Environment and Gene Regulatory Influence Network (EGRIN) model for C. difficile 630

The Environment and Gene Regulatory Influence Network (EGRIN) model of C. difficile 630 was inferred using cMonkey2 and a compendium of 136 transcriptomes (retrieved from the Gene Expression Omnibus repository) with 4,070 sequence features including 35 rRNAs and 90 tRNAs . The C. difficile EGRIN model groups genes in subsets (406 modules in total), that are co-regulated in specific environments, and also identifies the associated, putative cis-acting gene regulatory elements (GREs), which represent potential TF binding locations. Transcriptome compendium included conditions: response to iron limitation, response to oxygen, in vivo vs in vitro growth, short term infection (0, 30, 60, 120 mins), response to commensals and host diet, transition from exponential to stationary phase, fur KO, codY KO, sporulation TF (and sigma factors) KOs.

Explore Regulatory Modules

Displaying 111 - 120 of 406

Candidate transcriptional regulators for each module were determined with a linear regression based approach (Inferelator) and by evaluating the statistical significance of the overlap (Hypergeometric) between modules and putative TF and alternative sigma factor regulons (CcpA, CodY, Fur, PrdR, SigB, SigD, SigE, SigF, SigG, SigH, SigK, Spo0A) compiled from available literature.

* Given that translation start was used to define the 3' end of putative promoters, some cis-regulatory motifs are likely to be ribosome binding sites (i.e., Shine-Dalgarno sequence). RBS is typically a six nucleotide sequence 5'-GGAGGA-3'.

Title	Gene Count	Motif 1 e-value	Motif 2 e-value	Residual	TF Influences
Module_152	16 CD630_01870 - pyrE Type: Gene Product:Orotate phosphoribosyltransferase (OPRT)(OPRTase) \| Pathway: Pyrimidine metabolism \| COG: Nucleotide transport and metabolism CD630_02710 - fliN Type: Gene Product:Flagellar motor switch phosphatase FliN \| Pathway: \| COG: Cell motility CD630_30270 - Type: Gene Product:PTS system, glucose-like IIA component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_01860 - pyrD Type: Gene Product:Dihydroorotate dehydrogenase catalytic subunit \| Pathway: Pyrimidine metabolism \| COG: Nucleotide transport and metabolism CD630_01840 - pyrB Type: Gene Product:Aspartate carbamoyltransferase (Aspartatetranscarbamylase) (ATCase) \| Pathway: Pyrimidine metabolism \| COG: Nucleotide transport and metabolism CD630_02730 - htpG Type: Gene Product:Heat shock protein 90 (Heat shock proteinHtpG)(High temperature protein G) \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_32440 - prdA Type: Gene Product:D-proline reductase proprotein prdA \| Pathway: \| COG: Function unknown CD630_30290 - malY Type: Gene Product:Bifunctional protein: cystathionine beta-lyase /repressor \| Pathway: \| COG: Amino acid transport and metabolism CD630_02680 - flgG1 Type: Gene Product:Flagellar hook-basal body complex protein FlgG1 \| Pathway: \| COG: Cell motility CD630_30280 - Type: Gene Product:Putative phosphosugar isomerase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_02690 - flgG Type: Gene Product:Flagellar basal body rod protein FlgG \| Pathway: \| COG: Cell motility CD630_02700 - fliM Type: Gene Product:Flagellar motor switch protein FliM \| Pathway: \| COG: Cell motility CD630_30300 - Type: Gene Product:PTS system, glucose-like IIBC component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_01850 - pyrK Type: Gene Product:Dihydroorotate dehydrogenase electron transfersubunit \| Pathway: \| COG: Energy production and conversion CD630_32430 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_02720 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown	0.2	0.61	0.46	Inferelator: 2 Hypergeometric: 1 TF Influences from Inferelator CD630_05590 - Type: Gene Product:Transcriptional regulator, ArsR family \| Pathway: \| COG: Transcription CD630_26650 - Type: Gene Product:Transcriptional regulator, AraC family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test CD630_02660 - sigD Type: Gene Product:RNA polymerase sigma-28 factor for flagellaroperon \| Pathway: \| COG: Transcription
