Environment and Gene Regulatory Influence Network (EGRIN) model for C. difficile 630

The Environment and Gene Regulatory Influence Network (EGRIN) model of C. difficile 630 was inferred using cMonkey2 and a compendium of 136 transcriptomes (retrieved from the Gene Expression Omnibus repository) with 4,070 sequence features including 35 rRNAs and 90 tRNAs . The C. difficile EGRIN model groups genes in subsets (406 modules in total), that are co-regulated in specific environments, and also identifies the associated, putative cis-acting gene regulatory elements (GREs), which represent potential TF binding locations. Transcriptome compendium included conditions: response to iron limitation, response to oxygen, in vivo vs in vitro growth, short term infection (0, 30, 60, 120 mins), response to commensals and host diet, transition from exponential to stationary phase, fur KO, codY KO, sporulation TF (and sigma factors) KOs.

Explore Regulatory Modules

Displaying 131 - 140 of 406

Candidate transcriptional regulators for each module were determined with a linear regression based approach (Inferelator) and by evaluating the statistical significance of the overlap (Hypergeometric) between modules and putative TF and alternative sigma factor regulons (CcpA, CodY, Fur, PrdR, SigB, SigD, SigE, SigF, SigG, SigH, SigK, Spo0A) compiled from available literature.

* Given that translation start was used to define the 3' end of putative promoters, some cis-regulatory motifs are likely to be ribosome binding sites (i.e., Shine-Dalgarno sequence). RBS is typically a six nucleotide sequence 5'-GGAGGA-3'.

Title	Gene Count	Motif 1 e-value	Motif 2 e-value	Residual	TF Influences
Module_53	19 CD630_27470 - Type: Gene Product:Putative ubiquinone biosynthesis protein \| Pathway: \| COG: Coenzyme transport and metabolism CD630_27390 - aspS Type: Gene Product:Aspartyl-tRNA synthetase (Aspartate--tRNA ligase)(AspRS) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_27460 - recJ Type: Gene Product:Single-stranded-DNA-specific exonuclease \| Pathway: \| COG: Replication, recombination and repair CD630_07700 - spoIIAA Type: Gene Product:Anti-sigma F factor antagonist \| Pathway: \| COG: Signal transduction mechanisms CD630_22960 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Transcription CD630_27440 - relA Type: Gene Product:GTP pyrophosphokinase (RelA/SpoT) \| Pathway: \| COG: Transcription, Signal transduction mechanisms CD630_07710 - spoIIAB Type: Gene Product:Anti-sigma F factor (Stage II sporulation proteinAB) \| Pathway: \| COG: Signal transduction mechanisms CD630_24790 - Type: Gene Product:Putative molybdenum cofactor biosynthesis \| Pathway: \| COG: Coenzyme transport and metabolism CD630_10440 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_27400 - hisS Type: Gene Product:Histidyl-tRNA synthetase (Histidine--tRNA ligase)(HisRS) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_24910 - pmi Type: Gene Product:Mannose-6-phosphate isomerase (Phosphomannoseisomerase) (PMI) (Phosphohexomutase) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_08030 - Type: Gene Product:Putative acyl-CoA dehydrogenase \| Pathway: \| COG: Lipid transport and metabolism CD630_09100 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_24900 - Type: Gene Product:Putative peptidase, M20A family \| Pathway: \| COG: Amino acid transport and metabolism CD630_22970 - Type: Gene Product:Putative phage-related regulatory protein \| Pathway: \| COG: Transcription CD630_27430 - dtd Type: Gene Product:D-tyrosyl-tRNA(Tyr) deacylase \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_08050 - etfA Type: Gene Product:Electron transfer flavoprotein alpha-subunit \| Pathway: \| COG: Energy production and conversion CD630_07720 - sigF Type: Gene Product:RNA polymerase sigma-F factor \| Pathway: \| COG: Transcription CD630_27420 - Type: Gene Product:Putative hydrolase beta-lactamase-like \| Pathway: \| COG: Secondary metabolites biosynthesis, transport and catabolism	0.000023	0.03	0.47	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_31900 - Type: Gene Product:Transcriptional regulator, MerR family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_101	12 CD630_03480 - Type: Gene Product:Fragment of conserved hypothetical protein (Part1) \| Pathway: \| COG: Secondary metabolites biosynthesis, transport and catabolism, Secondary metabolites