Environment and Gene Regulatory Influence Network (EGRIN) model for C. difficile 630

The Environment and Gene Regulatory Influence Network (EGRIN) model of C. difficile 630 was inferred using cMonkey2 and a compendium of 136 transcriptomes (retrieved from the Gene Expression Omnibus repository) with 4,070 sequence features including 35 rRNAs and 90 tRNAs . The C. difficile EGRIN model groups genes in subsets (406 modules in total), that are co-regulated in specific environments, and also identifies the associated, putative cis-acting gene regulatory elements (GREs), which represent potential TF binding locations. Transcriptome compendium included conditions: response to iron limitation, response to oxygen, in vivo vs in vitro growth, short term infection (0, 30, 60, 120 mins), response to commensals and host diet, transition from exponential to stationary phase, fur KO, codY KO, sporulation TF (and sigma factors) KOs.

Explore Regulatory Modules

Displaying 241 - 250 of 406

Candidate transcriptional regulators for each module were determined with a linear regression based approach (Inferelator) and by evaluating the statistical significance of the overlap (Hypergeometric) between modules and putative TF and alternative sigma factor regulons (CcpA, CodY, Fur, PrdR, SigB, SigD, SigE, SigF, SigG, SigH, SigK, Spo0A) compiled from available literature.

* Given that translation start was used to define the 3' end of putative promoters, some cis-regulatory motifs are likely to be ribosome binding sites (i.e., Shine-Dalgarno sequence). RBS is typically a six nucleotide sequence 5'-GGAGGA-3'.

Title	Gene Count	Motif 1 e-value	Motif 2 e-value	Residual	TF Influences
Module_360	23 CD630_23800 - iorB Type: Gene Product:Indole pyruvate ferredoxin/flavodoxinoxidoreductase \| Pathway: \| COG: Energy production and conversion CD630_30920 - Type: Gene Product:Putative amino acid permease \| Pathway: \| COG: Amino acid transport and metabolism CD630_23790 - buk Type: Gene Product:Butyrate kinase (Branched-chain carboxylic acidkinase) (BK) \| Pathway: \| COG: Energy production and conversion CD630_28700 - kdgT1 Type: Gene Product:2-keto-3-deoxygluconate permease 1 \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_28720 - uxaA Type: Gene Product:Fragment of C-terminal D-galactatedehydratase/Altronate hydrolase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_23820 - Type: Gene Product:Putative pyridoxal phosphate-dependenttransferase \| Pathway: \| COG: Amino acid transport and metabolism CD630_20840 - Type: Gene Product:Putative peptidase, M20 family \| Pathway: \| COG: Amino acid transport and metabolism CD630_00430 - Type: Gene Product:PTS system, galactitol-specific IIC component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_00410 - Type: Gene Product:PTS system, galactitol-specific IIA component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_08000 - crt1 Type: Gene Product:3-hydroxybutyryl-CoA dehydratase (Crotonase) \| Pathway: \| COG: Lipid transport and metabolism CD630_04930 - Type: Gene Product:PTS system, mannose/fructose/sorbose IICcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_04910 - Type: Gene Product:PTS system, mannose/fructose/sorbose IIAcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_30930 - Type: Gene Product:Putative gamma-glutamyl-gamma-aminobutyratehydrolase \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_23810 - iorA Type: Gene Product:Indole pyruvate ferredoxin/flavodoxinoxidoreductase \| Pathway: \| COG: Energy production and conversion CD630_28710 - uxaA Type: Gene Product:Fragment of N-terminal carbohydrate hydrolase,SAF domain \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_00440 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_00400 - Type: Gene Product:Transcription antiterminator, PTS operonregulator \| Pathway: \| COG: Signal transduction mechanisms CD630_20850 - dpaL Type: Gene Product:Diaminopropionate ammonia-lyase \| Pathway: \| COG: Amino acid transport and metabolism CD630_00420 - Type: Gene Product:PTS system, galactitol-specific IIB component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_08010 - Type: Gene Product:Putative permease, divalent anion symporterfamily \| Pathway: \| COG: Amino acid transport