Environment and Gene Regulatory Influence Network (EGRIN) model for C. difficile 630

The Environment and Gene Regulatory Influence Network (EGRIN) model of C. difficile 630 was inferred using cMonkey2 and a compendium of 136 transcriptomes (retrieved from the Gene Expression Omnibus repository) with 4,070 sequence features including 35 rRNAs and 90 tRNAs . The C. difficile EGRIN model groups genes in subsets (406 modules in total), that are co-regulated in specific environments, and also identifies the associated, putative cis-acting gene regulatory elements (GREs), which represent potential TF binding locations. Transcriptome compendium included conditions: response to iron limitation, response to oxygen, in vivo vs in vitro growth, short term infection (0, 30, 60, 120 mins), response to commensals and host diet, transition from exponential to stationary phase, fur KO, codY KO, sporulation TF (and sigma factors) KOs.

Explore Regulatory Modules

Displaying 91 - 100 of 406

Candidate transcriptional regulators for each module were determined with a linear regression based approach (Inferelator) and by evaluating the statistical significance of the overlap (Hypergeometric) between modules and putative TF and alternative sigma factor regulons (CcpA, CodY, Fur, PrdR, SigB, SigD, SigE, SigF, SigG, SigH, SigK, Spo0A) compiled from available literature.

* Given that translation start was used to define the 3' end of putative promoters, some cis-regulatory motifs are likely to be ribosome binding sites (i.e., Shine-Dalgarno sequence). RBS is typically a six nucleotide sequence 5'-GGAGGA-3'.

Title	Gene Count	Motif 1 e-value	Motif 2 e-value	Residual	TF Influences
Module_216	20 CD630_21490 - Type: Gene Product:Putative vancomycin resistance protein, vanWfamily \| Pathway: \| COG: Defense mechanisms CD630_21480 - Type: Gene Product:Putative serine/threonine protein kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_23980 - Type: Gene Product:Putative 2-thiocytidine tRNA biosynthesis proteinTtcA \| Pathway: \| COG: Cell cycle control, cell division, chromosome partitioning CD630_06760 - rsiT Type: Gene Product:Anti Sigma factors, ECF family \| Pathway: \| COG: Function unknown CD630_36790 - rnpA Type: Gene Product:Ribonuclease P protein component (RNaseP protein)(RNase P protein) (Protein C5) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_00470 - ispD Type: Gene Product:2-C-methyl-D-erythritol 4-phosphatecytidylyltransferase \| Pathway: Isoprenoid biosynthesis \| COG: Lipid transport and metabolism CD630_22121 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_00480 - ispF Type: Gene Product:2-C-methyl-D-erythritol 2,4-cyclodiphosphatesynthase \| Pathway: Isoprenoid biosynthesis \| COG: Lipid transport and metabolism CD630_32550 - rgaR Type: Gene Product:Two-component response regulator VirR-like \| Pathway: \| COG: Signal transduction mechanisms CD630_23970 - Type: Gene Product:Putative exonuclease \| Pathway: \| COG: Replication, recombination and repair CD630_36760 - mnmE Type: Gene Product:tRNA modification GTPase MnmE \| Pathway: \| COG: Function unknown CD630_36800 - rpmH Type: Gene Product:50S ribosomal protein L34 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_36780 - oxaA1 Type: Gene Product:Sporulation membrane protein SpoIIIJ \| Pathway: \| COG: Intracellular trafficking, secretion, and vesicular transport CD630_36781 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_06770 - sigT Type: Gene Product:Extra-Cytoplasmic Function sigma factors, ECFfamily \| Pathway: \| COG: Transcription CD630_36770 - Type: Gene Product:Putative SpoIIIJ-associated RNA/ssDNA-bindingprotein Jag \| Pathway: \| COG: Function unknown CD630_19970 - Type: Gene Product:Putative proline iminopeptidase (PIP), S33family \| Pathway: \| COG: Function unknown CD630_19980 - Type: Gene Product:Transcriptional regulator, TetR family \| Pathway: \| COG: Transcription CD630_21320 - Type: Gene Product:Putative transcriptional regulator \| Pathway: \| COG: Transcription CD630_36750 - mnmG Type: Gene Product:tRNA uridine 5-carboxymethylaminomethylmodification enzyme MnmG (Glucose-inhibited divisionprotein A) \| Pathway: \| COG: Cell cycle control, cell division, chromosome partitioning	0	`NA`	0.44	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_06480 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_21110 - Type: Gene Product:Transcriptional