biosynthesis, transport and catabolism CD630_05071 - Type: Gene Product:Fragment of Tet(M) leader peptide Tn5397,CTn3-orf12 (C-terminal region) \| Pathway: \| COG: CD630_13880 - Type: Gene Product:Fragment of trancriptional regulator (Part 2) \| Pathway: \| COG: Transcription CD630_20052 - Type: Gene Product:Fragment of conserved hypothetical protein(Central region) \| Pathway: \| COG: Function unknown CD630_08580 - Type: Gene Product:Fragment of transcriptional regulator,sigma-54-dependent (Part 1), PRD domain \| Pathway: \| COG: Signal transduction mechanisms, Signal transduction mechanisms CD630_33580 - Type: Gene Product:Fragment of C-terminal transcriptional regulator,AsnC/Lrp family \| Pathway: \| COG: Transcription CD630_24591 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_06780 - Type: Gene Product:Fragment of conserved hypothetical protein(C-terminal region) \| Pathway: \| COG: CD630_36740 - rsmG Type: Gene Product:Fragment of 7-methylguanosine methyltransferasespecific for the 16S rRNA (Part 2) \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis, Cell wall/membrane/envelope biogenesis CD630_22210 - Type: Gene Product:Fragment of putative extrachromosomal protein(C-terminal region) \| Pathway: \| COG: Function unknown	`NA`	`NA`	0.47	Inferelator: 0 Hypergeometric: 0 TF Influences from Inferelator `No TF influences from Inferelator` TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_169	25 CD630_30190 - Type: Gene Product:Putative transporter \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_00220 - fusA1 Type: Gene Product:Elongation factor G (EF-G) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_00260 - clpC Type: Gene Product:class III stress response-related ATPase, AAA+superfamily \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_26330 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Energy production and conversion CD630_00240 - mcsA Type: Gene Product:Activator of protein kinase McsB \| Pathway: \| COG: Function unknown CD630_17980 - Type: Gene Product:Transcriptional regulator, LysR family \| Pathway: \| COG: Transcription CD630_00470 - ispD Type: Gene Product:2-C-methyl-D-erythritol 4-phosphatecytidylyltransferase \| Pathway: Isoprenoid biosynthesis \| COG: Lipid transport and metabolism CD630_17960 - Type: Gene Product:Putative nitrite and sulfite reductase subunit \| Pathway: \| COG: Energy production and conversion CD630_36020 - Type: Gene Product:Putative ATPase \| Pathway: \| COG: Cell cycle control, cell division, chromosome partitioning CD630_26300 - gpsA Type: Gene Product:Glycerol-3-phosphate dehydrogenase (NAD(P)+)(NAD(P)H-dependent glycerol-3-phosphate dehydrogenase) \| Pathway: Membrane lipid metabolism \| COG: Energy production and conversion CD630_05600 - nfo Type: Gene Product:Endonuclease IV \| Pathway: \| COG: Replication, recombination and repair CD630_00290 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_30180 - Type: Gene Product:Putative redox-active protein \| Pathway: \| COG: Function unknown CD630_00230 - ctsR Type: Gene Product:Transcriptional regulator, CtsR family \| Pathway: \| COG: Transcription CD630_00480 - ispF Type: Gene Product:2-C-methyl-D-erythritol 2,4-cyclodiphosphatesynthase \| Pathway: Isoprenoid biosynthesis \| COG: Lipid transport and metabolism CD630_35990 - rolA Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_26310 - Type: Gene Product:Putative membrane protein, UPF0078 family \| Pathway: Lipid metabolism \| COG: Function unknown CD630_26320 - Type: Gene Product:Putative GTP-binding protein EngA \| Pathway: \| COG: Nucleotide transport and metabolism CD630_00250 - mcsB Type: Gene Product:Tyrosine kinase protein \| Pathway: \| COG: Amino acid transport and metabolism CD630_00270 - radA Type: Gene Product:DNA repair protein \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_00460 - Type: Gene Product:Putative lipoate-protein ligase \| Pathway: Protein modification \| COG: Coenzyme transport and metabolism CD630_36010 - Type: Gene Product:D-alanyl-D-alanine carboxypeptidase, M15 family(DD-peptidase) (DD-carboxypeptidase) \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_17970 - Type: Gene Product:Coenzyme A disulfide reductase (CoA-disulfidereductase) (CoADR) \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_36000 - rolB Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_00280 - disA Type: Gene Product:DNA integrity