and metabolism, Carbohydrate transport and metabolism CD630_04940 - Type: Gene Product:PTS system, mannose/fructose/sorbose IIDcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_04900 - Type: Gene Product:Putative sugar-phosphate dehydrogenase \| Pathway: \| COG: Amino acid transport and metabolism CD630_04920 - Type: Gene Product:PTS system, mannose/fructose/sorbose IIBcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism	0.0000000000000069	0.00093	0.52	Inferelator: 1 Hypergeometric: 1 TF Influences from Inferelator CD630_17980 - Type: Gene Product:Transcriptional regulator, LysR family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test CD630_31760 - glnF Type: Gene Product:RNA polymerase sigma-54 factor \| Pathway: \| COG: Transcription
Module_376	24 CD630_04570 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: CD630_10680 - Type: Gene Product:Putative polysaccharide biosynthesis/sporulationprotein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_10710 - Type: Gene Product:Conserved hypothetical protein, UPF0291 proteinfamily \| Pathway: \| COG: Function unknown CD630_18880 - rsiU Type: Gene Product:Anti Sigma Factor, ECF family \| Pathway: \| COG: Function unknown CD630_31960 - Type: Gene Product:Putative penicillin-binding protein \| Pathway: \| COG: Defense mechanisms CD630_22120 - Type: Gene Product:Transcriptional regulator, MarR family \| Pathway: \| COG: Transcription CD630_18900 - Type: Gene Product:ABC-type transport system, multidrug-familypermease \| Pathway: \| COG: Function unknown CD630_31940 - Type: Gene Product:Transcriptional regulator, AraC family \| Pathway: \| COG: Transcription CD630_22100 - Type: Gene Product:ABC-type transport system, multidrug-familyATP-binding/permease \| Pathway: \| COG: Defense mechanisms CD630_16760 - pcp Type: Gene Product:Pyrrolidone-carboxylate peptidase \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_18860 - Type: Gene Product:Transcriptional regulator, PadR family \| Pathway: \| COG: Transcription CD630_04580 - Type: Gene Product:Putative beta-lactamase \| Pathway: \| COG: Defense mechanisms CD630_31980 - cme Type: Gene Product:Multidrug resistance protein Cme; Transporter,Major Facilitator Superfamily (MFS) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_16770 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_10720 - Type: Gene Product:Putative aminopeptidase I, M18 family \| Pathway: \| COG: Amino acid transport and metabolism CD630_10700 - Type: Gene Product:Putative aminotransferase \| Pathway: \| COG: Transcription CD630_16780 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_18890 - Type: Gene Product:ABC-type transport system, multidrug-familyATP-binding protein \| Pathway: \| COG: Defense mechanisms CD630_10690 - Type: Gene Product:Putative histidinol phosphatase/hydrolase, PHPfamily \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_31970 - Type: Gene Product:Transcriptional regulator, MerR family \| Pathway: \| COG: Transcription CD630_31950 - Type: Gene Product:Putative UvrABC system protein A 2 (UvrA protein2) (Excinuclease ABC subunit A 2) \| Pathway: \| COG: Replication, recombination and repair CD630_18870 - csfU Type: Gene Product:Extra-Cytoplasmic Function sigma factors, ECFfamily \| Pathway: \| COG: Transcription CD630_22110 - Type: Gene Product:ABC-type transport system, multidrug-familyATP-binding/permease \| Pathway: \| COG: Defense mechanisms CD630_18850 - Type: Gene Product:Putative acetylesterase \| Pathway: \| COG: Function unknown	0	`NA`	0.52	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_17820 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_22120 - Type: Gene Product:Transcriptional regulator, MarR family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_123	22 CD630_05880 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_20290 - Type: Gene Product:Putative lipoprotein \| Pathway: \| COG: Function unknown CD630_14960 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_12390 - Type: Gene Product:Transcriptional regulator, beta-lactams repressorPhage-type \| Pathway: \| COG: Transcription CD630_12400 - vanZ Type: Gene Product:Teicoplanin resistance protein \| Pathway: \| COG: Defense mechanisms CD630_15450 - Type: Gene Product:Conserved