Environment and Gene Regulatory Influence Network (EGRIN) model for C. difficile 630

The Environment and Gene Regulatory Influence Network (EGRIN) model of C. difficile 630 was inferred using cMonkey2 and a compendium of 136 transcriptomes (retrieved from the Gene Expression Omnibus repository) with 4,070 sequence features including 35 rRNAs and 90 tRNAs . The C. difficile EGRIN model groups genes in subsets (406 modules in total), that are co-regulated in specific environments, and also identifies the associated, putative cis-acting gene regulatory elements (GREs), which represent potential TF binding locations. Transcriptome compendium included conditions: response to iron limitation, response to oxygen, in vivo vs in vitro growth, short term infection (0, 30, 60, 120 mins), response to commensals and host diet, transition from exponential to stationary phase, fur KO, codY KO, sporulation TF (and sigma factors) KOs.

Explore Regulatory Modules

Displaying 101 - 110 of 406

Candidate transcriptional regulators for each module were determined with a linear regression based approach (Inferelator) and by evaluating the statistical significance of the overlap (Hypergeometric) between modules and putative TF and alternative sigma factor regulons (CcpA, CodY, Fur, PrdR, SigB, SigD, SigE, SigF, SigG, SigH, SigK, Spo0A) compiled from available literature.

* Given that translation start was used to define the 3' end of putative promoters, some cis-regulatory motifs are likely to be ribosome binding sites (i.e., Shine-Dalgarno sequence). RBS is typically a six nucleotide sequence 5'-GGAGGA-3'.

Title	Gene Count	Motif 1 e-value	Motif 2 e-value	Residual	TF Influences
Module_32	23 CD630_10370 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_19740 - hfq Type: Gene Product:Hfq RNA chaperone \| Pathway: \| COG: Signal transduction mechanisms CD630_18650 - Type: Gene Product:Putative DNA recombination protein Tn1549-like,CTn5-Orf24 \| Pathway: \| COG: Function unknown CD630_10400 - addB Type: Gene Product:ATP-dependent nuclease subunit B (ATP-dependenthelicase addB), Superfamily 1 UvrD-family \| Pathway: \| COG: Replication, recombination and repair CD630_10420 - sbcD Type: Gene Product:Nuclease SbcCD subunit D \| Pathway: \| COG: Replication, recombination and repair CD630_10390 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_18670 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn5-Orf26 \| Pathway: \| COG: Function unknown CD630_19720 - Type: Gene Product:Putative peptidase, M20A family \| Pathway: \| COG: Amino acid transport and metabolism CD630_00190 - Type: Gene Product:Putative glycosyl transferase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_14620 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_18680 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn5-Orf27 \| Pathway: \| COG: Function unknown CD630_23930 - Type: Gene Product:Putative glycosyl transferase, family 51 \| Pathway: Cell wall biogenesis \| COG: Cell wall/membrane/envelope biogenesis CD630_26730 - appB Type: Gene Product:ABC-type transport system, oligopeptide-familypermease protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_10430 - sbcC Type: Gene Product:Nuclease SbcCD subunit C \| Pathway: \| COG: Replication, recombination and repair CD630_10410 - addA Type: Gene Product:ATP-dependent nuclease subunit A (ATP-dependenthelicase addA) \| Pathway: \| COG: Replication, recombination and repair CD630_10380 - Type: Gene Product:Putative helicase, superfamily 1, UvrD-family \| Pathway: \| COG: Replication, recombination and repair CD630_18660 - Type: Gene Product:Putative conjugative transposon proteintn1549-like, CTn5-Orf25 \| Pathway: \| COG: Function unknown CD630_18640 - Type: Gene Product:Transcriptional regulator, HTH-type Tn1549-like,CTn5-Orf23 \| Pathway: \| COG: Transcription CD630_14610 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_19420 - trmB Type: Gene Product:tRNA (guanine-N(7)-)-methyltransferase(tRNA(m7G46)-methyltransferase) \| Pathway: tRNA modification \| COG: Energy production and conversion CD630_23940 - polC Type: Gene Product:DNA polymerase III, epsilon subunit \| Pathway: \| COG: Replication, recombination and repair CD630_23920 - Type: Gene Product:Putative tRNA-binding protein \| Pathway: \| COG: Function unknown CD630_14680 - Type: Gene Product:Putative iron-sulfur protein \| Pathway: \| COG: Energy production and conversion	0.05	`NA`	0.45	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_18100 - Type: Gene Product:Transcriptional regulator, beta-lactamsrepressor \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_238	9 CD630_06000 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Transcription CD630_17291 - Type: Gene Product:Fragment of putative transcriptional regulator,AraC family (C-terminal region) \| Pathway: \| COG: Signal transduction mechanisms CD630_22250 - Type: Gene Product:Fragment of putative integrase (N-terminalregion) \| Pathway: \| COG: Replication, recombination and repair CD630_12360 - Type: Gene Product:Fragment of putative phage protein (part 1) \| Pathway: \| COG: CD630_30200 - Type: Gene Product:Fragment of conserved hypothetical protein,DUF1848 family (Part 2) \| Pathway: \| COG: Function unknown CD630_23060 - Type: Gene Product:Fragment of putative tranposase (Central region) \| Pathway: \| COG: CD630_11140 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn4-Orf5 \| Pathway: \| COG: CD630_29721 - Type: Gene Product:Fragment of conserved hypothetical protein(Central region) \| Pathway: \| COG: Secondary metabolites biosynthesis, transport and catabolism CD630_01820 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG:	`NA`	`NA`	0.45	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_36460 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_190	13 CD630_04280 - Type: Gene Product:Transcriptional regulator, AraC familyTn1549-like, CTn2-Orf23 \| Pathway: \| COG: Transcription CD630_04300 - Type: Gene Product:ABC-type transport system, cobalt-specificpermease Tn1549-like, CTn2-Orf25 \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_04290 - Type: Gene Product:Putative membrane protein Tn1549-like,CTn2-Orf24 \| Pathway: \| COG: Function unknown CD630_04310 - Type: Gene Product:ABC-type transport system, cobalt-specificATP-binding protein Tn1549-like, CTn2-Orf26 \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_15910 - kdpA Type: Gene Product:Potassium-translocating ATPase A chain \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_04330 - Type: Gene Product:ABC-type transport system, multidrug-familypermease Tn1549-like, CTn2-Orf28 \| Pathway: \| COG: Defense mechanisms CD630_15930 - kdpC Type: Gene Product:Potassium-transporting ATPase C chain \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_04260 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn2-Orf21 \| Pathway: \| COG: Function unknown CD630_15920 - kdpB Type: Gene Product:Potassium-transporting ATPase B chain \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_04340 - Type: Gene Product:Putative drug/sodium antiporter, MATE family,Tn1549-like, CTn2-Orf29 \| Pathway: \| COG: Defense mechanisms CD630_04250 - Type: Gene Product:Putative endonuclease relaxase Tn1549-like,CTn2-Orf20 \| Pathway: \| COG: Intracellular trafficking, secretion, and vesicular transport CD630_04270 - Type: Gene Product:Transcriptional regulator, HTH-type Tn1549-like,CTn2-Orf22 \| Pathway: \| COG: Transcription CD630_04320 - Type: Gene Product:ABC-type transport system, multidrug-familypermease Tn1549-like, CTn2-Orf27 \| Pathway: \| COG: Defense mechanisms	`NA`	`NA`	0.45	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_32800 - Type: Gene Product:Sigma-54 dpendent regulator, PTS fructose family \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_319	26 CD630_27080 - aroE2 Type: Gene Product:Shikimate dehydrogenase 2 \| Pathway: Metabolic intermediate biosynthesis \| COG: Amino acid transport and metabolism CD630_21991 - Type: Gene Product:Putative 4Fe-4S ferredoxin iron-sulfur bindingdomain-containing protein \| Pathway: \| COG: Energy production and conversion CD630_21990 - Type: Gene Product:Putative ferredoxin/flavodoxin oxidoreductase,alpha subunit \| Pathway: \| COG: Energy production and conversion CD630_24280 - Type: Gene