Environment and Gene Regulatory Influence Network (EGRIN) model for C. difficile 630

The Environment and Gene Regulatory Influence Network (EGRIN) model of C. difficile 630 was inferred using cMonkey2 and a compendium of 136 transcriptomes (retrieved from the Gene Expression Omnibus repository) with 4,070 sequence features including 35 rRNAs and 90 tRNAs . The C. difficile EGRIN model groups genes in subsets (406 modules in total), that are co-regulated in specific environments, and also identifies the associated, putative cis-acting gene regulatory elements (GREs), which represent potential TF binding locations. Transcriptome compendium included conditions: response to iron limitation, response to oxygen, in vivo vs in vitro growth, short term infection (0, 30, 60, 120 mins), response to commensals and host diet, transition from exponential to stationary phase, fur KO, codY KO, sporulation TF (and sigma factors) KOs.

Explore Regulatory Modules

Displaying 241 - 250 of 406

Candidate transcriptional regulators for each module were determined with a linear regression based approach (Inferelator) and by evaluating the statistical significance of the overlap (Hypergeometric) between modules and putative TF and alternative sigma factor regulons (CcpA, CodY, Fur, PrdR, SigB, SigD, SigE, SigF, SigG, SigH, SigK, Spo0A) compiled from available literature.

* Given that translation start was used to define the 3' end of putative promoters, some cis-regulatory motifs are likely to be ribosome binding sites (i.e., Shine-Dalgarno sequence). RBS is typically a six nucleotide sequence 5'-GGAGGA-3'.

Title	Gene Count	Motif 1 e-value	Motif 2 e-value	Residual	TF Influences
Module_287	23 CD630_26550 - murF Type: Gene Product:UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase (UDP-MurNAc-pentapeptide synthetase)(D-alanyl-D-alanine-adding enzyme) \| Pathway: Cell wall biogenesis \| COG: Cell wall/membrane/envelope biogenesis CD630_33310 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn6-Orf7 \| Pathway: \| COG: Function unknown CD630_26470 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_26490 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_14640 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_07460 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: CD630_14660 - Type: Gene Product:ABC-type transport system, ATP-binding protein \| Pathway: \| COG: Defense mechanisms CD630_11850 - Type: Gene Product:Putative diguanylate kinase signaling protein \| Pathway: \| COG: Signal transduction mechanisms CD630_31680 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Amino acid transport and metabolism CD630_26520 - spoVE Type: Gene Product:Cell division/stage V sporulation protein \| Pathway: \| COG: Cell cycle control, cell division, chromosome partitioning CD630_07480 - Type: Gene Product:Putative diguanylate kinase signaling protein \| Pathway: \| COG: Signal transduction mechanisms CD630_26500 - Type: Gene Product:Putative cell division protein Fts-Q type \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_26540 - mraY Type: Gene Product:Phospho-N-acetylmuramoyl-pentapeptide-transferase(UDP- MurNAc-pentapeptide phosphotransferase) \| Pathway: Cell wall biogenesis \| COG: Cell wall/membrane/envelope biogenesis CD630_33320 - Type: Gene Product:Transcriptional regulator, TetR family;Tn916-like, CTn6-Orf8 \| Pathway: \| COG: Transcription CD630_26480 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_07470 - Type: Gene Product:Putative lipoprotein \| Pathway: \| COG: Function unknown CD630_14650 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_11860 - Type: Gene Product:Transcriptional regulator, sigma-54-dependent \| Pathway: \| COG: Transcription CD630_14670 - Type: Gene Product:ABC-type transport system, permease protein \| Pathway: \| COG: Defense mechanisms CD630_31690 - Type: Gene Product:Putative malate transporter \| Pathway: \| COG: Function unknown CD630_26530 - murD Type: Gene Product:UDP-N-acetylmuramoylalanine--D-glutamate ligase(UDP-N- acetylmuramoyl-L-alanyl-D-glutamate synthetase)(D-glutamic acid- adding enzyme) \| Pathway: Cell wall biogenesis \| COG: Cell wall/membrane/envelope biogenesis CD630_33330 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn6-Orf9 \| Pathway: \| COG: Transcription CD630_26510 - murG Type: Gene Product:UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosaminetransferase \| Pathway: Cell wall biogenesis \| COG: Cell wall/membrane/envelope biogenesis	0.13	`NA`	0.52	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_23900 - Type: Gene Product:Transcriptional regulator, beta-lactamsrepressor \| Pathway: \| COG: Transcription CD630_30940 - Type: Gene Product:Transcriptional regulator, sigma-54-dependent \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_381	