regulator, DeoR family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_126	7 CD630_31850 - Type: Gene Product:Fragment of putative RNA-binding protein (Part2) \| Pathway: \| COG: Function unknown, Function unknown CD630_12840 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_02731 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_06470 - Type: Gene Product:Fragment of putative fic family protein(C-terminal region) \| Pathway: \| COG: Function unknown CD630_18110 - Type: Gene Product:Fragment of putative two-component sensorhistidine kinase (N-terminal region) \| Pathway: \| COG: Signal transduction mechanisms CD630_28240 - Type: Gene Product:Fragment of putative membrane protein (C-terminalregion) \| Pathway: \| COG: Function unknown CD630_12830 - Type: Gene Product:Conserved hypothetical protein, UPF0297 family \| Pathway: \| COG: Function unknown	`NA`	`NA`	0.44	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_30620 - Type: Gene Product:Transcriptional regulator, RpiR family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_131	3 CD630_22950 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: CD630_15100 - Type: Gene Product:Conserved hypothetical protein, DUF1121 family \| Pathway: \| COG: Function unknown CD630_26170 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown	`NA`	`NA`	0.44	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_15100 - Type: Gene Product:Conserved hypothetical protein, DUF1121 family \| Pathway: \| COG: Function unknown TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_177	21 CD630_05690 - Type: Gene Product:Putative lipoprotein \| Pathway: \| COG: Function unknown CD630_24640 - hemN Type: Gene Product:Oxygen-independent coproporphyrinogen-III oxidase(Coproporphyrinogenase) (Coprogen oxidase) \| Pathway: \| COG: Coenzyme transport and metabolism CD630_24670 - lepA Type: Gene Product:GTP-binding protein LepA \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_24620 - grpE Type: Gene Product:Protein grpE (HSP-70 cofactor) \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_27440 - relA Type: Gene Product:GTP pyrophosphokinase (RelA/SpoT) \| Pathway: \| COG: Transcription, Signal transduction mechanisms CD630_27400 - hisS Type: Gene Product:Histidyl-tRNA synthetase (Histidine--tRNA ligase)(HisRS) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_24660 - Type: Gene Product:Putative tRNA-nucleotidyltransferase/Poly(A)polymerase family member \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_27240 - Type: Gene Product:Putative polysaccharide deacetylase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_01450 - Type: Gene Product:Putative resolvase, S1 RNA-bindingdomain-containing protein \| Pathway: \| COG: Transcription CD630_27250 - Type: Gene Product:Putative monogalactosyldiacylglycerol synthase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_05700 - Type: Gene Product:Putative lipoprotein \| Pathway: \| COG: Function unknown CD630_24630 - hrcA Type: Gene Product:Transcriptional regulator, Heat-induciblerepressor HrcA \| Pathway: \| COG: Transcription CD630_24600 - dnaJ Type: Gene Product:Chaperone protein DnaJ \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_27410 - hemZ Type: Gene Product:Coproporphyrinogen III oxidase \| Pathway: \| COG: Coenzyme transport and metabolism CD630_01460 - Type: Gene Product:Putative hydrolase \| Pathway: \| COG: Secondary metabolites biosynthesis, transport and catabolism CD630_28400 - serS1 Type: Gene Product:Seryl-tRNA synthetase 1 (Seryl-tRNA(Ser/Sec)synthetase 1) (Serine--tRNA ligase 1) (SerRS 1) \| Pathway: Aminoacyl-tRNA biosynthesis \| COG: Translation, ribosomal structure and biogenesis CD630_24610 - dnaK Type: Gene Product:Chaperone protein dnaK (Heat shock protein 70)(Heat shock 70 kDa protein) (HSP70) \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_27450 - apt Type: Gene Product:Adenine phosphoribosyltransferase (APRT) \| Pathway: Purine metabolism \| COG: Nucleotide transport and metabolism CD630_27430 - dtd Type: Gene Product:D-tyrosyl-tRNA(Tyr) deacylase \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_27230 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_27420 - Type: Gene Product:Putative hydrolase beta-lactamase-like \| Pathway: \| COG: Secondary metabolites biosynthesis, transport and catabolism	0.0000000037	`NA`	0.44	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_23830 - Type: Gene Product:Transcriptional regulator, sigma-54-dependent \| Pathway: \| COG: Transcription CD630_24630 - hrcA Type: Gene Product:Transcriptional regulator, Heat-induciblerepressor HrcA \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_194	20 CD630_08330 - acnB Type: Gene Product:Aconitate hydratase (Citrate hydro-lyase) \| Pathway: \| COG: Energy production and conversion CD630_08810 - Type: Gene Product:Putative protein modulating protease activity \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_33230 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_27210 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_09960 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_08340 - icd Type: Gene Product:Isocitrate dehydrogenase NAD-dependent \| Pathway: \| COG: Amino acid transport and metabolism CD630_07590 - plfB Type: Gene Product:Formate acetyltransferase (Pyruvateformate-lyase) \| Pathway: \| COG: Energy production and conversion CD630_07580 - pflA Type: Gene Product:Pyruvate formate-lyase activating enzyme \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_08800 - Type: Gene Product:Putative protease \| Pathway: \| COG: Function unknown CD630_36680 - rstA Type: Gene Product:Regulator of sporulation and toxins \| Pathway: \| COG: Transcription CD630_36650 - Type: Gene Product:Conserved hypothetical protein, DUF951 family \| Pathway: \| COG: Function unknown CD630_08320 - aksA Type: Gene Product:Trans-homoaconitate synthase \| Pathway: \| COG: Amino acid transport and metabolism CD630_33240 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_28300 - zmp1 Type: Gene Product:Extracellular Zinc metalloprotease \| Pathway: \| COG: Function unknown CD630_36670 - Type: Gene Product:Conserved hypothetical protein, TusA family \| Pathway: \| COG: Function unknown CD630_27220 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_36660 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_09940 - Type: Gene Product:Putative serine-pyruvate aminotransferase \| Pathway: \| COG: Amino acid transport and metabolism CD630_36640 - Type: Gene Product:Putative aminotransferase \| Pathway: \| COG: Transcription CD630_09950 - serA Type: Gene Product:Putative D-3-phosphoglycerate dehydrogenase \| Pathway: \| COG: Amino acid transport and metabolism	0.0000076	2.8	0.44	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_27220 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_385	21 CD630_10340 - Type: Gene Product:Putative mannosyl-glycoproteinendo-beta-N-acetylglucosamidase \| Pathway: \| COG: Cell motility, Intracellular trafficking, secretion, and vesicular transport CD630_02130 - Type: Gene Product:Putative spore coat protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_31770 - Type: Gene Product:Putative xanthine dehydrogenase \| Pathway: \| COG: Energy production and conversion CD630_10310 - Type: Gene Product:Putative cell wall anchored protein \| Pathway: \| COG: Function unknown CD630_02140 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_00340 - Type: Gene Product:Putative xylose transporter, sodium:galactosidesymporter family \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_31790 - pyrD Type: Gene Product:Dihydroorotate dehydrogenase, catalytic subunit \| Pathway: \| COG: Nucleotide transport and metabolism CD630_31170 - bglG Type: Gene Product:Transcription antiterminator, PTS operonregulator \| Pathway: \| COG: Transcription CD630_10280 - Type: Gene Product:Putative signaling protein \| Pathway: \| COG: Signal transduction mechanisms CD630_31820 - Type: Gene Product:Putative D-aminoacylase \| Pathway: \| COG: Secondary metabolites biosynthesis, transport and catabolism CD630_10330 - mnaA Type: Gene Product:UDP-N-acetylglucosamine 2-epimerase(UDP-GlcNAc-2-epimerase) \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_31830 - Type: Gene Product:Putative peptidase, M20 family \| Pathway: \| COG: Amino acid transport and metabolism CD630_31150 - bglA Type: Gene Product:6-phospho-beta-glucosidase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_31810 - Type: Gene Product:Putative amidohydrolase \| Pathway: \| COG: Nucleotide transport and metabolism CD630_10320 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_31160 - bglF Type: Gene Product:PTS system, beta-glucoside-specific IIABCcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_00330 - Type: Gene