Environment and Gene Regulatory Influence Network (EGRIN) model for C. difficile 630

The Environment and Gene Regulatory Influence Network (EGRIN) model of C. difficile 630 was inferred using cMonkey2 and a compendium of 136 transcriptomes (retrieved from the Gene Expression Omnibus repository) with 4,070 sequence features including 35 rRNAs and 90 tRNAs . The C. difficile EGRIN model groups genes in subsets (406 modules in total), that are co-regulated in specific environments, and also identifies the associated, putative cis-acting gene regulatory elements (GREs), which represent potential TF binding locations. Transcriptome compendium included conditions: response to iron limitation, response to oxygen, in vivo vs in vitro growth, short term infection (0, 30, 60, 120 mins), response to commensals and host diet, transition from exponential to stationary phase, fur KO, codY KO, sporulation TF (and sigma factors) KOs.

Explore Regulatory Modules

Displaying 251 - 260 of 406

Candidate transcriptional regulators for each module were determined with a linear regression based approach (Inferelator) and by evaluating the statistical significance of the overlap (Hypergeometric) between modules and putative TF and alternative sigma factor regulons (CcpA, CodY, Fur, PrdR, SigB, SigD, SigE, SigF, SigG, SigH, SigK, Spo0A) compiled from available literature.

* Given that translation start was used to define the 3' end of putative promoters, some cis-regulatory motifs are likely to be ribosome binding sites (i.e., Shine-Dalgarno sequence). RBS is typically a six nucleotide sequence 5'-GGAGGA-3'.

Title	Gene Count	Motif 1 e-value	Motif 2 e-value	Residual	TF Influences
Module_347	13 CD630_r0250 - 23s_rRNA Type: Gene Product: \| Pathway: \| COG: CD630_r0130 - 16s_rRNA Type: Gene Product: \| Pathway: \| COG: CD630_r0050 - 23s_rRNA Type: Gene Product: \| Pathway: \| COG: CD630_r0080 - 23s_rRNA Type: Gene Product: \| Pathway: \| COG: CD630_r0280 - 23s_rRNA Type: Gene Product: \| Pathway: \| COG: CD630_19360 - accA Type: Gene Product:Acetyl-coenzyme A carboxylase carboxyltransferase subunit alpha \| Pathway: Lipid metabolism \| COG: Lipid transport and metabolism CD630_r0200 - 23s_rRNA Type: Gene Product: \| Pathway: \| COG: CD630_19380 - accC Type: Gene Product:Acetyl-CoA carboxylase subunit \| Pathway: Lipid metabolism \| COG: Lipid transport and metabolism CD630_r0140 - 23s_rRNA Type: Gene Product: \| Pathway: \| COG: CD630_19370 - accD Type: Gene Product:Acetyl-CoA carboxylase subunit beta \| Pathway: Lipid metabolism \| COG: Lipid transport and metabolism CD630_19390 - accB Type: Gene Product:Acetyl-CoA carboxylase subunit \| Pathway: Lipid metabolism \| COG: Lipid transport and metabolism CD630_r0020 - 23s_rRNA Type: Gene Product: \| Pathway: \| COG: CD630_r0230 - 23s_rRNA Type: Gene Product: \| Pathway: \| COG:	0	2.8026e-43	0.53	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_11770 - fapR Type: Gene Product:Transcriptional regulator, DeoR family (Fattyacid and phospholipid biosynthesis regulator) \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_225	14 CD630_01330 - Type: Gene Product:Putative phosphoribosyl transferase \| Pathway: \| COG: Function unknown CD630_02770 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_01320 - Type: Gene Product:Putative DNA helicase, RecD/TraA type \| Pathway: \| COG: Replication, recombination and repair CD630_08650 - Type: Gene Product:Putative ADP-ribose binding protein \| Pathway: \| COG: Function unknown CD630_03690 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn1-Orf14 \| Pathway: \| COG: Function unknown CD630_03720 - Type: Gene Product:Putative cell wall hydrolase Tn916-like,CTn1-Orf17 \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_02120 - Type: Gene Product:Putative sulfatase \| Pathway: \| COG: Function unknown CD630_17010 - recQ Type: Gene Product:ATP-dependent DNA helicase \| Pathway: \| COG: Replication, recombination and repair CD630_03750 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn1-Orf20 \| Pathway: \| COG: Function unknown CD630_02400 - Type: Gene Product:Glycosyltransferase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_34080 - Type: Gene Product:Putative DNA mismatch repair ATPase MutS \| Pathway: \| COG: Replication, recombination and repair CD630_28850 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_02110 - licC Type: Gene Product:CTP:phosphocholine cytidylyltransferase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_20150 - Type: Gene Product:Putative VanZ-like transposon protein \| Pathway: \| COG: Defense mechanisms	0.01	`NA`	0.53	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_18100 - Type: Gene Product:Transcriptional regulator, beta-lactamsrepressor \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_16	31 CD630_17280 