Module 569 Residual: 0.58

Title Bicluster Model Residual Score
bicluster_0569 v02 0.58 -7.82
Displaying 1 - 14 of 14
Rv0189c Dihydroxy-acid dehydratase (EC 4.2.1.9)

Details for Rv0189c - Dihydroxy-acid dehydratase (EC 4.2.1.9)

GO Terms: GO:0004160, GO:0005886, GO:0040007

PATRIC Pathways: Pantothenate and CoA biosynthesis, Valine, leucine and isoleucine biosynthesis

Essentiality: Griffin Essential: 0.00 | In vitro Essential: 0.09 | In vivo Essential: NA

Go to Gene Page: Rv0189c

Tuberculist Genomic Region

Rv0356c

Details for Rv0356c -

GO Terms: NA

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.92 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv0356c

Tuberculist Genomic Region

Rv0357c Adenylosuccinate synthetase (EC 6.3.4.4)

Details for Rv0357c - Adenylosuccinate synthetase (EC 6.3.4.4)

GO Terms: GO:0004019, GO:0040007

PATRIC Pathways: Alanine, aspartate and glutamate metabolism, Purine metabolism

Essentiality: Griffin Essential: 0.00 | In vitro Essential: 0.17 | In vivo Essential: NA

Go to Gene Page: Rv0357c

Tuberculist Genomic Region

Rv0663 Arylsulfatase (EC 3.1.6.1)

Details for Rv0663 - Arylsulfatase (EC 3.1.6.1)

GO Terms: NA

PATRIC Pathways: C21-Steroid hormone metabolism, Sphingolipid metabolism

Essentiality: Griffin Essential: 0.02 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv0663

Tuberculist Genomic Region

Rv0686 FIG025093: Probable membrane protein

Details for Rv0686 - FIG025093: Probable membrane protein

GO Terms: GO:0005515, GO:0005886, GO:0005887

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 1.00 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv0686

Tuberculist Genomic Region

Rv0687 3-oxoacyl-[acyl-carrier protein] reductase (EC 1.1.1.100)

Details for Rv0687 - 3-oxoacyl-[acyl-carrier protein] reductase (EC 1.1.1.100)

GO Terms: NA

PATRIC Pathways: Fatty acid biosynthesis

Essentiality: Griffin Essential: 0.24 | In vitro Essential: NA | In vivo Essential: 0.39

Go to Gene Page: Rv0687

Tuberculist Genomic Region

Rv0688 Ferredoxin reductase

Details for Rv0688 - Ferredoxin reductase

GO Terms: GO:0005515, GO:0008860, GO:0009055, GO:0050660, GO:0051287

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.91 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv0688

Tuberculist Genomic Region

Rv1070c 3-methylthioacryloyl-CoA hydratase 2 (DmdD2)

Details for Rv1070c - 3-methylthioacryloyl-CoA hydratase 2 (DmdD2)

GO Terms: GO:0004300, GO:0005886

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.87 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv1070c

Tuberculist Genomic Region

Rv1071c 3-hydroxyisobutyryl-CoA hydrolase (EC 3.1.2.4)

Details for Rv1071c - 3-hydroxyisobutyryl-CoA hydrolase (EC 3.1.2.4)

GO Terms: GO:0003860, GO:0005829

PATRIC Pathways: beta-Alanine metabolism, Valine, leucine and isoleucine degradation, Propanoate metabolism

Essentiality: Griffin Essential: 0.96 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv1071c

Tuberculist Genomic Region

Rv1114 PIN domain protein

Details for Rv1114 - PIN domain protein

GO Terms: GO:0045926

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.78 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv1114

Tuberculist Genomic Region

Rv1116

Details for Rv1116 -

GO Terms: NA

PATRIC Pathways: NA

Essentiality: Griffin Essential: 0.17 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv1116

Tuberculist Genomic Region

Rv1430 PE family protein

Details for Rv1430 - PE family protein

GO Terms: NA

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.92 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv1430

Tuberculist Genomic Region

Rv1835c Glutaryl-7-ACA acylase

Details for Rv1835c - Glutaryl-7-ACA acylase

GO Terms: GO:0005886

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 1.00 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv1835c

Tuberculist Genomic Region

Rv3727 POSSIBLE OXIDOREDUCTASE

Details for Rv3727 - POSSIBLE OXIDOREDUCTASE

GO Terms: GO:0005886

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.99 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv3727

Tuberculist Genomic Region

Displaying 1 - 1 of 1
Motif 1 Motif 2
e-value: 500 e-value: 460
Displaying 1 - 1 of 1
Leucine-responsive regulatory protein, regulator for leucine (or lrp) regulon and high-affinity branched-chain amino acid transport system
regulates 24 modules
Weight: 
0.32
up-regulates
Lactate-responsive regulator LldR in Enterobacteria, GntR family
regulates 28 modules
Weight: 
0.26
up-regulates
Displaying 1 - 1 of 1
Module GO Term Enrichment Descriptions
GO:0004731 purine-nucleoside phosphorylase activity
Displaying 1 - 15 of 15
GO:0004160 |

dihydroxy-acid dehydratase activity

GO:0005886 |

plasma membrane

GO:0040007 |

growth

GO:0004019 |

adenylosuccinate synthase activity

GO:0005515 |

protein binding

GO:0005887 |

integral to plasma membrane

GO:0008860 |

ferredoxin-NAD+ reductase activity

GO:0009055 |

electron carrier activity

GO:0050660 |

flavin adenine dinucleotide binding

GO:0051287 |

NAD binding

GO:0004300 |

enoyl-CoA hydratase activity

GO:0003860 |

3-hydroxyisobutyryl-CoA hydrolase activity

GO:0005829 |

cytosol

GO:0045926 |

negative regulation of growth