Product:Putative flavodoxin/ferredoxin oxidoreductasebeta subunit \| Pathway: \| COG: Energy production and conversion CD630_27070 - Type: Gene Product:Transporter, Major Facilitator Superfamily (MFS) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_22000 - hisC Type: Gene Product:Histidinol-phosphate aminotransferase \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_30970 - bglF Type: Gene Product:PTS system, beta-glucoside-specific IIABCcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_24250 - ptb Type: Gene Product:Phosphate butyryltransferase(Phosphotransbutyrylase) \| Pathway: \| COG: Energy production and conversion CD630_04620 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_21970 - Type: Gene Product:Putative ferredoxin/flavodoxin oxidoreductase,gamma subunit \| Pathway: \| COG: Energy production and conversion CD630_24270 - Type: Gene Product:Putative flavodoxin/ferredoxin oxidoreductasegamma subunit \| Pathway: \| COG: Energy production and conversion CD630_04640 - Type: Gene Product:Putative beta-lactamase-like hydrolase \| Pathway: \| COG: Function unknown CD630_27090 - Type: Gene Product:Putative oxidoreductase \| Pathway: \| COG: Energy production and conversion CD630_24230 - Type: Gene Product:Transporter, Major Facilitator Superfamily (MFS) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_21980 - Type: Gene Product:Putative ferredoxin/flavodoxin oxidoreductase,beta subunit \| Pathway: \| COG: Energy production and conversion CD630_30950 - bglA Type: Gene Product:6-phospho-beta-glucosidase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_24291 - Type: Gene Product:Putative 4Fe-4S ferredoxin, iron-sulfur bindingdomain protein, delta subunit \| Pathway: \| COG: Energy production and conversion CD630_24290 - Type: Gene Product:Putative flavodoxin/ferredoxin oxidoreductasealpha subunit \| Pathway: \| COG: Energy production and conversion CD630_30980 - bglG Type: Gene Product:Transcription antiterminator, PTS operonregulator \| Pathway: \| COG: Transcription CD630_27100 - Type: Gene Product:Putative sugar phosphate epimerase/isomerase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_30960 - bglA Type: Gene Product:6-phospho-beta-glucosidase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_04630 - Type: Gene Product:Transcriptional regulator, TetR family \| Pathway: \| COG: Transcription CD630_24240 - Type: Gene Product:Putative pyridoxal phosphate-dependenttransferase \| Pathway: \| COG: Transcription CD630_21960 - Type: Gene Product:Putative succinyl-CoA synthetase-like ATP-bindingprotein \| Pathway: \| COG: Energy production and conversion CD630_24260 - buk1 Type: Gene Product:Butyrate kinase 1 (BK 1) (Branched-chaincarboxylic acid kinase 1) \| Pathway: \| COG: Energy production and conversion CD630_04610 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms	0.07	`NA`	0.45	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_01710 - rex Type: Gene Product:Transcriptional regulator, Redox-sensingrepressor Rex \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_83	15 CD630_05830 - Type: Gene Product:Putative diguanylate kinase signaling protein \| Pathway: \| COG: Signal transduction mechanisms CD630_25340 - Type: Gene Product:ABC-type transport system, ATP-binding protein \| Pathway: \| COG: Defense mechanisms CD630_25350 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_32550 - rgaR Type: Gene Product:Two-component response regulator VirR-like \| Pathway: \| COG: Signal transduction mechanisms CD630_20640 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_28870 - Type: Gene Product:Putative diguanylate kinase signaling protein \| Pathway: \| COG: Signal transduction mechanisms CD630_03410 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_05840 - Type: Gene Product:Putative diguanylate kinase signaling protein \| Pathway: \| COG: Signal transduction mechanisms CD630_08390 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_36250 - Type: Gene Product:Putative signaling protein \| Pathway: \| COG: Signal transduction mechanisms CD630_25330 - Type: Gene Product:ABC-type transport system, permease \| Pathway: \| COG: Defense