Environment and Gene Regulatory Influence Network (EGRIN) model for C. difficile 630

The Environment and Gene Regulatory Influence Network (EGRIN) model of C. difficile 630 was inferred using cMonkey2 and a compendium of 136 transcriptomes (retrieved from the Gene Expression Omnibus repository) with 4,070 sequence features including 35 rRNAs and 90 tRNAs . The C. difficile EGRIN model groups genes in subsets (406 modules in total), that are co-regulated in specific environments, and also identifies the associated, putative cis-acting gene regulatory elements (GREs), which represent potential TF binding locations. Transcriptome compendium included conditions: response to iron limitation, response to oxygen, in vivo vs in vitro growth, short term infection (0, 30, 60, 120 mins), response to commensals and host diet, transition from exponential to stationary phase, fur KO, codY KO, sporulation TF (and sigma factors) KOs.

Explore Regulatory Modules

Displaying 321 - 330 of 406

Candidate transcriptional regulators for each module were determined with a linear regression based approach (Inferelator) and by evaluating the statistical significance of the overlap (Hypergeometric) between modules and putative TF and alternative sigma factor regulons (CcpA, CodY, Fur, PrdR, SigB, SigD, SigE, SigF, SigG, SigH, SigK, Spo0A) compiled from available literature.

* Given that translation start was used to define the 3' end of putative promoters, some cis-regulatory motifs are likely to be ribosome binding sites (i.e., Shine-Dalgarno sequence). RBS is typically a six nucleotide sequence 5'-GGAGGA-3'.

Title	Gene Count	Motif 1 e-value	Motif 2 e-value	Residual	TF Influences
Module_58	4 CD630_03780 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn1-Orf23 \| Pathway: \| COG: Function unknown CD630_05400 - cheW Type: Gene Product:Chemotaxis protein CheW \| Pathway: \| COG: Cell motility, Signal transduction mechanisms CD630_22170 - aroD Type: Gene Product:Dehydroquinate dehydratase (3-dehydroquinatedehydratase) (Dehydroquinase) (DHQase) \| Pathway: Metabolic intermediate biosynthesis \| COG: Amino acid transport and metabolism CD630_03280 - pcrA Type: Gene Product:DNA helicase, UvrD/REP type \| Pathway: \| COG: Replication, recombination and repair	0.11	`NA`	0.57	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_05400 - cheW Type: Gene Product:Chemotaxis protein CheW \| Pathway: \| COG: Cell motility, Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_299	20 CD630_28090 - Type: Gene Product:Conserved hypothetical protein, DUF1540 family \| Pathway: \| COG: Function unknown CD630_29150 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_29170 - Type: Gene Product:Putative scaffold protein \| Pathway: \| COG: Function unknown CD630_28970 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_03110 - GerG Type: Gene Product:Germination regulator \| Pathway: \| COG: CD630_29000 - Type: Gene Product:Putative phage tail protein \| Pathway: \| COG: Function unknown CD630_29010 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_29030 - Type: Gene Product:Putative phage tail protein \| Pathway: \| COG: Function unknown CD630_10633 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_29140 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_29120 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_28980 - Type: Gene Product:Putative phage tail fiber protein \| Pathway: \| COG: Function unknown CD630_29020 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_29050 - Type: Gene Product:Putative phage tail tape measure protein \| Pathway: \| COG: Function unknown CD630_10632 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_28080 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_29040 - Type: Gene Product:Putative phage cell wall hydrolase \| Pathway: \| COG: Function unknown CD630_29090 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_29060 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_29080 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown	0	`NA`	0.57	Inferelator: 1 Hypergeometric: 1 TF Influences from Inferelator CD630_34990 - spoVT Type: Gene Product:Stage V sporulation protein T \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test CD630_12140 - spo0A Type: Gene Product:Stage 0 sporulation protein A \| Pathway: \| COG: Signal transduction mechanisms
