Environment and Gene Regulatory Influence Network (EGRIN) model for C. difficile 630

The Environment and Gene Regulatory Influence Network (EGRIN) model of C. difficile 630 was inferred using cMonkey2 and a compendium of 136 transcriptomes (retrieved from the Gene Expression Omnibus repository) with 4,070 sequence features including 35 rRNAs and 90 tRNAs . The C. difficile EGRIN model groups genes in subsets (406 modules in total), that are co-regulated in specific environments, and also identifies the associated, putative cis-acting gene regulatory elements (GREs), which represent potential TF binding locations. Transcriptome compendium included conditions: response to iron limitation, response to oxygen, in vivo vs in vitro growth, short term infection (0, 30, 60, 120 mins), response to commensals and host diet, transition from exponential to stationary phase, fur KO, codY KO, sporulation TF (and sigma factors) KOs.

Explore Regulatory Modules

Displaying 281 - 290 of 406

Candidate transcriptional regulators for each module were determined with a linear regression based approach (Inferelator) and by evaluating the statistical significance of the overlap (Hypergeometric) between modules and putative TF and alternative sigma factor regulons (CcpA, CodY, Fur, PrdR, SigB, SigD, SigE, SigF, SigG, SigH, SigK, Spo0A) compiled from available literature.

* Given that translation start was used to define the 3' end of putative promoters, some cis-regulatory motifs are likely to be ribosome binding sites (i.e., Shine-Dalgarno sequence). RBS is typically a six nucleotide sequence 5'-GGAGGA-3'.

Title	Gene Count	Motif 1 e-value	Motif 2 e-value	Residual	TF Influences
Module_200	23 CD630_21700 - Type: Gene Product:Putative cNMP-binding regulatory protein \| Pathway: \| COG: Signal transduction mechanisms CD630_26600 - Type: Gene Product:Putative peptidase, M16 family \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_28660 - Type: Gene Product:Putative modulator of DNA gyrase, peptidase U62 \| Pathway: \| COG: Function unknown CD630_16310 - sodA Type: Gene Product:Spore coat protein, superoxide dismutase \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_23470 - Type: Gene Product:Putative Xaa-Pro dipeptidase \| Pathway: \| COG: Amino acid transport and metabolism CD630_23000 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_28680 - Type: Gene Product:Putative oxidoreductase \| Pathway: \| COG: Energy production and conversion CD630_17090 - mobA Type: Gene Product:Molybdopterin-guanine dinucleotide biosynthesisprotein A \| Pathway: \| COG: Coenzyme transport and metabolism CD630_21690 - Type: Gene Product:Putative iron-sulfur binding protein \| Pathway: \| COG: Energy production and conversion CD630_35780 - Type: Gene Product:Resolvase \| Pathway: \| COG: Replication, recombination and repair CD630_26610 - Type: Gene Product:Putative peptidase, M16 family \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_28670 - Type: Gene Product:Putative regulatory protease, U62 family \| Pathway: \| COG: Function unknown CD630_17100 - Type: Gene Product:Putative NAD(P)-binding protein \| Pathway: \| COG: Function unknown CD630_07820 - Type: Gene Product:Putative sporulation protein YunB \| Pathway: \| COG: Function unknown CD630_16300 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_16320 - asnB Type: Gene Product:Asparagine synthetase \| Pathway: \| COG: Amino acid transport and metabolism CD630_19840 - Type: Gene Product:Putative hydrolase, NUDIX family \| Pathway: \| COG: Replication, recombination and repair CD630_17080 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_23010 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_21680 - hcp Type: Gene Product:Hydroxylamine reductase \| Pathway: \| COG: Energy production and conversion CD630_07390 - Type: Gene Product:Putative exported protein \| Pathway: \| COG: CD630_35790 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_32040 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Intracellular trafficking, secretion, and vesicular transport	0.000000000021	0.0001	0.54	Inferelator: 4 Hypergeometric: 0 TF Influences from Inferelator CD630_12390 - Type: Gene Product:Transcriptional regulator, beta-lactams repressorPhage-type \| Pathway: \| COG: Transcription CD630_16860 - Type: Gene Product:Transcriptional regulator, repressor-like \| Pathway: \| COG: Transcription CD630_33530 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_34990 - spoVT Type: Gene Product:Stage V sporulation protein T \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_185	6 CD630_08670 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_08660 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_07141 - Type: Gene Product:Fragment of sugar O-acetyltransferase (C-terminalregion) \| Pathway: \| COG: Function unknown CD630_21670 - Type: Gene Product:Acyl transferase/acylhydrolase/lysophospholipase \| Pathway: \| COG: Function unknown CD630_12401 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_08790 - Type: Gene Product:Putative carbohydrate kinase \| Pathway: \| COG: Carbohydrate transport and metabolism	`NA`	`NA`	0.55	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_21430 - Type: Gene Product:Transcriptional regulator, HTH-type \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_401	21 CD630_06880 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_32470 - prdC Type: Gene Product:Putative electron transfer protein \| Pathway: \| COG: Energy production and conversion CD630_19340 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_30180 - Type: Gene Product:Putative redox-active protein \| Pathway: \| COG: Function unknown CD630_19330 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_30190 - Type: Gene Product:Putative transporter \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_26210 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_22070 - Type: Gene Product:Putative flavodoxin \| Pathway: \| COG: Function unknown CD630_15111 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_06820 - Type: Gene Product:Putative sodium:solute symporter \| Pathway: \| COG: Amino acid transport and metabolism CD630_12890 - Type: Gene Product:Ribonuclease J family protein \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_00650 - Type: Gene Product:Putative NADP-dependent deshydrogenase \| Pathway: \| COG: Function unknown CD630_16671 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_22090 - Type: Gene Product:Putative GTP-binding protein, HflX type \| Pathway: \| COG: Function unknown CD630_08040 - etfB Type: Gene Product:Electron transfer flavoprotein beta-subunit,core \| Pathway: \| COG: Energy production and conversion CD630_04030 - fba Type: Gene Product:Fructose-1,6-bisphosphate aldolase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_08020 - Type: Gene Product:Putative CoA-transferase, family III \| Pathway: \| COG: Energy production and conversion CD630_22080 - Type: Gene Product:Transcriptional regulator, MarR family \| Pathway: \| COG: Transcription CD630_27680 - Type: Gene Product:Putative cell-wall hydrolase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_06830 - Type: Gene Product:Transcriptional regulator, LacI family \| Pathway: \| COG: Transcription CD630_26620 - Type: Gene Product:Putative GTP-binding protein \| Pathway: \| COG: Translation, ribosomal structure and biogenesis	0.00000000016	`NA`	0.55	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_17820 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_19310 - lexA Type: Gene Product:Transcriptional regulator, LexA repressor \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_353	24 CD630_21050 - Type: Gene Product:ABC-type transport system, multidrug-familyATP-binding protein \| Pathway: \| COG: Defense mechanisms CD630_20410 - Type: Gene Product:Transcriptional regulator, HTH-type \| Pathway: \| COG: Transcription CD630_21060 - Type: Gene Product:Putative ATP-dependent RNA helicase \| Pathway: \| COG: Replication, recombination and repair CD630_31990 - Type: Gene Product:ABC-type transport system, multidrug-familypermease \| Pathway: \| COG: Function unknown CD630_21040 - Type: Gene Product:ABC-type transport system, permease \| Pathway: \| COG: Function unknown CD630_22240 - Type: Gene Product:Putative extrachromosomal origin protein \| Pathway: \| COG: Function unknown CD630_27030 - Type: Gene Product:Putative pentapeptide repeat-containing protein \| Pathway: \| COG: Function unknown CD630_09200 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_09220 