mechanisms CD630_21020 - Type: Gene Product:Putative Na(+)/H(+) antiporter \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_29280 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_08380 - Type: Gene Product:Putative DNA-binding protein \| Pathway: \| COG: CD630_25360 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms	0	`NA`	0.45	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_30540 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_342	18 CD630_05360 - cheW Type: Gene Product:Purine-binding chemotaxis protein CheW \| Pathway: \| COG: Cell motility, Signal transduction mechanisms CD630_32730 - feoA Type: Gene Product:Ferrous iron transport protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_23190 - rpe Type: Gene Product:Putative ribulose-phosphate 3-epimerase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_05350 - cheD Type: Gene Product:Probable chemoreceptor glutamine deamidase CheD \| Pathway: \| COG: Cell motility, Signal transduction mechanisms CD630_32720 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_05390 - cheA Type: Gene Product:Chemotaxis protein CheA \| Pathway: \| COG: Signal transduction mechanisms CD630_05420 - Type: Gene Product:Putative protein-glutamate methylesterase \| Pathway: \| COG: Signal transduction mechanisms CD630_05380 - Type: Gene Product:Putative methyl-accepting chemotaxis receptor,MCP family \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_32710 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_32740 - feoB Type: Gene Product:Ferrous iron transport protein B \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_05410 - cheR Type: Gene Product:Methyl-accepting chemotaxis proteinsmethyltransferase, MCP family \| Pathway: \| COG: Signal transduction mechanisms CD630_23200 - rpiB1 Type: Gene Product:Ribose-5-phosphate isomerase B1(Phosphoriboisomerase B) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_23220 - tkt Type: Gene Product:Transketolase, N-terminal(Sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphateglycolaldehydetransferase) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_05400 - cheW Type: Gene Product:Chemotaxis protein CheW \| Pathway: \| COG: Cell motility, Signal transduction mechanisms CD630_23210 - tkt Type: Gene Product:Transketolase, central and C-terminal(Sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphateglycolaldehydetransferase) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_05340 - cheC Type: Gene Product:Chemotaxis protein CheY-P phosphatase CheC \| Pathway: \| COG: Cell motility, Signal transduction mechanisms CD630_05370 - Type: Gene Product:Putative CheY-like chemosensory protein \| Pathway: \| COG: Signal transduction mechanisms CD630_05330 - cheY Type: Gene Product:Chemotaxis protein CheY \| Pathway: \| COG: Signal transduction mechanisms	0.02	`NA`	0.45	Inferelator: 1 Hypergeometric: 1 TF Influences from Inferelator CD630_01710 - rex Type: Gene Product:Transcriptional regulator, Redox-sensingrepressor Rex \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test CD630_02660 - sigD Type: Gene Product:RNA polymerase sigma-28 factor for flagellaroperon \| Pathway: \| COG: Transcription
Module_20	27 CD630_30250 - Type: Gene Product:Putative ferredoxin, iron-sulphurdomain-containing protein \| Pathway: \| COG: Energy production and conversion CD630_00170 - Type: Gene Product:DNA binding protein \| Pathway: \| COG: Function unknown CD630_01720 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Energy production and conversion CD630_35330 - phnL Type: Gene Product:ABC-type transport system, phosphonate-specificATP-binding protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_08450 - Type: Gene Product:Putative nuclease \| Pathway: \| COG: Transcription CD630_14570 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_14550 - sigA1 Type: Gene Product:RNA polymerase sigma factor SigA1 (sigma-43) \| Pathway: \| COG: Transcription CD630_02960 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_25920 - fbpA Type: Gene Product:Fibronectin-binding protein A \| Pathway: \| COG: Transcription CD630_08430 - Type: Gene Product:Putative glycosyl