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_08480 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_03470 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_03430 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_03450 - Type: Gene Product:Putative GTP pyrophosphokinase \| Pathway: \| COG: Function unknown CD630_36200 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_20940 - Type: Gene Product:Putative restriction enzyme \| Pathway: \| COG: Defense mechanisms CD630_19600 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_19620 - Type: Gene Product:ABC-type transport system, permease \| Pathway: \| COG: Defense mechanisms CD630_20960 - Type: Gene Product:Putative DNA-binding protein \| Pathway: \| COG: Transcription CD630_06011 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_33510 - clpP2 Type: Gene Product:ATP-dependent Clp protease proteolytic subunit 2(Endopeptidase Clp 2) \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_08470 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_33530 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_33520 - Type: Gene Product:Transcriptional regulator, AraC family \| Pathway: \| COG: Transcription CD630_19590 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_03460 - Type: Gene Product:Putative phosphoesterase \| Pathway: \| COG: Function unknown CD630_33490 - bclA3 Type: Gene Product:Exosporium glycoprotein \| Pathway: \| COG: Function unknown CD630_04352 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn2-Orf33 \| Pathway: \| COG: CD630_17270 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_04351 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn2-Orf32 \| Pathway: \| COG: CD630_08490 - Type: Gene Product:Putative glutamate carboxypeptidase \| Pathway: \| COG: Amino acid transport and metabolism CD630_03440 - Type: Gene Product:Putative beta-lactamase-like protein \| Pathway: \| COG: Function unknown CD630_03420 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_20950 - Type: Gene Product:Putative cell division GTPase \| Pathway: \| COG: CD630_20970 - Type: Gene Product:Putative membrane protein, DUF988 family \| Pathway: \| COG: Function unknown CD630_19610 - Type: Gene Product:ABC-type transport system, ATP-binding protein \| Pathway: \| COG: Defense mechanisms CD630_20930 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Defense mechanisms CD630_33540 - Type: Gene Product:Putative tRNA-binding protein \| Pathway: \| COG: Function unknown CD630_09180 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_08500 - Type: Gene Product:Putative NifU-like protein \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones	0.0000011	0.06	0.53	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_10090 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_226	22 CD630_13230 - tepA Type: Gene Product:Protein export-enhancing factor \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones, Intracellular trafficking, secretion, and vesicular transport CD630_07600 - Type: Gene Product:Putative Ca2+/Na+ antiporter \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_20550 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_13210 - Type: Gene Product:Putative sporulation protein \| Pathway: \| COG: Function unknown CD630_13250 - Type: Gene Product:Putative tRNA 2-selenouridine synthase,selenophosphate-dependent; Rhodanese-like domain protein \| Pathway: \| COG: Function unknown CD630_13270 - pgsA Type: Gene Product:CDP-diacylglycerol--glycerol-3-phosphate3-phosphatidyltransferase \| Pathway: \| COG: Lipid transport and metabolism CD630_07610 - Type: Gene Product:Putative ATP-dependent RNA helicase \| Pathway: \| COG: Replication, recombination and repair CD630_13540 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_22470 - cspBA Type: Gene Product:Subtilisin-like serine germination relatedprotease \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_16770 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_19290 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_13220 - dapG Type: Gene Product:Aspartokinase 1 (Aspartokinase I) (1spartatekinase I) \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_13260 - rimO Type: Gene Product:Ribosomal protein S12 methylthiotransferase \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_13200 - Type: Gene Product:Putative peptidase, M16 family \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_13240 - ftsK Type: Gene Product:DNA FtsK/SpoIIIE translocase \| Pathway: \| COG: Cell cycle control, cell division, chromosome partitioning CD630_16780 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_20560 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_13190 - Type: Gene Product:Putative polysaccharide deacetylase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_22460 - cspC Type: Gene Product:Germination- specific