Module_283	10 CD630_13970 - Type: Gene Product:Conserved hypothetical protein, UPF0066 family \| Pathway: \| COG: Function unknown CD630_16510 - Type: Gene Product:Putative signaling protein \| Pathway: \| COG: Signal transduction mechanisms CD630_27110 - Type: Gene Product:Transcriptional regulator, LysR family \| Pathway: \| COG: Transcription CD630_27360 - Type: Gene Product:Transcriptional regulator, LysR family \| Pathway: \| COG: Transcription CD630_21220 - Type: Gene Product:Putative cations transporter \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_13980 - Type: Gene Product:Putative peptidase, M20D family \| Pathway: \| COG: Amino acid transport and metabolism CD630_09970 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_22940 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_18782 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn5-Orf39 \| Pathway: \| COG: Function unknown CD630_16600 - Type: Gene Product:Conserved hypothetical protein, DUF 1255 family \| Pathway: \| COG: Function unknown	0.85	`NA`	0.46	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_06290 - Type: Gene Product:Transcriptional regulator, Crp family \| Pathway: \| COG: Transcription CD630_14070 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_204	24 CD630_20160 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_03100 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_20750 - pbuX Type: Gene Product:Putative xanthine permease \| Pathway: \| COG: Nucleotide transport and metabolism CD630_23450 - Type: Gene Product:Transcriptional regulator, LysR family \| Pathway: \| COG: Transcription CD630_25940 - uraA Type: Gene Product:Putative uracil permease \| Pathway: \| COG: Nucleotide transport and metabolism CD630_21260 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_22730 - Type: Gene Product:Putative sporulation integral membrane protein \| Pathway: \| COG: Function unknown CD630_22170 - aroD Type: Gene Product:Dehydroquinate dehydratase (3-dehydroquinatedehydratase) (Dehydroquinase) (DHQase) \| Pathway: Metabolic intermediate biosynthesis \| COG: Amino acid transport and metabolism CD630_10060 - Type: Gene Product:Putative acyl-CoA N-acyltransferase \| Pathway: \| COG: Function unknown CD630_27030 - Type: Gene Product:Putative pentapeptide repeat-containing protein \| Pathway: \| COG: Function unknown CD630_01990 - Type: Gene Product:Putative membrane-associated nucleotidase \| Pathway: \| COG: Nucleotide transport and metabolism CD630_33200 - cprR Type: Gene Product:Two-component response regulator, cationicantimicrobial peptide resistance \| Pathway: \| COG: Signal transduction mechanisms CD630_16590 - Type: Gene Product:Cation-transporting ATPase \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_r0020 - 23s_rRNA Type: Gene Product: \| Pathway: \| COG: CD630_27190 - Type: Gene Product:Putative polysaccharide deacetylase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_10020 - Type: Gene Product:Putative nucleotide/oligonucleotide bindingprotein \| Pathway: \| COG: Function unknown CD630_30080 - Type: Gene Product:Fragment of conserved hypothetical protein(N-terminal region) \| Pathway: \| COG: Function unknown CD630_25950 - pyrR Type: Gene Product:Bifunctional protein PyrR [Includes: Pyrimidineoperon regulatory protein; Uracil phosphoribosyltransferase(UPRTase)] \| Pathway: \| COG: Nucleotide transport and metabolism CD630_20680 - Type: Gene Product:ABC drug efflux pump \| Pathway: \| COG: Function unknown CD630_27040 - Type: Gene Product:Putative permease \| Pathway: \| COG: Function unknown CD630_05630 - Type: Gene Product:Putative iron-sulfur cluster-binding protein \| Pathway: \| COG: Energy production and conversion CD630_22500 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_02170 - Type: Gene Product:Putative nitroreductase \| Pathway: \| COG: Energy production and conversion