transferase, group 1 \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_35290 - Type: Gene Product:ABC-type transport system, iron-family permease \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_13280 - recA Type: Gene Product:Protein RecA (Recombinase A) \| Pathway: \| COG: Replication, recombination and repair CD630_28100 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Replication, recombination and repair CD630_28550 - Type: Gene Product:Putative NAD(P)-binding oxidoreductase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_23590 - Type: Gene Product:Putative hydrolase, HAD superfamily, subfamilyIIB \| Pathway: \| COG: Function unknown CD630_30260 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Transcription CD630_00160 - dnaX Type: Gene Product:DNA polymerase III subunits gamma and tau \| Pathway: \| COG: Replication, recombination and repair CD630_09870 - Type: Gene Product:Putative phosphatase/hydrolase \| Pathway: \| COG: Replication, recombination and repair CD630_14540 - dnaG Type: Gene Product:DNA primase \| Pathway: \| COG: Replication, recombination and repair CD630_02950 - Type: Gene Product:Putative iron-sulfur-binding protein \| Pathway: \| COG: Energy production and conversion CD630_05250 - Type: Gene Product:Fragment of aminobenzoyl-glutamate transporter(Part 2) \| Pathway: \| COG: Coenzyme transport and metabolism, Coenzyme transport and metabolism CD630_08440 - cwp25 Type: Gene Product:Putative cell wall-binding protein \| Pathway: \| COG: Function unknown CD630_00180 - recR Type: Gene Product:DNA repair and recombination protein \| Pathway: \| COG: Replication, recombination and repair CD630_25910 - ltaE Type: Gene Product:Low specificity L-threonine aldolase \| Pathway: \| COG: Amino acid transport and metabolism CD630_14580 - wrbA Type: Gene Product:Putative flavodoxin protein \| Pathway: \| COG: Function unknown CD630_08420 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_13290 - Type: Gene Product:RNase Y \| Pathway: \| COG: Function unknown	0	`NA`	0.45	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_20480 - Type: Gene Product:Transcriptional regulator, RpiR family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_5	31 CD630_27320 - Type: Gene Product:Transcriptional regulator, sigma-54-dependent \| Pathway: \| COG: Transcription CD630_27290 - Type: Gene Product:Putative regulator of the sigma(E) factor \| Pathway: \| COG: Signal transduction mechanisms CD630_13020 - Type: Gene Product:Putative MazG-like pyrophosphohydrolase \| Pathway: \| COG: Function unknown CD630_10070 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Transcription CD630_08190 - Type: Gene Product:Transcription antiterminator, PTS operonregulator \| Pathway: \| COG: Transcription CD630_17500 - Type: Gene Product:Putative CoA enzyme activase \| Pathway: \| COG: Lipid transport and metabolism CD630_31280 - pgmB Type: Gene Product:Beta-phosphoglucomutase (beta-D-Glucose1,6-phosphomutase) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_08180 - Type: Gene Product:6-phospho-beta-glucosidase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_14310 - Type: Gene Product:Putative helicase, DinG family \| Pathway: \| COG: Replication, recombination and repair CD630_11290 - coaE Type: Gene Product:Dephospho-CoA kinase (Dephosphocoenzyme Akinase) \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism CD630_15100 - Type: Gene Product:Conserved hypothetical protein, DUF1121 family \| Pathway: \| COG: Function unknown CD630_22530 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_13990 - Type: Gene Product:putative muramoyltetrapeptide carboxypeptidase,S66 family \| Pathway: \| COG: Defense mechanisms CD630_17490 - Type: Gene Product:Putative 2-hydroxyacyl-CoA dehydratase \| Pathway: \| COG: Amino acid transport and metabolism CD630_04870 - Type: Gene Product:Putative carbon-nitrogen hydrolase \| Pathway: \| COG: Function unknown CD630_27310 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: CD630_23770 - Type: Gene Product:Putative hydrolase, NUDIX family \| Pathway: \| COG: Replication, recombination and repair CD630_19450 - Type: Gene Product:Putative