Environment and Gene Regulatory Influence Network (EGRIN) model for C. difficile 630

The Environment and Gene Regulatory Influence Network (EGRIN) model of C. difficile 630 was inferred using cMonkey2 and a compendium of 136 transcriptomes (retrieved from the Gene Expression Omnibus repository) with 4,070 sequence features including 35 rRNAs and 90 tRNAs . The C. difficile EGRIN model groups genes in subsets (406 modules in total), that are co-regulated in specific environments, and also identifies the associated, putative cis-acting gene regulatory elements (GREs), which represent potential TF binding locations. Transcriptome compendium included conditions: response to iron limitation, response to oxygen, in vivo vs in vitro growth, short term infection (0, 30, 60, 120 mins), response to commensals and host diet, transition from exponential to stationary phase, fur KO, codY KO, sporulation TF (and sigma factors) KOs.

Explore Regulatory Modules

Displaying 261 - 270 of 406

Candidate transcriptional regulators for each module were determined with a linear regression based approach (Inferelator) and by evaluating the statistical significance of the overlap (Hypergeometric) between modules and putative TF and alternative sigma factor regulons (CcpA, CodY, Fur, PrdR, SigB, SigD, SigE, SigF, SigG, SigH, SigK, Spo0A) compiled from available literature.

* Given that translation start was used to define the 3' end of putative promoters, some cis-regulatory motifs are likely to be ribosome binding sites (i.e., Shine-Dalgarno sequence). RBS is typically a six nucleotide sequence 5'-GGAGGA-3'.

Title	Gene Count	Motif 1 e-value	Motif 2 e-value	Residual	TF Influences
Module_259	21 CD630_32270 - dapH Type: Gene Product:2,3,4,5-tetrahydropyridine-2,6-dicarboxylateN-acetyltransferase \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_19790 - Type: Gene Product:ABC-type transport system, extracellularsolute-binding protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_19780 - Type: Gene Product:ABC-type transport system, ATP-binding protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_14330 - cotE Type: Gene Product:Spore coat protein CotE; peroxiredoxin/chitinase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_24550 - Type: Gene Product:Putative CRISPR-associated protein \| Pathway: \| COG: Replication, recombination and repair CD630_24540 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_14340 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_24510 - Type: Gene Product:Putative CRISPR-associated ATP-dependenthelicase \| Pathway: \| COG: Replication, recombination and repair CD630_15080 - Type: Gene Product:Putative iron-sulfur binding protein \| Pathway: \| COG: Energy production and conversion CD630_32260 - dapB1 Type: Gene Product:Dihydrodipicolinate reductase 1 (DHPR 1) \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_24530 - Type: Gene Product:Putative CRISPR-associated negativeautoregulator \| Pathway: \| COG: Replication, recombination and repair CD630_15070 - Type: Gene Product:Putative thioredoxin \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_32240 - asd Type: Gene Product:Aspartate-semialdehyde dehydrogenase \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_24520 - Type: Gene Product:Putative CRISPR-associated protein \| Pathway: \| COG: Replication, recombination and repair CD630_14360 - Type: Gene Product:Putative hydrolase \| Pathway: \| COG: Defense mechanisms CD630_15071 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_32250 - dapA3 Type: Gene Product:Dihydrodipicolinate synthase 3 \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_15090 - Type: Gene Product:Putative lipoprotein \| Pathway: \| COG: CD630_19800 - Type: Gene Product:ABC-type transport system, permease \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_19801 - Type: Gene Product:Conserved hypothetical protein, DUF77 family \| Pathway: \| COG: Function unknown CD630_14350 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG:	`NA`	`NA`	0.54	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_34990 - spoVT Type: Gene Product:Stage V sporulation protein T \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_54	24 CD630_20061 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_17130 - moaA Type: Gene Product:Molybdenum cofactor biosynthesis protein MoaA \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism CD630_29630 - ldtcd1 Type: Gene Product:L,D-transpeptidases \| Pathway: \| COG: Function unknown CD630_20100 - ermB Type: Gene Product:rRNA adenine N-6-methyltransferase \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_17400 - Type: Gene Product:Glycine/sarcosine/betaine reductase complex,protein B, alpha and beta subunits \| Pathway: \| COG: Function unknown CD630_10830 - Type: Gene Product:PTS system, lactose/cellobiose specific IIBcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_10810 - moeA Type: Gene Product:Molybdenum cofactor