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_09150 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_08060 - Type: Gene Product:Transcriptional regulator, sigma-54-dependent \| Pathway: \| COG: Transcription CD630_09110 - Type: Gene Product:Transcriptional regulator, Phage-type \| Pathway: \| COG: CD630_09130 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_32010 - Type: Gene Product:ABC-type transport system, multidrug-familyATP-binding protein \| Pathway: \| COG: Defense mechanisms CD630_19270 - Type: Gene Product:Fragment of ABC-type transport system,ATP-binding protein (Part 2) \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_32000 - Type: Gene Product:ABC-type transport system, multidrug-familypermease \| Pathway: \| COG: Function unknown CD630_22230 - Type: Gene Product:Putative extrachromosomal origin protein \| Pathway: \| COG: Function unknown CD630_28181 - Type: Gene Product:Fragment of dihydrofolate reductase familyprotein \| Pathway: \| COG: CD630_05060 - Type: Gene Product:Reverse transcriptase/maturase/endonuclease,Group II intron \| Pathway: \| COG: Replication, recombination and repair CD630_09230 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_25930 - Type: Gene Product:ABC-type transport system,pristinamycin/multidrug-family ATP-binding protein \| Pathway: \| COG: Function unknown CD630_09160 - Type: Gene Product:Putative phage protein involved in bacteriophageresistance \| Pathway: \| COG: Function unknown CD630_09210 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_09140 - Type: Gene Product:Putative phage protein \| Pathway: \| COG:	0.00000000012	`NA`	0.55	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_14550 - sigA1 Type: Gene Product:RNA polymerase sigma factor SigA1 (sigma-43) \| Pathway: \| COG: Transcription CD630_22140 - SinR Type: Gene Product:Transcriptional regulator, HTH-type \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_370	24 CD630_19780 - Type: Gene Product:ABC-type transport system, ATP-binding protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_24050 - Type: Gene Product:Transcriptional regulator, MarR family \| Pathway: \| COG: Transcription CD630_20040 - effR Type: Gene Product:Transcriptional regulator, MarR family \| Pathway: \| COG: Transcription CD630_01530 - hpdB Type: Gene Product:4-hydroxyphenylacetate decarboxylase, catalyticsubunit \| Pathway: \| COG: Energy production and conversion CD630_07810 - Type: Gene Product:Putative penicillin-binding protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_01550 - hpdA Type: Gene Product:4-hydroxyphenylacetate decarboxylase, activatingsubunit \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_25190 - Type: Gene Product:Integrase \| Pathway: \| COG: Replication, recombination and repair CD630_24080 - Type: Gene Product:Putative multidrug efflux pump \| Pathway: \| COG: Function unknown CD630_03250 - cbiN Type: Gene Product:ABC-type transport system, cobalt-specificextracellular solute-binding protein \| Pathway: Cofactor biosynthesis \| COG: Inorganic ion transport and metabolism CD630_20030 - effD Type: Gene Product:Putative drug/sodium antiporter, MATE family \| Pathway: \| COG: Defense mechanisms CD630_03270 - cbiO Type: Gene Product:ABC-type transport system, cobalt-specificATP-binding protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_24060 - Type: Gene Product:Putative lipoprotein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_19790 - Type: Gene Product:ABC-type transport system, extracellularsolute-binding protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_10220 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_18270 - Type: Gene Product:Transcriptional regulator, MarR family \| Pathway: \| COG: Transcription CD630_25180 - cwp29 Type: Gene Product:Cell surface protein \| Pathway: \| COG: Function unknown CD630_01540 - hpdC Type: Gene Product:4-hydroxyphenylacetate decarboxylase, regulatorysubunit \| Pathway: \| COG: Function unknown CD630_19800 - Type: Gene Product:ABC-type transport system, permease \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_19801 - Type: Gene Product:Conserved hypothetical protein, DUF77 family \| Pathway: \| COG: Function unknown CD630_31691 - secG Type: Gene