hypothetical protein, DUF1836 family \| Pathway: \| COG: Function unknown CD630_26870 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_22510 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_08920 - cspA Type: Gene Product:Cold shock protein \| Pathway: \| COG: Transcription CD630_35170 - purR Type: Gene Product:Transcriptional regulator, Purine operonrepressor \| Pathway: \| COG: Transcription CD630_05870 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_21261 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_14850 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_06060 - Type: Gene Product:Fragment of chloride ion channel protein (part1) \| Pathway: \| COG: Inorganic ion transport and metabolism, Inorganic ion transport and metabolism CD630_04500 - Type: Gene Product:Putative transcriptional regulator \| Pathway: \| COG: Transcription CD630_20720 - Type: Gene Product:Putative transposase \| Pathway: \| COG: Replication, recombination and repair CD630_35180 - murC Type: Gene Product:UDP-N-acetylmuramate--L-alanine ligase(UDP-N-acetylmuramoyl-L-alanine synthetase) \| Pathway: Cell wall biogenesis \| COG: Cell wall/membrane/envelope biogenesis CD630_15460 - Type: Gene Product:Putative channel-forming hemolysin \| Pathway: \| COG: Function unknown CD630_13550 - cspB Type: Gene Product:Cold shock protein CspB \| Pathway: \| COG: Transcription CD630_26840 - Type: Gene Product:Putative flavodoxin-related protein \| Pathway: \| COG: Function unknown CD630_26860 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: CD630_07250 - Type: Gene Product:Bifunctional carbon monoxidedehydrogenase/acetyl-CoA synthase, subunit delta \| Pathway: \| COG: Energy production and conversion	0.000000000000032	`NA`	0.53	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_23900 - Type: Gene Product:Transcriptional regulator, beta-lactamsrepressor \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_202	6 CD630_17720 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_26040 - Type: Gene Product:Fragment of ADP-ribosyltransferase CdtAB (Part1) \| Pathway: \| COG: CD630_28240 - Type: Gene Product:Fragment of putative membrane protein (C-terminalregion) \| Pathway: \| COG: Function unknown CD630_33810 - Type: Gene Product:Fragment of putative membrane protein Tn916-like,CTn7-orf17 (Part 2) \| Pathway: \| COG: Function unknown, Function unknown CD630_32210 - Type: Gene Product:Putative peptidase, M20D family \| Pathway: \| COG: Amino acid transport and metabolism CD630_18130 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown	`NA`	`NA`	0.53	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_17250 - Type: Gene Product:Transcriptional regulator, AraC family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_347	13 CD630_r0250 - 23s_rRNA Type: Gene Product: \| Pathway: \| COG: CD630_r0130 - 16s_rRNA Type: Gene Product: \| Pathway: \| COG: CD630_r0050 - 23s_rRNA Type: Gene Product: \| Pathway: \| COG: CD630_r0080 - 23s_rRNA Type: Gene Product: \| Pathway: \| COG: CD630_r0280 - 23s_rRNA Type: Gene Product: \| Pathway: \| COG: CD630_19360 - accA Type: Gene Product:Acetyl-coenzyme A carboxylase carboxyltransferase subunit alpha \| Pathway: Lipid metabolism \| COG: Lipid transport and metabolism CD630_r0200 - 23s_rRNA Type: Gene Product: \| Pathway: \| COG: CD630_19380 - accC Type: Gene Product:Acetyl-CoA carboxylase subunit \| Pathway: Lipid metabolism \| COG: Lipid transport and metabolism CD630_r0140 - 23s_rRNA Type: Gene Product: \| Pathway: \| COG: CD630_19370 - accD Type: Gene Product:Acetyl-CoA carboxylase subunit beta \| Pathway: Lipid metabolism \| COG: Lipid transport and metabolism CD630_19390 - accB Type: Gene Product:Acetyl-CoA carboxylase subunit \| Pathway: Lipid metabolism \| COG: Lipid transport and metabolism CD630_r0020 - 23s_rRNA Type: Gene Product: \| Pathway: \| COG: CD630_r0230 - 23s_rRNA Type: Gene Product: \| Pathway: \| COG:	0	2.8026e-43	0.53	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_11770 - fapR Type: Gene Product:Transcriptional regulator, DeoR family (Fattyacid and phospholipid biosynthesis regulator) \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_253	9 CD630_17292 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_04981 - Type: Gene