biosynthesis protein \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism CD630_10850 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_20091 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_31410 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: CD630_31390 - Type: Gene Product:Transcriptional regulator, Phage-type \| Pathway: \| COG: Transcription CD630_27480 - Type: Gene Product:Putative acyltransferase \| Pathway: \| COG: Replication, recombination and repair CD630_20070 - ermB Type: Gene Product:rRNA adenine N-6-methyltransferase \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_17140 - moaC Type: Gene Product:Molybdenum cofactor biosynthesis protein MoaC \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism CD630_10820 - mobB Type: Gene Product:Molybdopterin-guanine dinucleotide biosynthesisprotein B \| Pathway: \| COG: Coenzyme transport and metabolism CD630_27490 - Type: Gene Product:Putative radical SAM-family protein \| Pathway: \| COG: Function unknown CD630_05270 - Type: Gene Product:Putative beta-lactamase-like hydrolase \| Pathway: \| COG: Function unknown CD630_29620 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_10840 - Type: Gene Product:ABC-type transport system, multidrug-familyATP-binding/permease protein \| Pathway: \| COG: Defense mechanisms CD630_10860 - Type: Gene Product:Putative peptidase, M20D family \| Pathway: \| COG: Amino acid transport and metabolism CD630_17150 - Type: Gene Product:Putative molybdenum cofactor sulfurase \| Pathway: \| COG: Function unknown CD630_20080 - Type: Gene Product:Putative hydrolase \| Pathway: \| COG: Cell cycle control, cell division, chromosome partitioning CD630_31400 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: CD630_17120 - moaB Type: Gene Product:Molybdenum cofactor biosynthesis protein MoaB \| Pathway: \| COG: Coenzyme transport and metabolism	0.00000036	`NA`	0.54	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_08870 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_17820 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_333	18 CD630_26180 - ileS Type: Gene Product:Isoleucyl-tRNA synthetase \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_12860 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_32560 - valS Type: Gene Product:valyl-tRNA synthetase \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_35400 - metG Type: Gene Product:Methionyl-tRNA synthetase (Methionine--tRNAligase) (MetRS) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_00500 - proS Type: Gene Product:Prolyl-tRNA synthetase \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_26950 - asnA Type: Gene Product:Aspartate--ammonia ligase (Asparagine synthetaseA) \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_26940 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_26100 - trpS Type: Gene Product:Tryptophanyl-tRNA synthetase (Tryptophan--tRNAligase) (TrpRS) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_26110 - mtnN Type: Gene Product:MTA/SAH nucleosidase (5'-methylthioadenosinenucleosidase) (S-adenosylhomocysteine nucleosidase) \| Pathway: Amino-acid biosynthesis \| COG: Nucleotide transport and metabolism CD630_35390 - Type: Gene Product:Putative deoxyribonuclease \| Pathway: \| COG: Replication, recombination and repair CD630_00140 - serS1 Type: Gene Product:Seryl-tRNA synthetase 1 \| Pathway: Aminoacyl-tRNA biosynthesis \| COG: Translation, ribosomal structure and biogenesis CD630_00490 - proS Type: Gene Product:Prolyl-tRNA synthetase \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_25210 - leuS Type: Gene Product:Leucyl-tRNA synthetase \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_07010 - Type: Gene Product:Putative cell-division protein \| Pathway: \| COG: Function unknown CD630_12850 - Type: Gene Product:Putative Holliday junction resolvase \| Pathway: \| COG: Replication, recombination and repair CD630_07000 - pheT Type: Gene Product:Phenylalanyl-tRNA synthetase subunit beta(Phenylalanine--tRNA ligase beta chain) (PheRS) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_15210 - tyrS Type: Gene Product:Tyrosyl-tRNA synthetase (Tyrosine--tRNA ligase)(TyrRS) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_12820 - alaS Type: Gene Product:Alanyl-tRNA synthetase \| Pathway: \| COG: Translation, ribosomal structure and biogenesis	0	8.5e-16	0.54	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_11770 - fapR Type: Gene Product:Transcriptional regulator, DeoR family (Fattyacid and phospholipid biosynthesis regulator) \| Pathway: \| COG: Transcription CD630_21110 - Type: Gene Product:Transcriptional regulator, DeoR family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_310	23 CD630_24670 - lepA Type: Gene Product:GTP-binding protein LepA \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_34810 - Type: Gene Product:Protein-tyrosine phosphatase reductase \| Pathway: \| COG: Signal transduction mechanisms CD630_34850 - hemK Type: Gene