Environment and Gene Regulatory Influence Network (EGRIN) model for C. difficile 630

The Environment and Gene Regulatory Influence Network (EGRIN) model of C. difficile 630 was inferred using cMonkey2 and a compendium of 136 transcriptomes (retrieved from the Gene Expression Omnibus repository) with 4,070 sequence features including 35 rRNAs and 90 tRNAs . The C. difficile EGRIN model groups genes in subsets (406 modules in total), that are co-regulated in specific environments, and also identifies the associated, putative cis-acting gene regulatory elements (GREs), which represent potential TF binding locations. Transcriptome compendium included conditions: response to iron limitation, response to oxygen, in vivo vs in vitro growth, short term infection (0, 30, 60, 120 mins), response to commensals and host diet, transition from exponential to stationary phase, fur KO, codY KO, sporulation TF (and sigma factors) KOs.

Explore Regulatory Modules

Displaying 341 - 350 of 406

Candidate transcriptional regulators for each module were determined with a linear regression based approach (Inferelator) and by evaluating the statistical significance of the overlap (Hypergeometric) between modules and putative TF and alternative sigma factor regulons (CcpA, CodY, Fur, PrdR, SigB, SigD, SigE, SigF, SigG, SigH, SigK, Spo0A) compiled from available literature.

* Given that translation start was used to define the 3' end of putative promoters, some cis-regulatory motifs are likely to be ribosome binding sites (i.e., Shine-Dalgarno sequence). RBS is typically a six nucleotide sequence 5'-GGAGGA-3'.

Title	Gene Count	Motif 1 e-value	Motif 2 e-value	Residual	TF Influences
Module_227	24 CD630_03780 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn1-Orf23 \| Pathway: \| COG: Function unknown CD630_27340 - Type: Gene Product:Putative Na+/H+ antiporter, NhaC family \| Pathway: \| COG: Energy production and conversion CD630_19340 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_33701 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn7-Orf2 \| Pathway: \| COG: Function unknown CD630_33861 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn7-Orf23 \| Pathway: \| COG: Function unknown CD630_32950 - pilC Type: Gene Product:Type IV pilus secretion protein \| Pathway: \| COG: Intracellular trafficking, secretion, and vesicular transport CD630_28430 - Type: Gene Product:Putative zinc-binding dehydrogenase \| Pathway: \| COG: Energy production and conversion CD630_32970 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_32930 - pilMN Type: Gene Product:Type IV pilus assembly protein \| Pathway: \| COG: Function unknown CD630_32910 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_19330 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_33340 - Type: Gene Product:Putative transcriptional regulator Tn916-like,CTn6-Orf11 \| Pathway: \| COG: Function unknown CD630_33710 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn7-Orf3 \| Pathway: \| COG: Function unknown CD630_27330 - Type: Gene Product:Putative pyridoxal phosphate-dependenttransferase \| Pathway: \| COG: Amino acid transport and metabolism CD630_30240 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_28440 - Type: Gene Product:Transcriptional regulator, MarR family \| Pathway: \| COG: Transcription CD630_32940 - pilA Type: Gene Product:Type IV pilus protein PilA \| Pathway: \| COG: Intracellular trafficking, secretion, and vesicular transport CD630_32960 - pilB Type: Gene Product:Type IV pilus transporter system, ATP-binding \| Pathway: \| COG: Intracellular trafficking, secretion, and vesicular transport CD630_32920 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_05140 - cwpV Type: Gene Product:Cell surface protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_06220 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_33720 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn7-Orf4 \| Pathway: \| COG: CD630_33331 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn6-Orf10 \| Pathway: \| COG: Function unknown CD630_30230 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG:	0.00006	0.04	0.58	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_23900 - Type: Gene