CD630_33600 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms	`NA`	`NA`	0.46	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_10640 - ccpA Type: Gene Product:Transcriptional regulator, LacI family \| Pathway: \| COG: Transcription CD630_33600 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_41	23 CD630_35940 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Energy production and conversion CD630_28520 - dltB Type: Gene Product:D-alanyl transferase DltB, MBOAT family \| Pathway: Cell wall biogenesis \| COG: Cell wall/membrane/envelope biogenesis CD630_28540 - dltD Type: Gene Product:D-alanine transferase \| Pathway: Cell wall biogenesis \| COG: Cell wall/membrane/envelope biogenesis CD630_22260 - sat Type: Gene Product:Streptogramin A acetyltransferase (Virginiamycinacetyltransferase D) (Vat(D)) \| Pathway: \| COG: Function unknown CD630_26030 - cdtR Type: Gene Product:Clostridium difficile binary toxin regulatorygene, LytTR family \| Pathway: \| COG: Signal transduction mechanisms CD630_16250 - vanS Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_01300 - metK Type: Gene Product:S-adenosylmethionine synthetase \| Pathway: Amino-acid biosynthesis \| COG: Coenzyme transport and metabolism CD630_17840 - truA2 Type: Gene Product:Pseudouridylate synthase (tRNA pseudouridinesynthase A) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_27151 - mldC Type: Gene Product:Midcell localizing division proteins \| Pathway: \| COG: CD630_27170 - mldA Type: Gene Product:Midcell localizing division proteins \| Pathway: \| COG: Function unknown CD630_35930 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_17820 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_28510 - dltC Type: Gene Product:D-alanine--poly(phosphoribitol) ligase subunit 2(D-alanyl carrier protein) (DCP) \| Pathway: Cell wall biogenesis \| COG: Cell wall/membrane/envelope biogenesis CD630_28530 - dltA Type: Gene Product:D-alanine--poly(phosphoribitol) ligase subunit 1 \| Pathway: Cell wall biogenesis \| COG: Secondary metabolites biosynthesis, transport and catabolism CD630_16220 - Type: Gene Product:Putative lipoprotein \| Pathway: \| COG: Function unknown CD630_17790 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Replication, recombination and repair CD630_23350 - guaB Type: Gene Product:Inositol-5'-monophosphate dehydrogenase (IMPdehydrogenase) (IMPDH) (IMPD) \| Pathway: \| COG: Nucleotide transport and metabolism CD630_16240 - vanR Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_27160 - mldB Type: Gene Product:Midcell localizing division proteins \| Pathway: \| COG: Function unknown CD630_06680 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_01980 - guaA Type: Gene Product:Glutamine amidotransferase \| Pathway: Purine metabolism \| COG: Nucleotide transport and metabolism CD630_17830 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_17810 - Type: Gene Product:Putative lipoprotein \| Pathway: \| COG: Function unknown	0.0000000032	`NA`	0.46	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_01710 - rex Type: Gene Product:Transcriptional regulator, Redox-sensingrepressor Rex \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_74	20 CD630_09540 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_09550 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_29200 - Type: Gene Product:Putative phage head protein \| Pathway: \| COG: Signal transduction mechanisms CD630_29240 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_09470 - Type: Gene Product:Putative phage scaffold protein \| Pathway: \| COG: Function unknown CD630_29100 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_29101 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_09531 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_09530 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_09490 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_29220 - Type: Gene Product:Putative phage terminase large subunit \| Pathway: \| COG: Replication, recombination and