Module_188	6 CD630_22130 - cynT Type: Gene Product:Carbonic anhydrase \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_34532 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_04870 - Type: Gene Product:Putative carbon-nitrogen hydrolase \| Pathway: \| COG: Function unknown CD630_05040 - Type: Gene Product:Fragment of putative cell wall hydrolase NLPC/P60family Tn5397, CTn3-Orf14 (Part 1) \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_07540 - thiI Type: Gene Product:Thiamine biosynthesis protein ThiI \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism CD630_07530 - iscS1 Type: Gene Product:Cysteine desulfurase \| Pathway: \| COG: Amino acid transport and metabolism	`NA`	`NA`	0.58	Inferelator: 0 Hypergeometric: 0 TF Influences from Inferelator `No TF influences from Inferelator` TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_139	24 CD630_29340 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_18360 - pheA Type: Gene Product:Bifunctional P-protein, chorismatemutase/prephenate dehydratase \| Pathway: \| COG: Amino acid transport and metabolism CD630_18340 - aroA Type: Gene Product:3-phosphoshikimate 1-carboxyvinyltransferase \| Pathway: Metabolic intermediate biosynthesis \| COG: Amino acid transport and metabolism CD630_15490 - hisC Type: Gene Product:Histidinol-phosphate aminotransferase (Imidazoleacetol-phosphate transaminase) \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_15510 - hisH Type: Gene Product:Imidazole glycerol phosphate synthase subunitHisH \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_15530 - hisF Type: Gene Product:Imidazole glycerol phosphate synthase subunitHisF \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_15470 - hisZ Type: Gene Product:ATP phosphoribosyltransferase regulatory subunit \| Pathway: \| COG: Amino acid transport and metabolism CD630_18390 - tyrC Type: Gene Product:Prephenate dehydrogenase \| Pathway: \| COG: Amino acid transport and metabolism CD630_29330 - Type: Gene Product:Hypothetical protein \| Pathway: \| COG: CD630_18330 - aroB Type: Gene Product:3-dehydroquinate synthase \| Pathway: Metabolic intermediate biosynthesis \| COG: Amino acid transport and metabolism CD630_29310 - Type: Gene Product:Putative phage endodeoxyribonuclease RusA-like \| Pathway: \| COG: Replication, recombination and repair CD630_18350 - aroC Type: Gene Product:Chorismate synthase(5-enolpyruvylshikimate-3-phosphate phospholyase) \| Pathway: Metabolic intermediate biosynthesis \| COG: Amino acid transport and metabolism CD630_15480 - hisG Type: Gene Product:ATP phosphoribosyltransferase (ATP-PRTase)(ATP-PRT) \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_18370 - aroE1 Type: Gene Product:Shikimate dehydrogenase 1 \| Pathway: Metabolic intermediate biosynthesis \| COG: Amino acid transport and metabolism CD630_29290 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_15540 - hisI Type: Gene Product:Histidine biosynthesis bifunctional protein HisIE[Includes: Phosphoribosyl-AMP cyclohydrolase ;Phosphoribosyl-ATP pyrophosphatase] \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_15520 - hisA Type: Gene Product:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_18380 - aroK Type: Gene Product:Shikimate kinase (SK) \| Pathway: Metabolic intermediate biosynthesis \| COG: Amino acid transport and metabolism CD630_15500 - hisB Type: Gene Product:Imidazoleglycerol-phosphate dehydratase \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_29320 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_29300 - Type: Gene Product:Putative phage anti-repressor protein \| Pathway: \| COG: Transcription CD630_18320 - aroF Type: Gene Product:3-deoxy-D-arabino-heptulosonate 7-phosphatesynthase \| Pathway: \| COG: Amino acid transport and metabolism	`NA`	`NA`	0.58	Inferelator: 3 Hypergeometric: 1 TF Influences from Inferelator CD630_19960 - Type: Gene Product:Transcriptional regulator, AraC family \| Pathway: \| COG: Signal transduction mechanisms CD630_26150 - Type: Gene Product:Transcriptional regulator, TetR family \| Pathway: \| COG: Transcription CD630_32090 - Type: Gene Product:Transcriptional regulator, PadR family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test CD630_12750 - codY Type: Gene Product:Transcriptional regulator, GTP-sensingpleiotropic repressor \| Pathway: \| COG: Transcription
