen synthase (Starch [bacterial glycogen]synthase) \| Pathway: Glycan biosynthesis \| COG: Carbohydrate transport and metabolism CD630_08860 - Type: Gene Product:Putative alpha-amylase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_10550 - etfB Type: Gene Product:Electron transfer flavoproteins subunit beta \| Pathway: \| COG: Energy production and conversion CD630_31450 - cbpA Type: Gene Product:Surface-exposed adhesin \| Pathway: \| COG: Function unknown CD630_10610 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_28320 - Type: Gene Product:Putative cation efflux protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_10570 - crt2 Type: Gene Product:3-hydroxybutyryl-CoA dehydratase (Crotonase) \| Pathway: \| COG: Lipid transport and metabolism CD630_08830 - glgD Type: Gene Product:Glycogen biosynthesis protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_10590 - thlA1 Type: Gene Product:Acetoacetyl-CoA thiolase 1 \| Pathway: Metabolic intermediate biosynthesis \| COG: Lipid transport and metabolism CD630_21900 - Type: Gene Product:Cyclomaltodextrinase (maltogenic alpha-amylase)(cyclomaltodextrin dextrin-hydrolase (decyclizing)) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_17740 - Type: Gene Product:ABC-type transport system, aminoacid-familyextracellular solute-binding protein \| Pathway: \| COG: Amino acid transport and metabolism CD630_25030 - Type: Gene Product:Putative cation-transporting P-type ATPase \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_15230 - Type: Gene Product:Putative transporter \| Pathway: \| COG: Function unknown CD630_17760 - Type: Gene Product:ABC-type transport system, aminoacid-familyATP-binding protein \| Pathway: \| COG: Amino acid transport and metabolism	0.00000000000026	`NA`	0.61	Inferelator: 2 Hypergeometric: 3 TF Influences from Inferelator CD630_05160 - Type: Gene Product:Transcription antiterminator \| Pathway: \| COG: Signal transduction mechanisms CD630_29800 - Type: Gene Product:Putative CRISPR-associated autoregulator DevRfamily protein protein \| Pathway: \| COG: Replication, recombination and repair TF Influences from Hypergeometric Test CD630_12750 - codY Type: Gene Product:Transcriptional regulator, GTP-sensingpleiotropic repressor \| Pathway: \| COG: Transcription CD630_32450 - prdR Type: Gene Product:Transcriptional regulator, sigma-54-dependent \| Pathway: \| COG: Transcription CD630_10640 - ccpA Type: Gene Product:Transcriptional regulator, LacI family \| Pathway: \| COG: Transcription
Module_366	16 CD630_22740 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_16781 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_09401 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_22750 - topB2 Type: Gene Product:DNA topoisomerase III \| Pathway: \| COG: Replication, recombination and repair CD630_t0240 - tRNA-Leu Type: Gene Product: \| Pathway: \| COG: CD630_11360 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_21840 - Type: Gene Product:Putative N-acetylmuramoyl-L-alanine amidase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_06840 - Type: Gene Product:Putative ATP-dependent peptidase, M41 family \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_17010 - recQ Type: Gene Product:ATP-dependent DNA helicase \| Pathway: \| COG: Replication, recombination and repair CD630_23460 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_20680 - Type: Gene Product:ABC drug efflux pump \| Pathway: \| COG: Function unknown CD630_16731 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_01960 - Type: Gene Product:Fragment of conserved hypothetical protein,DUF111 family (Part 1) \| Pathway: \| COG: Function unknown, Function unknown CD630_20021 - Type: Gene Product:Fragment of conserved hypothetical protein(N-terminal region) \| Pathway: \| COG: Function unknown	`NA`	`NA`	0.61	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_26400 - nrdR Type: Gene Product:Transcriptional regulator, repressor NrdR family \| Pathway: \| COG: Transcription CD630_34990 - spoVT Type: Gene Product:Stage V sporulation protein T \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_398	25 CD630_29341 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_17170 - Type: Gene Product:Conserved hypothetical protein, DUF917 family \| Pathway: \| COG: Function unknown CD630_07790 - Type: Gene Product:Putative