protease \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_01310 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_16760 - pcp Type: Gene Product:Pyrrolidone-carboxylate peptidase \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones	0.00012	`NA`	0.53	Inferelator: 4 Hypergeometric: 2 TF Influences from Inferelator CD630_12390 - Type: Gene Product:Transcriptional regulator, beta-lactams repressorPhage-type \| Pathway: \| COG: Transcription CD630_25990 - Type: Gene Product:Putative transcriptional regulator \| Pathway: \| COG: Transcription CD630_26430 - sigE Type: Gene Product:RNA polymerase sigma-E factor \| Pathway: \| COG: Transcription CD630_34990 - spoVT Type: Gene Product:Stage V sporulation protein T \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test CD630_12140 - spo0A Type: Gene Product:Stage 0 sporulation protein A \| Pathway: \| COG: Signal transduction mechanisms CD630_26430 - sigE Type: Gene Product:RNA polymerase sigma-E factor \| Pathway: \| COG: Transcription
Module_144	24 CD630_18050 - scrB Type: Gene Product:Sucrose-6-phosphate hydrolase (Sucrase)(Invertase) \| Pathway: Glycan biosynthesis \| COG: Carbohydrate transport and metabolism CD630_12950 - scpA Type: Gene Product:Segregation and condensation protein A \| Pathway: \| COG: Function unknown CD630_20510 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_12290 - Type: Gene Product:Putative peptidoglycan glycosyltransferase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_10290 - Type: Gene Product:Putative cell wall anchored protein \| Pathway: \| COG: Function unknown CD630_01510 - rimI Type: Gene Product:Putative alanine acetyltransferase, ribosomalfamily \| Pathway: \| COG: Function unknown CD630_20490 - Type: Gene Product:Putative rRNA methylase \| Pathway: \| COG: Secondary metabolites biosynthesis, transport and catabolism CD630_12270 - Type: Gene Product:Putative O-methyltransferase \| Pathway: \| COG: Function unknown CD630_32810 - proC Type: Gene Product:Pyrroline-5-carboxylate reductase \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_10320 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_10300 - Type: Gene Product:Putative glycosyl transferase, family 2 \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_12960 - scpB Type: Gene Product:Segregation and condensation protein B \| Pathway: \| COG: Transcription CD630_10340 - Type: Gene Product:Putative mannosyl-glycoproteinendo-beta-N-acetylglucosamidase \| Pathway: \| COG: Cell motility, Intracellular trafficking, secretion, and vesicular transport CD630_12940 - Type: Gene Product:Putative membrane-associated peptidase, M50family \| Pathway: \| COG: Function unknown CD630_18060 - scrK Type: Gene Product:Fructokinase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_20500 - rluB Type: Gene Product:Ribosomal large subunit pseudouridine synthase B \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_01520 - gcp Type: Gene Product:Putative O-sialoglycoprotein endopeptidase \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_12280 - Type: Gene Product:Putative peptidase, U32 family \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_01500 - Type: Gene Product:Putative peptidase, M22 family \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_12260 - Type: Gene Product:Putative aminodeoxychorismate lyase \| Pathway: \| COG: Nucleotide transport and metabolism CD630_10280 - Type: Gene Product:Putative signaling protein \| Pathway: \| COG: Signal transduction mechanisms CD630_10330 - mnaA Type: Gene Product:UDP-N-acetylglucosamine 2-epimerase(UDP-GlcNAc-2-epimerase) \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_01490 - Type: Gene Product:Putative P-loop ATPases \| Pathway: \| COG: Function unknown CD630_10310 - Type: Gene Product:Putative cell wall anchored protein \| Pathway: \| COG: Function unknown	2.2	`NA`	0.53	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_01710 - rex Type: Gene Product:Transcriptional regulator, Redox-sensingrepressor Rex \| Pathway: \| COG: Transcription CD630_06290 - Type: Gene Product:Transcriptional regulator, Crp family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_196	20 CD630_23180 - Type: Gene Product:Putative phosphohexomutase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_08950 - Type: Gene Product:Metallo-beta-lactamase superfamily exportedprotein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_00400 - Type: Gene Product:Transcription antiterminator, PTS operonregulator \| Pathway: \| COG: Signal transduction mechanisms CD630_23190 - rpe Type: Gene Product:Putative ribulose-phosphate 3-epimerase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_10200 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_23270 - gatA Type: Gene Product:PTS system, galactitol-specific IIA