24 CD630_08480 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_17130 - moaA Type: Gene Product:Molybdenum cofactor biosynthesis protein MoaA \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism CD630_17150 - Type: Gene Product:Putative molybdenum cofactor sulfurase \| Pathway: \| COG: Function unknown CD630_01510 - rimI Type: Gene Product:Putative alanine acetyltransferase, ribosomalfamily \| Pathway: \| COG: Function unknown CD630_08200 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_23710 - nadB Type: Gene Product:L-aspartate oxidase (Quinolinate synthetase B) \| Pathway: \| COG: Coenzyme transport and metabolism CD630_05150 - Type: Gene Product:D-alanyl-D-alanine carboxypeptidase, S11peptidase family \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_08470 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_06310 - Type: Gene Product:Putative transcriptional regulator \| Pathway: \| COG: Transcription CD630_20440 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: CD630_02160 - Type: Gene Product:Transposase IS200/IS605-like OrfB \| Pathway: \| COG: Replication, recombination and repair CD630_08490 - Type: Gene Product:Putative glutamate carboxypeptidase \| Pathway: \| COG: Amino acid transport and metabolism CD630_01520 - gcp Type: Gene Product:Putative O-sialoglycoprotein endopeptidase \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_17140 - moaC Type: Gene Product:Molybdenum cofactor biosynthesis protein MoaC \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism CD630_17120 - moaB Type: Gene Product:Molybdenum cofactor biosynthesis protein MoaB \| Pathway: \| COG: Coenzyme transport and metabolism CD630_08210 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_05160 - Type: Gene Product:Transcription antiterminator \| Pathway: \| COG: Signal transduction mechanisms CD630_23700 - nadC Type: Gene Product:Nicotinate-nucleotide pyrophosphorylase \| Pathway: \| COG: Coenzyme transport and metabolism CD630_08500 - Type: Gene Product:Putative NifU-like protein \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_23720 - nadA Type: Gene Product:Quinolinate synthetase A \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism CD630_02150 - Type: Gene Product:Transposase IS200/IS605-like OrfA \| Pathway: \| COG: Replication, recombination and repair CD630_01490 - Type: Gene Product:Putative P-loop ATPases \| Pathway: \| COG: Function unknown CD630_06320 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_20450 - Type: Gene Product:Transcriptional regulator, HTH-type \| Pathway: \| COG: Transcription	0	`NA`	0.52	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_19100 - eutV Type: Gene Product:Two-component response regulator, Ethanolaminespecific \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_225	14 CD630_01330 - Type: Gene Product:Putative phosphoribosyl transferase \| Pathway: \| COG: Function unknown CD630_02770 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_01320 - Type: Gene Product:Putative DNA helicase, RecD/TraA type \| Pathway: \| COG: Replication, recombination and repair CD630_08650 - Type: Gene Product:Putative ADP-ribose binding protein \| Pathway: \| COG: Function unknown CD630_03690 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn1-Orf14 \| Pathway: \| COG: Function unknown CD630_03720 - Type: Gene Product:Putative cell wall hydrolase Tn916-like,CTn1-Orf17 \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_02120 - Type: Gene Product:Putative sulfatase \| Pathway: \| COG: Function unknown CD630_17010 - recQ Type: Gene Product:ATP-dependent DNA helicase \| Pathway: \| COG: Replication, recombination and repair CD630_03750 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn1-Orf20 \| Pathway: \| COG: Function unknown CD630_02400 - Type: Gene Product:Glycosyltransferase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_34080 - Type: Gene Product:Putative DNA mismatch repair ATPase MutS \| Pathway: \| COG: Replication, recombination and repair CD630_28850 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_02110 - licC Type: Gene Product:CTP:phosphocholine cytidylyltransferase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_20150 - Type: Gene Product:Putative VanZ-like transposon protein \| Pathway: \| COG: Defense mechanisms	0.01	`NA`	0.53	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_18100 - Type: Gene Product:Transcriptional regulator, beta-lactamsrepressor \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_226	22 CD630_13230 - tepA Type: Gene Product:Protein export-enhancing factor \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones, Intracellular trafficking, secretion, and vesicular transport CD630_07600 - Type: Gene Product:Putative Ca2+/Na+ antiporter \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_20550 