scanning protein disA \| Pathway: \| COG: Replication, recombination and repair	0.00000018	0.0000076	0.47	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_19980 - Type: Gene Product:Transcriptional regulator, TetR family \| Pathway: \| COG: Transcription CD630_27220 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_281	27 CD630_20430 - Type: Gene Product:Putative hydrolase \| Pathway: \| COG: Function unknown CD630_09290 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_29120 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_09260 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_09340 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_09341 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_09300 - Type: Gene Product:Putative phage reductase \| Pathway: \| COG: Function unknown CD630_09301 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_09360 - Type: Gene Product:Putative phage endodeoxyribonuclease \| Pathway: \| COG: Replication, recombination and repair CD630_06110 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_09320 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_04950 - Type: Gene Product:Fragment of putative regulatory protein (Part 1) \| Pathway: \| COG: Function unknown, Function unknown CD630_18120 - Type: Gene Product:Fragment of putative two-component responseregulator (N-terminal region) \| Pathway: \| COG: CD630_09380 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_09280 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_29130 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_22190 - Type: Gene Product:Fragment of conjugative transposon protein(central region) \| Pathway: \| COG: Function unknown CD630_29150 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_09350 - Type: Gene Product:Putative S-adenosyl-L-methionine-dependentmethyltransferase \| Pathway: \| COG: Replication, recombination and repair CD630_09270 - Type: Gene Product:Putative phage DNA modification methylase \| Pathway: \| COG: Replication, recombination and repair CD630_06100 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_23051 - Type: Gene Product:Fragment of transposase (N-terminal region) \| Pathway: \| COG: Replication, recombination and repair CD630_09250 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_09370 - Type: Gene Product:Putative phage anti-repressor \| Pathway: \| COG: Transcription CD630_09330 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_09310 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_28390 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms	4.1	`NA`	0.47	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_30540 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_36390 - Type: Gene Product:Transcriptional regulator, LysR family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_89	27 CD630_26550 - murF Type: Gene Product:UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase (UDP-MurNAc-pentapeptide synthetase)(D-alanyl-D-alanine-adding enzyme) \| Pathway: Cell wall biogenesis \| COG: Cell wall/membrane/envelope biogenesis CD630_34380 - cobU Type: Gene Product:Bifunctional adenosylcobalamin biosynthesisprotein CobU [Adenosylcobinamide kinase;Adenosylcobinamide-phosphate guanylyltransferase] \| Pathway: \| COG: Coenzyme transport and metabolism CD630_26470 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_18150 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_26490 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_35880 - carB1 Type: Gene Product:Carbamoyl-phosphate synthase large chain 1 \| Pathway: Amino-acid biosynthesis \| COG: Nucleotide transport and metabolism CD630_18170 - Type: Gene Product:Putative acyltransferase \| Pathway: \| COG: Lipid transport and metabolism CD630_35400 - metG Type: Gene Product:Methionyl-tRNA synthetase (Methionine--tRNAligase) (MetRS) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_34370 - cobS Type: Gene Product:Cobalamin synthase CobS (Cobalamin-5-phosphatesynthase) \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism CD630_26520 - spoVE Type: Gene Product:Cell division/stage V sporulation protein \| Pathway: \| COG: Cell cycle control, cell division, chromosome partitioning CD630_35390 - Type: Gene Product:Putative deoxyribonuclease \| Pathway: \| COG: Replication, recombination and repair CD630_18140 - Type: Gene Product:Putative phosphoglycerate