Product:Putative glycoside hydrolase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_00320 - Type: Gene Product:Putative beta-glucosidase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_10300 - Type: Gene Product:Putative glycosyl transferase, family 2 \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_31800 - Type: Gene Product:Putative purine permease \| Pathway: \| COG: Nucleotide transport and metabolism CD630_31780 - Type: Gene Product:D-hydantoinase (Dihydropyrimidinase) \| Pathway: \| COG: Nucleotide transport and metabolism	0.49	`NA`	0.45	Inferelator: 2 Hypergeometric: 1 TF Influences from Inferelator CD630_25990 - Type: Gene Product:Putative transcriptional regulator \| Pathway: \| COG: Transcription CD630_34990 - spoVT Type: Gene Product:Stage V sporulation protein T \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test CD630_12140 - spo0A Type: Gene Product:Stage 0 sporulation protein A \| Pathway: \| COG: Signal transduction mechanisms
Module_14	28 CD630_30250 - Type: Gene Product:Putative ferredoxin, iron-sulphurdomain-containing protein \| Pathway: \| COG: Energy production and conversion CD630_10770 - Type: Gene Product:PTS system, mannose/fructose/sorbose IICcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_31320 - Type: Gene Product:PTS system, fructose-like IIA component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_13600 - Type: Gene Product:Transcriptional regulator, Phage-type \| Pathway: \| COG: Transcription CD630_34440 - Type: Gene Product:PTS system, lactose/cellobiose-family IIBcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_10750 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_31340 - Type: Gene Product:PTS system, fructose-like IIABC component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_34460 - Type: Gene Product:Aminopeptidase, M42 family \| Pathway: \| COG: Amino acid transport and metabolism CD630_34420 - Type: Gene Product:Putative peptidase, M24 family \| Pathway: \| COG: Amino acid transport and metabolism CD630_14150 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_10730 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_10780 - Type: Gene Product:PTS system, mannose/fructose/sorbose IIDcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_30260 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Transcription CD630_10760 - Type: Gene Product:PTS system, mannose/fructose/sorbose IIBcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_13590 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_05310 - Type: Gene Product:Transcriptional regulator, DeoR family \| Pathway: \| COG: Transcription CD630_31350 - Type: Gene Product:Putative fructose-1-6-bisphosphate aldolase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_13610 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_10740 - Type: Gene Product:PTS system, mannose/fructose/sorbose IIAcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_31310 - Type: Gene Product:Transcriptional regulator, AraC family \| Pathway: \| COG: Transcription CD630_34450 - Type: Gene Product:PTS system, lactose/cellobiose-family IIAcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_19030 - Type: Gene Product:Putative lipoprotein signal peptidase \| Pathway: \| COG: Function unknown CD630_34410 - Type: Gene Product:Putative pyridoxal phosphate-dependenttransferase (PLP-dependent transferase) \| Pathway: \| COG: Amino acid transport and metabolism CD630_34470 - Type: Gene Product:Transcription antiterminator, PTS operonregulator \| Pathway: \| COG: Transcription CD630_34430 - Type: Gene Product:PTS system, lactose/cellobiose-family IICcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_13601 - Type: Gene Product:Transcriptional regulator, Phage-type \| Pathway: \| COG: Transcription CD630_14220 - Type: Gene Product:Transcriptional regulator, MerR family \| Pathway: \| COG: Transcription CD630_31330 - Type: Gene Product:Transcription antiterminator, PTS operonregulator \| Pathway: \| COG: Transcription	0.0000000015	0.05	0.45	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_05160 - Type: Gene Product:Transcription antiterminator \| Pathway: \| COG: Signal transduction mechanisms CD630_35580 - birA Type: Gene Product:BirA bifunctional protein [Includes: biotinoperon repressor and biotin--[acetyl-CoA-carboxylase]synthetase \| Pathway: \| COG: Coenzyme transport and metabolism TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_64	23 CD630_30460 - murQ Type: Gene Product:N-acetylmuramic acid 6-phosphate etherase \| Pathway: Amino-sugar metabolism \| COG: Carbohydrate transport and metabolism CD630_30480 - Type: Gene Product:PTS system, lactose/cellobiose-family IICmembrane component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_30960 - bglA Type: Gene Product:6-phospho-beta-glucosidase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_30970 - bglF Type: Gene Product:PTS system, beta-glucoside-specific IIABCcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_33510 - clpP2 Type: Gene Product:ATP-dependent Clp protease proteolytic subunit 2(Endopeptidase Clp 2) \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_24290 - Type: Gene Product:Putative flavodoxin/ferredoxin oxidoreductasealpha subunit \| Pathway: \| COG: Energy production and conversion CD630_33530 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_24250 - ptb Type: Gene Product:Phosphate butyryltransferase(Phosphotransbutyrylase) \| Pathway: \| COG: Energy production and conversion CD630_24260 - buk1 Type: Gene Product:Butyrate kinase 1 (BK 1) (Branched-chaincarboxylic acid kinase 1) \| Pathway: \| COG: Energy production and conversion CD630_24270 - Type: Gene Product:Putative flavodoxin/ferredoxin oxidoreductasegamma subunit \| Pathway: \| COG: Energy production and conversion CD630_30470 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_24230 - Type: Gene Product:Transporter, Major Facilitator Superfamily (MFS) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_35890 - carA Type: Gene Product:Carbamoyl-phosphate synthase small chain \| Pathway: Amino-acid biosynthesis \| COG: Nucleotide transport and metabolism CD630_30490 - Type: Gene Product:PTS system, lactose/cellobiose-family IIBsubunit \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_30950 - bglA Type: Gene Product:6-phospho-beta-glucosidase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_24291 - Type: Gene Product:Putative 4Fe-4S ferredoxin, iron-sulfur bindingdomain protein, delta subunit \| Pathway: \| COG: Energy production and conversion CD630_28180 - Type: Gene Product:ABC-type transport system, multidrug-familyATP-binding/permease protein \| Pathway: \| COG: Defense mechanisms CD630_33540 - Type: Gene Product:Putative tRNA-binding protein \| Pathway: \| COG: Function unknown CD630_30980 - bglG Type: Gene Product:Transcription antiterminator, PTS operonregulator \| Pathway: \| COG: Transcription CD630_24280 - Type: Gene Product:Putative flavodoxin/ferredoxin oxidoreductasebeta subunit \| Pathway: \| COG: Energy production and conversion CD630_33520 - Type: Gene Product:Transcriptional regulator, AraC family \| Pathway: \| COG: Transcription CD630_24240 - Type: Gene Product:Putative pyridoxal phosphate-dependenttransferase \| Pathway: \| COG: Transcription CD630_28170 - Type: Gene Product:ABC-type transport system, multidrug-familyATP-binding/permease protein \| Pathway: \| COG: Defense mechanisms	0.26	0.02	0.45	Inferelator: 0 Hypergeometric: 0 TF Influences from Inferelator `No TF influences from Inferelator` TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_32	23 CD630_10370 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_19740 - hfq Type: Gene Product:Hfq RNA chaperone \| Pathway: \| COG: Signal transduction mechanisms CD630_18650 - Type: Gene Product:Putative DNA recombination protein Tn1549-like,CTn5-Orf24 \| Pathway: \| COG: Function unknown CD630_10400 - addB Type: Gene Product:ATP-dependent nuclease subunit B (ATP-dependenthelicase addB), Superfamily 1 UvrD-family \| Pathway: \| COG: Replication, recombination and repair CD630_10420 - sbcD Type: Gene Product:Nuclease SbcCD subunit D \| Pathway: \| COG: Replication, recombination and repair CD630_10390 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_18670 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn5-Orf26 \| Pathway: \| COG: Function unknown CD630_19720 - Type: Gene Product:Putative peptidase, M20A family \| Pathway: \| COG: Amino acid transport and metabolism CD630_00190 - Type: Gene Product:Putative glycosyl transferase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_14620 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_18680 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn5-Orf27 \| Pathway: \| COG: Function unknown CD630_23930 - Type: Gene