Module_285	23 CD630_13480 - Type: Gene Product:Putative lipoprotein \| Pathway: \| COG: CD630_29410 - Type: Gene Product:Putative phage single-strand DNA-binding protein \| Pathway: \| COG: Replication, recombination and repair CD630_13310 - sip3 Type: Gene Product:Signal peptidase I, S26A family \| Pathway: \| COG: Intracellular trafficking, secretion, and vesicular transport CD630_29900 - ssuB2 Type: Gene Product:ABC-type transport system, sulfonate-familyATP-binding protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_13330 - Type: Gene Product:Putative phage tyrosine recombinase \| Pathway: \| COG: Replication, recombination and repair CD630_29920 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_13440 - Type: Gene Product:Putative cell wall biosynthesis protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_13460 - Type: Gene Product:Conserved hypothetical protein, DUF1700 \| Pathway: \| COG: Function unknown CD630_13500 - cprB Type: Gene Product:ABC-type transport system, cationic antimicrobialpeptide resistance permease \| Pathway: \| COG: Function unknown CD630_13520 - cprK Type: Gene Product:Two-component sensor histidine kinase, cationicantimicrobial peptide resistance \| Pathway: \| COG: Signal transduction mechanisms CD630_32480 - Type: Gene Product:Polysaccharide deacetylase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_15300 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_13340 - purB Type: Gene Product:Adenylosuccinate lyase \| Pathway: Purine metabolism \| COG: Nucleotide transport and metabolism CD630_29910 - ssuC2 Type: Gene Product:ABC-type transport system, sulfonate-familypermease \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_13490 - cprA Type: Gene Product:ABC-type transport system, cationic antimicrobialpeptide resistance ATP-binding protein \| Pathway: \| COG: Defense mechanisms CD630_13450 - Type: Gene Product:Transcriptional regulator, PadR family \| Pathway: \| COG: Transcription CD630_13320 - uppP1 Type: Gene Product:Undecaprenyl-diphosphatase 1 (Undecaprenylpyrophosphate phosphatase 1) (Bacitracin resistance protein1) \| Pathway: \| COG: Defense mechanisms CD630_13470 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_13510 - cprC Type: Gene Product:ABC-type transport system, cationic antimicrobialpeptide resistance permease \| Pathway: \| COG: Function unknown CD630_32490 - sspB Type: Gene Product:Small, acid-soluble spore protein beta \| Pathway: \| COG: Function unknown CD630_29890 - ssuA2 Type: Gene Product:ABC-type transport system, sulfonate-familyextracellular solute-binding protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_17620 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_25250 - recX Type: Gene Product:Regulatory protein RecX \| Pathway: \| COG: Function unknown	0.00000019	0.0000097	0.58	Inferelator: 3 Hypergeometric: 0 TF Influences from Inferelator CD630_10090 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_19100 - eutV Type: Gene Product:Two-component response regulator, Ethanolaminespecific \| Pathway: \| COG: Signal transduction mechanisms CD630_34990 - spoVT Type: Gene Product:Stage V sporulation protein T \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_384	17 CD630_04730 - Type: Gene Product:Transcriptional regulator, MarR family \| Pathway: \| COG: Transcription CD630_30130 - Type: Gene Product:PTS system, mannose-specfic IIC component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_04720 - Type: Gene Product:Putative reductase \| Pathway: \| COG: Function unknown CD630_04700 - blaR Type: Gene Product:Beta-lactamase-inducing penicillin-bindingprotein \| Pathway: \| COG: Transcription, Signal transduction mechanisms CD630_30120 - Type: Gene Product:Putative alpha-mannosidase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_30160 - Type: Gene Product:Transcription antiterminator, PTS operonregulator \| Pathway: \| COG: Transcription CD630_17000 - ribD Type: Gene Product:Riboflavin biosynthesis protein ribD [Includes:Diaminohydroxyphosphoribosylaminopyrimidine deaminase ;5-amino-6-(5-phosphoribosylamino)uracil reductase] \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism CD630_22540 - Type: Gene Product:Asp/Glu racemase \| Pathway: \| COG: Amino acid transport and metabolism CD630_30140 - Type: Gene Product:PTS system, mannose-specfic IIB component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_04740 - Type: Gene Product:Putative iron-sulfur protein \| Pathway: \| COG: Energy production and conversion CD630_30150 - Type: Gene Product:PTS system, mannose-specfic IIA component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_16980 - ribBA Type: Gene Product:Riboflavin biosynthesis protein ribBA [Includes:3,4-dihydroxy-2-butanone 4-phosphate synthase; GTPcyclohydrolase-2] \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism CD630_30170 - Type: Gene Product:Putative glucose uptake protein \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_16990 - ribE Type: Gene Product:Riboflavin synthase alpha