Product:Modification methylase HemK \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_34830 - Type: Gene Product:Putative zinc/iron permease \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_34870 - rho Type: Gene Product:Transcription termination factor Rho \| Pathway: \| COG: Transcription CD630_34840 - prfA Type: Gene Product:Peptide chain release factor 1 (RF-1) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_27250 - Type: Gene Product:Putative monogalactosyldiacylglycerol synthase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_03090 - Type: Gene Product:Putative hydrolase, HAD superfamily, subfamilyIB \| Pathway: \| COG: Amino acid transport and metabolism CD630_27230 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_00290 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_27240 - Type: Gene Product:Putative polysaccharide deacetylase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_24660 - Type: Gene Product:Putative tRNA-nucleotidyltransferase/Poly(A)polymerase family member \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_34800 - rpiB2 Type: Gene Product:Ribose-5-phosphate isomerase 2 \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_34790 - upp Type: Gene Product:Uracil phosphoribosyltransferase (UMPpyrophosphorylase) (UPRTase) \| Pathway: Pyrimidine metabolism \| COG: Nucleotide transport and metabolism CD630_03100 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_34820 - Type: Gene Product:Putative RNA-binding protein \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_34861 - rpmE Type: Gene Product:50S ribosomal protein L31 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_34860 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_00270 - radA Type: Gene Product:DNA repair protein \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_22700 - fruK Type: Gene Product:Fructose 1-phosphate kinase \| Pathway: Carbohydrate metabolism \| COG: Carbohydrate transport and metabolism CD630_22690 - fruABC Type: Gene Product:PTS system, fructose-specific IIABC component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_05430 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_00280 - disA Type: Gene Product:DNA integrity scanning protein disA \| Pathway: \| COG: Replication, recombination and repair	0.0000059	0.16	0.54	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_16920 - Type: Gene Product:Transcriptional regulator, ArsR family \| Pathway: \| COG: Transcription CD630_17820 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_246	30 CD630_18711 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn5-Orf31 \| Pathway: \| COG: CD630_20000 - isp Type: Gene Product:Intracellular serine protease \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_18730 - vexP1 Type: Gene Product:ABC-type transport system, permease Tn1549-like,CTn5-Orf33 \| Pathway: \| COG: Defense mechanisms CD630_10110 - nagB Type: Gene Product:Glucosamine-6-phosphate deaminase \| Pathway: Amino-sugar metabolism \| COG: Carbohydrate transport and metabolism CD630_17260 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_17240 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_02430 - Type: Gene Product:Methyltransferase \| Pathway: \| COG: Function unknown CD630_26850 - Type: Gene Product:Putative sporulation stage II, protein E \| Pathway: \| COG: Signal transduction mechanisms CD630_23360 - Type: Gene Product:Putative toxic anion resistance protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_26870 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_21110 - Type: Gene Product:Transcriptional regulator, DeoR family \| Pathway: \| COG: Transcription CD630_05720 - Type: Gene Product:Putative sporulation protein \| Pathway: \| COG: Function unknown CD630_35610 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_10080 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_10100 - nagA Type: Gene Product:N-acetylglucosamine-6-phosphate deacetylase(GlcNAc 6-P deacetylase) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_17511 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_17250 - Type: Gene Product:Transcriptional regulator, AraC family \| Pathway: \| COG: Transcription CD630_00460 - Type: Gene Product:Putative lipoate-protein ligase \| Pathway: Protein modification \| COG: Coenzyme transport and metabolism CD630_26840 - Type: Gene Product:Putative flavodoxin-related protein \| Pathway: \| COG: Function unknown CD630_10090 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_26860 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: CD630_23370 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_18770 - vncS Type: Gene Product:Two-component sensor histidine kinase;Tn1549-like, CTn5-Orf37 \| Pathway: \| COG: Signal transduction mechanisms CD630_35620 - murI Type: Gene Product:Glutamate racemase \| Pathway: Cell wall biogenesis \| COG: Cell wall/membrane/envelope biogenesis CD630_33500 - sgtA Type: Gene Product:Glycosyl