Product:Protein-export membrane protein SecG \| Pathway: \| COG: Intracellular trafficking, secretion, and vesicular transport CD630_03240 - cbiM Type: Gene Product:Cobalamin biosynthesis protein \| Pathway: Cofactor biosynthesis \| COG: Inorganic ion transport and metabolism CD630_18280 - ftsH1 Type: Gene Product:Cell division protease FtsH1 \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_24070 - Type: Gene Product:Putative multidrug efflux pump \| Pathway: \| COG: Defense mechanisms CD630_03260 - cbiQ Type: Gene Product:ABC-type transport system, cobalt-specificpermease \| Pathway: \| COG: Inorganic ion transport and metabolism	0.00000009	1.9	0.55	Inferelator: 2 Hypergeometric: 1 TF Influences from Inferelator CD630_16920 - Type: Gene Product:Transcriptional regulator, ArsR family \| Pathway: \| COG: Transcription CD630_22200 - Type: Gene Product:Putative cyclic nucleotides-binding protein \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test CD630_32450 - prdR Type: Gene Product:Transcriptional regulator, sigma-54-dependent \| Pathway: \| COG: Transcription
Module_157	23 CD630_34280 - cbiE Type: Gene Product:Cobalt-precorrin-6Y C(5)-methyltransferase(Cobalt-precorrin-6 methyltransferase) (Cobalt-precorrin-6Ymethylase) \| Pathway: \| COG: Coenzyme transport and metabolism CD630_16180 - Type: Gene Product:ABC-type transport system, multidrug-familyATP-binding protein \| Pathway: \| COG: Defense mechanisms CD630_34180 - sirC Type: Gene Product:Precorrin-2 dehydrogenase \| Pathway: Porphyrin-containing compound metabolism \| COG: Coenzyme transport and metabolism CD630_34350 - cobQ Type: Gene Product:Cobyric acid synthase CobQ \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism CD630_33550 - Type: Gene Product:Putative nitroreductase \| Pathway: \| COG: Energy production and conversion CD630_34230 - cbiJ Type: Gene Product:Cobalt-precorrin-6A reductase \| Pathway: \| COG: Coenzyme transport and metabolism CD630_34250 - cbiG Type: Gene Product:Cobalamin biosynthesis protein CbiG \| Pathway: \| COG: Coenzyme transport and metabolism CD630_29980 - Type: Gene Product:ABC-type transport system, iron-family permease \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_34330 - cbiB Type: Gene Product:Cobalamin biosynthesis protein CbiB, CobD/CbiBfamily \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism CD630_34310 - Type: Gene Product:Putative cobalamin biosynthesis L-threoninePduX-like kinase \| Pathway: \| COG: Secondary metabolites biosynthesis, transport and catabolism CD630_04760 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_04750 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Replication, recombination and repair CD630_16190 - Type: Gene Product:ABC-type transport system, multidrug-familypermease \| Pathway: \| COG: Function unknown CD630_34260 - cbiF Type: Gene Product:Cobalt-precorrin-4 C(11)-methyltransferase(Cobalt-precorrin-3 methylase) \| Pathway: \| COG: Coenzyme transport and metabolism CD630_29970 - Type: Gene Product:ABC-type transport system, iron-familyATP-binding protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_34340 - cobB Type: Gene Product:Cobyrinic acid A,C-diamide synthase \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism CD630_29990 - Type: Gene Product:ABC-type transport system, iron-familyextracellular solute-binding protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_34300 - cbiC Type: Gene Product:Cobalt-precorrin-8X methylmutase(Cobalt-precorrin isomerase) (HBA synthase) \| Pathway: \| COG: Coenzyme transport and metabolism CD630_16170 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_34240 - cbiH Type: Gene Product:Cobalt-precorrin-3B C(17)-methyltransferase(Cobalt-precorrin-3 methyltransferase) (Cobalt-precorrin-3methylase) \| Pathway: \| COG: Coenzyme transport and metabolism CD630_34320 - cobD Type: Gene Product:Threonine-phosphate decarboxylase(L-threonine-O-3-phosphate decarboxylase), CobD/CbiBfamily \| Pathway: \| COG: Amino acid transport and metabolism CD630_34220 - cbiK Type: Gene Product:Sirohydrochlorin cobaltochelatase \| Pathway: \| COG: Coenzyme transport and metabolism CD630_01810 - Type: Gene Product:Putative membrane-associated metalloprotease, M56family \| Pathway: \| COG: Transcription, Signal