subunit \| Pathway: \| COG: Coenzyme transport and metabolism CD630_04710 - blaI Type: Gene Product:Transcriptional regulator, Penicillinaserepressor \| Pathway: \| COG: Transcription CD630_22530 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_16970 - ribH Type: Gene Product:6,7-dimethyl-8-ribityllumazine synthase \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism	0.000000047	0.09	0.58	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_23900 - Type: Gene Product:Transcriptional regulator, beta-lactamsrepressor \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_318	21 CD630_29780 - Type: Gene Product:Putative CRISPR-associated Cas3 family helicase \| Pathway: \| COG: Replication, recombination and repair CD630_07150 - ptb Type: Gene Product:Phosphate butyryltransferase(Phosphotransbutyrylase) \| Pathway: \| COG: Energy production and conversion CD630_29790 - Type: Gene Product:Putative CRISPR-associated Cas5 family protein \| Pathway: \| COG: Replication, recombination and repair CD630_21150 - Type: Gene Product:Putative copper-transporting P-type ATPase \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_29820 - Type: Gene Product:Putative CRISPR-associated Cas6 family protein \| Pathway: \| COG: Replication, recombination and repair CD630_27500 - agrB Type: Gene Product:Accessory gene regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_29770 - Type: Gene Product:Putative CRISPR-associated Cas4 family protein \| Pathway: \| COG: Replication, recombination and repair CD630_31720 - tpi Type: Gene Product:Triosephosphate isomerase (TIM) (Triose-phosphateisomerase) \| Pathway: Carbohydrate biosynthesis \| COG: Carbohydrate transport and metabolism CD630_31710 - gpmI Type: Gene Product:2,3-bisphosphoglycerate-independentphosphoglycerate mutase (Phosphoglyceromutase)(BPG-independent PGAM) (iPGM) \| Pathway: Carbohydrate degradation \| COG: Carbohydrate transport and metabolism CD630_29760 - Type: Gene Product:Putative CRISPR-associated Cas1 family protein \| Pathway: \| COG: Replication, recombination and repair CD630_27491 - agrD Type: Gene Product:Autoinducer prepeptide \| Pathway: \| COG: CD630_31730 - pgk Type: Gene Product:Phosphoglycerate kinase \| Pathway: Carbohydrate degradation \| COG: Carbohydrate transport and metabolism CD630_07140 - Type: Gene Product:Putative protein involved in protein-proteininteractions \| Pathway: \| COG: Function unknown CD630_29750 - Type: Gene Product:Putative CRISPR-associated Cas2 family protein \| Pathway: \| COG: Replication, recombination and repair CD630_07121 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_31740 - gapA Type: Gene Product:Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_07130 - Type: Gene Product:Putative radical SAM domain-containing protein \| Pathway: \| COG: Energy production and conversion CD630_29810 - Type: Gene Product:Putative CRISPR-associated protein, CXXC-CXXC \| Pathway: \| COG: Replication, recombination and repair CD630_20720 - Type: Gene Product:Putative transposase \| Pathway: \| COG: Replication, recombination and repair CD630_31750 - cggR Type: Gene Product:Transcriptional regulator, SorC family \| Pathway: \| COG: Transcription CD630_29800 - Type: Gene Product:Putative CRISPR-associated autoregulator DevRfamily protein protein \| Pathway: \| COG: Replication, recombination and repair	0	1.8	0.58	Inferelator: 1 Hypergeometric: 2 TF Influences from Inferelator CD630_31750 - cggR Type: Gene Product:Transcriptional regulator, SorC family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test CD630_32450 - prdR Type: Gene Product:Transcriptional regulator, sigma-54-dependent \| Pathway: \| COG: Transcription CD630_10640 - ccpA Type: Gene Product:Transcriptional regulator, LacI family \| Pathway: \| COG: Transcription
Module_46	23 CD630_04730 - Type: Gene Product:Transcriptional regulator, MarR family \| Pathway: \| COG: Transcription CD630_03470 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_03430 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_03450 - Type: Gene Product:Putative GTP pyrophosphokinase \| Pathway: \| COG: Function unknown CD630_11420 - rnfB Type: Gene Product:Electron transport complex protein \| Pathway: \| COG: Energy production and conversion CD630_17290 - Type: Gene Product:Putative sodium:phosphate symporter \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_11400 - rnfE Type: Gene Product:Electron transport complex protein \| Pathway: \| COG: Energy production and conversion CD630_10170 - Type: Gene Product:ABC-type transport system, multidrug-familyATP-binding