Product:Transcriptional regulator, beta-lactamsrepressor \| Pathway: \| COG: Transcription CD630_30540 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_139	24 CD630_29340 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_18360 - pheA Type: Gene Product:Bifunctional P-protein, chorismatemutase/prephenate dehydratase \| Pathway: \| COG: Amino acid transport and metabolism CD630_18340 - aroA Type: Gene Product:3-phosphoshikimate 1-carboxyvinyltransferase \| Pathway: Metabolic intermediate biosynthesis \| COG: Amino acid transport and metabolism CD630_15490 - hisC Type: Gene Product:Histidinol-phosphate aminotransferase (Imidazoleacetol-phosphate transaminase) \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_15510 - hisH Type: Gene Product:Imidazole glycerol phosphate synthase subunitHisH \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_15530 - hisF Type: Gene Product:Imidazole glycerol phosphate synthase subunitHisF \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_15470 - hisZ Type: Gene Product:ATP phosphoribosyltransferase regulatory subunit \| Pathway: \| COG: Amino acid transport and metabolism CD630_18390 - tyrC Type: Gene Product:Prephenate dehydrogenase \| Pathway: \| COG: Amino acid transport and metabolism CD630_29330 - Type: Gene Product:Hypothetical protein \| Pathway: \| COG: CD630_18330 - aroB Type: Gene Product:3-dehydroquinate synthase \| Pathway: Metabolic intermediate biosynthesis \| COG: Amino acid transport and metabolism CD630_29310 - Type: Gene Product:Putative phage endodeoxyribonuclease RusA-like \| Pathway: \| COG: Replication, recombination and repair CD630_18350 - aroC Type: Gene Product:Chorismate synthase(5-enolpyruvylshikimate-3-phosphate phospholyase) \| Pathway: Metabolic intermediate biosynthesis \| COG: Amino acid transport and metabolism CD630_15480 - hisG Type: Gene Product:ATP phosphoribosyltransferase (ATP-PRTase)(ATP-PRT) \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_18370 - aroE1 Type: Gene Product:Shikimate dehydrogenase 1 \| Pathway: Metabolic intermediate biosynthesis \| COG: Amino acid transport and metabolism CD630_29290 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_15540 - hisI Type: Gene Product:Histidine biosynthesis bifunctional protein HisIE[Includes: Phosphoribosyl-AMP cyclohydrolase ;Phosphoribosyl-ATP pyrophosphatase] \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_15520 - hisA Type: Gene Product:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_18380 - aroK Type: Gene Product:Shikimate kinase (SK) \| Pathway: Metabolic intermediate biosynthesis \| COG: Amino acid transport and metabolism CD630_15500 - hisB Type: Gene Product:Imidazoleglycerol-phosphate dehydratase \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_29320 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_29300 - Type: Gene Product:Putative phage anti-repressor protein \| Pathway: \| COG: Transcription CD630_18320 - aroF Type: Gene Product:3-deoxy-D-arabino-heptulosonate 7-phosphatesynthase \| Pathway: \| COG: Amino acid transport and metabolism	`NA`	`NA`	0.58	Inferelator: 3 Hypergeometric: 1 TF Influences from Inferelator CD630_19960 - Type: Gene Product:Transcriptional regulator, AraC family \| Pathway: \| COG: Signal transduction mechanisms CD630_26150 - Type: Gene Product:Transcriptional regulator, TetR family \| Pathway: \| COG: Transcription CD630_32090 - Type: Gene Product:Transcriptional regulator, PadR family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test CD630_12750 - codY Type: Gene Product:Transcriptional regulator, GTP-sensingpleiotropic repressor \| Pathway: \| COG: Transcription