amidohydrolase, M20D peptidase family \| Pathway: \| COG: Amino acid transport and metabolism CD630_16570 - gcvTPA Type: Gene Product:Bi-functional glycine dehydrogenase/aminomethyltransferase protein \| Pathway: \| COG: Amino acid transport and metabolism CD630_33390 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn6-Orf16 \| Pathway: \| COG: Function unknown CD630_07770 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_33360 - Type: Gene Product:Putative cell wall hydrolase Tn916-like,CTn6-Orf13 \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_08410 - Type: Gene Product:5-aminoimidazole-4-carboxamide ribonucleotidetransformylase \| Pathway: \| COG: Nucleotide transport and metabolism CD630_17920 - Type: Gene Product:Putative L-threonine 3-dehydrogenase \| Pathway: \| COG: Carbohydrate transport and metabolism, Cell wall/membrane/envelope biogenesis CD630_17160 - Type: Gene Product:Putative permease \| Pathway: \| COG: Nucleotide transport and metabolism CD630_27370 - Type: Gene Product:Putative nitrilase/cyanide hydratase andapolipoprotein N-acyltransferase \| Pathway: \| COG: Function unknown CD630_07780 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_15071 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_15070 - Type: Gene Product:Putative thioredoxin \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_07800 - Type: Gene Product:Conserved hypothetical protein, DUF1177 family \| Pathway: \| COG: Function unknown CD630_33380 - Type: Gene Product:Putative ATPase Tn916-like, CTn6-Orf15 \| Pathway: \| COG: Function unknown CD630_07760 - Type: Gene Product:Transcriptional regulator, LacI family \| Pathway: \| COG: Transcription CD630_27380 - Type: Gene Product:Putative cytosine permease \| Pathway: \| COG: Nucleotide transport and metabolism CD630_33420 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn6-Orf19 \| Pathway: \| COG: Function unknown CD630_17180 - Type: Gene Product:Putative hydantoinase (Disrupted IStron) \| Pathway: \| COG: Amino acid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism, Amino acid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism CD630_33400 - Type: Gene Product:Putative antirestriction protein Tn916-like,CTn6-Orf17 \| Pathway: \| COG: Function unknown CD630_33370 - Type: Gene Product:Putative membrane protein Tn916-like, CTn6-Orf14 \| Pathway: \| COG: Function unknown CD630_16580 - gcvPB Type: Gene Product:Glycine decarboxylase \| Pathway: \| COG: Amino acid transport and metabolism CD630_15090 - Type: Gene Product:Putative lipoprotein \| Pathway: \| COG: CD630_33350 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn6-Orf12 \| Pathway: \| COG: Function unknown	0.000014	0.06	0.61	Inferelator: 3 Hypergeometric: 1 TF Influences from Inferelator CD630_06930 - Type: Gene Product:Transcriptional regulator, MerR family \| Pathway: \| COG: Transcription CD630_20230 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_32550 - rgaR Type: Gene Product:Two-component response regulator VirR-like \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test CD630_10640 - ccpA Type: Gene Product:Transcriptional regulator, LacI family \| Pathway: \| COG: Transcription
Module_151	8 CD630_31561 - Type: Gene Product:Fragment of conserved hypothetical protein (Part2) \| Pathway: \| COG: Function unknown, Function unknown CD630_06470 - Type: Gene Product:Fragment of putative fic family protein(C-terminal region) \| Pathway: \| COG: Function unknown CD630_33410 - Type: Gene Product:Fragment of putative conjugative transposonprotein Tn916-like, CTn6-Orf18 (N-terminal region) \| Pathway: \| COG: Function unknown CD630_17930 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_21940 - Type: Gene Product:Putative ROK protein \| Pathway: \| COG: Transcription CD630_31110 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_18120 - Type: Gene Product:Fragment of putative two-component responseregulator (N-terminal region) \| Pathway: \| COG: CD630_16330 - Type: Gene Product:Putative serine protease \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones	`NA`	`NA`	0.61	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_11770 - fapR Type: Gene Product:Transcriptional regulator, DeoR family (Fattyacid and phospholipid biosynthesis regulator) \| Pathway: \| COG: Transcription CD630_30110 - Type: Gene Product:Transcriptional