Module 482 Residual: 0.61

Title Bicluster Model Residual Score
bicluster_0482 v02 0.61 -15.41
Displaying 1 - 19 of 19
Rv0490 Phosphate regulon sensor protein PhoR (SphS) (EC 2.7.13.3); Sensor-like histidine kinase senX3 (EC 2.7.13.3)

Details for Rv0490 - Phosphate regulon sensor protein PhoR (SphS) (EC 2.7.13.3); Sensor-like histidine kinase senX3 (EC 2.7.13.3)

GO Terms: GO:0008150, GO:0005576, GO:0009405, GO:0018106, GO:0046777

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.40 | In vitro Essential: NA | In vivo Essential: 0.21

Go to Gene Page: Rv0490

Tuberculist Genomic Region

Rv0410c serine/threonine protein kinase

Details for Rv0410c - serine/threonine protein kinase

GO Terms: GO:0001899, GO:0004674, GO:0005515, GO:0005829, GO:0005886, GO:0006538, GO:0006543, GO:0009405, GO:0040007, GO:0044413, GO:0046777, GO:0052027, GO:0052190, GO:0052369

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.00 | In vitro Essential: 0.13 | In vivo Essential: NA

Go to Gene Page: Rv0410c

Tuberculist Genomic Region

Rv0411c \Glutamine ABC transporter, periplasmic glutamine-binding protein (TC 3.A.1.3.2)\\\""

Details for Rv0411c - \Glutamine ABC transporter, periplasmic glutamine-binding protein (TC 3.A.1.3.2)\\\""

GO Terms: GO:0005576, GO:0040007

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.01 | In vitro Essential: 0.10 | In vivo Essential: NA

Go to Gene Page: Rv0411c

Tuberculist Genomic Region

Rv0412c Possible membrane protein

Details for Rv0412c - Possible membrane protein

GO Terms: GO:0005887, GO:0040007

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.00 | In vitro Essential: 0.14 | In vivo Essential: NA

Go to Gene Page: Rv0412c

Tuberculist Genomic Region

Rv0413 \Possible mutator protein MutT3 (7,8-dihydro-8-oxoguanine-triphosphatase) \\\""

Details for Rv0413 - \Possible mutator protein MutT3 (7,8-dihydro-8-oxoguanine-triphosphatase) \\\""

GO Terms: NA

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.63 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv0413

Tuberculist Genomic Region

Rv0486 Glycosyltransferase MshA involved in mycothiol biosynthesis (EC 2.4.1.-)
Rv0487 Uncharacterized protein Rv0487/MT0505 clustered with mycothiol biosynthesis gene

Details for Rv0487 - Uncharacterized protein Rv0487/MT0505 clustered with mycothiol biosynthesis gene

GO Terms: NA

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.99 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv0487

Tuberculist Genomic Region

Rv1330c Nicotinate phosphoribosyltransferase (EC 2.4.2.11)

Details for Rv1330c - Nicotinate phosphoribosyltransferase (EC 2.4.2.11)

GO Terms: GO:0004516, GO:0004516, GO:0009435, GO:0034355, GO:0047280

PATRIC Pathways: Nicotinate and nicotinamide metabolism

Essentiality: Griffin Essential: 0.94 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv1330c

Tuberculist Genomic Region

Rv1331 ATP-dependent Clp protease adaptor protein ClpS

Details for Rv1331 - ATP-dependent Clp protease adaptor protein ClpS

GO Terms: NA

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.71 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv1331

Tuberculist Genomic Region

Rv1332 Transcriptional regulatory protein

Details for Rv1332 - Transcriptional regulatory protein

GO Terms: NA

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.59 | In vitro Essential: NA | In vivo Essential: 0.20

Go to Gene Page: Rv1332

Tuberculist Genomic Region

Rv2130c L-cysteine:1D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase MshC

Details for Rv2130c - L-cysteine:1D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase MshC

GO Terms: GO:0004817, GO:0005886, GO:0010125, GO:0016049, GO:0035446, GO:0040007, GO:0004817

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.00 | In vitro Essential: 0.06 | In vivo Essential: NA

Go to Gene Page: Rv2130c

Tuberculist Genomic Region

Rv2131c Protein cysQ homolog

Details for Rv2131c - Protein cysQ homolog

GO Terms: GO:0000287, GO:0005886, GO:0008441, GO:0008934, GO:0030145, GO:0040007, GO:0042132, GO:0042803, GO:0050427, GO:0050897

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.01 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv2131c

Tuberculist Genomic Region

Rv2234 Low molecular weight protein tyrosine phosphatase (EC 3.1.3.48)

Details for Rv2234 - Low molecular weight protein tyrosine phosphatase (EC 3.1.3.48)

GO Terms: GO:0004725, GO:0004725, GO:0005515, GO:0005576, GO:0005886, GO:0006470, GO:0009405, GO:0052046, GO:0052083, GO:0004438

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.11 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv2234

Tuberculist Genomic Region

Rv2235 Cytochrome oxidase biogenesis protein Surf1, facilitates heme A insertion

Details for Rv2235 - Cytochrome oxidase biogenesis protein Surf1, facilitates heme A insertion