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_13210 - Type: Gene Product:Putative sporulation protein \| Pathway: \| COG: Function unknown CD630_13250 - Type: Gene Product:Putative tRNA 2-selenouridine synthase,selenophosphate-dependent; Rhodanese-like domain protein \| Pathway: \| COG: Function unknown CD630_13270 - pgsA Type: Gene Product:CDP-diacylglycerol--glycerol-3-phosphate3-phosphatidyltransferase \| Pathway: \| COG: Lipid transport and metabolism CD630_07610 - Type: Gene Product:Putative ATP-dependent RNA helicase \| Pathway: \| COG: Replication, recombination and repair CD630_13540 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_22470 - cspBA Type: Gene Product:Subtilisin-like serine germination relatedprotease \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_16770 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_19290 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_13220 - dapG Type: Gene Product:Aspartokinase 1 (Aspartokinase I) (1spartatekinase I) \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_13260 - rimO Type: Gene Product:Ribosomal protein S12 methylthiotransferase \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_13200 - Type: Gene Product:Putative peptidase, M16 family \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_13240 - ftsK Type: Gene Product:DNA FtsK/SpoIIIE translocase \| Pathway: \| COG: Cell cycle control, cell division, chromosome partitioning CD630_16780 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_20560 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_13190 - Type: Gene Product:Putative polysaccharide deacetylase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_22460 - cspC Type: Gene Product:Germination- specific protease \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_01310 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_16760 - pcp Type: Gene Product:Pyrrolidone-carboxylate peptidase \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones	0.00012	`NA`	0.53	Inferelator: 4 Hypergeometric: 2 TF Influences from Inferelator CD630_12390 - Type: Gene Product:Transcriptional regulator, beta-lactams repressorPhage-type \| Pathway: \| COG: Transcription CD630_25990 - Type: Gene Product:Putative transcriptional regulator \| Pathway: \| COG: Transcription CD630_26430 - sigE Type: Gene Product:RNA polymerase sigma-E factor \| Pathway: \| COG: Transcription CD630_34990 - spoVT Type: Gene Product:Stage V sporulation protein T \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test CD630_12140 - spo0A Type: Gene Product:Stage 0 sporulation protein A \| Pathway: \| COG: Signal transduction mechanisms CD630_26430 - sigE Type: Gene Product:RNA polymerase sigma-E factor \| Pathway: \| COG: Transcription
Module_78	19 CD630_25270 - Type: Gene Product:Transcriptional regulator, TetR family \| Pathway: \| COG: Transcription CD630_36590 - Type: Gene Product:Putative signal transduction phosphoesterase \| Pathway: \| COG: Signal transduction mechanisms CD630_25280 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_02990 - rbsK Type: Gene Product:Ribokinase, pfkB family \| Pathway: Carbohydrate metabolism \| COG: Carbohydrate transport and metabolism CD630_36620 - ssb Type: Gene Product:Single-stranded DNA-binding protein(Helix-destabilizing protein) \| Pathway: \| COG: Replication, recombination and repair CD630_36570 - dnaB Type: Gene Product:Replicative DNA helicase \| Pathway: \| COG: Replication, recombination and repair CD630_36610 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_36611 - rpsR Type: Gene Product:30S ribosomal protein S18 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_03000 - rbsB Type: Gene Product:ABC-type transport system, ribose-specificextracellular solute-binding protein \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_03290 - Type: Gene Product:Putative aminopeptidase I, M18 family \| Pathway: \| COG: Amino acid transport and metabolism CD630_36630 - rpsF Type: Gene Product:30S ribosomal protein S6 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_02980 - rbsR Type: Gene Product:Transcriptional regulator, LacI family \| Pathway: \| COG: Transcription CD630_36600 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_03010 - rbsA Type: Gene Product:ABC-type transport system, ribose-specificATP-binding protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_36580 - rplI Type: Gene Product:50S ribosomal protein L9 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_03300 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_03280 - pcrA Type: Gene Product:DNA helicase, UvrD/REP type \| Pathway: \| COG: Replication, recombination and repair CD630_03020 - rbsC Type: Gene Product:ABC-type transport system, ribose-specificpermease \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_03310 - ppiB Type: Gene Product:Peptidyl-prolyl cis-trans isomerase B (PPIase B)(Rotamase B) \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones	0.13	`NA`	0.53	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_02980 - rbsR Type: Gene Product:Transcriptional regulator, LacI family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_164	4 CD630_19500 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_19300 - Type: Gene Product:Putative lipoprotein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_28980 - Type: Gene Product:Putative phage tail fiber protein \| Pathway: \| COG: Function unknown CD630_15900 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown	0.12	`NA`	0.53	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_26400 - nrdR Type: Gene Product:Transcriptional regulator, repressor NrdR family \| Pathway: \| COG: Transcription CD630_26430 - sigE Type: Gene Product:RNA polymerase sigma-E factor \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_196	20 CD630_23180 - Type: Gene Product:Putative phosphohexomutase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_08950 - Type: Gene Product:Metallo-beta-lactamase superfamily exportedprotein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_00400 - Type: Gene Product:Transcription antiterminator, PTS operonregulator \| Pathway: \| COG: Signal transduction mechanisms CD630_23190 - rpe Type: Gene Product:Putative ribulose-phosphate 3-epimerase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_10200 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_23270 - gatA Type: Gene Product:PTS system, galactitol-specific IIA component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_23260 - gatB Type: Gene Product:PTS system, galactitol-specific IIB component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_00420 - Type: Gene Product:PTS system, galactitol-specific IIB component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_23230 - Type: Gene Product:Putative sugar-phosphate dehydrogenase \| Pathway: \| COG: Amino acid transport and metabolism CD630_00430 - Type: Gene Product:PTS system, galactitol-specific IIC component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_23250 - gatC Type: Gene Product:PTS system, galactitol-specific IIC component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_00410 - Type: Gene Product:PTS system, galactitol-specific IIA component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_23240 - Type: Gene Product:Putative sugar-phosphate dehydrogenase \| Pathway: \| COG: Amino acid transport and metabolism CD630_23210 - tkt Type: Gene Product:Transketolase, central and C-terminal(Sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphateglycolaldehydetransferase) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_10190 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_23200 - rpiB1 Type: Gene Product:Ribose-5-phosphate isomerase B1(Phosphoriboisomerase B) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_23220 - tkt Type: Gene Product:Transketolase, N-terminal(Sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphateglycolaldehydetransferase) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_10210 - Type: Gene Product:Putative spore coat protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_00440 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_08960 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG:	0	`NA`	0.53	Inferelator: 2 Hypergeometric: 3 TF Influences from Inferelator CD630_10090 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_19100 - eutV Type: Gene Product:Two-component response regulator, Ethanolaminespecific \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test CD630_02660 - sigD Type: Gene Product:RNA polymerase sigma-28 factor for flagellaroperon \| Pathway: \| COG: Transcription CD630_10640 - ccpA Type: Gene Product:Transcriptional regulator, LacI family \| Pathway: \| COG: Transcription CD630_31760 - glnF Type: Gene Product:RNA polymerase sigma-54 factor \| Pathway: \| COG: Transcription
Module_245	31 CD630_05822 - Type: Gene Product:Fragment of putative signaling protein precursor(N-terminal region) \| Pathway: \| COG: Signal transduction mechanisms CD630_26050 - Type: Gene Product:Fragment of ADP-ribosyltransferase CdtAB (Part3) \| Pathway: \| COG: CD630_18090 - Type: Gene Product:Fragment of putative permease, MFS family (Part1) \| Pathway: \| COG: Carbohydrate transport and metabolism, Carbohydrate transport and metabolism CD630_07650 - srlEa Type: Gene Product:PTS system, sorbitol-specific IIB N-terminalcomponent (Glucitol) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_06421 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_11031 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn4-Orf20 \| Pathway: \| COG: CD630_08570 - oppF Type: Gene Product:Fragment of ABC-type transport system,oligopeptide-family ATP-binding protein (Part 1) \| Pathway: \| COG: Amino acid transport and metabolism, Amino acid transport and metabolism CD630_01981 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_25201 - Type: Gene Product:Fragment of conserved hypothetical protein(N-terminal part) \| Pathway: \| COG: CD630_21930 - cwp24 Type: Gene Product:Putative cell wall-binding protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_t0790 - tRNA-Ser Type: Gene Product: \| Pathway: \| COG: CD630_36740 - rsmG Type: Gene Product:Fragment of 7-methylguanosine methyltransferasespecific for the 16S rRNA (Part 2) \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis, Cell wall/membrane/envelope biogenesis CD630_08160 - bglF Type: Gene Product:PTS system, beta-glucoside-specific IIABCcomponent (Disrupted IStron) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_19020 - Type: Gene Product:Fragment of putative conjugative transposonprotein (Central region) \| Pathway: \| COG: Replication, recombination and repair CD630_19270 - Type: Gene Product:Fragment of ABC-type transport system,ATP-binding protein (Part 2) \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_18311 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_12382 - Type: Gene Product:Fragment of conserved hypothetical protein(C-terminal region) \| Pathway: \| COG: CD630_20051 - Type: Gene Product:Fragment of conserved hypothetical protein(N-terminal region) \| Pathway: \| COG: Transcription CD630_20050 - Type: Gene Product:Fragment of conserved hypothetical protein(C-terminal region) \| Pathway: \| COG: Function unknown CD630_13110 - Type: Gene Product:Putative phosphoesterase (Disrupted IStron) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis, Translation, ribosomal structure and biogenesis CD630_30080 - Type: Gene Product:Fragment of conserved hypothetical protein(N-terminal region) \| Pathway: \| COG: Function unknown CD630_22980 - srl Type: Gene Product:Actin aggregate factor \| Pathway: \| COG: CD630_05040 - Type: Gene Product:Fragment of putative cell wall hydrolase NLPC/P60family Tn5397, CTn3-Orf14 (Part 1) \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_21510 - Type: Gene Product:Putative membrane protein, DUF819 family \| Pathway: \| COG: Function unknown CD630_13880 - Type: Gene Product:Fragment of trancriptional regulator (Part 2) \| Pathway: \| COG: Transcription CD630_23590 - Type: Gene Product:Putative hydrolase, HAD superfamily, subfamilyIIB \| Pathway: \| COG: Function unknown CD630_03480 - Type: Gene Product:Fragment of conserved hypothetical protein (Part1) \| Pathway: \| COG: Secondary metabolites biosynthesis, transport and catabolism, Secondary metabolites biosynthesis, transport and catabolism CD630_36110 - Type: Gene Product:Fragment of putative drug/sodium antiporter, MATEfamily (Part 2) \| Pathway: \| COG: Defense mechanisms, Defense mechanisms CD630_33721 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn7-Orf5 \| Pathway: \| COG: CD630_14260 - Type: Gene Product:Fragment of isochorismatase (Part 2) \| Pathway: \| COG: Secondary metabolites biosynthesis, transport and catabolism, Secondary metabolites biosynthesis, transport and catabolism CD630_19440 - Type: Gene Product:Fragment of conserved hypothetical protein(C-terminal region) \| Pathway: \| COG: Function unknown	`NA`	`NA`	0.53	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_07630 - srlM Type: Gene Product:Sorbitol operon activator protein (Glucitol) \| Pathway: \| COG: Function unknown TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_144	24 CD630_18050 - scrB Type: Gene Product:Sucrose-6-phosphate hydrolase (Sucrase)(Invertase) \| Pathway: Glycan biosynthesis \| COG: Carbohydrate transport and metabolism CD630_12950 - scpA Type: Gene Product:Segregation and condensation protein A \| Pathway: \| COG: Function unknown CD630_20510 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_12290 - Type: Gene Product:Putative peptidoglycan glycosyltransferase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_10290 - Type: Gene Product:Putative cell wall anchored protein \| Pathway: \| COG: Function unknown CD630_01510 - rimI Type: Gene Product:Putative alanine acetyltransferase, ribosomalfamily \| Pathway: \| COG: Function unknown CD630_20490 - Type: Gene Product:Putative rRNA methylase \| Pathway: \| COG: Secondary metabolites biosynthesis, transport and catabolism CD630_12270 - Type: Gene Product:Putative O-methyltransferase \| Pathway: \| COG: Function unknown CD630_32810 - proC Type: Gene Product:Pyrroline-5-carboxylate reductase \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_10320 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_10300 - Type: Gene Product:Putative