transduction mechanisms	0.14	`NA`	0.55	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_11770 - fapR Type: Gene Product:Transcriptional regulator, DeoR family (Fattyacid and phospholipid biosynthesis regulator) \| Pathway: \| COG: Transcription CD630_17820 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_93	25 CD630_31200 - Type: Gene Product:Transcriptional regulator, AbrB family \| Pathway: \| COG: Transcription CD630_31201 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_24160 - Type: Gene Product:Transcription antiterminator, PTS operonregulator \| Pathway: \| COG: Transcription CD630_24140 - Type: Gene Product:PTS system, Sorbitol-like IIA component(Glucitol) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_r0130 - 16s_rRNA Type: Gene Product: \| Pathway: \| COG: CD630_24850 - Type: Gene Product:Putative Xaa-Pro aminopeptidase, M24 family \| Pathway: \| COG: Amino acid transport and metabolism CD630_12130 - spoIVB Type: Gene Product:Stage IV sporulation protein B, peptidase S55family \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_31190 - Type: Gene Product:Putative UDP-glycosyltransferase, MGT subfamily \| Pathway: \| COG: Energy production and conversion, Carbohydrate transport and metabolism CD630_r0250 - 23s_rRNA Type: Gene Product: \| Pathway: \| COG: CD630_25560 - Type: Gene Product:PTS system, fructose/mannitol-family IIABcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_17940 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_24150 - Type: Gene Product:Putative sorbitol-like operon activator protein(Glucitol) \| Pathway: \| COG: CD630_24130 - Type: Gene Product:Putative NAD(P)-binding protein \| Pathway: \| COG: Amino acid transport and metabolism CD630_36160 - Type: Gene Product:Na(+)/H(+) antiporter \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_31210 - Type: Gene Product:Putative flavodoxin/nitric oxide synthase \| Pathway: \| COG: Energy production and conversion CD630_31230 - Type: Gene Product:Putative nitroreductase \| Pathway: \| COG: Energy production and conversion CD630_21340 - Type: Gene Product:Putative signaling protein \| Pathway: \| COG: Signal transduction mechanisms CD630_24840 - Type: Gene Product:Putative pyridoxal phosphate-dependenttransferase \| Pathway: \| COG: Amino acid transport and metabolism CD630_25550 - Type: Gene Product:PTS system, fructose/mannitol-family IIBcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_02671 - Type: Gene Product:Putative flagellar protein \| Pathway: \| COG: CD630_30390 - Type: Gene Product:Putative ATPase \| Pathway: \| COG: Function unknown CD630_14710 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_17950 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_31220 - Type: Gene Product:Transcriptional regulator, ArsR family \| Pathway: \| COG: Transcription CD630_36150 - Type: Gene Product:Transcriptional regulator, MerR family \| Pathway: \| COG: Transcription	0.00000044	1.4	0.55	Inferelator: 3 Hypergeometric: 0 TF Influences from Inferelator CD630_02760 - Type: Gene Product:Transcriptional regulator, AraC family \| Pathway: \| COG: Transcription CD630_22140 - SinR Type: Gene Product:Transcriptional regulator, HTH-type \| Pathway: \| COG: Transcription CD630_30540 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_389	11 CD630_25640 - Type: Gene Product:Transcriptional regulator, MerR family \| Pathway: \| COG: Transcription CD630_35450 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_31090 - Type: Gene Product:Putative pentose-5-phosphate 3-epimerase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_02810 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_21610 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: CD630_25630 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_14181 - Type: Gene Product:Fragment of putative phage protein (Part 3) \| Pathway: \| COG: Replication, recombination and repair, Replication, recombination and repair CD630_30420 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_12401 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_20451 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_25040 - Type: Gene Product:Putative D-alanyl-D-alanine carboxypeptidase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis	0	`NA`	0.55	