transferase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_08290 - Type: Gene Product:Putative metallo-beta-lactamase superfamilyprotein \| Pathway: \| COG: Function unknown CD630_05730 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_12580 - Type: Gene Product:Putative GTPase, MG442 type \| Pathway: \| COG: Transcription CD630_05710 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_18750 - vexP3 Type: Gene Product:ABC-type transport system, permease Tn1549-like,CTn5-Orf35 \| Pathway: \| COG: Defense mechanisms	0.000000000025	`NA`	0.54	Inferelator: 1 Hypergeometric: 1 TF Influences from Inferelator CD630_10090 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test CD630_12140 - spo0A Type: Gene Product:Stage 0 sporulation protein A \| Pathway: \| COG: Signal transduction mechanisms
Module_368	28 CD630_06980 - Type: Gene Product:Putative tRNA/rRNA methyltransferase, SpoU \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_10770 - Type: Gene Product:PTS system, mannose/fructose/sorbose IICcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_17330 - hemE Type: Gene Product:Uroporphyrinogen decarboxylase (URO-D) \| Pathway: \| COG: Coenzyme transport and metabolism CD630_00070 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_00050 - gyrB Type: Gene Product:DNA gyrase subunit B \| Pathway: \| COG: Replication, recombination and repair CD630_10750 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_00090 - rsbV Type: Gene Product:Anti-anti-sigma factor \| Pathway: \| COG: Signal transduction mechanisms CD630_10730 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_14070 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_22640 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_14050 - Type: Gene Product:ABC-type transport system, ATP-binding protein \| Pathway: \| COG: Function unknown CD630_15300 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_10780 - Type: Gene Product:PTS system, mannose/fructose/sorbose IIDcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_00110 - sigB Type: Gene Product:RNA polymerase sigma-B factor \| Pathway: \| COG: Transcription CD630_00040 - recF Type: Gene Product:DNA replication and repair protein RecF \| Pathway: \| COG: Replication, recombination and repair CD630_00020 - dnaN Type: Gene Product:DNA polymerase III subunit beta \| Pathway: \| COG: Replication, recombination and repair CD630_10760 - Type: Gene Product:PTS system, mannose/fructose/sorbose IIBcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_17320 - Type: Gene Product:Putative cobalamin-binding protein \| Pathway: \| COG: Function unknown CD630_00060 - gyrA Type: Gene Product:DNA gyrase subunit A \| Pathway: \| COG: Replication, recombination and repair CD630_10740 - Type: Gene Product:PTS system, mannose/fructose/sorbose IIAcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_17340 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Energy production and conversion CD630_06970 - Type: Gene Product:Putative regulator of K+ conductance \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_14080 - ddl Type: Gene Product:D-alanine--D-alanine ligase (D-alanylalaninesynthetase) (D-Ala-D-Ala ligase) \| Pathway: Cell wall biogenesis \| COG: Cell wall/membrane/envelope biogenesis CD630_14060 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_23051 - Type: Gene Product:Fragment of transposase (N-terminal region) \| Pathway: \| COG: Replication, recombination and repair CD630_06960 - Type: Gene Product:Putative cation transport protein, Trk family \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_15310 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_22630 - prsA Type: Gene Product:Peptidyl-prolyl cis-trans isomerase, PpiC-type \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones	1.3	`NA`	0.54	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_11770 - fapR Type: Gene Product:Transcriptional regulator, DeoR family (Fattyacid and phospholipid biosynthesis regulator) \| Pathway: \| COG: Transcription CD630_17820 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_247	14 CD630_15390 - Type: Gene Product:ABC-type transport system, ATP-binding protein \| Pathway: \| COG: Defense mechanisms CD630_19920 - Type: Gene Product:Putative lipoprotein \| Pathway: \| COG: CD630_13910 - Type: Gene Product:Putative hydrolase, CocE/NonD family \| Pathway: \| COG: Function unknown CD630_05800 - gapN Type: Gene Product:Glyceraldehyde-3-phosphate dehydrogenase(NADP(+)) (GADPH) \| Pathway: \| COG: Energy production and conversion CD630_15410 - Type: Gene Product:Putative drug/sodium antiporter, MATE family \| Pathway: \| COG: Defense mechanisms CD630_t0030 - tRNA-Asn Type: Gene Product: \| Pathway: \| COG: CD630_33570 - Type: Gene Product:Putative protease/amidase \| Pathway: \| COG: Function unknown CD630_04020 - Type: Gene Product:Transcriptional regulator, sigma-54-dependent \| Pathway: \| COG: Transcription CD630_03140 