GO Terms: GO:0005618, GO:0040007, GO:0044119

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.00 | In vitro Essential: 0.10 | In vivo Essential: NA

Go to Gene Page: Rv2235

Tuberculist Genomic Region

Rv2358 Transcriptional regulator, ArsR family

Details for Rv2358 - Transcriptional regulator, ArsR family

GO Terms: GO:0010043

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.15 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv2358

Tuberculist Genomic Region

Rv2359 Zinc uptake regulation protein ZUR

Details for Rv2359 - Zinc uptake regulation protein ZUR

GO Terms: GO:0003700, GO:0005886, GO:0008270, GO:0010043, GO:0042803, GO:0045893

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.09 | In vitro Essential: NA | In vivo Essential: 0.30

Go to Gene Page: Rv2359

Tuberculist Genomic Region

Rv2372c Ribosomal RNA small subunit methyltransferase E (EC 2.1.1.-)
Rv2583c GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I

Details for Rv2583c - GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I

GO Terms: GO:0005618, GO:0005886, GO:0008728, GO:0008893, GO:0009405, GO:0015968, GO:0030145

PATRIC Pathways: Purine metabolism

Essentiality: Griffin Essential: 0.00 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv2583c

Tuberculist Genomic Region

Rv2589 Gamma-aminobutyrate:alpha-ketoglutarate aminotransferase (EC 2.6.1.19)

Details for Rv2589 - Gamma-aminobutyrate:alpha-ketoglutarate aminotransferase (EC 2.6.1.19)

GO Terms: GO:0005886

PATRIC Pathways: Alanine, aspartate and glutamate metabolism, Propanoate metabolism, Butanoate metabolism, beta-Alanine metabolism

Essentiality: Griffin Essential: 0.94 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv2589

Tuberculist Genomic Region

Displaying 1 - 1 of 1
Motif 1 Motif 2
e-value: 0.019 e-value: 0.93
Displaying 1 - 1 of 1
Module GO Term Enrichment Descriptions
GO:0034645 | GO:0009059 | GO:0043170 | GO:0005737 cellular macromolecule biosynthetic proc... | macromolecule biosynthetic process | macromolecule metabolic process | cytoplasm
Displaying 1 - 50 of 50
GO:0008150 |

biological_process

GO:0005576 |

extracellular region

GO:0009405 |

pathogenesis

GO:0018106 |

peptidyl-histidine phosphorylation

GO:0046777 |

protein autophosphorylation

GO:0001899 |

negative regulation of cytolysis by symbiont of host cells

GO:0004674 |

protein serine/threonine kinase activity

GO:0005515 |

protein binding

GO:0005829 |

cytosol

GO:0005886 |

plasma membrane

GO:0006538 |

glutamate catabolic process

GO:0006543 |

glutamine catabolic process

GO:0040007 |

growth

GO:0044413 |

avoidance of host defenses

GO:0052027 |

modulation by symbiont of host signal transduction pathway

GO:0052190 |

modulation by symbiont of host phagocytosis

GO:0052369 |

positive regulation by symbiont of defense-related host reactive oxygen species production

GO:0005887 |

integral to plasma membrane

GO:0008375 |

acetylglucosaminyltransferase activity

GO:0010125 |

mycothiol biosynthetic process

GO:0004516 |

nicotinate phosphoribosyltransferase activity

GO:0009435 |

NAD biosynthetic process

GO:0034355 |

NAD salvage

GO:0047280 |

nicotinamide phosphoribosyltransferase activity

GO:0004817 |

cysteine-tRNA ligase activity

GO:0016049 |

cell growth

GO:0035446 |

cysteine-glucosaminylinositol ligase activity

GO:0000287 |

magnesium ion binding

GO:0008441 |

3'(2'),5'-bisphosphate nucleotidase activity

GO:0008934 |

inositol monophosphate 1-phosphatase activity

GO:0030145 |

manganese ion binding

GO:0042132 |

fructose 1,6-bisphosphate 1-phosphatase activity

GO:0042803 |

protein homodimerization activity

GO:0050427 |

3'-phosphoadenosine 5'-phosphosulfate metabolic process

GO:0050897 |

cobalt ion binding

GO:0004725 |

protein tyrosine phosphatase activity

GO:0006470 |

protein dephosphorylation

GO:0052046 |

modification by symbiont of host morphology or physiology via secreted substance

GO:0052083 |

negative regulation by symbiont of host cell-mediated immune response

GO:0004438 |

phosphatidylinositol-3-phosphatase activity

GO:0005618 |

cell wall

GO:0044119 |

growth of symbiont in host cell

GO:0010043 |

response to zinc ion

GO:0003700 |

sequence-specific DNA binding transcription factor activity

GO:0008270 |

zinc ion binding

GO:0045893 |

positive regulation of transcription, DNA-dependent

GO:0008728 |

GTP diphosphokinase activity

GO:0008893 |

guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity

GO:0015968 |

stringent response