mutase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_35910 - carA Type: Gene Product:Carbamoyl-phosphate synthase small chain \| Pathway: Amino-acid biosynthesis \| COG: Nucleotide transport and metabolism CD630_36250 - Type: Gene Product:Putative signaling protein \| Pathway: \| COG: Signal transduction mechanisms CD630_26500 - Type: Gene Product:Putative cell division protein Fts-Q type \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_18160 - cmk Type: Gene Product:Cytidylate kinase (CK) (Cytidine monophosphatekinase) (CMP kinase) \| Pathway: \| COG: Nucleotide transport and metabolism CD630_26540 - mraY Type: Gene Product:Phospho-N-acetylmuramoyl-pentapeptide-transferase(UDP- MurNAc-pentapeptide phosphotransferase) \| Pathway: Cell wall biogenesis \| COG: Cell wall/membrane/envelope biogenesis CD630_35890 - carA Type: Gene Product:Carbamoyl-phosphate synthase small chain \| Pathway: Amino-acid biosynthesis \| COG: Nucleotide transport and metabolism CD630_34390 - cobT Type: Gene Product:Nicotinate-nucleotide--dimethylbenzimidazolephosphoribosyltransferase (NN:DBI PRT)(N(1)-alpha-phosphoribosyltransferase) \| Pathway: Nucleoside biosynthesis \| COG: Coenzyme transport and metabolism CD630_26480 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_24800 - Type: Gene Product:Putative hydrolase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_18180 - ispH Type: Gene Product:4-hydroxy-3-methylbut-2-enyl diphosphatereductase \| Pathway: Isoprenoid biosynthesis \| COG: Lipid transport and metabolism CD630_34360 - cobC Type: Gene Product:Cobalamin biosynthesis phosphoglycerate mutaseCobC \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_35920 - pyrF Type: Gene Product:Orotidine 5'-phosphate decarboxylase (OMPdecarboxylase) (OMPDCase) (OMPdecase) \| Pathway: Pyrimidine metabolism \| COG: Nucleotide transport and metabolism CD630_26530 - murD Type: Gene Product:UDP-N-acetylmuramoylalanine--D-glutamate ligase(UDP-N- acetylmuramoyl-L-alanyl-D-glutamate synthetase)(D-glutamic acid- adding enzyme) \| Pathway: Cell wall biogenesis \| COG: Cell wall/membrane/envelope biogenesis CD630_26510 - murG Type: Gene Product:UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosaminetransferase \| Pathway: Cell wall biogenesis \| COG: Cell wall/membrane/envelope biogenesis CD630_35900 - carB2 Type: Gene Product:Carbamoyl-phosphate synthase large chain 2 \| Pathway: Amino-acid biosynthesis \| COG: Nucleotide transport and metabolism	8.7	`NA`	0.47	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_17820 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_300	4 CD630_05500 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_08600 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_06330 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Replication, recombination and repair CD630_05760 - virS Type: Gene Product:Sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms	`NA`	`NA`	0.47	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_27300 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_236	21 CD630_26010 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_08680 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_25690 - Type: Gene Product:Putative glycoside hydrolase, family 38; Putativealpha-mannosidase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_08690 - modA Type: Gene Product:ABC-type transport system, molybdenum-specificextracellular solute-binding protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_31100 - Type: Gene Product:6-phosphofructokinase \| Pathway: Carbohydrate degradation \| COG: Carbohydrate transport and metabolism CD630_08710 - modC Type: Gene Product:ABC-type transport system, molybdenum-specificATP-binding protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_25650 - Type: Gene Product:Transcription antiterminator \| Pathway: \| COG: Transcription CD630_08700 - modB Type: Gene Product:ABC-type transport system, molybdenum-specificpermease \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_25670 - Type: Gene Product:PTS system, mannose-specfic IIB component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_25680 - Type: Gene Product:PTS system, mannose-specfic IIC component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_25660 - Type: Gene Product:PTS system, mannose-specfic IIA component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_26820 - pfo