Product:Putative glycosyl transferase, family 51 \| Pathway: Cell wall biogenesis \| COG: Cell wall/membrane/envelope biogenesis CD630_26730 - appB Type: Gene Product:ABC-type transport system, oligopeptide-familypermease protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_10430 - sbcC Type: Gene Product:Nuclease SbcCD subunit C \| Pathway: \| COG: Replication, recombination and repair CD630_10410 - addA Type: Gene Product:ATP-dependent nuclease subunit A (ATP-dependenthelicase addA) \| Pathway: \| COG: Replication, recombination and repair CD630_10380 - Type: Gene Product:Putative helicase, superfamily 1, UvrD-family \| Pathway: \| COG: Replication, recombination and repair CD630_18660 - Type: Gene Product:Putative conjugative transposon proteintn1549-like, CTn5-Orf25 \| Pathway: \| COG: Function unknown CD630_18640 - Type: Gene Product:Transcriptional regulator, HTH-type Tn1549-like,CTn5-Orf23 \| Pathway: \| COG: Transcription CD630_14610 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_19420 - trmB Type: Gene Product:tRNA (guanine-N(7)-)-methyltransferase(tRNA(m7G46)-methyltransferase) \| Pathway: tRNA modification \| COG: Energy production and conversion CD630_23940 - polC Type: Gene Product:DNA polymerase III, epsilon subunit \| Pathway: \| COG: Replication, recombination and repair CD630_23920 - Type: Gene Product:Putative tRNA-binding protein \| Pathway: \| COG: Function unknown CD630_14680 - Type: Gene Product:Putative iron-sulfur protein \| Pathway: \| COG: Energy production and conversion	0.05	`NA`	0.45	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_18100 - Type: Gene Product:Transcriptional regulator, beta-lactamsrepressor \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_237	20 CD630_34900 - spoIIE Type: Gene Product:Phosphoprotein phosphatase \| Pathway: \| COG: Signal transduction mechanisms CD630_34910 - Type: Gene Product:Putative exopolyphosphatase \| Pathway: \| COG: Nucleotide transport and metabolism, Inorganic ion transport and metabolism CD630_34990 - spoVT Type: Gene Product:Stage V sporulation protein T \| Pathway: \| COG: Transcription CD630_22960 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Transcription CD630_00180 - recR Type: Gene Product:DNA repair and recombination protein \| Pathway: \| COG: Replication, recombination and repair CD630_35010 - mfd Type: Gene Product:Transcription-repair coupling factor (TRCFATP-dependent helicase mfd) \| Pathway: \| COG: Replication, recombination and repair CD630_00170 - Type: Gene Product:DNA binding protein \| Pathway: \| COG: Function unknown CD630_34970 - Type: Gene Product:Bifunctional protein [Includes: Tetrapyrrolemethylase; NTP pyrophosphohydrolase MazG] \| Pathway: \| COG: Function unknown CD630_34930 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_35000 - prsA Type: Gene Product:Peptidylprolyl isomerase PrsA-like \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_26110 - mtnN Type: Gene Product:MTA/SAH nucleosidase (5'-methylthioadenosinenucleosidase) (S-adenosylhomocysteine nucleosidase) \| Pathway: Amino-acid biosynthesis \| COG: Nucleotide transport and metabolism CD630_35020 - pth Type: Gene Product:Peptidyl-tRNA hydrolase (PTH) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_00160 - dnaX Type: Gene Product:DNA polymerase III subunits gamma and tau \| Pathway: \| COG: Replication, recombination and repair CD630_34960 - hbs Type: Gene Product:DNA-binding protein, non-specific \| Pathway: \| COG: Replication, recombination and repair CD630_34980 - spoVB Type: Gene Product:Stage V sporulation protein B \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_22970 - Type: Gene Product:Putative phage-related regulatory protein \| Pathway: \| COG: Transcription CD630_26100 - trpS Type: Gene Product:Tryptophanyl-tRNA synthetase (Tryptophan--tRNAligase) (TrpRS) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_34940 - Type: Gene Product:Putative spore protein \| Pathway: \| COG: Function unknown CD630_34920 - Type: Gene Product:Septum formation initiation protein \| Pathway: \| COG: CD630_34950 - Type: Gene Product:Putative RNA-binding S4 domain-containingprotein \| Pathway: \| COG: Translation, ribosomal structure and biogenesis	0.05	`NA`	0.45	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_34990 - spoVT Type: Gene Product:Stage V sporulation protein T \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`