protein/permease \| Pathway: \| COG: Defense mechanisms CD630_14700 - Type: Gene Product:Putative rhodanese-like domain-containingprotein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_21830 - csdA Type: Gene Product:ATP-dependent RNA helicase \| Pathway: \| COG: Replication, recombination and repair CD630_04740 - Type: Gene Product:Putative iron-sulfur protein \| Pathway: \| COG: Energy production and conversion CD630_10180 - Type: Gene Product:ABC-type transport system, multidrug-familyATP-binding protein/permease \| Pathway: \| COG: Defense mechanisms CD630_11390 - rnfG Type: Gene Product:Electron transport complex protein \| Pathway: \| COG: Energy production and conversion CD630_03460 - Type: Gene Product:Putative phosphoesterase \| Pathway: \| COG: Function unknown CD630_04720 - Type: Gene Product:Putative reductase \| Pathway: \| COG: Function unknown CD630_04700 - blaR Type: Gene Product:Beta-lactamase-inducing penicillin-bindingprotein \| Pathway: \| COG: Transcription, Signal transduction mechanisms CD630_14690 - cwp20 Type: Gene Product:Putative cell surface protein ; putativepenicillin-binding protein \| Pathway: \| COG: Defense mechanisms CD630_03440 - Type: Gene Product:Putative beta-lactamase-like protein \| Pathway: \| COG: Function unknown CD630_10160 - Type: Gene Product:Transcriptional regulator, MerR family \| Pathway: \| COG: Transcription CD630_11410 - rnfA Type: Gene Product:Electron transport complex protein \| Pathway: \| COG: Energy production and conversion CD630_15830 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_04710 - blaI Type: Gene Product:Transcriptional regulator, Penicillinaserepressor \| Pathway: \| COG: Transcription CD630_11380 - rnfD Type: Gene Product:Electron transport complex protein \| Pathway: \| COG: Energy production and conversion	0.000000000057	0.0000054	0.58	Inferelator: 4 Hypergeometric: 1 TF Influences from Inferelator CD630_11770 - fapR Type: Gene Product:Transcriptional regulator, DeoR family (Fattyacid and phospholipid biosynthesis regulator) \| Pathway: \| COG: Transcription CD630_16930 - Type: Gene Product:Putative dinitrogenase iron-molybdenum cofactor \| Pathway: \| COG: Function unknown CD630_19100 - eutV Type: Gene Product:Two-component response regulator, Ethanolaminespecific \| Pathway: \| COG: Signal transduction mechanisms CD630_26650 - Type: Gene Product:Transcriptional regulator, AraC family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test CD630_32450 - prdR Type: Gene Product:Transcriptional regulator, sigma-54-dependent \| Pathway: \| COG: Transcription
Module_191	28 CD630_01620 - Type: Gene Product:Putative radical SAM-family protein \| Pathway: \| COG: Function unknown CD630_13000 - pepA Type: Gene Product:Leucine aminopeptidase \| Pathway: \| COG: Amino acid transport and metabolism CD630_04410 - Type: Gene Product:Transcriptional regulator, sigma-54-dependent \| Pathway: \| COG: Transcription CD630_01600 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_28310 - Type: Gene Product:Collagen binding protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_28350 - abgT Type: Gene Product:Aminobenzoyl-glutamate transport protein \| Pathway: \| COG: Coenzyme transport and metabolism CD630_02410 - Type: Gene Product:Phosphate-threonine kinase \| Pathway: \| COG: Amino acid transport and metabolism CD630_32830 - pflE Type: Gene Product:Pyruvate formate-lyase (activating enzyme) \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_36390 - Type: Gene Product:Transcriptional regulator, LysR family \| Pathway: \| COG: Transcription CD630_12980 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_02020 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_24310 - Type: Gene Product:Putative nitrite/sulphite reductase \| Pathway: \| COG: Energy production and conversion CD630_01632 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_01630 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_01631 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_02750 - splB Type: Gene Product:Spore photoproduct (thymine dimer) lyase, radicalS-adenosylmethionine superfamily \| Pathway: \| COG: Replication, recombination and repair CD630_01610 - Type: Gene Product:ABC-type transport system, multidrug-familyATP-binding protein \| Pathway: \| COG: Defense mechanisms CD630_01290 - Type: Gene Product:Conserved hypothetical protein, DUF1256 family \| Pathway: \| COG: Function unknown CD630_02420 - Type: Gene Product:Phosphothreonine N-acetylglucosamine catalysis \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_28340 - glyA Type: Gene Product:Serine hydroxymethyltransferase (Serinemethylase) (SHMT) \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_28360 - Type: Gene Product:Putative peptidase, M20D family \| Pathway: \| COG: Amino acid transport and metabolism CD630_00181 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_05750 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_32820 - pflD Type: Gene Product:Pyruvate formate-lyase \| Pathway: \| COG: Energy production and conversion CD630_12990 - Type: Gene Product:Transcriptional regulator, MarR family \| Pathway: \| COG: Transcription CD630_32140 - Type: Gene Product:Transcriptional regulator, AraC family \| Pathway: \| COG: Transcription CD630_12970 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG:	0.0000000000000077	`NA`	0.58	Inferelator: 3 Hypergeometric: 0 TF Influences from Inferelator CD630_16930 - Type: Gene Product:Putative dinitrogenase iron-molybdenum cofactor \| Pathway: \| COG: Function unknown CD630_19100 - eutV Type: Gene Product:Two-component response regulator, Ethanolaminespecific \| Pathway: \| COG: Signal transduction mechanisms CD630_31750 - cggR Type: Gene Product:Transcriptional regulator, SorC family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_143	22 CD630_36050 - Type: Gene Product:Putative phosphatase \| Pathway: \| COG: Function unknown CD630_31480 - Type: Gene Product:Hypothetical protein \| Pathway: \| COG: Function unknown CD630_14510 - folB Type: Gene Product:Dihydroneopterin aldolase \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism CD630_14430 - Type: Gene Product:Putative Ca++-chelating serine protease, SCP-likeextracellular domain protein \| Pathway: \| COG: Secondary metabolites biosynthesis, transport and catabolism CD630_14470 - pabC Type: Gene Product:Aminodeoxychorismate lyase(4-amino-4-deoxychorismate lyase) (ADC lyase) (ADCL) \| Pathway: \| COG: Amino acid transport and metabolism CD630_14530 - aroF Type: Gene Product:Phospho-2-dehydro-3-deoxyheptonate aldolase \| Pathway: \| COG: Amino acid transport and metabolism CD630_14450 - pabA Type: Gene Product:Para-aminobenzoate/anthranilate synthaseglutamine amidotransferase component II [Includes:Para-aminobenzoate synthase glutamine amidotransferasecomponent II; Anthranilate synthase component II] \| Pathway: \| COG: Amino acid transport and metabolism CD630_34370 - cobS Type: Gene Product:Cobalamin synthase CobS (Cobalamin-5-phosphatesynthase) \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism CD630_14490 - folE Type: Gene Product:GTP cyclohydrolase 1 (GTP cyclohydrolase I)(GTP-CH-I) \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism CD630_36040 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Carbohydrate transport and metabolism, Cell wall/membrane/envelope biogenesis CD630_31490 - Type: Gene Product:DNA helicase \| Pathway: \| COG: Replication, recombination and repair CD630_34390 - cobT Type: Gene Product:Nicotinate-nucleotide--dimethylbenzimidazolephosphoribosyltransferase (NN:DBI PRT)(N(1)-alpha-phosphoribosyltransferase) \| Pathway: Nucleoside biosynthesis \| COG: Coenzyme transport and metabolism CD630_01500 - Type: Gene Product:Putative peptidase, M22 family \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_14500 - folP Type: Gene Product:Dihydropteroate synthase \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism CD630_14520 - folK Type: Gene Product:2-amino-4-hydroxy-6-hydroxymethyldihydropteridinepyrophosphokinase \| Pathway: \| COG: Coenzyme transport and metabolism CD630_14440 - Type: Gene Product:Putative exported polysaccharide deacetylase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_14460 - pabB Type: Gene Product:Para-aminobenzoate synthase component I \| Pathway: \| COG: Amino acid transport and metabolism, Coenzyme transport and metabolism CD630_34360 - cobC Type: Gene Product:Cobalamin biosynthesis phosphoglycerate mutaseCobC \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_01980 - guaA Type: Gene Product:Glutamine amidotransferase \| Pathway: Purine metabolism \| COG: Nucleotide transport and metabolism CD630_36030 - Type: Gene Product:Putative phosphoesterase \| Pathway: \| COG: Function unknown CD630_14480 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_31500 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown	`NA`	`NA`	0.58	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_04020 - Type: Gene Product:Transcriptional regulator, sigma-54-dependent \| Pathway: \| COG: Transcription CD630_17820 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`