repair CD630_29110 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_09520 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_29130 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_09560 - Type: Gene Product:Putative XkdN-like phage protein \| Pathway: \| COG: Function unknown CD630_09561 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_09500 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_09480 - Type: Gene Product:Putative phage major capsid protein \| Pathway: \| COG: Function unknown CD630_10921 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn4-Orf32 \| Pathway: \| COG: Function unknown CD630_09510 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown	0.0002	2.5	0.46	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_06580 - cdu1 Type: Gene Product:Transcriptional regulator, beta-lactamsrepressor \| Pathway: \| COG: Transcription CD630_22140 - SinR Type: Gene Product:Transcriptional regulator, HTH-type \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_11	22 CD630_11480 - Type: Gene Product:Putative penicillin-binding protein with aN-terminal TonB-box \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_11510 - minE Type: Gene Product:Cell division topological specificity factor \| Pathway: \| COG: Cell cycle control, cell division, chromosome partitioning CD630_01720 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Energy production and conversion CD630_13350 - Type: Gene Product:Transcriptional regulator, MarR family \| Pathway: \| COG: Transcription CD630_11440 - radC Type: Gene Product:DNA repair protein RadC homolog \| Pathway: \| COG: Replication, recombination and repair CD630_32990 - Type: Gene Product:Transporter, Major Facilitator Superfamily (MFS) \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_11530 - mgsA Type: Gene Product:Methylglyoxal synthase (MGS) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_28270 - Type: Gene Product:Transcriptional regulator, MarR family \| Pathway: \| COG: Transcription CD630_28250 - Type: Gene Product:Putative flavodoxin \| Pathway: \| COG: Energy production and conversion CD630_28280 - Type: Gene Product:Putative pyridoxal phosphate-dependenttransferase \| Pathway: \| COG: Amino acid transport and metabolism CD630_33260 - Type: Gene Product:Integrase, lambdoid phage family Tn916-like,CTn6-Orf1 \| Pathway: \| COG: Replication, recombination and repair CD630_11500 - minD Type: Gene Product:Septum site-determining protein MinD (Celldivision inhibitor MinD) \| Pathway: \| COG: Cell cycle control, cell division, chromosome partitioning CD630_11490 - minC Type: Gene Product:Cell division regulator (septum placement) \| Pathway: \| COG: Cell cycle control, cell division, chromosome partitioning CD630_02770 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_11470 - Type: Gene Product:Putative permease \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_11520 - mrdB Type: Gene Product:Rod shape-determining protein MrdB \| Pathway: \| COG: Cell cycle control, cell division, chromosome partitioning CD630_11450 - mreB2 Type: Gene Product:Rod shape-determining protein MreB \| Pathway: \| COG: Cell cycle control, cell division, chromosome partitioning CD630_28260 - Type: Gene Product:Putative aldolase \| Pathway: \| COG: Energy production and conversion CD630_11430 - Type: Gene Product:Putative Maf-like protein \| Pathway: \| COG: Cell cycle control, cell division, chromosome partitioning CD630_27040 - Type: Gene Product:Putative permease \| Pathway: \| COG: Function unknown CD630_05103 - Type: Gene Product:Putative conjugative transposon protein Tn5397,CTn3-Orf4 \| Pathway: \| COG: CD630_33270 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn6-Orf2 \| Pathway: \| COG: Function unknown	`NA`	`NA`	0.46	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_11770 - fapR Type: Gene Product:Transcriptional regulator, DeoR family (Fattyacid and phospholipid biosynthesis regulator) \| Pathway: \| COG: Transcription CD630_17820 