Type: Gene Product:Pyruvate-ferredoxin oxidoreductase \| Pathway: \| COG: Energy production and conversion CD630_26270 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Signal transduction mechanisms CD630_26000 - cstA Type: Gene Product:Carbon starvation protein, CstA \| Pathway: \| COG: Signal transduction mechanisms CD630_05450 - Type: Gene Product:Putative lipoprotein \| Pathway: \| COG: CD630_26260 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_26020 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_08720 - maa Type: Gene Product:maltose O-acetyltransferase \| Pathway: \| COG: Amino acid transport and metabolism CD630_28390 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_35160 - spoVG Type: Gene Product:Regulator required for spore cortex synthesis \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_28380 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms	0.00000017	0	0.47	Inferelator: 3 Hypergeometric: 0 TF Influences from Inferelator CD630_02760 - Type: Gene Product:Transcriptional regulator, AraC family \| Pathway: \| COG: Transcription CD630_19310 - lexA Type: Gene Product:Transcriptional regulator, LexA repressor \| Pathway: \| COG: Transcription CD630_35440 - Type: Gene Product:Transcriptional regulator, AsnC/Lrp family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_390	23 CD630_02040 - Type: Gene Product:Putative signaling protein \| Pathway: \| COG: Signal transduction mechanisms CD630_00380 - acoC Type: Gene Product:Acetoin dehydrogenase E2 component(dihydrolipoamide acetyltransferase) \| Pathway: \| COG: Energy production and conversion CD630_26640 - murE Type: Gene Product:UDP-N-acetylmuramyl-tripeptide synthetase \| Pathway: Cell wall biogenesis \| COG: Cell wall/membrane/envelope biogenesis CD630_25440 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_25460 - Type: Gene Product:Endoglucanase (cellulase) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_12290 - Type: Gene Product:Putative peptidoglycan glycosyltransferase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_00360 - acoA Type: Gene Product:Acetoin dehydrogenase E1 component (TPP-dependentalpha subunit) \| Pathway: \| COG: Energy production and conversion CD630_12270 - Type: Gene Product:Putative O-methyltransferase \| Pathway: \| COG: Function unknown CD630_33210 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_00390 - acoL Type: Gene Product:Acetoin dehydrogenase E3 component(dihydrolipoamide dehydrogenase) \| Pathway: \| COG: Energy production and conversion CD630_r0310 - 23s_rRNA Type: Gene Product: \| Pathway: \| COG: CD630_25430 - Type: Gene Product:Putative membrane-bound 0-ACYL transferase, MBOATfamily \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_27640 - Type: Gene Product:Putative hydrolase, HAD superfamily, IIBsubfamily \| Pathway: \| COG: Function unknown CD630_33220 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_25450 - bcsA Type: Gene Product:Cellulose synthase catalytic subunit(UDP-forming) \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_26650 - Type: Gene Product:Transcriptional regulator, AraC family \| Pathway: \| COG: Transcription CD630_00350 - Type: Gene Product:Transcriptional regulator \| Pathway: \| COG: Transcription CD630_12280 - Type: Gene Product:Putative peptidase, U32 family \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_00370 - acoB Type: Gene Product:Acetoin dehydrogenase E1 component (TPP-dependentbeta subunit) \| Pathway: \| COG: Energy production and conversion CD630_27860 - cwp5 Type: Gene Product:Putative cell surface protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_12260 - Type: Gene Product:Putative aminodeoxychorismate lyase \| Pathway: \| COG: Nucleotide transport and metabolism CD630_25420 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_24200 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown	0.00027	0.02	0.47	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_26650 - Type: Gene Product:Transcriptional regulator, AraC family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_75	12 CD630_16632 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_35871 - Type: Gene Product:Fragment of putative transposase (N-terminalregion) \| Pathway: \| COG: CD630_34400 - Type: Gene Product:Putative glycoside hydrolase-typecarbohydrate-binding protein \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_06012 