enzyme \| Pathway: \| COG: Amino acid transport and metabolism CD630_19430 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_13030 - npdA Type: Gene Product:NAD-dependent deacetylase, Sir2 family \| Pathway: \| COG: Transcription CD630_23870 - Type: Gene Product:Alpha-hydroxy acid dehydrogenase, FMN-dependent \| Pathway: \| COG: Energy production and conversion CD630_31270 - Type: Gene Product:PTS system, beta-glucoside-like IIBC component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_14320 - Type: Gene Product:Putative ribonuclease \| Pathway: \| COG: Function unknown CD630_06040 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_17990 - terD Type: Gene Product:Tellurium resistance protein \| Pathway: \| COG: Signal transduction mechanisms CD630_23350 - guaB Type: Gene Product:Inositol-5'-monophosphate dehydrogenase (IMPdehydrogenase) (IMPDH) (IMPD) \| Pathway: \| COG: Nucleotide transport and metabolism CD630_22540 - Type: Gene Product:Asp/Glu racemase \| Pathway: \| COG: Amino acid transport and metabolism CD630_23580 - Type: Gene Product:Oligoendopeptidase-related, clade2, M3B family \| Pathway: \| COG: Amino acid transport and metabolism CD630_20140 - ilvD Type: Gene Product:Dihydroxy-acid dehydratase \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_14000 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_27300 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown	6.2e-17	`NA`	0.45	Inferelator: 3 Hypergeometric: 0 TF Influences from Inferelator CD630_05090 - Type: Gene Product:Transcriptional regulator, HTH-type Tn5397,CTn3-Orf9 \| Pathway: \| COG: Transcription CD630_17820 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_20920 - Type: Gene Product:Transcriptional regulator, sigma-54-dependent \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_394	19 CD630_11130 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn4-Orf6 \| Pathway: \| COG: Function unknown CD630_22241 - Type: Gene Product:Putative extrachromosomal origin protein \| Pathway: \| COG: CD630_11042 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn4-Orf17 \| Pathway: \| COG: Function unknown CD630_11120 - Type: Gene Product:Putative membrane protein Tn1549-like, CTn4-Orf7 \| Pathway: \| COG: Function unknown CD630_11071 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn4-Orf12 \| Pathway: \| COG: Function unknown CD630_11070 - Type: Gene Product:Putative cell surface protein Tn1549-like,CTn4-Orf13 \| Pathway: \| COG: Function unknown CD630_10540 - bcd2 Type: Gene Product:Butyryl-CoA dehydrogenase \| Pathway: \| COG: Lipid transport and metabolism CD630_10550 - etfB Type: Gene Product:Electron transfer flavoproteins subunit beta \| Pathway: \| COG: Energy production and conversion CD630_10560 - etfA Type: Gene Product:Electron transfer flavoprotein subunit alpha \| Pathway: \| COG: Energy production and conversion CD630_10580 - hbd Type: Gene Product:3-hydroxybutyryl-CoA dehydrogenase \| Pathway: \| COG: Lipid transport and metabolism CD630_10570 - crt2 Type: Gene Product:3-hydroxybutyryl-CoA dehydratase (Crotonase) \| Pathway: \| COG: Lipid transport and metabolism CD630_10590 - thlA1 Type: Gene Product:Acetoacetyl-CoA thiolase 1 \| Pathway: Metabolic intermediate biosynthesis \| COG: Lipid transport and metabolism CD630_11050 - Type: Gene Product:Putative antirestriction protein Tn1549-like,CTn4-Orf16 \| Pathway: \| COG: Function unknown CD630_11080 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn4-Orf11 \| Pathway: \| COG: Function unknown CD630_11090 - Type: Gene Product:DNA-methyltransferase, cytosine-N4-specific;Tn1549-like, CTn4-Orf10 \| Pathway: \| COG: Replication, recombination and repair CD630_11110 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn4-Orf8 \| Pathway: \| COG: Function unknown CD630_11061 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn4-Orf14 \| Pathway: \| COG: Function unknown CD630_11060 - topB Type: Gene Product:DNA topoisomerase III; Tn1549-like, CTn4-Orf15 \| Pathway: \| COG: Replication, recombination and repair CD630_11100 - Type: Gene Product:Putative hydrolase Tn1549-like, CTn4-Orf9 \| Pathway: \| COG: Intracellular trafficking, secretion, and vesicular transport	`NA`	`NA`	0.45	Inferelator: 0 Hypergeometric: 3 TF Influences from Inferelator `No TF influences from Inferelator` TF Influences from Hypergeometric Test CD630_12750 - codY Type: Gene Product:Transcriptional regulator, GTP-sensingpleiotropic repressor \| Pathway: \| COG: Transcription CD630_32450 - prdR Type: Gene Product:Transcriptional regulator, sigma-54-dependent \| Pathway: \| COG: Transcription CD630_10640 - ccpA Type: Gene Product:Transcriptional regulator, LacI family \| Pathway: \| COG: Transcription