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_393	26 CD630_00670 - rpoC Type: Gene Product:DNA-directed RNA polymerase subunit beta' \| Pathway: \| COG: Transcription CD630_26720 - appA Type: Gene Product:ABC-type transport system, oligopeptide-familysolute-binding protein \| Pathway: \| COG: Amino acid transport and metabolism CD630_26700 - appF Type: Gene Product:ABC-type transport system, ATP-binding protein \| Pathway: \| COG: Amino acid transport and metabolism CD630_28520 - dltB Type: Gene Product:D-alanyl transferase DltB, MBOAT family \| Pathway: Cell wall biogenesis \| COG: Cell wall/membrane/envelope biogenesis CD630_05480 - Type: Gene Product:Putative penicillin-binding peptidase BlaR1-like,M56 family \| Pathway: \| COG: Transcription, Signal transduction mechanisms CD630_28540 - dltD Type: Gene Product:D-alanine transferase \| Pathway: Cell wall biogenesis \| COG: Cell wall/membrane/envelope biogenesis CD630_35560 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_28510 - dltC Type: Gene Product:D-alanine--poly(phosphoribitol) ligase subunit 2(D-alanyl carrier protein) (DCP) \| Pathway: Cell wall biogenesis \| COG: Cell wall/membrane/envelope biogenesis CD630_35540 - dusB Type: Gene Product:tRNA-dihydrouridine synthase \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_35520 - lysS Type: Gene Product:Lysyl-tRNA synthetase (Lysine--tRNA ligase)(LysRS) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_18100 - Type: Gene Product:Transcriptional regulator, beta-lactamsrepressor \| Pathway: \| COG: Transcription CD630_07040 - Type: Gene Product:Putative metal-dependent phosphohydrolase \| Pathway: \| COG: Function unknown CD630_26710 - appD Type: Gene Product:ABC-type transport system, ATP-binding protein \| Pathway: \| COG: Amino acid transport and metabolism, Inorganic ion transport and metabolism CD630_00660 - rpoB Type: Gene Product:DNA-directed RNA polymerase subunit beta \| Pathway: \| COG: Transcription CD630_35580 - birA Type: Gene Product:BirA bifunctional protein [Includes: biotinoperon repressor and biotin--[acetyl-CoA-carboxylase]synthetase \| Pathway: \| COG: Coenzyme transport and metabolism CD630_28530 - dltA Type: Gene Product:D-alanine--poly(phosphoribitol) ligase subunit 1 \| Pathway: Cell wall biogenesis \| COG: Secondary metabolites biosynthesis, transport and catabolism CD630_19630 - Type: Gene Product:Putative methyltransferase \| Pathway: \| COG: Secondary metabolites biosynthesis, transport and catabolism CD630_35570 - Type: Gene Product:Putative peptidase \| Pathway: \| COG: Amino acid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism CD630_35530 - greA Type: Gene Product:Transcription elongation factor greA (Transcriptcleavage factor GreA) \| Pathway: \| COG: Transcription CD630_35550 - coaX Type: Gene Product:Type III pantothenate kinase (Pantothenic acidkinase) (PanK-III) \| Pathway: Cofactor biosynthesis \| COG: Transcription CD630_02030 - Type: Gene Product:Putative UvrABC system protein A 1 (UvrA protein1) (Excinuclease ABC subunit A 1) \| Pathway: \| COG: Replication, recombination and repair CD630_07030 - Type: Gene Product:Putative peptidase, U32 family \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_07050 - Type: Gene Product:Putative hydrolase, NUDIX family \| Pathway: \| COG: Replication, recombination and repair CD630_36690 - Type: Gene Product:Putative lipoprotein \| Pathway: \| COG: Function unknown CD630_05470 - Type: Gene Product:Transcriptional regulator, beta-lactamsrepressor \| Pathway: \| COG: Transcription CD630_26740 - appC Type: Gene Product:ABC-type transport system, oligopeptide-familypermease protein \| Pathway: \| COG: Inorganic ion transport and metabolism	0.0000000000019	`NA`	0.46	Inferelator: 1 Hypergeometric: 1 TF Influences from Inferelator CD630_18100 - Type: Gene Product:Transcriptional regulator, beta-lactamsrepressor \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test CD630_32450 - prdR Type: Gene Product:Transcriptional regulator, sigma-54-dependent \| Pathway: \| COG: Transcription