Product:Putative conjugative transposon protein Tn5397,CTn3-Orf20.1 \| Pathway: \| COG: Function unknown CD630_17151 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_34392 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_29720 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_05490 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_11230 - Type: Gene Product:Putative phosphoesterase \| Pathway: \| COG: Function unknown CD630_19910 - Type: Gene Product:Fragment of integrase (C-terminal region) \| Pathway: \| COG: Replication, recombination and repair CD630_14260 - Type: Gene Product:Fragment of isochorismatase (Part 2) \| Pathway: \| COG: Secondary metabolites biosynthesis, transport and catabolism, Secondary metabolites biosynthesis, transport and catabolism	0.59	`NA`	0.53	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_12870 - fur Type: Gene Product:Transcriptional regulator, Fur family \| Pathway: \| COG: Inorganic ion transport and metabolism TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_78	19 CD630_25270 - Type: Gene Product:Transcriptional regulator, TetR family \| Pathway: \| COG: Transcription CD630_36590 - Type: Gene Product:Putative signal transduction phosphoesterase \| Pathway: \| COG: Signal transduction mechanisms CD630_25280 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_02990 - rbsK Type: Gene Product:Ribokinase, pfkB family \| Pathway: Carbohydrate metabolism \| COG: Carbohydrate transport and metabolism CD630_36620 - ssb Type: Gene Product:Single-stranded DNA-binding protein(Helix-destabilizing protein) \| Pathway: \| COG: Replication, recombination and repair CD630_36570 - dnaB Type: Gene Product:Replicative DNA helicase \| Pathway: \| COG: Replication, recombination and repair CD630_36610 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_36611 - rpsR Type: Gene Product:30S ribosomal protein S18 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_03000 - rbsB Type: Gene Product:ABC-type transport system, ribose-specificextracellular solute-binding protein \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_03290 - Type: Gene Product:Putative aminopeptidase I, M18 family \| Pathway: \| COG: Amino acid transport and metabolism CD630_36630 - rpsF Type: Gene Product:30S ribosomal protein S6 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_02980 - rbsR Type: Gene Product:Transcriptional regulator, LacI family \| Pathway: \| COG: Transcription CD630_36600 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_03010 - rbsA Type: Gene Product:ABC-type transport system, ribose-specificATP-binding protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_36580 - rplI Type: Gene Product:50S ribosomal protein L9 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_03300 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_03280 - pcrA Type: Gene Product:DNA helicase, UvrD/REP type \| Pathway: \| COG: Replication, recombination and repair CD630_03020 - rbsC Type: Gene Product:ABC-type transport system, ribose-specificpermease \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_03310 - ppiB Type: Gene Product:Peptidyl-prolyl cis-trans isomerase B (PPIase B)(Rotamase B) \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones	0.13	`NA`	0.53	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_02980 - rbsR Type: Gene Product:Transcriptional regulator, LacI family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_144	24 CD630_18050 - scrB Type: Gene Product:Sucrose-6-phosphate hydrolase (Sucrase)(Invertase) \| Pathway: Glycan biosynthesis \| COG: Carbohydrate transport and metabolism CD630_12950 - scpA Type: Gene Product:Segregation and condensation protein A \| Pathway: \| COG: Function unknown CD630_20510 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_12290 - Type: Gene Product:Putative peptidoglycan glycosyltransferase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_10290 - Type: Gene Product:Putative cell wall anchored protein \| Pathway: \| COG: Function unknown CD630_01510 - rimI Type: Gene Product:Putative alanine acetyltransferase, ribosomalfamily \| Pathway: \| COG: Function unknown CD630_20490 - Type: Gene Product:Putative rRNA methylase \| Pathway: \| COG: Secondary metabolites biosynthesis, transport and