Module_367	32 CD630_27930 - slpA Type: Gene Product:Precursor of the S-layer proteins \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_01740 - cooS Type: Gene Product:Carbon monoxide dehydrogenase \| Pathway: \| COG: Energy production and conversion CD630_20670 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_01760 - Type: Gene Product:Putative oxidoreductase, NAD/FAD binding subunit \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_35090 - pilO Type: Gene Product:Type IV pilus assembly protein \| Pathway: \| COG: CD630_27870 - cwp84 Type: Gene Product:Cell surface protein \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_27910 - cwp2 Type: Gene Product:Cell wall binding protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_20570 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_20610 - Type: Gene Product:Conserved hypothetical protein, DUF1121 family \| Pathway: \| COG: Function unknown CD630_35130 - pilA Type: Gene Product:Type IV pilus secretion protein \| Pathway: \| COG: Function unknown CD630_14250 - Type: Gene Product:Putative magnesium transporter \| Pathway: \| COG: Function unknown CD630_35110 - pilC Type: Gene Product:Type IV pilus secretion protein \| Pathway: \| COG: Intracellular trafficking, secretion, and vesicular transport CD630_08100 - Type: Gene Product:Putative flavodoxin/nitric oxide synthase \| Pathway: \| COG: Function unknown CD630_35070 - pilU Type: Gene Product:Type IV pilus protein \| Pathway: \| COG: CD630_35050 - pilT Type: Gene Product:Type IV pilus twitching motility protein \| Pathway: \| COG: Cell motility, Intracellular trafficking, secretion, and vesicular transport CD630_10470 - cwp18 Type: Gene Product:Putative cell wall-binding protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_27840 - cwp6 Type: Gene Product:Putative N-acetylmuramoyl-L-alanine amidase,autolysin \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_23600 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_27350 - cwp14 Type: Gene Product:Putative cell wall-binding protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_20600 - Type: Gene Product:Putative lipid kinase \| Pathway: \| COG: Lipid transport and metabolism CD630_27900 - Type: Gene Product:Putative LmbE-like deacetylase \| Pathway: \| COG: Function unknown CD630_01750 - Type: Gene Product:Putative oxidoreductase, Fe-S subunit \| Pathway: \| COG: Energy production and conversion CD630_35080 - pilV Type: Gene Product:Type IV pilus protein \| Pathway: \| COG: CD630_27860 - cwp5 Type: Gene Product:Putative cell surface protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_27940 - cwp12 Type: Gene Product:Cell wall binding protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_23680 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_35120 - pilB Type: Gene Product:Type IV pilus transporter system, ATP-binding \| Pathway: \| COG: Intracellular trafficking, secretion, and vesicular transport CD630_26680 - Type: Gene Product:Transcription antiterminator, licT family \| Pathway: \| COG: Transcription CD630_35100 - pilMN Type: Gene Product:Type IV pilus protein \| Pathway: \| COG: Function unknown CD630_35060 - pilK Type: Gene Product:Type IV pilus protein \| Pathway: \| COG: CD630_17510 - cwp13 Type: Gene Product:Cell surface protein \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_27890 - cwp66 Type: Gene Product:Cell surface protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis	1.9e-27	`NA`	0.46	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_27220 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`