glycosyl transferase, family 2 \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_12960 - scpB Type: Gene Product:Segregation and condensation protein B \| Pathway: \| COG: Transcription CD630_10340 - Type: Gene Product:Putative mannosyl-glycoproteinendo-beta-N-acetylglucosamidase \| Pathway: \| COG: Cell motility, Intracellular trafficking, secretion, and vesicular transport CD630_12940 - Type: Gene Product:Putative membrane-associated peptidase, M50family \| Pathway: \| COG: Function unknown CD630_18060 - scrK Type: Gene Product:Fructokinase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_20500 - rluB Type: Gene Product:Ribosomal large subunit pseudouridine synthase B \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_01520 - gcp Type: Gene Product:Putative O-sialoglycoprotein endopeptidase \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_12280 - Type: Gene Product:Putative peptidase, U32 family \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_01500 - Type: Gene Product:Putative peptidase, M22 family \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_12260 - Type: Gene Product:Putative aminodeoxychorismate lyase \| Pathway: \| COG: Nucleotide transport and metabolism CD630_10280 - Type: Gene Product:Putative signaling protein \| Pathway: \| COG: Signal transduction mechanisms CD630_10330 - mnaA Type: Gene Product:UDP-N-acetylglucosamine 2-epimerase(UDP-GlcNAc-2-epimerase) \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_01490 - Type: Gene Product:Putative P-loop ATPases \| Pathway: \| COG: Function unknown CD630_10310 - Type: Gene Product:Putative cell wall anchored protein \| Pathway: \| COG: Function unknown	2.2	`NA`	0.53	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_01710 - rex Type: Gene Product:Transcriptional regulator, Redox-sensingrepressor Rex \| Pathway: \| COG: Transcription CD630_06290 - Type: Gene Product:Transcriptional regulator, Crp family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_16	31 CD630_17280 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_08480 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_03470 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_03430 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_03450 - Type: Gene Product:Putative GTP pyrophosphokinase \| Pathway: \| COG: Function unknown CD630_36200 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_20940 - Type: Gene Product:Putative restriction enzyme \| Pathway: \| COG: Defense mechanisms CD630_19600 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_19620 - Type: Gene Product:ABC-type transport system, permease \| Pathway: \| COG: Defense mechanisms CD630_20960 - Type: Gene Product:Putative DNA-binding protein \| Pathway: \| COG: Transcription CD630_06011 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_33510 - clpP2 Type: Gene Product:ATP-dependent Clp protease proteolytic subunit 2(Endopeptidase Clp 2) \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_08470 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_33530 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_33520 - Type: Gene Product:Transcriptional regulator, AraC family \| Pathway: \| COG: Transcription CD630_19590 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_03460 - Type: Gene Product:Putative phosphoesterase \| Pathway: \| COG: Function unknown CD630_33490 - bclA3 Type: Gene Product:Exosporium glycoprotein \| Pathway: \| COG: Function unknown CD630_04352 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn2-Orf33 \| Pathway: \| COG: CD630_17270 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_04351 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn2-Orf32 \| Pathway: \| COG: CD630_08490 - Type: Gene Product:Putative glutamate carboxypeptidase \| Pathway: \| COG: Amino acid transport and metabolism CD630_03440 - Type: Gene Product:Putative beta-lactamase-like protein \| Pathway: \| COG: Function unknown CD630_03420 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_20950 - Type: Gene Product:Putative cell division GTPase \| Pathway: \| COG: CD630_20970 - Type: Gene Product:Putative membrane protein, DUF988 family \| Pathway: \| COG: Function unknown CD630_19610 - Type: Gene Product:ABC-type transport system, ATP-binding protein \| Pathway: \| COG: Defense mechanisms CD630_20930 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Defense mechanisms CD630_33540 - Type: Gene Product:Putative tRNA-binding protein \| Pathway: \| COG: Function unknown CD630_09180 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_08500 - Type: Gene Product:Putative NifU-like protein \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones	0.0000011	0.06	0.53	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_10090 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`