Module_272	29 CD630_06890 - Type: Gene Product:Putative nucleotide phosphodiesterase \| Pathway: \| COG: Nucleotide transport and metabolism CD630_18260 - metA Type: Gene Product:Homoserine O-succinyltransferase \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_14900 - metI Type: Gene Product:ABC-type transport system, methionine-specificpermease \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_29670 - dpaB Type: Gene Product:Dipicolinate synthase subunit B \| Pathway: \| COG: Coenzyme transport and metabolism CD630_35230 - ksgA Type: Gene Product:Dimethyladenosine transferase(S-adenosylmethionine-6-N', N'-adenosyl(rRNA)dimethyltransferase) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_29720 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_29700 - Type: Gene Product:Putative thiolase \| Pathway: \| COG: Lipid transport and metabolism CD630_21420 - Type: Gene Product:Putative transporter \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_29690 - Type: Gene Product:Putative AMP-binding protein \| Pathway: \| COG: Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism CD630_01300 - metK Type: Gene Product:S-adenosylmethionine synthetase \| Pathway: Amino-acid biosynthesis \| COG: Coenzyme transport and metabolism CD630_16530 - Type: Gene Product:Putative Probable D-methionine-bindinglipoprotein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_00510 - gltX Type: Gene Product:Glutamyl-tRNA synthetase \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_06350 - Type: Gene Product:Putative hydrolase \| Pathway: \| COG: Function unknown CD630_05580 - glsA Type: Gene Product:Glutaminase (L-glutamine amidohydrolase) \| Pathway: \| COG: Amino acid transport and metabolism CD630_30630 - Type: Gene Product:Putative peptidase, S41 family \| Pathway: \| COG: Function unknown CD630_15160 - Type: Gene Product:Transcriptional regulator, MerR family \| Pathway: \| COG: Transcription CD630_18250 - metY Type: Gene Product:O-acetylhomoserine sulfhydrylase \| Pathway: \| COG: Amino acid transport and metabolism CD630_02440 - Type: Gene Product:Putative CDP-glycerol:Poly(glycerophosphate)glycerophosphotransferase \| Pathway: \| COG: Function unknown CD630_14910 - metQ Type: Gene Product:ABC-type transport system, methionine-specificsubstrate-binding lipoprotein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_35220 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_21410 - Type: Gene Product:Serine-type D-Ala-D-Ala carboxypeptidase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_29680 - dpaA Type: Gene Product:Dipicolinate synthase subunit A \| Pathway: \| COG: Function unknown CD630_16520 - Type: Gene Product:Putative tellurium resistance protein \| Pathway: \| COG: Signal transduction mechanisms CD630_29710 - bioY Type: Gene Product:Biotin synthase \| Pathway: \| COG: Function unknown CD630_35240 - Type: Gene Product:Putative DNA-binding protein \| Pathway: \| COG: Replication, recombination and repair CD630_14890 - metN Type: Gene Product:ABC-type transport system, methionine-specificATP-binding protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_06340 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_17660 - Type: Gene Product:Putative lipoprotein \| Pathway: \| COG: CD630_05590 - Type: Gene Product:Transcriptional regulator, ArsR family \| Pathway: \| COG: Transcription	0.00000077	0.07	0.46	Inferelator: 3 Hypergeometric: 0 TF Influences from Inferelator CD630_06290 - Type: Gene Product:Transcriptional regulator, Crp family \| Pathway: \| COG: Transcription CD630_26420 - sigG Type: Gene Product:RNA polymerase sigma-G factor \| Pathway: \| COG: Transcription CD630_34990 - spoVT Type: Gene Product:Stage V sporulation protein T \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_361	8 CD630_06380 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_05800 - gapN Type: Gene Product:Glyceraldehyde-3-phosphate dehydrogenase(NADP(+)) (GADPH) \| Pathway: \| COG: Energy production and conversion