Module_45	5 CD630_29960 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_16660 - Type: Gene Product:Putative membrane glycerophosphoryl diesterphosphodiesterase \| Pathway: \| COG: Energy production and conversion CD630_21650 - Type: Gene Product:Transcriptional regulator, HTH-type \| Pathway: \| COG: Transcription CD630_06040 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_01590 - Type: Gene Product:Putative enzyme, glyoxalase family \| Pathway: \| COG: Amino acid transport and metabolism	`NA`	`NA`	0.59	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_13790 - Type: Gene Product:Transcriptional regulator, Phage-type \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_141	8 CD630_32540 - Type: Gene Product:Putative peptidase, S8 or S52 family \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_13420 - Type: Gene Product:Putative ribonuclease \| Pathway: \| COG: Replication, recombination and repair CD630_09050 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_11740 - Type: Gene Product:Conserved hypothetical protein, DUF795 family,UPF0348 family \| Pathway: \| COG: Function unknown CD630_28190 - Type: Gene Product:Putative amino acid racemase \| Pathway: \| COG: Amino acid transport and metabolism CD630_22500 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_05440 - Type: Gene Product:Putative ornithine cyclodeaminase \| Pathway: \| COG: Amino acid transport and metabolism CD630_03080 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown	`NA`	`NA`	0.59	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_20230 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_25270 - Type: Gene Product:Transcriptional regulator, TetR family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_142	28 CD630_34910 - Type: Gene Product:Putative exopolyphosphatase \| Pathway: \| COG: Nucleotide transport and metabolism, Inorganic ion transport and metabolism CD630_34930 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_35090 - pilO Type: Gene Product:Type IV pilus assembly protein \| Pathway: \| COG: CD630_03530 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_28310 - Type: Gene Product:Collagen binding protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_05670 - Type: Gene Product:Conserved hypothetical protein, DegV family \| Pathway: \| COG: Function unknown CD630_14720 - Type: Gene Product:ABC-type transport system, multidrug-familyATP-binding protein/permease \| Pathway: \| COG: Defense mechanisms CD630_35010 - mfd Type: Gene Product:Transcription-repair coupling factor (TRCFATP-dependent helicase mfd) \| Pathway: \| COG: Replication, recombination and repair CD630_35110 - pilC Type: Gene Product:Type IV pilus secretion protein \| Pathway: \| COG: Intracellular trafficking, secretion, and vesicular transport CD630_34960 - hbs Type: Gene Product:DNA-binding protein, non-specific \| Pathway: \| COG: Replication, recombination and repair CD630_35030 - pilD Type: Gene Product:Type IV prepilin leader peptidase \| Pathway: \| COG: Cell motility, Posttranslational modification, protein turnover, chaperones, Intracellular trafficking, secretion, and vesicular transport CD630_35070 - pilU Type: Gene Product:Type IV pilus protein \| Pathway: \| COG: CD630_35050 - pilT Type: Gene Product:Type IV pilus twitching motility protein \| Pathway: \| COG: Cell motility, Intracellular trafficking, secretion, and vesicular transport CD630_03541 - Type: Gene Product:Fragment of putative membrane protein \| Pathway: \| COG: Function unknown CD630_03520 - Type: Gene Product:Transcriptional regulator, RmlC-type \| Pathway: \| COG: Transcription CD630_35080 - pilV Type: Gene Product:Type IV pilus protein \| Pathway: \| COG: CD630_26140 - Type: Gene Product:Conserved hypothetical protein, DegV family \| Pathway: \| COG: Function unknown CD630_34980 - spoVB Type: Gene Product:Stage V sporulation protein B \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_14730 - Type: Gene Product:ABC-type transport system, multidrug-familyATP-binding/permease \| Pathway: \| COG: Defense mechanisms CD630_35120 - pilB Type: Gene Product:Type IV pilus transporter system, ATP-binding \| Pathway: \| COG: Intracellular trafficking, secretion, and vesicular transport CD630_35000 - prsA Type: Gene Product:Peptidylprolyl isomerase PrsA-like \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_35040 - pilD Type: Gene Product:Type IV prepilin peptidase, A24A family \| Pathway: \| COG: Cell motility, Posttranslational modification, protein turnover, chaperones, Intracellular trafficking, secretion, and vesicular transport CD630_35020 - pth Type: Gene Product:Peptidyl-tRNA hydrolase (PTH) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_35100 - pilMN Type: Gene Product:Type IV pilus protein \| Pathway: \| COG: Function unknown CD630_35060 - pilK