catabolism CD630_12270 - Type: Gene Product:Putative O-methyltransferase \| Pathway: \| COG: Function unknown CD630_32810 - proC Type: Gene Product:Pyrroline-5-carboxylate reductase \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_10320 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_10300 - Type: Gene Product:Putative glycosyl transferase, family 2 \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_12960 - scpB Type: Gene Product:Segregation and condensation protein B \| Pathway: \| COG: Transcription CD630_10340 - Type: Gene Product:Putative mannosyl-glycoproteinendo-beta-N-acetylglucosamidase \| Pathway: \| COG: Cell motility, Intracellular trafficking, secretion, and vesicular transport CD630_12940 - Type: Gene Product:Putative membrane-associated peptidase, M50family \| Pathway: \| COG: Function unknown CD630_18060 - scrK Type: Gene Product:Fructokinase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_20500 - rluB Type: Gene Product:Ribosomal large subunit pseudouridine synthase B \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_01520 - gcp Type: Gene Product:Putative O-sialoglycoprotein endopeptidase \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_12280 - Type: Gene Product:Putative peptidase, U32 family \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_01500 - Type: Gene Product:Putative peptidase, M22 family \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_12260 - Type: Gene Product:Putative aminodeoxychorismate lyase \| Pathway: \| COG: Nucleotide transport and metabolism CD630_10280 - Type: Gene Product:Putative signaling protein \| Pathway: \| COG: Signal transduction mechanisms CD630_10330 - mnaA Type: Gene Product:UDP-N-acetylglucosamine 2-epimerase(UDP-GlcNAc-2-epimerase) \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_01490 - Type: Gene Product:Putative P-loop ATPases \| Pathway: \| COG: Function unknown CD630_10310 - Type: Gene Product:Putative cell wall anchored protein \| Pathway: \| COG: Function unknown	2.2	`NA`	0.53	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_01710 - rex Type: Gene Product:Transcriptional regulator, Redox-sensingrepressor Rex \| Pathway: \| COG: Transcription CD630_06290 - Type: Gene Product:Transcriptional regulator, Crp family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_16	31 CD630_17280 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_08480 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_03470 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_03430 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_03450 - Type: Gene Product:Putative GTP pyrophosphokinase \| Pathway: \| COG: Function unknown CD630_36200 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_20940 - Type: Gene Product:Putative restriction enzyme \| Pathway: \| COG: Defense mechanisms CD630_19600 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_19620 - Type: Gene Product:ABC-type transport system, permease \| Pathway: \| COG: Defense mechanisms CD630_20960 - Type: Gene Product:Putative DNA-binding protein \| Pathway: \| COG: Transcription CD630_06011 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_33510 - clpP2 Type: Gene Product:ATP-dependent Clp protease proteolytic subunit 2(Endopeptidase Clp 2) \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_08470 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_33530 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_33520 - Type: Gene Product:Transcriptional regulator, AraC family \| Pathway: \| COG: Transcription CD630_19590 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_03460 - Type: Gene Product:Putative phosphoesterase \| Pathway: \| COG: Function unknown CD630_33490 - bclA3 Type: Gene Product:Exosporium glycoprotein \| Pathway: \| COG: Function unknown CD630_04352 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn2-Orf33 \| Pathway: \| COG: CD630_17270 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_04351 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn2-Orf32 \| Pathway: \| COG: CD630_08490 - Type: Gene Product:Putative glutamate carboxypeptidase \| Pathway: \| COG: Amino acid transport and metabolism CD630_03440 - Type: Gene Product:Putative beta-lactamase-like protein \| Pathway: \| COG: Function unknown