Inferelator: 0 Hypergeometric: 0 TF Influences from Inferelator `No TF influences from Inferelator` TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_328	27 CD630_08370 - Type: Gene Product:Nitroreductase \| Pathway: \| COG: Function unknown CD630_30720 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_27930 - slpA Type: Gene Product:Precursor of the S-layer proteins \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_09820 - ubiA Type: Gene Product:Putative UbiA prenyltransferase \| Pathway: \| COG: Coenzyme transport and metabolism CD630_02740 - Type: Gene Product:Putative iron-containing alcohol dehydrogenase \| Pathway: \| COG: Energy production and conversion CD630_08340 - icd Type: Gene Product:Isocitrate dehydrogenase NAD-dependent \| Pathway: \| COG: Amino acid transport and metabolism CD630_20670 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_20630 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_09840 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_08320 - aksA Type: Gene Product:Trans-homoaconitate synthase \| Pathway: \| COG: Amino acid transport and metabolism CD630_22710 - Type: Gene Product:Transcription antiterminator, PTS operonregulator \| Pathway: \| COG: Transcription CD630_14590 - Type: Gene Product:Putative FMN-binding protein \| Pathway: \| COG: Nucleotide transport and metabolism CD630_27010 - Type: Gene Product:Putative lipoprotein \| Pathway: \| COG: Function unknown CD630_30410 - pepI Type: Gene Product:Proline iminopeptidase (Proline aminopeptidase)(PIP), peptidase S33 family \| Pathway: \| COG: Amino acid transport and metabolism CD630_30730 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_33030 - chrA Type: Gene Product:Chromate transport protein ChrA \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_09810 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: CD630_09850 - Type: Gene Product:Putative drug/sodium antiporter, MATE family \| Pathway: \| COG: Defense mechanisms CD630_01770 - cfa Type: Gene Product:Cyclopropane-fatty-acyl-phospholipid synthase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_09830 - Type: Gene Product:Putative hydrolase, HAD superfamily, subfamilyIB \| Pathway: \| COG: Amino acid transport and metabolism CD630_08350 - Type: Gene Product:Transcriptional regulator, MarR family \| Pathway: \| COG: Transcription CD630_20620 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_27940 - cwp12 Type: Gene Product:Cell wall binding protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_08330 - acnB Type: Gene Product:Aconitate hydratase (Citrate hydro-lyase) \| Pathway: \| COG: Energy production and conversion CD630_28420 - Type: Gene Product:Nitrilase (carbon-nitrogen hydrolase) \| Pathway: \| COG: Function unknown CD630_22720 - Type: Gene Product:Putative protein-tyrosine phosphatase \| Pathway: \| COG: Signal transduction mechanisms CD630_34040 - cls Type: Gene Product:Cardiolipin synthetase (Cardiolipin synthase) (CLsynthase) \| Pathway: \| COG: Lipid transport and metabolism	0.00000000000016	0.26	0.55	Inferelator: 3 Hypergeometric: 1 TF Influences from Inferelator CD630_16920 - Type: Gene Product:Transcriptional regulator, ArsR family \| Pathway: \| COG: Transcription CD630_17820 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_22200 - Type: Gene Product:Putative cyclic nucleotides-binding protein \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test CD630_10640 - ccpA Type: Gene Product:Transcriptional regulator, LacI family \| Pathway: \| COG: Transcription
Module_116	6 CD630_06740 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_13380 - Type: Gene Product:Putative 6-phospho-beta-glucosidase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_07141 - Type: Gene Product:Fragment of sugar O-acetyltransferase (C-terminalregion) \| Pathway: \| COG: Function unknown CD630_13370 - Type: Gene Product:Transcriptional regulator, RpiR family \| Pathway: \| COG: Transcription CD630_06050 - Type: Gene Product:Fragment of conserved hypothetical protein(N-terminal region) \| Pathway: \| COG: Function unknown	`NA`	`NA`	0.55	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_13370 - Type: Gene Product:Transcriptional regulator, RpiR family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`