Type: Gene Product:Type IV pilus protein \| Pathway: \| COG: CD630_26150 - Type: Gene Product:Transcriptional regulator, TetR family \| Pathway: \| COG: Transcription CD630_05660 - Type: Gene Product:Putative tRNA/rRNA methyltransferase \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_34950 - Type: Gene Product:Putative RNA-binding S4 domain-containingprotein \| Pathway: \| COG: Translation, ribosomal structure and biogenesis	0.000081	0.02	0.59	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_16860 - Type: Gene Product:Transcriptional regulator, repressor-like \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_17	15 CD630_13011 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_21910 - Type: Gene Product:Putative phosphoesterase \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_24461 - rpsU Type: Gene Product:30S ribosomal protein S21 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_04400 - cwp27 Type: Gene Product:Putative cell wall binding protein \| Pathway: \| COG: Function unknown CD630_21920 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: CD630_11241 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_06350 - Type: Gene Product:Putative hydrolase \| Pathway: \| COG: Function unknown CD630_26920 - Type: Gene Product:Putative threonine-phosphate decarboxylase \| Pathway: \| COG: Amino acid transport and metabolism CD630_26691 - Type: Gene Product:Putative Na(+)/H(+) antiporter \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_05130 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_04880 - Type: Gene Product:Putative small multidrug resistance SugE-likeprotein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_06340 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_26120 - Type: Gene Product:Putative amino acid permease \| Pathway: \| COG: Amino acid transport and metabolism CD630_04390 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_27990 - cwp8 Type: Gene Product:Cell wall binding protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis	0.000002	`NA`	0.59	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_06940 - Type: Gene Product:Transcriptional regulator, TetR family \| Pathway: \| COG: Transcription CD630_11770 - fapR Type: Gene Product:Transcriptional regulator, DeoR family (Fattyacid and phospholipid biosynthesis regulator) \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_173	6 CD630_18040 - scrR Type: Gene Product:Transcriptional regulator, LacI family \| Pathway: \| COG: Transcription CD630_20170 - Type: Gene Product:Transcriptional regulator, HTH-type \| Pathway: \| COG: Transcription CD630_06480 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_09070 - Type: Gene Product:Transcriptional regulator, Phage-type \| Pathway: \| COG: Transcription CD630_29660 - adhE Type: Gene Product:Aldehyde-alcohol dehydrogenase \| Pathway: \| COG: Energy production and conversion CD630_06641 - cdd1 Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown	`NA`	`NA`	0.59	Inferelator: 4 Hypergeometric: 0 TF Influences from Inferelator CD630_05590 - Type: Gene Product:Transcriptional regulator, ArsR family \| Pathway: \| COG: Transcription CD630_06480 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_17980 - Type: Gene Product:Transcriptional regulator, LysR family \| Pathway: \| COG: Transcription CD630_31750 - cggR Type: Gene Product:Transcriptional regulator, SorC family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_117	27 CD630_01920 - cls Type: Gene Product:Cardiolipin synthetase 1 \| Pathway: \| COG: Lipid transport and metabolism CD630_22870 - Type: Gene Product:Putative transporter \| Pathway: \| COG: Amino acid transport and metabolism CD630_30440 - Type: Gene Product:Transcriptional regulator, RpiR family \| Pathway: \| COG: Transcription CD630_12630 - Type: Gene Product:Putative FMN-dependent dehydrogenase \| Pathway: \| COG: Energy production and conversion CD630_24750 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_12610 - Type: Gene Product:Putative ribonucleotide-diphosphate reductase \| Pathway: \| COG: Nucleotide transport and metabolism CD630_24770 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_25220 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_10130 