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_t0470 - tRNA-Asn Type: Gene Product: \| Pathway: \| COG: CD630_05640 - Type: Gene Product:putative ATP-dependent protease \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_15400 - Type: Gene Product:ABC-type transport system, permease protein \| Pathway: \| COG: Defense mechanisms CD630_15420 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_05860 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown	0.000023	0.01	0.54	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_30540 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_34990 - spoVT Type: Gene Product:Stage V sporulation protein T \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_336	27 CD630_10460 - pepT Type: Gene Product:Peptidase T \| Pathway: \| COG: Amino acid transport and metabolism CD630_28470 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_05190 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_04360 - Type: Gene Product:Putative recombinase Tn1549-like, CTn2-Orf34 \| Pathway: \| COG: Replication, recombination and repair CD630_17680 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_21640 - ldh Type: Gene Product:L-lactate dehydrogenase (L-LDH) \| Pathway: Fermentation \| COG: Energy production and conversion CD630_06420 - Type: Gene Product:Transcriptional regulator, HTH-type \| Pathway: \| COG: Transcription CD630_06400 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_08300 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_18820 - Type: Gene Product:Site-specific recombinase \| Pathway: \| COG: Replication, recombination and repair CD630_31820 - Type: Gene Product:Putative D-aminoacylase \| Pathway: \| COG: Secondary metabolites biosynthesis, transport and catabolism CD630_16120 - Type: Gene Product:Putative amidohydrolase \| Pathway: \| COG: Secondary metabolites biosynthesis, transport and catabolism CD630_28480 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_32320 - CdsB Type: Gene Product:Cysteine desulfidase \| Pathway: \| COG: Function unknown CD630_08940 - Type: Gene Product:Putative iron-dependent hydrogenase \| Pathway: \| COG: Energy production and conversion CD630_13790 - Type: Gene Product:Transcriptional regulator, Phage-type \| Pathway: \| COG: Transcription CD630_06590 - tcdR Type: Gene Product:Alternative RNA polymerase sigma factors \| Pathway: \| COG: CD630_27510 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_28460 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_12600 - brnQ-2 Type: Gene Product:Branched chain amino acid transport systemcarrier protein \| Pathway: \| COG: Amino acid transport and metabolism CD630_30050 - Type: Gene Product:Transcriptional regulator, IclR family \| Pathway: \| COG: Transcription CD630_06410 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: CD630_22130 - cynT Type: Gene Product:Carbonic anhydrase \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_06300 - Type: Gene Product:Putative drug/sodium antiporter, MATE family \| Pathway: \| COG: Defense mechanisms CD630_10470 - cwp18 Type: Gene Product:Putative cell wall-binding protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_26250 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Carbohydrate transport and metabolism	1.9e-23	`NA`	0.54	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_11770 - fapR Type: Gene Product:Transcriptional regulator, DeoR family (Fattyacid and phospholipid biosynthesis regulator) \| Pathway: \| COG: Transcription CD630_16930 - Type: Gene Product:Putative dinitrogenase iron-molybdenum cofactor \| Pathway: \| COG: Function unknown TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_200	23 CD630_21700 - Type: Gene Product:Putative cNMP-binding regulatory protein \| Pathway: \| COG: Signal transduction mechanisms CD630_26600 - Type: Gene Product:Putative peptidase, M16 family \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_28660 - Type: Gene Product:Putative modulator of DNA gyrase, peptidase U62 \| Pathway: \| COG: Function unknown CD630_16310 - sodA Type: Gene Product:Spore coat protein, superoxide dismutase \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_23470 - Type: Gene Product:Putative Xaa-Pro dipeptidase \| Pathway: \| COG: Amino acid transport and metabolism CD630_23000 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_28680 - Type: Gene Product:Putative oxidoreductase \| Pathway: \| COG: Energy production and conversion CD630_17090 - mobA Type: Gene Product:Molybdopterin-guanine dinucleotide biosynthesisprotein A \| Pathway: \| COG: Coenzyme transport and metabolism CD630_21690 - Type: Gene Product:Putative iron-sulfur binding protein \| Pathway: \| COG: Energy production and conversion CD630_35780 - Type: Gene Product:Resolvase \| Pathway: \| COG: Replication, recombination and repair CD630_26610 - Type: Gene Product:Putative peptidase, M16 family \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_28670 - Type: Gene Product:Putative regulatory protease, U62 