CD630_06910 - Type: Gene Product:Putative short chain dehydrogenase/reductase, SDRfamily \| Pathway: \| COG: Function unknown CD630_27120 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_06370 - Type: Gene Product:Putative acetyltransferase \| Pathway: \| COG: Function unknown CD630_05620 - Type: Gene Product:Putative RusA-like endodeoxyribonuclease \| Pathway: \| COG: Function unknown CD630_10640 - ccpA Type: Gene Product:Transcriptional regulator, LacI family \| Pathway: \| COG: Transcription CD630_17920 - Type: Gene Product:Putative L-threonine 3-dehydrogenase \| Pathway: \| COG: Carbohydrate transport and metabolism, Cell wall/membrane/envelope biogenesis	6.4	`NA`	0.46	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_10640 - ccpA Type: Gene Product:Transcriptional regulator, LacI family \| Pathway: \| COG: Transcription CD630_24120 - Type: Gene Product:Putative negative regulator of gluconeogenesis \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_30	22 CD630_25270 - Type: Gene Product:Transcriptional regulator, TetR family \| Pathway: \| COG: Transcription CD630_34380 - cobU Type: Gene Product:Bifunctional adenosylcobalamin biosynthesisprotein CobU [Adenosylcobinamide kinase;Adenosylcobinamide-phosphate guanylyltransferase] \| Pathway: \| COG: Coenzyme transport and metabolism CD630_08870 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_11750 - ackA Type: Gene Product:Acetate kinase (Acetokinase) \| Pathway: Metabolic intermediate biosynthesis \| COG: Energy production and conversion CD630_07580 - pflA Type: Gene Product:Pyruvate formate-lyase activating enzyme \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_05200 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_15380 - Type: Gene Product:Putative signaling protein \| Pathway: \| COG: Signal transduction mechanisms CD630_14190 - Type: Gene Product:Putative diguanylate kinase signaling protein \| Pathway: \| COG: Signal transduction mechanisms CD630_05210 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_14210 - Type: Gene Product:Putative diguanylate kinase signaling protein \| Pathway: \| COG: Signal transduction mechanisms CD630_08410 - Type: Gene Product:5-aminoimidazole-4-carboxamide ribonucleotidetransformylase \| Pathway: \| COG: Nucleotide transport and metabolism CD630_08100 - Type: Gene Product:Putative flavodoxin/nitric oxide synthase \| Pathway: \| COG: Function unknown CD630_26630 - Type: Gene Product:Putative signaling protein \| Pathway: \| COG: Signal transduction mechanisms CD630_08360 - Type: Gene Product:Putative acetyltransferase \| Pathway: \| COG: Transcription CD630_25280 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_16540 - Type: Gene Product:Putative lipoate-protein ligase \| Pathway: Protein modification \| COG: Coenzyme transport and metabolism CD630_24920 - Type: Gene Product:Two-component sensor histidine kinase,sporulation-associated spo0A \| Pathway: \| COG: Signal transduction mechanisms CD630_07590 - plfB Type: Gene Product:Formate acetyltransferase (Pyruvateformate-lyase) \| Pathway: \| COG: Energy production and conversion CD630_08400 - Type: Gene Product:Putative isomerase/hydrolase \| Pathway: \| COG: Secondary metabolites biosynthesis, transport and catabolism CD630_15150 - Type: Gene Product:Putative diguanylate kinase signaling protein \| Pathway: \| COG: Signal transduction mechanisms CD630_14200 - dccA Type: Gene Product:Diguanylate cyclase protein \| Pathway: \| COG: Signal transduction mechanisms CD630_13920 - Type: Gene Product:Putative endoribonuclease \| Pathway: \| COG: Translation, ribosomal structure and biogenesis	0.000000000000032	`NA`	0.46	Inferelator: 3 Hypergeometric: 0 TF Influences from Inferelator CD630_10640 - ccpA Type: Gene Product:Transcriptional regulator, LacI family \| Pathway: \| COG: Transcription CD630_17820 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_25270 - Type: Gene Product:Transcriptional regulator, TetR family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`