CD630_03420 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_20950 - Type: Gene Product:Putative cell division GTPase \| Pathway: \| COG: CD630_20970 - Type: Gene Product:Putative membrane protein, DUF988 family \| Pathway: \| COG: Function unknown CD630_19610 - Type: Gene Product:ABC-type transport system, ATP-binding protein \| Pathway: \| COG: Defense mechanisms CD630_20930 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Defense mechanisms CD630_33540 - Type: Gene Product:Putative tRNA-binding protein \| Pathway: \| COG: Function unknown CD630_09180 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_08500 - Type: Gene Product:Putative NifU-like protein \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones	0.0000011	0.06	0.53	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_10090 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_256	22 CD630_30270 - Type: Gene Product:PTS system, glucose-like IIA component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_02210 - purG Type: Gene Product:Phosphoribosylformylglycinamidine cyclo-ligase \| Pathway: Purine metabolism \| COG: Nucleotide transport and metabolism CD630_26660 - ptsG-A Type: Gene Product:PTS system, glucose-specific IIA component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_02190 - purC Type: Gene Product:Phosphoribosylaminoimidazole-succinocarboxamidesynthase \| Pathway: Purine metabolism \| COG: Nucleotide transport and metabolism CD630_02230 - purH Type: Gene Product:Bifunctional purine biosynthesis protein purH[Includes: Phosphoribosylaminoimidazolecarboxamideformyltransferase ; IMP cyclohydrolase] \| Pathway: Purine metabolism \| COG: Nucleotide transport and metabolism CD630_02250 - purL Type: Gene Product:Phosphoribosylformylglycinamidine synthase \| Pathway: Purine metabolism \| COG: Nucleotide transport and metabolism CD630_22120 - Type: Gene Product:Transcriptional regulator, MarR family \| Pathway: \| COG: Transcription CD630_03590 - Type: Gene Product:Putative RNA polymerase sigma factor Tn916-like,CTn1-Orf4 \| Pathway: \| COG: Function unknown CD630_30280 - Type: Gene Product:Putative phosphosugar isomerase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_22100 - Type: Gene Product:ABC-type transport system, multidrug-familyATP-binding/permease \| Pathway: \| COG: Defense mechanisms CD630_05720 - Type: Gene Product:Putative sporulation protein \| Pathway: \| COG: Function unknown CD630_30300 - Type: Gene Product:PTS system, glucose-like IIBC component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_26670 - ptsG-BC Type: Gene Product:PTS system, glucose-specific IIBC component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_02200 - purF Type: Gene Product:Amidophosphoribosyltransferase \| Pathway: Purine metabolism \| COG: Nucleotide transport and metabolism CD630_02240 - purD Type: Gene Product:Phosphoribosylamine--glycine ligase \| Pathway: Purine metabolism \| COG: Nucleotide transport and metabolism CD630_02220 - purN Type: Gene Product:Phosphoribosylglycinamide formyltransferase \| Pathway: Purine metabolism \| COG: Nucleotide transport and metabolism CD630_02180 - purE Type: Gene Product:Phosphoribosylaminoimidazole carboxylasecatalytic subunit \| Pathway: Purine metabolism \| COG: Nucleotide transport and metabolism CD630_03580 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn1-Orf3 \| Pathway: \| COG: Function unknown CD630_30290 - malY Type: Gene Product:Bifunctional protein: cystathionine beta-lyase /repressor \| Pathway: \| COG: Amino acid transport and metabolism CD630_22110 - Type: Gene Product:ABC-type transport system, multidrug-familyATP-binding/permease \| Pathway: \| COG: Defense mechanisms CD630_05730 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_05710 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown	0.11	`NA`	0.53	Inferelator: 2 Hypergeometric: 1 TF Influences from Inferelator CD630_26650 - Type: Gene Product:Transcriptional regulator, AraC family \| Pathway: \| COG: Transcription CD630_31900 - Type: Gene Product:Transcriptional regulator, MerR family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test CD630_12140 - spo0A Type: Gene Product:Stage 0 sporulation protein A \| Pathway: \| COG: Signal transduction mechanisms