family \| Pathway: \| COG: Function unknown CD630_17100 - Type: Gene Product:Putative NAD(P)-binding protein \| Pathway: \| COG: Function unknown CD630_07820 - Type: Gene Product:Putative sporulation protein YunB \| Pathway: \| COG: Function unknown CD630_16300 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_16320 - asnB Type: Gene Product:Asparagine synthetase \| Pathway: \| COG: Amino acid transport and metabolism CD630_19840 - Type: Gene Product:Putative hydrolase, NUDIX family \| Pathway: \| COG: Replication, recombination and repair CD630_17080 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_23010 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_21680 - hcp Type: Gene Product:Hydroxylamine reductase \| Pathway: \| COG: Energy production and conversion CD630_07390 - Type: Gene Product:Putative exported protein \| Pathway: \| COG: CD630_35790 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_32040 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Intracellular trafficking, secretion, and vesicular transport	0.000000000021	0.0001	0.54	Inferelator: 4 Hypergeometric: 0 TF Influences from Inferelator CD630_12390 - Type: Gene Product:Transcriptional regulator, beta-lactams repressorPhage-type \| Pathway: \| COG: Transcription CD630_16860 - Type: Gene Product:Transcriptional regulator, repressor-like \| Pathway: \| COG: Transcription CD630_33530 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_34990 - spoVT Type: Gene Product:Stage V sporulation protein T \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_248	30 CD630_32120 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_34810 - Type: Gene Product:Protein-tyrosine phosphatase reductase \| Pathway: \| COG: Signal transduction mechanisms CD630_34870 - rho Type: Gene Product:Transcription termination factor Rho \| Pathway: \| COG: Transcription CD630_34850 - hemK Type: Gene Product:Modification methylase HemK \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_34830 - Type: Gene Product:Putative zinc/iron permease \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_10830 - Type: Gene Product:PTS system, lactose/cellobiose specific IIBcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_21780 - Type: Gene Product:Putative oxidoreductase, Fe-S subunit \| Pathway: \| COG: Energy production and conversion CD630_09860 - rpsA Type: Gene Product:30S ribosomal protein S1 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_10810 - moeA Type: Gene Product:Molybdenum cofactor biosynthesis protein \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism CD630_34860 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_14590 - Type: Gene Product:Putative FMN-binding protein \| Pathway: \| COG: Nucleotide transport and metabolism CD630_34030 - Type: Gene Product:Putative formate/nitrite transporter \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_33090 - ligA Type: Gene Product:DNA ligase (Polydeoxyribonucleotide synthase[NAD+]) \| Pathway: \| COG: Replication, recombination and repair CD630_27480 - Type: Gene Product:Putative acyltransferase \| Pathway: \| COG: Replication, recombination and repair CD630_21850 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_22840 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_18000 - terD Type: Gene Product:Tellurium resistance protein \| Pathway: \| COG: Signal transduction mechanisms CD630_32130 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_17671 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_34800 - rpiB2 Type: Gene Product:Ribose-5-phosphate isomerase 2 \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_10820 - mobB Type: Gene Product:Molybdopterin-guanine dinucleotide biosynthesisprotein B \| Pathway: \| COG: Coenzyme transport and metabolism CD630_27490 - Type: Gene Product:Putative radical SAM-family protein \| Pathway: \| COG: Function unknown CD630_34820 - Type: Gene Product:Putative RNA-binding protein \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_34861 - rpmE Type: Gene Product:50S ribosomal protein L31 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_21790 - Type: Gene Product:Putative anaerobic dehydrogenase \| Pathway: \| COG: Energy production and conversion CD630_34840 - prfA Type: Gene Product:Peptide chain release factor 1 (RF-1) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_17990 - terD Type: Gene Product:Tellurium resistance protein \| Pathway: \| COG: Signal transduction mechanisms CD630_34790 - upp Type: Gene Product:Uracil phosphoribosyltransferase (UMPpyrophosphorylase) (UPRTase) \| Pathway: Pyrimidine metabolism \| COG: Nucleotide transport and metabolism CD630_17680 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_21860 - Type: Gene Product:Putative phage-like protein \| Pathway: \| COG:	0.06	`NA`	0.54	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_17820 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_27220 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`