Module 585 Residual: 0.58

Title Bicluster Model Residual Score
bicluster_0585 v02 0.58 -10.81
Displaying 1 - 17 of 17
Rv2574

Details for Rv2574 -

GO Terms: GO:0005886

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.90 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv2574

Tuberculist Genomic Region

Rv0092 Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4)

Details for Rv0092 - Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4)

GO Terms: GO:0004008

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.85 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv0092

Tuberculist Genomic Region

Rv0314c Cell division protein DivIC (FtsB), stabilizes FtsL against RasP cleavage

Details for Rv0314c - Cell division protein DivIC (FtsB), stabilizes FtsL against RasP cleavage

GO Terms: NA

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.83 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv0314c

Tuberculist Genomic Region

Rv0337c Alanine transaminase (EC 2.6.1.2)

Details for Rv0337c - Alanine transaminase (EC 2.6.1.2)

GO Terms: GO:0005886, GO:0040007

PATRIC Pathways: Carbon fixation in photosynthetic organisms, Alanine, aspartate and glutamate metabolism

Essentiality: Griffin Essential: 0.00 | In vitro Essential: 0.06 | In vivo Essential: NA

Go to Gene Page: Rv0337c

Tuberculist Genomic Region

Rv1074c 3-ketoacyl-CoA thiolase (EC 2.3.1.16) @ Acetyl-CoA acetyltransferase (EC 2.3.1.9)
Rv1932 Thiol peroxidase, Tpx-type (EC 1.11.1.15)

Details for Rv1932 - Thiol peroxidase, Tpx-type (EC 1.11.1.15)

GO Terms: GO:0004601, GO:0005576, GO:0042803, GO:0051920, GO:0055114, GO:0070402

PATRIC Pathways: Glutathione metabolism

Essentiality: Griffin Essential: 0.90 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv1932

Tuberculist Genomic Region

Rv2046 Probable lipoprotein lppI

Details for Rv2046 - Probable lipoprotein lppI

GO Terms: GO:0005886

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.92 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv2046

Tuberculist Genomic Region

Rv2054 Dienelactone hydrolase family protein

Details for Rv2054 - Dienelactone hydrolase family protein

GO Terms: GO:0005829, GO:0005886

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.88 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv2054

Tuberculist Genomic Region

Rv2259 Formaldehyde dehydrogenase MscR, NAD/mycothiol-dependent (EC 1.2.1.66) / S-nitrosomycothiol reductase MscR

Details for Rv2259 - Formaldehyde dehydrogenase MscR, NAD/mycothiol-dependent (EC 1.2.1.66) / S-nitrosomycothiol reductase MscR

GO Terms: GO:0010127, GO:0016491, GO:0050607, GO:0055114

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.20 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv2259

Tuberculist Genomic Region

Rv2260 Putative hydrolase in cluster with formaldehyde/S-nitrosomycothiol reductase MscR

Details for Rv2260 - Putative hydrolase in cluster with formaldehyde/S-nitrosomycothiol reductase MscR

GO Terms: GO:0004416, GO:0040007

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.53 | In vitro Essential: 0.17 | In vivo Essential: NA

Go to Gene Page: Rv2260

Tuberculist Genomic Region

Rv2482c Glycerol-3-phosphate acyltransferase (EC 2.3.1.15)

Details for Rv2482c - Glycerol-3-phosphate acyltransferase (EC 2.3.1.15)

GO Terms: GO:0004366, GO:0005886

PATRIC Pathways: Glycerolipid metabolism, Glycerophospholipid metabolism

Essentiality: Griffin Essential: 0.49 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv2482c

Tuberculist Genomic Region

Rv2483c Phosphoserine phosphatase (EC 3.1.3.3) / 1-acyl-sn-glycerol-3-phosphate acyltransferase (EC 2.3.1.51)

Details for Rv2483c - Phosphoserine phosphatase (EC 3.1.3.3) / 1-acyl-sn-glycerol-3-phosphate acyltransferase (EC 2.3.1.51)

GO Terms: GO:0005886

PATRIC Pathways: Methane metabolism, Glycine, serine and threonine metabolism, Glycerophospholipid metabolism, Glycerolipid metabolism

Essentiality: Griffin Essential: 0.57 | In vitro Essential: NA | In vivo Essential: 0.31

Go to Gene Page: Rv2483c

Tuberculist Genomic Region

Rv2484c Acyltransferase, ws/dgat/mgat subfamily protein

Details for Rv2484c - Acyltransferase, ws/dgat/mgat subfamily protein

GO Terms: GO:0005886

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 1.00 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv2484c

Tuberculist Genomic Region

Rv3035

Details for Rv3035 -

GO Terms: NA

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.00 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv3035

Tuberculist Genomic Region

Rv3042c Phosphoserine phosphatase (EC 3.1.3.3)

Details for Rv3042c - Phosphoserine phosphatase (EC 3.1.3.3)

GO Terms: GO:0004647, GO:0040007

PATRIC Pathways: Glycine, serine and threonine metabolism, Methane metabolism

Essentiality: Griffin Essential: 0.00 | In vitro Essential: 0.12 | In vivo Essential: 0.15

Go to Gene Page: Rv3042c

Tuberculist Genomic Region

Rv3732

Details for Rv3732 -

GO Terms: GO:0005887

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.99 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv3732

Tuberculist Genomic Region

Rv3853 Ribonuclease E inhibitor RraA

Details for Rv3853 - Ribonuclease E inhibitor RraA

GO Terms: GO:0070207, GO:0008757

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.40 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv3853

Tuberculist Genomic Region

Displaying 1 - 1 of 1
Motif 1 Motif 2
e-value: 0.055 e-value: 350
Displaying 1 - 1 of 1
Transcriptional regulator, TetR family
regulates 10 modules
Weight: 
0.25
up-regulates
cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases
regulates 28 modules
Weight: 
0.25
up-regulates
Disease resistance domain-containing protein / Transcriptional regulator, LuxR family
regulates 26 modules
Weight: 
0.24
up-regulates
Displaying 1 - 1 of 1
Module GO Term Enrichment Descriptions
GO:0051188 | GO:0006732 | GO:0051186 cofactor biosynthetic process | coenzyme metabolic process | cofactor metabolic process
Displaying 1 - 20 of 20
GO:0005886 |

plasma membrane

GO:0004008 |

copper-exporting ATPase activity

GO:0040007 |

growth

GO:0005576 |

extracellular region

GO:0004601 |

peroxidase activity

GO:0042803 |

protein homodimerization activity

GO:0051920 |

peroxiredoxin activity

GO:0055114 |

oxidation-reduction process

GO:0070402 |

NADPH binding

GO:0005829 |

cytosol

GO:0010127 |

mycothiol-dependent detoxification

GO:0016491 |

oxidoreductase activity

GO:0050607 |

mycothiol-dependent formaldehyde dehydrogenase activity

GO:0004416 |

hydroxyacylglutathione hydrolase activity

GO:0004366 |

glycerol-3-phosphate O-acyltransferase activity

GO:0004647 |

phosphoserine phosphatase activity

GO:0005887 |

integral to plasma membrane

GO:0070207 |

protein homotrimerization

GO:0008757 |

S-adenosylmethionine-dependent methyltransferase activity