component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_23260 - gatB Type: Gene Product:PTS system, galactitol-specific IIB component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_00420 - Type: Gene Product:PTS system, galactitol-specific IIB component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_23230 - Type: Gene Product:Putative sugar-phosphate dehydrogenase \| Pathway: \| COG: Amino acid transport and metabolism CD630_00430 - Type: Gene Product:PTS system, galactitol-specific IIC component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_23250 - gatC Type: Gene Product:PTS system, galactitol-specific IIC component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_00410 - Type: Gene Product:PTS system, galactitol-specific IIA component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_23240 - Type: Gene Product:Putative sugar-phosphate dehydrogenase \| Pathway: \| COG: Amino acid transport and metabolism CD630_23210 - tkt Type: Gene Product:Transketolase, central and C-terminal(Sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphateglycolaldehydetransferase) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_10190 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_23200 - rpiB1 Type: Gene Product:Ribose-5-phosphate isomerase B1(Phosphoriboisomerase B) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_23220 - tkt Type: Gene Product:Transketolase, N-terminal(Sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphateglycolaldehydetransferase) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_10210 - Type: Gene Product:Putative spore coat protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_00440 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_08960 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG:	0	`NA`	0.53	Inferelator: 2 Hypergeometric: 3 TF Influences from Inferelator CD630_10090 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_19100 - eutV Type: Gene Product:Two-component response regulator, Ethanolaminespecific \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test CD630_02660 - sigD Type: Gene Product:RNA polymerase sigma-28 factor for flagellaroperon \| Pathway: \| COG: Transcription CD630_10640 - ccpA Type: Gene Product:Transcriptional regulator, LacI family \| Pathway: \| COG: Transcription CD630_31760 - glnF Type: Gene Product:RNA polymerase sigma-54 factor \| Pathway: \| COG: Transcription
Module_164	4 CD630_19500 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_19300 - Type: Gene Product:Putative lipoprotein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_28980 - Type: Gene Product:Putative phage tail fiber protein \| Pathway: \| COG: Function unknown CD630_15900 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown	0.12	`NA`	0.53	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_26400 - nrdR Type: Gene Product:Transcriptional regulator, repressor NrdR family \| Pathway: \| COG: Transcription CD630_26430 - sigE Type: Gene Product:RNA polymerase sigma-E factor \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_19	31 CD630_33170 - fdhF Type: Gene Product:Formate dehydrogenase-H (selenocysteine) \| Pathway: \| COG: Energy production and conversion CD630_24160 - Type: Gene Product:Transcription antiterminator, PTS operonregulator \| Pathway: \| COG: Transcription CD630_00380 - acoC Type: Gene Product:Acetoin dehydrogenase E2 component(dihydrolipoamide acetyltransferase) \| Pathway: \| COG: Energy production and conversion CD630_28210 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_07830 - spoIVB Type: Gene Product:Stage IV sporulation protein SpoIVB, S55peptidase family \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_27080 - aroE2 Type: Gene Product:Shikimate dehydrogenase 2 \| Pathway: Metabolic intermediate biosynthesis \| COG: Amino acid transport and metabolism CD630_00360 - acoA Type: Gene Product:Acetoin dehydrogenase E1 component (TPP-dependentalpha subunit) \| Pathway: \| COG: Energy production and conversion CD630_24140 - Type: Gene Product:PTS system, Sorbitol-like IIA component(Glucitol) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_27070 - Type: Gene Product:Transporter, Major Facilitator Superfamily (MFS) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_07990 - Type: Gene Product:Putative beta-alanine CoA-transferase, familyIII \| Pathway: \| COG: Energy production and conversion CD630_16450 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_22800 - Type: Gene Product:PTS system, fructose/mannitol family IICcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_00390 - acoL Type: Gene Product:Acetoin dehydrogenase E3 component(dihydrolipoamide dehydrogenase) \| Pathway: \| COG: Energy production and conversion CD630_22820 - Type: Gene Product:PTS system, fructose/mannitol family IIAcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_27090 - Type: Gene Product:Putative oxidoreductase \| Pathway: \| COG: Energy production and conversion CD630_33160 - fdhD Type: Gene Product:Formate dehydrogenase formation protein \| Pathway: \| COG: Energy production and conversion CD630_33140 - hydA Type: Gene Product:Iron hydrogenase \| Pathway: \| COG: Energy production and conversion CD630_00350 - Type: Gene Product:Transcriptional regulator \| Pathway: \| COG: Transcription CD630_07840 - Type: Gene Product:Putative N-acetylmuramoyl-L-alanine amidase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_00370 - acoB Type: Gene Product:Acetoin dehydrogenase E1 component (TPP-dependentbeta subunit) \| Pathway: \| COG: Energy production and conversion CD630_28200 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_24150 - Type: Gene Product:Putative sorbitol-like operon activator protein(Glucitol) \| Pathway: \| COG: CD630_07980 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_16460 - Type: Gene Product:Putative peptidase, M19 family \| Pathway: \| COG: Amino acid transport and metabolism CD630_24130 - Type: Gene Product:Putative NAD(P)-binding protein \| Pathway: \| COG: Amino acid transport and metabolism CD630_27100 - Type: Gene Product:Putative sugar phosphate epimerase/isomerase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_28220 - Type: Gene Product:Putative glutamate carboxypeptidase, M20 family \| Pathway: \| COG: Amino acid transport and metabolism CD630_33150 - hydN2 Type: Gene Product:Putative oxidoreductase, Fe-S subunit \| Pathway: \| COG: Energy production and conversion CD630_33151 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_33130 - hydN1 Type: Gene Product:Putative oxidoreductase, Fe-S subunit \| Pathway: \| COG: Energy production and conversion CD630_22830 - Type: Gene Product:Sigma-54-dependent regulator, PTS regulatorydomain \| Pathway: \| COG: Transcription	0.31	`NA`	0.53	Inferelator: 3 Hypergeometric: 0 TF Influences from Inferelator CD630_02760 - Type: Gene Product:Transcriptional regulator, AraC family \| Pathway: \| COG: Transcription CD630_05790 - Type: Gene Product:Transcriptional regulator, TetR family \| Pathway: \| COG: Transcription CD630_22830 - Type: Gene Product:Sigma-54-dependent regulator, PTS regulatorydomain \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_245	31 CD630_05822 - Type: Gene Product:Fragment of putative signaling protein precursor(N-terminal region) \| Pathway: \| COG: Signal transduction mechanisms CD630_26050 - Type: Gene Product:Fragment of ADP-ribosyltransferase CdtAB (Part3) \| Pathway: \| COG: CD630_18090 - Type: Gene Product:Fragment of putative permease, MFS family (Part1) \| Pathway: \| COG: Carbohydrate transport and metabolism, Carbohydrate transport and metabolism CD630_07650 - srlEa Type: Gene Product:PTS system, sorbitol-specific IIB N-terminalcomponent (Glucitol) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_06421 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_11031 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn4-Orf20 \| Pathway: \| COG: CD630_08570 - oppF Type: Gene Product:Fragment of ABC-type transport system,oligopeptide-family ATP-binding protein (Part 1) \| Pathway: \| COG: Amino acid transport and metabolism, Amino acid transport and metabolism CD630_01981 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_25201 - Type: Gene Product:Fragment of conserved hypothetical protein(N-terminal part) \| Pathway: \| COG: CD630_21930 - cwp24 Type: Gene Product:Putative cell wall-binding protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_t0790 - tRNA-Ser Type: Gene Product: \| Pathway: \| COG: CD630_36740 - rsmG Type: Gene Product:Fragment of 7-methylguanosine methyltransferasespecific for the 16S rRNA (Part 2) \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis, Cell wall/membrane/envelope biogenesis CD630_08160 - bglF Type: Gene Product:PTS system, beta-glucoside-specific IIABCcomponent (Disrupted IStron) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_19020 - Type: Gene Product:Fragment of putative conjugative transposonprotein (Central region) \| Pathway: \| COG: Replication, recombination and repair CD630_19270 - Type: Gene Product:Fragment of ABC-type transport system,ATP-binding protein (Part 2) \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_18311 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_12382 - Type: Gene Product:Fragment of conserved hypothetical protein(C-terminal region) \| Pathway: \| COG: CD630_20051 - Type: Gene Product:Fragment of conserved hypothetical protein(N-terminal region) \| Pathway: \| COG: Transcription CD630_20050 - Type: Gene Product:Fragment of conserved hypothetical protein(C-terminal region) \| Pathway: \| COG: Function unknown CD630_13110 - Type: Gene Product:Putative phosphoesterase (Disrupted