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_24780 - Type: Gene Product:Putative DNA uptake transporter \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_25710 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_34120 - uvrB Type: Gene Product:Excinuclease ABC subunit B \| Pathway: \| COG: Replication, recombination and repair CD630_34100 - uvrC Type: Gene Product:Excinuclease ABC subunit C \| Pathway: \| COG: Replication, recombination and repair CD630_30450 - Type: Gene Product:Putative ATPase, BadF/BadG/BcrA/BcrD type \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_34090 - hprK Type: Gene Product:PTS system, HPr kinase/phosphorylase \| Pathway: \| COG: Signal transduction mechanisms CD630_32170 - Type: Gene Product:ABC-type transport system, ATP-binding protein \| Pathway: \| COG: Replication, recombination and repair CD630_22860 - Type: Gene Product:Putative transporter \| Pathway: \| COG: Amino acid transport and metabolism CD630_12620 - rnhB Type: Gene Product:Ribonuclease HII (RNase HII) \| Pathway: \| COG: Replication, recombination and repair CD630_24740 - Type: Gene Product:Putative DNA polymerase III, delta subunit \| Pathway: \| COG: Replication, recombination and repair CD630_25240 - nadD Type: Gene Product:Nicotinate-nucleotide adenylyltransferase \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism CD630_01910 - Type: Gene Product:Putative DNA glycosylase \| Pathway: \| COG: Replication, recombination and repair CD630_24760 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_10140 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_12640 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_25700 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_34110 - uvrA Type: Gene Product:Excinuclease ABC subunit A \| Pathway: \| COG: Replication, recombination and repair CD630_25230 - Type: Gene Product:Putative hydrolase \| Pathway: \| COG: Coenzyme transport and metabolism	0.04	`NA`	0.59	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_23900 - Type: Gene Product:Transcriptional regulator, beta-lactamsrepressor \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_292	25 CD630_17281 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_08350 - Type: Gene Product:Transcriptional regulator, MarR family \| Pathway: \| COG: Transcription CD630_17310 - Type: Gene Product:Putative acetyltransferase \| Pathway: \| COG: Function unknown CD630_27200 - Type: Gene Product:Putative transporter \| Pathway: \| COG: Function unknown CD630_26580 - mraW Type: Gene Product:S-adenosyl-L-methionine-dependentmethyltransferase MraW \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_32180 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_26590 - lgt Type: Gene Product:Prolipoprotein diacylglyceryl transferase \| Pathway: Protein modification \| COG: Cell wall/membrane/envelope biogenesis CD630_08360 - Type: Gene Product:Putative acetyltransferase \| Pathway: \| COG: Transcription CD630_24950 - selA Type: Gene Product:L-seryl-tRNA(Sec) selenium transferase(Selenocysteine synthase) (Sec synthase)(Selenocysteinyl-tRNA(Sec) synthase ) \| Pathway: Aminoacyl-tRNA biosynthesis \| COG: Amino acid transport and metabolism CD630_24930 - selB Type: Gene Product:Selenocysteinyl-tRNA-specific translation factor \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_24970 - comE Type: Gene Product:Competence protein ComEA \| Pathway: \| COG: Replication, recombination and repair CD630_32150 - Type: Gene Product:ABC-type transport system, glycinebetaine/carnitine/choline ATP-binding protein \| Pathway: \| COG: Amino acid transport and metabolism CD630_30220 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_17610 - Type: Gene Product:Putative phenazine biosynthesis PhzC/PhzFprotein \| Pathway: \| COG: Function unknown CD630_24980 - dacF Type: Gene Product:D-alanyl-D-alanine carboxypeptidase (putativesporulation-specific penicillin-binding protein) \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_25260 - glgB Type: Gene Product:1,4-alpha-glucan branching enzyme \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_06060 - Type: Gene Product:Fragment of chloride ion channel protein (part1) \| Pathway: \| COG: Inorganic ion transport and metabolism, Inorganic ion transport and metabolism CD630_32160 - Type: Gene Product:ABC-type transport system, glycinebetaine/carnitine/choline permease \| Pathway: \| COG: Amino acid transport and metabolism CD630_08370 - Type: Gene Product:Nitroreductase \| Pathway: \| COG: Function unknown CD630_04770 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_24960 - selD Type: Gene Product:Selenide, water dikinase (Selenophosphatesynthetase) (Selenium donor protein) \| Pathway: \| COG: Amino acid transport and metabolism CD630_07110 - argS Type: Gene Product:Arginyl-tRNA synthetase (Arginine--tRNA ligase)(ArgRS) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_17600 - Type: Gene Product:Putative iron-sulfur protein \| Pathway: \| COG: Energy production and conversion CD630_16620 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_26620 - Type: Gene Product:Putative GTP-binding protein \| Pathway: \| COG: Translation, ribosomal structure and biogenesis	0	0.0000000000002	0.59	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_01710 - rex Type: Gene Product:Transcriptional regulator, Redox-sensingrepressor Rex \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_261	24 CD630_31770 - Type: Gene Product:Putative xanthine dehydrogenase \| Pathway: \| COG: Energy production and conversion CD630_28640 - Type: Gene Product:Putative hydrolase \| Pathway: \| COG: Function unknown CD630_24010 - cotD Type: Gene Product:Spore coat protein CotD; manganese catalase \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_29670 - dpaB Type: Gene Product:Dipicolinate synthase subunit B \| Pathway: \| COG: Coenzyme transport and metabolism CD630_15180 - feoA Type: Gene Product:Ferrous iron transport protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_29700 - Type: Gene Product:Putative thiolase \| Pathway: \| COG: Lipid transport and metabolism CD630_07730 - spoVAC Type: Gene Product:Stage V sporulation protein AC \| Pathway: \| COG: Function unknown CD630_17880 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_29690 - Type: Gene Product:Putative AMP-binding protein \| Pathway: \| COG: Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism CD630_29710 - bioY Type: Gene Product:Biotin synthase \| Pathway: \| COG: Function unknown CD630_31800 - Type: Gene Product:Putative purine permease \| Pathway: \| COG: Nucleotide transport and metabolism CD630_07750 - spoVAE Type: Gene Product:Stage V sporulation protein AE \| Pathway: \| COG: Function unknown CD630_31780 - Type: Gene Product:D-hydantoinase (Dihydropyrimidinase) \| Pathway: \| COG: Nucleotide transport and metabolism CD630_21850 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_17900 - Type: Gene Product:Putative exonuclease \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_24000 - cotJB2 Type: Gene Product:Spore coat peptide assembly protein CotJB 2 \| Pathway: \| COG: Function unknown CD630_28320 - Type: Gene Product:Putative cation efflux protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_17910 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_29680 - dpaA Type: Gene Product:Dipicolinate synthase subunit A \| Pathway: \| COG: Function unknown CD630_23990 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_17890 - Type: Gene Product:Putative membrane protein, DUF421 family \| Pathway: \| COG: Function unknown CD630_07740 - spoVAD Type: Gene Product:Stage V sporulation protein AD \| Pathway: \| COG: Function unknown CD630_15170 - feoB Type: Gene Product:Ferrous iron transport protein B \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_21860 - Type: Gene Product:Putative phage-like protein \| Pathway: \| COG:	0	`NA`	0.59	Inferelator: 1 Hypergeometric: 3 TF Influences from Inferelator CD630_34990 - spoVT Type: Gene Product:Stage V sporulation protein T \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test CD630_12140 - spo0A Type: Gene Product:Stage 0 sporulation protein A \| Pathway: \| COG: Signal transduction mechanisms CD630_26420 - sigG Type: Gene Product:RNA polymerase sigma-G factor \| Pathway: \| COG: Transcription CD630_12300 - Type: Gene Product:RNA polymerase sigma-K factor SigK (Part 2) \| Pathway: \| COG: Transcription, Transcription