regulator, HxlR family DUF24 \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_138	17 CD630_05510 - sleC Type: Gene Product:Spore exo-acting lytic transglycosylase \| Pathway: \| COG: Function unknown CD630_03320 - bclA1 Type: Gene Product:Exosporium glycoprotein \| Pathway: \| COG: Intracellular trafficking, secretion, and vesicular transport, Extracellular structures CD630_16600 - Type: Gene Product:Conserved hypothetical protein, DUF 1255 family \| Pathway: \| COG: Function unknown CD630_06610 - tcdE Type: Gene Product:Holin-like pore-forming protein \| Pathway: \| COG: Function unknown CD630_36220 - Type: Gene Product:Conserved hypothetical protein, PhnA family \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_25200 - Type: Gene Product:Putative conjugative transposon antibioticresistance protein \| Pathway: \| COG: Defense mechanisms CD630_t0710 - tRNA-Leu Type: Gene Product: \| Pathway: \| COG: CD630_10120 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: CD630_12340 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_32210 - Type: Gene Product:Putative peptidase, M20D family \| Pathway: \| COG: Amino acid transport and metabolism CD630_16781 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_32230 - dapA2 Type: Gene Product:Dihydrodipicolinate synthase 2 \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_07020 - Type: Gene Product:Putative membrane protein, DUF1275 family \| Pathway: \| COG: Function unknown CD630_27991 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown	0	`NA`	0.61	Inferelator: 3 Hypergeometric: 0 TF Influences from Inferelator CD630_06290 - Type: Gene Product:Transcriptional regulator, Crp family \| Pathway: \| COG: Transcription CD630_12390 - Type: Gene Product:Transcriptional regulator, beta-lactams repressorPhage-type \| Pathway: \| COG: Transcription CD630_34990 - spoVT Type: Gene Product:Stage V sporulation protein T \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_405	26 CD630_29220 - Type: Gene Product:Putative phage terminase large subunit \| Pathway: \| COG: Replication, recombination and repair CD630_29200 - Type: Gene Product:Putative phage head protein \| Pathway: \| COG: Signal transduction mechanisms CD630_27360 - Type: Gene Product:Transcriptional regulator, LysR family \| Pathway: \| COG: Transcription CD630_14182 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_17440 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_22991 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_09450 - Type: Gene Product:Putative phage portal protein \| Pathway: \| COG: Function unknown CD630_09410 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_09430 - Type: Gene Product:Putative phage DNA-binding protein \| Pathway: \| COG: Function unknown CD630_12331 - Type: Gene Product:Fragment of phage protein \| Pathway: \| COG: CD630_29190 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_29250 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_29210 - Type: Gene Product:Putative phage portal protein \| Pathway: \| COG: Function unknown CD630_29230 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_12450 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_09440 - Type: Gene Product:Putative phage terminase, large subunit \| Pathway: \| COG: Replication, recombination and repair CD630_29071 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_17430 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_09562 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_17450 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_09461 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_09460 - Type: Gene Product:Putative phage minor head protein \| Pathway: \| COG: Signal transduction mechanisms CD630_09420 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_29240 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_28630 - Type: Gene Product:Transcriptional regulator, sigma-54-dependent \| Pathway: \| COG: Transcription CD630_25171 - Type: Gene Product:Putative phage protein \| Pathway: \| COG:	1.68156e-44	8.90007e-41	0.61	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_22140 - SinR Type: Gene Product:Transcriptional regulator, HTH-type \| Pathway: \| COG: Transcription CD630_23900 - Type: Gene Product:Transcriptional regulator, beta-lactamsrepressor \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`