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_23020 - tlpB Type: Gene Product:Fragment of transposase-like protein B(C-terminal region) \| Pathway: \| COG: Replication, recombination and repair CD630_04370 - Type: Gene Product:Fragment of integrase Tn1549-like, CTn2(C-terminal region) \| Pathway: \| COG: Replication, recombination and repair CD630_18110 - Type: Gene Product:Fragment of putative two-component sensorhistidine kinase (N-terminal region) \| Pathway: \| COG: Signal transduction mechanisms CD630_29721 - Type: Gene Product:Fragment of conserved hypothetical protein(Central region) \| Pathway: \| COG: Secondary metabolites biosynthesis, transport and catabolism CD630_21450 - Type: Gene Product:DNA mismatch repair protein \| Pathway: \| COG: Replication, recombination and repair CD630_21930 - cwp24 Type: Gene Product:Putative cell wall-binding protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_01820 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_06050 - Type: Gene Product:Fragment of conserved hypothetical protein(N-terminal region) \| Pathway: \| COG: Function unknown	`NA`	`NA`	0.47	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_26650 - Type: Gene Product:Transcriptional regulator, AraC family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_174	24 CD630_18490 - Type: Gene Product:Putative conjugative transfer proteinTn1549-like, CTn5-Orf5 \| Pathway: \| COG: Intracellular trafficking, secretion, and vesicular transport CD630_32350 - ssb Type: Gene Product:Single-stranded DNA-binding protein \| Pathway: \| COG: Replication, recombination and repair CD630_24650 - Type: Gene Product:Putative amino acid/polyamine transporter \| Pathway: \| COG: Amino acid transport and metabolism CD630_18470 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn5-Orf3 \| Pathway: \| COG: Function unknown CD630_16570 - gcvTPA Type: Gene Product:Bi-functional glycine dehydrogenase/aminomethyltransferase protein \| Pathway: \| COG: Amino acid transport and metabolism CD630_18450 - Type: Gene Product:Putative membrane protein Tn1549-like, CTn5-Orf1 \| Pathway: \| COG: Function unknown CD630_16040 - Type: Gene Product:ABC-type transport system, multidrug-familyATP-binding protein \| Pathway: \| COG: Defense mechanisms CD630_24680 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_13540 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_31880 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_18480 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn5-Orf4 \| Pathway: \| COG: Function unknown CD630_05970 - cotF Type: Gene Product:Spore coat protein \| Pathway: \| COG: Function unknown CD630_24700 - gpr Type: Gene Product:Spore endopeptidase \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_18460 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn5-Orf2 \| Pathway: \| COG: Function unknown CD630_06930 - Type: Gene Product:Transcriptional regulator, MerR family \| Pathway: \| COG: Transcription CD630_16580 - gcvPB Type: Gene Product:Glycine decarboxylase \| Pathway: \| COG: Amino acid transport and metabolism CD630_16050 - Type: Gene Product:Putative transcriptional regulator \| Pathway: \| COG: Transcription CD630_24690 - spoIIP Type: Gene Product:Stage II sporulation protein P \| Pathway: \| COG: Function unknown CD630_13530 - Type: Gene Product:Putative phosphomethylpyrimidine kinase \| Pathway: Cofactor metabolism \| COG: Coenzyme transport and metabolism CD630_13550 - cspB Type: Gene Product:Cold shock protein CspB \| Pathway: \| COG: Transcription CD630_16030 - Type: Gene Product:ABC-type transport system, multidrug-familypermease \| Pathway: \| COG: Defense mechanisms CD630_09100 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_05980 - cotCB Type: Gene Product:Spore-coat protein CotCB; manganese catalase \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_05960 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG:	0.000000021	0.00045	0.47	Inferelator: 1 Hypergeometric: 2 TF Influences from Inferelator CD630_34990 - spoVT Type: Gene Product:Stage V sporulation protein T \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test CD630_12140 - spo0A Type: Gene Product:Stage 0 sporulation protein A \| Pathway: \| COG: Signal transduction mechanisms CD630_12300 - Type: Gene Product:RNA polymerase sigma-K factor SigK (Part 2) \| Pathway: \| COG: Transcription, Transcription