IStron) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis, Translation, ribosomal structure and biogenesis CD630_30080 - Type: Gene Product:Fragment of conserved hypothetical protein(N-terminal region) \| Pathway: \| COG: Function unknown CD630_22980 - srl Type: Gene Product:Actin aggregate factor \| Pathway: \| COG: CD630_05040 - Type: Gene Product:Fragment of putative cell wall hydrolase NLPC/P60family Tn5397, CTn3-Orf14 (Part 1) \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_21510 - Type: Gene Product:Putative membrane protein, DUF819 family \| Pathway: \| COG: Function unknown CD630_13880 - Type: Gene Product:Fragment of trancriptional regulator (Part 2) \| Pathway: \| COG: Transcription CD630_23590 - Type: Gene Product:Putative hydrolase, HAD superfamily, subfamilyIIB \| Pathway: \| COG: Function unknown CD630_03480 - Type: Gene Product:Fragment of conserved hypothetical protein (Part1) \| Pathway: \| COG: Secondary metabolites biosynthesis, transport and catabolism, Secondary metabolites biosynthesis, transport and catabolism CD630_36110 - Type: Gene Product:Fragment of putative drug/sodium antiporter, MATEfamily (Part 2) \| Pathway: \| COG: Defense mechanisms, Defense mechanisms CD630_33721 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn7-Orf5 \| Pathway: \| COG: CD630_14260 - Type: Gene Product:Fragment of isochorismatase (Part 2) \| Pathway: \| COG: Secondary metabolites biosynthesis, transport and catabolism, Secondary metabolites biosynthesis, transport and catabolism CD630_19440 - Type: Gene Product:Fragment of conserved hypothetical protein(C-terminal region) \| Pathway: \| COG: Function unknown	`NA`	`NA`	0.53	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_07630 - srlM Type: Gene Product:Sorbitol operon activator protein (Glucitol) \| Pathway: \| COG: Function unknown TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_386	20 CD630_17050 - thiH Type: Gene Product:Thiamine biosynthesis protein ThiH \| Pathway: \| COG: Coenzyme transport and metabolism CD630_16010 - thiE Type: Gene Product:Thiamine-phosphate pyrophosphorylase \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism CD630_07670 - srlB Type: Gene Product:PTS system, sorbitol-specific IIA component(Glucitol) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_17040 - thiG Type: Gene Product:Thiazole biosynthesis protein ThiG \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism CD630_17021 - thiS Type: Gene Product:Thiamine biosynthesis protein ThiS \| Pathway: \| COG: Coenzyme transport and metabolism CD630_07630 - srlM Type: Gene Product:Sorbitol operon activator protein (Glucitol) \| Pathway: \| COG: Function unknown CD630_16040 - Type: Gene Product:ABC-type transport system, multidrug-familyATP-binding protein \| Pathway: \| COG: Defense mechanisms CD630_07620 - srlR Type: Gene Product:PTS operon regulator \| Pathway: \| COG: Transcription CD630_17060 - thiE2 Type: Gene Product:Thiamine-phosphate pyrophosphorylase ThiE2 \| Pathway: \| COG: Coenzyme transport and metabolism CD630_16000 - thiM Type: Gene Product:Hydroxyethylthiazole kinase \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism CD630_17020 - thiC Type: Gene Product:Thiamine biosynthesis protein ThiC \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism CD630_16030 - Type: Gene Product:ABC-type transport system, multidrug-familypermease \| Pathway: \| COG: Defense mechanisms CD630_17030 - thiF Type: Gene Product:Thiamine biosynthesis protein ThiF \| Pathway: \| COG: Coenzyme transport and metabolism CD630_07680 - srlD Type: Gene Product:Sorbitol 6-phosphate 2-dehydrogenase (Glucitol) \| Pathway: \| COG: Function unknown CD630_32510 - Type: Gene Product:Putative dehydrogenase \| Pathway: \| COG: Function unknown CD630_07640 - srlA Type: Gene Product:PTS system, sorbitol-specific IIC component(Glucitol) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_16050 - Type: Gene Product:Putative transcriptional regulator \| Pathway: \| COG: Transcription CD630_15990 - thiD Type: Gene Product:Phosphomethylpyrimidine kinase \| Pathway: \| COG: Coenzyme transport and metabolism CD630_32520 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown	0	2.9	0.54	Inferelator: 3 Hypergeometric: 2 TF Influences from Inferelator CD630_07620 - srlR Type: Gene Product:PTS operon regulator \| Pathway: \| COG: Transcription CD630_07630 - srlM Type: Gene Product:Sorbitol operon activator protein (Glucitol) \| Pathway: \| COG: Function unknown CD630_27360 - Type: Gene Product:Transcriptional regulator, LysR family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test CD630_32450 - prdR Type: Gene Product:Transcriptional regulator, sigma-54-dependent \| Pathway: \| COG: Transcription CD630_02660 - sigD Type: Gene Product:RNA polymerase sigma-28 factor for flagellaroperon \| Pathway: \| COG: Transcription